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Send EmailCalcium Hydrogen Phosphate, Dicalcium Phosphate, Calcium Orthophosphate, E341ii, 7757-93-9, 7789-77-7, 10031-30-8, 7758-87-4
CALCIUM HYDROGEN PHOSPHATE – KALSIYUM HİDROJEN FOSFAT
CAS Number: 7757-93-9 (Anhydrous), 7789-77-7 (Dihydrate), 10031-30-8 (Monohydrate)
EC Number (EINECS): 231-826-1 (Anhydrous)
Molecular Formula: CaHPO₄ (Anhydrous), CaHPO₄·2H₂O (Dihydrate)
Molecular Weight: 136.06 g/mol (Anhydrous), 172.09 g/mol (Dihydrate)
E Number: E341(ii)
SECTION 1: CHEMICAL IDENTITY AND DEFINITION
| Parameter | Information |
|---|---|
| Chemical Name (IUPAC) | Calcium hydrogen phosphate |
| Other Names | Dibasic Calcium Phosphate, Dicalcium Phosphate, Calcium Orthophosphate, Phosphoric Acid Calcium Salt (1:1) |
| Chemical Formula (Anhydrous) | CaHPO₄ |
| Chemical Formula (Dihydrate) | CaHPO₄·2H₂O |
| Molecular Weight (Anhydrous) | 136.06 g/mol |
| Molecular Weight (Dihydrate) | 172.09 g/mol |
| CAS Number (Anhydrous) | 7757-93-9 |
| CAS Number (Dihydrate) | 7789-77-7 |
| CAS Number (Monohydrate) | 10031-30-8 |
| EC Number (EINECS) | 231-826-1 |
| E Number | E341(ii) (Food additive) |
| Chemical Class | Inorganic calcium salt (phosphate) |
| Appearance | White, crystalline powder |
| Odor | Odorless |
| Physical State (20°C) | Solid (powder) |
SECTION 2: PHYSICAL PROPERTIES
| Property | Anhydrous (7757-93-9) | Dihydrate (7789-77-7) |
|---|---|---|
| Appearance | White, crystalline powder | White, crystalline powder |
| Molecular Weight | 136.06 g/mol | 172.09 g/mol |
| Density (20°C) | 2.89 g/cm³ | 2.31 g/cm³ |
| Melting Point | ~370°C (decomposes) | ~100°C (loses water) |
| Solubility in Water (20°C) | Slightly soluble (~0.5 g/L) | Slightly soluble |
| Solubility in Dilute Acids | Soluble | Soluble |
| pH (suspension) | 6.0 – 7.5 | 6.0 – 7.5 |
| Calcium Content (Anhydrous) | ~29.5% | ~23.3% |
SECTION 3: FORMS OF CALCIUM HYDROGEN PHOSPHATE
| Form | CAS Number | Formula | Molecular Weight | Description |
|---|---|---|---|---|
| Anhydrous | 7757-93-9 | CaHPO₄ | 136.06 g/mol | Most common form; pharmaceutical filler, food additive |
| Dihydrate (Brushite) | 7789-77-7 | CaHPO₄·2H₂O | 172.09 g/mol | Less stable; dental/bone mineralization studies |
| Monohydrate | 10031-30-8 | CaHPO₄·H₂O | 154.08 g/mol | Rare; some pharmaceutical applications |
| Tribasic | 7758-87-4 | Ca₃(PO₄)₂ | 310.18 g/mol | Different phosphate salt; often confused |
SECTION 4: CHEMICAL PROPERTIES
| Property | Information |
|---|---|
| Chemical Formula (Anhydrous) | CaHPO₄ |
| Molecular Weight (Anhydrous) | 136.06 g/mol |
| Chemical Class | Inorganic calcium salt (phosphate) |
| Structure | Calcium ion and hydrogen phosphate anion |
| Calcium Content (Anhydrous) | ~29.5% |
| Phosphorus Content (Anhydrous) | ~22.8% |
| pH (suspension) | 6.0 – 7.5 |
| Stability | Stable under normal storage conditions |
| Thermal Decomposition | Decomposes at 370°C; forms calcium pyrophosphate |
| Incompatible Materials | Strong acids, strong bases |
SECTION 5: APPLICATION AREAS
5.1. Food Industry (E341(ii))
| Application | Function |
|---|---|
| Food Additive | Calcium source, acidity regulator |
| Dietary Supplements | Calcium and phosphorus source |
| Cereals | Calcium fortification |
| Infant Formulas | Calcium source |
| Flour and Bakery | Dough conditioner |
| Dairy Products | Stabilizer |
5.2. Pharmaceutical Applications
