Sodium Laurylsulfate, SDS, SLS, monododecyl sodium sulfate, sodium monolauryl sulfate, Sodium dodecyl sulfate, Sodium dodecane sulfate, 151-21-3, 12765-21-8, 12738-53-3 ,1334-67-4

Sodium Laurylsulfate, SDS, SLS, monododecyl sodium sulfate, sodium monolauryl sulfate, Sodium dodecyl sulfate, Sodium dodecane sulfate, 151-21-3, 12765-21-8, 12738-53-3 ,1334-67-4

CAS: 151-21-3;12765-21-8;12738-53-3;1334-67-4

Molecular Formula: C12H25NaO4S

Names and Identifiers

Physico-chemical Properties

Risk and Safety

Hazard Symbols	F - Flammable Xn - Harmful
Risk Codes	R11 - Highly Flammable R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	UN 2926

Upstream Downstream Industry

Nature

white or pale yellow powder or liquid, with a slightly oily odor. Soluble in water, can reduce the surface tension of aqueous solution, so that oil emulsification. It is not sensitive to alkali and hard water, and has good compatibility with anionic and non-ionic complex. This product is flammable, irritating and allergenic. Flammable in case of open flame and high heat. Toxic gases are released by thermal decomposition.

Preparation Method

obtained by sulfonation of decanediol (lauryl alcohol) with sulfur trioxide or chlorosulfonic acid, followed by alkali neutralization, bleaching and spray drying.

Standard

This product is a mixture of sodium alkyl sulfate (C12 H25 Na04 S).

Trait

• This product is white to light yellow crystal or powder; Characteristic odor.
• This product is soluble in water, almost insoluble in ether.

 Introduction

There is a special smell. Dissolved in water is an opaque solution, and the solution is neutral. Can emulsify fat. There is decomposition in hot and humid air. There's a glossy feel. 1g is dissolved in 10ml of water to form an emulsion. The surface tension of the aqueous solution is small, and it is a neutral reaction. It is partially soluble in ethanol, and almost insoluble in chloroform, ether and light petroleum. Low toxicity, half lethal dose (rat, oral) 1288mg/kg. It's irritating. Solubility: 150g/l water (20°C),75g/l ethanol (20°C)

Use

has good emulsification, foaming, penetration, decontamination and dispersion properties, good biodegradability. It is mainly used as a foaming agent for toothpaste, shampoo, etc. It can also be used as emulsifier, fire extinguishing agent, foaming agent and textile industry additives, electroplating additives, etc. The commercial product is a mixture of sodium alkyl sulfate homologs based on sodium dodecyl sulfate.

Differential diagnosis

1. identification reaction of sodium salt in aqueous solution (1-10) of this product (General rule 0301).
2. This product aqueous solution (1 - 10) plus hydrochloric acid acidification, slowly heated boiling for 20 minutes, the solution of sulfate identification reaction (General 0301).

Safety

rat oral LD50 1300mg/kg, fish semi-lethal dose (TML) 24.5 × 10-6. It has a stimulating effect on the mucosa and upper respiratory tract, and has a stimulating effect on the eyes and skin. Can cause allergic reactions in the respiratory system. Staff should be protected. Store in a cool, ventilated warehouse. Keep away from fire and heat source. Protection from direct sunlight. Keep the container sealed. Should be stored separately from the oxidant, acid, alkali.

Exam

alkalinity

take l.O g of this product, add 100ml of water to dissolve, add 2 drops of phenol red indicator solution, and titrate with hydrochloric acid titration solution (0. lm o l/L). Consumption of hydrochloric acid titration solution (0. lm o l/L) should not exceed 0. 60ml.

sodium chloride

take about 5 g of this product, weigh it accurately, add 50ml of water to dissolve it, and neutralize it with dilute nitric acid (adjust p H value to 6. 5 to 10. 5, add potassium chromate indicator solution 2 m l, with silver nitrate titration solution (0. lm o l/L) titration. Silver nitrate titration per l M
The solution (0.1 M o l/L) corresponds to 5.844 mg of NaCl.

