Levome Folate Clacium, , Calcium L-5-Methyl tetra hydro folate, Calcium L Methyl Tetrahydrofolate, L-Methylfolate calcium, Calcium levome folate, METHYL FOLATE CALCIUM SALT, 151533-22-1

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Calcium L-5-Methyl tetra hydro folate, Calcium L Methyl Tetrahydrofolate, L-Methylfolate calcium, Calcium levome folate, METHYL FOLATE CALCIUM SALT, 151533-22-1

Chemical and Physical Properties

Chemical Formula: C₂₀H₂₃CaN₇O₆ (anhydrous form)
Molecular Weight: 497.5 g/mol (anhydrous form)
CAS Number: 151533-22-1
Appearance: White to light yellow, nearly odorless crystalline powder
Solubility: Slightly soluble in water, very slightly soluble or insoluble in most organic solvents; soluble in alkaline solutions

Uses

Dietary Supplement: Used in dietary supplements, special dietary foods, and other foods as a replacement for folic acid.
Medical Applications: Used in the treatment of megaloblastic anemia due to folic acid deficiency.

Other Names

L-5-Methyltetrahydrofolic acid, calcium salt
L-Methyltetrahydrofolate, calcium salt
L-Methylfolate, calcium
L-5-MTHF-Ca

L-5-Methyltetrahydrofolate calcium

Molecular Formula: C20H27CaN7O6

Names and Identifiers

Name	L-5-Methyltetrahydrofolate calcium
Synonyms	L-5-MTHF-Ca Calcium levomefolate L-5- Methyl leucovorin L-Methylfolate, calcium CALCIUML-5-METHYLTETRAHYDROFOLATE L-5-Methyltetrahydrofolate calcium L-5-Methyltetrahydrofolate calcium L-Methyltetrahydrofolate, calcium salt METHYL FOLATE CALCIUM SALT (METAFOLIN)(P) L-5-Methyltetrahydrofolic acid, calcium salt Calcium (S)-2-(4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino (S)-2-(4-((((S)-2-AMino-5-Methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid, calciuM salt
CAS	151533-22-1
EINECS	691-636-3
InChI	InChI=1/C20H25N7O6.Ca/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29;/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31);/q;+2/p-2/t12-,13-;/m0./s1

Physico-chemical Properties

Molecular Formula	C20H27CaN7O6
Molar Mass	501.56
Melting Point	>300°C
Solubility	Aqueous Acid (Heated), Water (Slightly, Heated)
Appearance	Solid
Color	Off-White to Light Yellow
Storage Condition	Inert atmosphere,2-8°C

Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29339900

Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.01 ml	10.05 ml	20.1 ml
5 mM	0.402 ml	2.01 ml	4.02 ml
10 mM	0.201 ml	1.005 ml	2.01 ml
5 mM	0.04 ml	0.201 ml	0.402 ml

Reference Information

introduction	this product is a calcium salt of L-5-methyltetrahydrofolic acid, which belongs to folic acid family vitamins (vitamin B9, folic acid), which is a coenzyme form of folic acid. l-5-methyltetrahydrofolate calcium (5-mthf) is a naturally occurring salt-forming methyl derivative form of folic acid. 5-mthf is also called L-methylfolic acid. It is the most biologically active and functional form of folic acid and is easier to absorb than ordinary folic acid.
function	lack of folic acid will reduce the ability of cells to synthesize and repair DNA. folic acid supplementation may be a more favorable method to increase folic acid to reduce homocysteine levels and support normal cell proliferation and vascular endothelial function. Cardiovascular diseases, nervous system function, especially 5-MTHF supplementation during pregnancy have been shown to reduce the risk of neural tube defects and recurrence.
Metabolic pathway	The two main metabolic pathways that ordinary folic acid must be converted to l-type methylfolic acid to participate in: methylation process and dna synthesis, which usually appear in human plasma and The only form of free folic acid in cells is 5-mthf. Lack of folic acid is usually due to insufficient absorption due to vitamin deficiency. During pregnancy and breastfeeding, the need for folic acid is increased during the growth of children. Under the influence of absorption or metabolic changes or drugs, the dosage provided by eating folic acid-rich foods cannot be guaranteed, so it needs to be given. supplement.
Mechanism of Action	Bioactive folic acid in biochemical pathway involves a series of enzymatic reactions and cofactors. Absorbed folic acid is reduced and methylated to 5-MTHF during the metabolism of intestinal mucosal cells over . This transition is limited and does not alter the presence of folic acid in the blood circulation, and the dialine is subsequently converted to s adenosylmethionine (SAMe), a methyl donor involved in a number of biochemical processes. It can also be used as a donor to participate in the synthesis of nucleotides and support biosynthetic DNA.
biological activity	Levomefolate calcium is an artificial form of folic acid and has an anti-folic acid effect.