| Application | Function |
|---|---|
| Tablet Filler | Filler in tablet production |
| Dietary Supplements | Calcium and phosphorus source |
| Antacids | Excipient |
| Bone and Dental Research | Mineralization studies |
5.3. Toothpaste
| Application | Function |
|---|---|
| Polishing Agent | Abrasive in toothpaste formulations |
| Dental Health | Enamel remineralization |
5.4. Animal Feed
| Application | Function |
|---|---|
| Animal Feed Additive | Calcium and phosphorus source |
| Poultry Feed | Bone and eggshell health |
| Cattle Feed | Mineral supplementation |
5.5. Industrial Applications
| Application | Function |
|---|---|
| Fertilizers | Phosphorus source |
| Ceramics | Raw material |
SECTION 6: QUALITY SPECIFICATIONS (FOOD/PHARMACEUTICAL GRADE)
| Parameter | Specification (USP / Ph. Eur. / FCC) |
|---|---|
| Appearance | White, crystalline powder |
| Identification | Positive (Calcium and Phosphate tests) |
| Assay (CaHPO₄) | 98.0 – 103.0% |
| Loss on Drying (Anhydrous) | ≤ 1.0% |
| Loss on Drying (Dihydrate) | 18.0 – 23.0% |
| Residue on Ignition | ≤ 1.0% |
| pH (suspension) | 6.0 – 7.5 |
| Chlorides (Cl) | ≤ 0.02% |
| Sulfates (SO₄) | ≤ 0.02% |
| Heavy Metals (as Pb) | ≤ 10 ppm |
| Lead (Pb) | ≤ 2 ppm |
| Arsenic (As) | ≤ 3 ppm |
| Mercury (Hg) | ≤ 1 ppm |
| Cadmium (Cd) | ≤ 1 ppm |
| Barium (Ba) | ≤ 0.01% |
| Iron (Fe) | ≤ 0.02% |
| Water Insoluble | ≤ 0.2% |
SECTION 7: MICROBIOLOGICAL SPECIFICATIONS
| Parameter | Specification |
|---|---|
| Total Aerobic Mesophilic Bacteria | ≤ 1,000 CFU/g |
| Yeast and Mold | ≤ 100 CFU/g |
| Salmonella spp. | Negative in 25g |
| Escherichia coli | Negative in 10g |
SECTION 8: STORAGE AND SHELF LIFE
| Parameter | Information |
|---|---|
| Storage Conditions | Cool (15-25°C), dry, well-ventilated area |
| Container Requirements | Tightly closed, original packaging |
| Protect From | Moisture, strong acids, strong bases |
| Shelf Life | 36-60 months (unopened original packaging) |
SECTION 9: PACKAGING OPTIONS
| Packaging Type | Quantity | Material |
|---|---|---|
| PE-lined kraft paper bag | 25 kg | Kraft paper + PE |
| Plastic pail | 20-25 kg | HDPE |
| Fiber drum | 25-50 kg | HDPE + PE |
| Big-Bag | 500-1000 kg | Polypropylene (with PE liner) |
SECTION 10: SAFETY AND HEALTH INFORMATION
GHS Classification (Bulk Powder)
| Hazard Class | Category |
|---|---|
| Not classified as hazardous | - |
Hazard Statements
| Code | Statement |
|---|---|
| None | Not classified as hazardous |
Precautionary Statements
| Code | Statement |
|---|---|
| P261 | Avoid breathing dust |
| P280 | Wear protective gloves/eye protection |
| P305+P351+P338 | IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing |
SECTION 11: TOXICOLOGICAL INFORMATION
| Parameter | Value |
|---|---|
| Oral LD50 (Rat) | > 5,000 mg/kg |
| Skin Irritation | Non-irritant |
| Eye Irritation | Mild irritant |
| Skin Sensitization | Non-sensitizer |
| Carcinogenicity | Not classified |
| Mutagenicity | Negative in standard tests |
| FDA GRAS | 21 CFR 182.1217 |
SECTION 12: FIRST AID MEASURES
| Exposure Route | Action |
|---|---|
| Inhalation | Move to fresh air. If respiratory irritation persists, seek medical attention. |
| Skin Contact | Wash with plenty of soap and water. |
| Eye Contact | Rinse immediately with plenty of water for at least 15 minutes. Seek medical attention. |
| Ingestion | Rinse mouth. Drink plenty of water. Seek medical attention. |