sodium sulfate

take about l g of this product, weigh it precisely, add water 1 0 m l to dissolve, add ethanol 1 0 m l, heat to near boiling for 2 hours, take advantage of heat filtration, filter residue is washed with boiling ethanol 1 0 0 m l, then water 1 5 0 m l is added to dissolve, and the container is washed, and the aqueous solution is heated to boiling with hydrochloric acid 1 0 m l, add 25% barium chloride solution 1 0 m l, place overnight, filter, filter, filter residue with water to no longer show the reaction of the gasification product, and burn to constant weight at 500~60 0 C, the total amount of residual residue and sodium chloride should not exceed 8 .0%. '

unesterified alcohol

take about 10g of this product, weigh it accurately, add 100ml of water to dissolve, Add 10 ml of ethanol, extract with n-hexane for 3 times, 50ml each time, if necessary, add sodium chloride to assist stratification, combine n-hexane layers, wash with water for 3 times, 50ml each time, then use anhydrous sodium sulfate to dehydrate, filter, and evaporate the filtrate on a water bath, dry at 105°C for 3 0 minutes, cool, weigh: This product contains no esterified alcohol should not pass 4. 0%.

Total fermentation quantity

take about 5g of this product, precision weighing, add water 150ml to dissolve, add hydrochloric acid 50m l, slowly heat reflux for 4 hours, let cool, extract the solution with ether for 2 times, each time, the ether layers were combined, evaporated to dryness on a water bath, dried at 105 ° C. For 30 minutes, allowed to cool and weighed. The total alcohol content of this product shall not be less than 59.0%.

Heavy metals

take this product l .O g, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 20 parts per million.

 Category

pharmaceutical excipients, wetting agents and emulsifiers.

Storage

sealed storage.

Introduction

Sodium dodecyl sulfate (SDS) or Sodium lauryl sulfate SLS, NaC12H25SO4, one of the commonly used surfactants, is the main component of a detergent. Commonly used in the DNA extraction process, the protein is denatured and separated from the DNA. It is commonly misread as sodium dodecyl sulfate (SDS')(NaC12H25SO3). Sodium dodecyl sulfate (SDS) as a foaming agent is widely used in toothpaste, soap, body wash, shampoo, washing powder, and cosmetics. 95% of personal skin care products and household cleaning products contain sodium dodecyl sulfate.

Technical indicators

Physical and chemical properties

White to slightly yellow powder, with slightly special odor. Soluble in water.

sodium dodecyl sulfate is a kind of anionic surfactant, which belongs to the typical representative of sulfate surfactant, referred to AS SDS, also known AS AS, K12, coconut oil alcohol sodium sulfate, sodium lauryl sulfate, foaming agent, the goods on the market are usually white to yellowish crystalline powder, non-toxic, slightly soluble in alcohol, insoluble in chloroform, ether, soluble in water, and anion, non-ionic complex, it has good emulsifying, foaming, foaming, penetration, decontamination and dispersion properties, rich foam, fast biodegradation, but the water soluble degree is inferior to fatty alcohol polyoxyethylene ether sodium sulfate (AES).

is not sensitive to alkali and hard water, but the stability under acidic conditions is inferior to the general sulfonate, close to AES, long-term heating should not exceed 95 ℃, irritation in the surfactant belongs to the medium level, 10% solution stimulation index 3.3, higher than AES, lower than the sodium dodecyl benzene sulfonate (LAS).

toxicity LD50 was 1300mg/kg. There is no evidence to prove that this product is carcinogenic, high dose may indeed be irritating to the skin, but in the general bathroom products used as a foaming agent when the concentration is limited, and is in line with the norms of the world, so don't worry.
Sodium dodecyl sulfate is the main component of detergent. Commonly used in the DNA extraction process, the protein is denatured and separated from the DNA. It is often misread as sodium dodecylsulfonate. As a foaming agent is widely used in toothpaste, soap, bath, shampoo, washing powder, and cosmetics. 95% of personal skin care products and household cleaning products contain sodium dodecyl sulfate.

