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Send EmailAmmonium Acetate, Ammonium Ethanoate, 631-61-8
AMMONIUM ACETATE – AMONYUM ASETAT
CAS Number: 631-61-8
EC Number (EINECS): 211-162-9
Molecular Formula: CH₃COONH₄
Molecular Weight: 77.08 g/mol
Chemical Class: Inorganic ammonium salt (acetate)
SECTION 1: CHEMICAL IDENTITY AND DEFINITION
| Parameter | Information |
|---|---|
| Chemical Name (IUPAC) | Ammonium acetate |
| Other Names | Ammonium Ethanoate, Acetic Acid Ammonium Salt, Ammonium Acetate Buffer |
| Chemical Formula | CH₃COONH₄ |
| Molecular Weight | 77.08 g/mol |
| CAS Number | 631-61-8 |
| EC Number (EINECS) | 211-162-9 |
| Chemical Class | Inorganic ammonium salt (acetate) |
| Appearance | White, hygroscopic, crystalline solid |
| Odor | Slight acetic acid odor (when moist) |
| Physical State (20°C) | Solid (crystalline) |
| Hygroscopicity | High (deliquescent) |
SECTION 2: PHYSICAL PROPERTIES
| Property | Value |
|---|---|
| Appearance | White, hygroscopic, crystalline solid |
| Odor | Slight acetic acid odor (when moist) |
| Molecular Weight | 77.08 g/mol |
| Density (20°C) | 1.17 g/cm³ |
| Melting Point | 114 °C |
| Boiling Point | 117 °C (decomposes to acetamide) |
| Solubility in Water (20°C) | Highly soluble (~1,480 g/L) |
| Solubility in Water (100°C) | Very highly soluble |
| Solubility in Ethanol | Soluble |
| Solubility in Acetone | Slightly soluble |
| pH (5% solution) | 6.0 – 7.5 (neutral to slightly acidic) |
| Hygroscopicity | High (deliquescent) |
| Vapor Pressure | Low |
SECTION 3: CHEMICAL PROPERTIES
| Property | Information |
|---|---|
| Chemical Formula | CH₃COONH₄ |
| Molecular Weight | 77.08 g/mol |
| Chemical Class | Inorganic ammonium salt (acetate) |
| Structure | Ammonium cation (NH₄⁺) and acetate anion (CH₃COO⁻) |
| pH (5% solution) | 6.0 – 7.5 (neutral to slightly acidic) |
| Stability | Stable under normal storage conditions |
| Thermal Decomposition | Heated above 117°C → Acetamide (CH₃CONH₂) |
| Hygroscopicity | High (deliquescent) |
| Incompatible Materials | Strong oxidizing agents, strong acids, strong bases |
Chemical Structure:
CH₃COONH₄
Ammonium Acetate / Ammonium Ethanoate
SECTION 4: EQUILIBRIUM IN SOLUTION
| Equilibrium | Description |
|---|---|
| CH₃COONH₄ ⇌ CH₃COO⁻ + NH₄⁺ | Dissociation in water |
| NH₄⁺ ⇌ NH₃ + H⁺ | Ammonium acts as weak acid |
| CH₃COO⁻ + H₂O ⇌ CH₃COOH + OH⁻ | Acetate acts as weak base |
| Buffer System | CH₃COOH/CH₃COO⁻ + NH₄⁺/NH₃ (pH ~7) |
| pH | Near neutral (~7) due to weak acid/weak base salt |
SECTION 5: APPLICATION AREAS
5.1. Laboratory and Analytical Chemistry
| Application | Function |
|---|---|
| Buffer Solutions | Widely used in biochemical and molecular biology applications |
| Protein Precipitation | Removal of proteins from solutions |
| DNA/RNA Extraction | Salt for nucleic acid precipitation |
| HPLC and LC-MS | Volatile buffer for mass spectrometry |
| pH Adjustment | Preparation of neutral pH buffers |
5.2. Food Industry
| Application | Function |
|---|---|
| Food Additive | Acidity regulator, preservative |
