What is the Klimisch score? How is it assessed?

What is the Klimisch score? How is it assessed?

The Klimisch score is a method used to assess the reliability of toxicological and ecotoxicological studies. This method was proposed by H.J. Klimisch, M. Andreae and U. Tillmann in 1997. The Klimisch score divides studies into four categories:

Reliable (Without Restrictions): This category includes studies performed according to generally accepted test guidelines or in accordance with GLP (Good Laboratory Practice) standards.

Reliable with Restrictions: This category includes studies where the test parameters are not fully compatible but the data are acceptable.

Not Reliable: This category includes studies where there are interactions between the measurement system and the test substance or where the methods are inappropriate.

Not Assignable: This category includes studies that do not provide sufficient experimental details or are only available in brief summaries or secondary literature.

The Klimisch score is used as a standard method, especially in EU regulations (e.g. REACH Regulation)