Supplementary Information

td is used as a washing and textile aid, and also used as a toothpaste foaming agent, a fire-extinguishing foam liquid, an emulsion polymerization emulsifier, an emulsifying dispersant for medicine, a cosmetic product such as a shampoo, and a wool detergent.

Use

is a white or yellowish tacky substance that is commonly used in the detergent and textile industries. It is an anionic surfactant. Soluble in water, and anionic, non-ionic complex compatibility, with good emulsification, foaming, penetration, decontamination and dispersion properties, widely used in toothpaste, shampoo, shampoo, shampoo, washing powder, liquid washing, cosmetics and plastics demoulding, lubrication and pharmaceutical, paper, building materials, chemical and other industries.

• used as detergent and textile auxiliaries, also used as toothpaste foaming agent, mine fire extinguishing agent, emulsion polymerization emulsifier, wool detergent, etc.
• used as anionic surfactant, emulsifier and foaming agent
•  GB 2760-96 for the food industry processing aids. Foaming agent; Emulsifier; Anionic surfactant. For cakes, beverages, protein, fresh fruit, fruit drinks, edible oil, etc.
• for drugs, cosmetics, synthetic resin emulsifier. Foaming agents for toothpastes, fire retardants. It is used as a detergent for fine fabrics of silk and wool. Flotation agents for metal beneficiation.
• used as washing and textile auxiliaries, also used as toothpaste foaming agent, fire foam, emulsion polymerization emulsifier, pharmaceutical emulsion dispersant, shampoo and other cosmetic products, wool detergent.
• Biochemical Analysis, electrophoresis, ion pair reagent

Production method

1, the ten diol and chlorosulfonic acid according to the molar ratio of 1:1.03 feeding, sulfonation reaction at 30-35 ℃, the formation of the sulfonic acid ester with 30% sodium hydroxide neutralization, the formation of sodium dodecyl sulfate, hydrogen peroxide bleaching, the final product was obtained by spray-drying. Feedstock consumption (kg/t) lauryl alcohol (C12>85%) 725 Solid alkali (NaOH>95%) 183 chlorosulfonic acid (>95%) 458.

2, from the ten diol and chlorosulfonic acid in 40~50 Deg C by sulfation to produce lauryl sulfate, and sodium hydroxide neutralization, bleaching, sedimentation, spray drying.

3. Sulfur trioxide method: the reaction apparatus was a vertical reactor. Nitrogen was passed through a gas nozzle into the reactor at 32 °c. The nitrogen flow rate was 85.9 L · min-1. At 82.7 kPa, lauryl alcohol was introduced at a flow rate of 58 g · min-1. The liquid sulfur trioxide was passed into the flash evaporator at 124.1 kPa, The Flash temperature was maintained at 100 ℃, and the flow rate of sulfur trioxide was controlled at 0.907 · h-1. The sulfated product was then rapidly quenched to 50 °c and the aging device was driven into and left for 10-20min. Finally, it was neutralized with alkali by introducing a neutralizing beaker. Neutralization temperature control at 50 deg C, when the pH value of 7~8.5 when the discharge, that is, the liquid product. Spray-drying gave a solid finished product.

chlorosulfonation method
4. Batch Method: Put the lauryl alcohol into the reaction kettle and preheat to 30 °c. Chlorosulfonic acid in an excess of 0.03 mol to the theoretical amount is then sprayed as a mist into the alcohol under high-speed stirring. The reaction temperature was controlled at 30-35 °c. After completion of the sulfation reaction, it is neutralized to a pH of 7 to 30% with 8.5 alkali solution in a neutralization pot. Finally, 0.4% (mass) of hydrogen peroxide was used for bleaching. Spray-drying gave a solid. Can also be prepared according to the quality standard solution.

5. Continuous process: the reaction apparatus was a tubular reactor. Lauryl alcohol was first saturated with hydrogen chloride. Lauryl alcohol was passed through the meter into the saturation chamber at a flow rate of 334 g · min-1 and hydrogen chloride at a flow rate of 40.5g · min-1. A solution of lauryl alcohol in hydrogen chloride was then passed into the reactor at 21.4 °c for reaction with chlorosulfonic acid. After gas-liquid separation of the reactants, The sulfated product flows from the bottom of the separator into the neutralization kettle. The liquid product was neutralized with 30% sodium hydroxide at 50 °c. Spray-drying gave a solid product.