SECTION 13: REGULATORY STATUS
| Region / Authority | Status |
|---|---|
| European Union | Approved as E341(ii) |
| USA (FDA) | GRAS (21 CFR 182.1217) |
| Turkey | Approved (Turkish Food Codex) |
| JECFA (FAO/WHO) | Approved; ADI: Not specified |
| Codex Alimentarius | Approved (INS 341(ii)) |
| USP | Monograph available |
| Ph. Eur. | Monograph available |
SECTION 14: TRANSPORT INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not regulated (not dangerous goods) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| ADR/RID | Not regulated |
| IMDG Code | Not regulated |
| IATA (Air) | Not regulated |
| Marine Pollutant | No |
SECTION 15: FIRE-FIGHTING MEASURES
| Parameter | Information |
|---|---|
| Fire Hazard | Non-combustible (inorganic salt) |
| Suitable Extinguishing Media | Water spray (mist), CO₂, dry chemical powder |
| Specific Hazards | When heated, emits calcium oxide and phosphorus oxide fumes |
| Decomposition Products | CaO, P₂O₅ |
| Protective Equipment | Self-contained breathing apparatus (SCBA), full protective clothing |
SECTION 16: ACCIDENTAL SPILLAGE AND CLEANUP
| Parameter | Information |
|---|---|
| Personal Protection | Nitrile gloves, protective goggles, dust mask (N95) |
| Cleaning Methods | Sweep or vacuum; avoid dust generation |
| Environmental Precautions | Prevent entry into drains, soil, and surface waters |
| Waste Disposal | According to local regulations; landfilling at licensed facilities |
SECTION 17: OTHER NAMES AND SYNONYMS
| Type | Name |
|---|---|
| Turkish Names | Kalsiyum Hidrojen Fosfat, Dibazik Kalsiyum Fosfat, Dikalsiyum Fosfat |
| English Names | Calcium Hydrogen Phosphate, Dicalcium Phosphate, Dibasic Calcium Phosphate |
| Chemical Names | Calcium Orthophosphate, Phosphoric Acid Calcium Salt (1:1) |
| E Number | E341(ii) |
| CAS (Anhydrous) | 7757-93-9 |
| CAS (Dihydrate) | 7789-77-7 |
| CAS (Monohydrate) | 10031-30-8 |
| EC Number | 231-826-1 |
SECTION 18: SUMMARY AND CRITICAL NOTES
Product Summary
| Parameter | Value |
|---|---|
| Product | Calcium Hydrogen Phosphate (Dibasic Calcium Phosphate) |
| CAS Number (Anhydrous) | 7757-93-9 |
| E Number | E341(ii) |
| Appearance | White, crystalline powder |
| Molecular Weight | 136.06 g/mol |
| Primary Function | Calcium source, filler |
| GRAS | Yes |
Critical Notes
-
Multiple Forms: Available as anhydrous (7757-93-9), dihydrate (7789-77-7), and monohydrate (10031-30-8).
-
Most Common Form: Anhydrous form (CAS 7757-93-9) is the most widely used form.
-
Food Additive (E341(ii)): Used as calcium source and acidity regulator in the food industry.
-
Tablet Filler: Widely used as filler in pharmaceutical tablets.
-
Toothpaste: Used as polishing agent in toothpaste formulations.
-
Animal Feed: Used as calcium and phosphorus source in animal feed.
-
Slightly Soluble: Slightly soluble in water; soluble in dilute acids.
-
Calcium Content: Anhydrous form contains ~29.5% calcium.
-
FDA GRAS: Approved as GRAS by FDA (21 CFR 182.1217).
-
Regulatory Status: Approved in EU (E341(ii)), FDA, JECFA, and Turkish Food Codex.
IMPORTANT DECLARATION: This Technical Data Sheet (TDS) is for informational purposes only and has been prepared based on available technical data. The user is responsible for determining the product's suitability for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, use, transport, waste, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier.