Carcinogenicity

This ingredient has been suspected to be a carcinogen for some time, and The Cosme, tend, and Fraud Association is therefore publicly available on its official website (www.ctfa.org). To clarify, there is currently no evidence that this component causes cancer. The American Cancer Society also says so. High doses of this substance may indeed be irritating to the skin, however its use as a foaming agent in general bathroom products is of limited concentration and is in accordance with the norms of all countries of the world.

Hazards and protection

hazard

• the physical properties and health hazards of sodium dodecyl sulfate aqueous solution: it has a stimulating effect on the mucosa and upper respiratory tract, and has a stimulating effect on the eyes and skin. Can cause allergic reactions in the respiratory system.
• explosion hazard: This product is flammable, irritating and allergenic. Flammable in case of open flame and high heat. By high heat decomposition of toxic gases.
• harmful combustion products: carbon monoxide, carbon dioxide, sulfide, sodium oxide.

contact treatment

• Skin Contact: remove contaminated clothing and rinse with plenty of running water.
• eye contact: lift the eyelid and rinse with running water or normal saline. The patient visited hospital.
• inhalation: leave the site to fresh air. Such as Dyspnea, to the delivery of oxygen. The patient visited hospital.
• ingestion: drink enough warm water to induce vomiting. The patient visited hospital.
• fire extinguishing method: fire-fighting personnel shall wear gas masks and full-body fire-fighting suits, and fire-fighting in the upward wind direction. Fire extinguishing agents: water mist, foam, dry powder, carbon dioxide, sand.

Emergency response and safety

sodium dodecyl sulfate-emergency treatment

Isolation leakage of contaminated area, restricted access. Cut off the fire source. Emergency personnel are advised to wear dust masks (full face mask) and anti-virus clothing. Avoid dust, sweep up carefully, put in the bag and transfer to a safe place. If there is a large amount of leakage, cover with plastic cloth and canvas. Collection and recovery or transport to waste disposal sites for disposal.

sodium dodecyl sulfate-safe operation

closed operation, strengthen ventilation. Operators must be specially trained and strictly follow the operating procedures. It is recommended that operators wear self-priming filter type dust masks, chemical safety glasses, anti-virus penetration work clothes and rubber gloves. Stay away from fire and heat source. No smoking is allowed in the workplace. The use of explosion-proof ventilation systems and equipment. Dust should be avoided. Avoid contact with oxidizing agents. Handling should be light and light unloading, to prevent packaging and container damage. Fire fighting equipment and emergency treatment equipment for leakage shall be provided with corresponding varieties and quantities. Harmful substances may remain in the empty container.

sodium dodecyl sulfate-safe storage

in a cool, ventilated warehouse. Keep away from fire and heat source. It should be stored separately from the oxidant, and mixed storage should not be avoided. With the corresponding varieties and quantity of fire fighting equipment. The storage area shall be provided with suitable materials for containment of the leakage.

sodium dodecyl sulfate-safety

engineering control: the production process is closed and the ventilation is strengthened.
Respiratory system protection: When the dust concentration in the air exceeds the standard, the self-suction filter dust mask must be worn. Air respirators should be worn during emergency rescue or evacuation.
Eye protection: wear chemical safety glasses.
Body Protection: wear anti-virus penetration work clothes.
Hand Protection: wear rubber gloves.
Other Protection: change work clothes in time. Maintain good hygiene practices.

Storage characteristics

Store at RT.

solid products: storage in a cool and dry place to prevent moisture and heat;

liquid product: prevent squeezing

[precautions for storage] store in a cool and ventilated warehouse. Keep away from fire and heat source. It should be stored separately from the oxidant, and mixed storage should not be avoided. With the corresponding varieties and quantity of fire fighting equipment. The storage area shall be provided with suitable materials for containment of the leakage.

Contact control/personal protection