| Flavor Enhancer | Flavor enhancement in certain foods |
| Meat Products | Preservative and flavor enhancer |
5.3. Pharmaceutical Applications
| Application | Function |
|---|---|
| Drug Formulation | Excipient in pharmaceutical preparations |
| Diuretic | Historical use as a diuretic |
| Analgesic | Historical use in some formulations |
5.4. Industrial Applications
| Application | Function |
|---|---|
| Textile Dyeing | Mordant and dyeing aid |
| Rubber Industry | Accelerator in rubber vulcanization |
| Chemical Synthesis | Precursor for other ammonium compounds |
| Leather Processing | Tanning and finishing agent |
SECTION 6: QUALITY SPECIFICATIONS (ANALYTICAL GRADE)
| Parameter | Specification (ACS / USP / Ph. Eur.) |
|---|---|
| Appearance | White, hygroscopic crystalline solid |
| Identification | Positive (Ammonium and Acetate tests) |
| Assay (CH₃COONH₄) | 98.0 – 102.0% |
| pH (5% solution) | 6.0 – 7.5 |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.01% |
| Chlorides (Cl) | ≤ 0.001% |
| Sulfates (SO₄) | ≤ 0.002% |
| Heavy Metals (as Pb) | ≤ 5 ppm |
| Lead (Pb) | ≤ 2 ppm |
| Arsenic (As) | ≤ 3 ppm |
| Iron (Fe) | ≤ 0.001% |
| Water Insoluble | ≤ 0.005% |
| Nitrates (NO₃) | ≤ 0.001% |
SECTION 7: MICROBIOLOGICAL SPECIFICATIONS
| Parameter | Specification |
|---|---|
| Total Aerobic Mesophilic Bacteria | ≤ 1,000 CFU/g |
| Yeast and Mold | ≤ 100 CFU/g |
| Salmonella spp. | Negative in 25g |
| Escherichia coli | Negative in 10g |
SECTION 8: STORAGE AND SHELF LIFE
| Parameter | Information |
|---|---|
| Storage Conditions | Cool (15-25°C), dry, well-ventilated area |
| Container Requirements | Tightly closed, original packaging (hygroscopic) |
| Protect From | Moisture (hygroscopic), heat, strong oxidizing agents, strong acids, strong bases |
| Shelf Life | 24-48 months (unopened original packaging) |
| Stability Note | Highly hygroscopic; store in airtight containers |
SECTION 9: PACKAGING OPTIONS
| Packaging Type | Quantity | Material |
|---|---|---|
| PE-lined kraft paper bag | 25 kg | Kraft paper + PE |
| Plastic pail | 20-25 kg | HDPE |
| Fiber drum | 25-50 kg | HDPE + PE |
| Glass bottle | 100-500 g | Amber glass |
| Aluminum foil bag | 1-5 kg | Laminated aluminum |
SECTION 10: SAFETY AND HEALTH INFORMATION
GHS Classification (Bulk Powder)
| Hazard Class | Category |
|---|---|
| Skin Irritation | Category 2 (H315) |
| Eye Irritation | Category 2A (H319) |
| Signal Word | Warning |
Hazard Statements (H-Codes)
| Code | Statement |
|---|---|
| H315 | Causes skin irritation |
| H319 | Causes serious eye irritation |
Precautionary Statements (P-Codes)
| Code | Statement |
|---|---|
| P261 | Avoid breathing dust |
| P280 | Wear protective gloves/eye protection |
| P302+P352 | IF ON SKIN: Wash with plenty of soap and water |
| P305+P351+P338 | IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing |
SECTION 11: TOXICOLOGICAL INFORMATION
| Parameter | Value |
|---|---|
| Oral LD50 (Rat) | ~2,500 mg/kg |
| Skin Irritation | Irritant |
| Eye Irritation | Irritant |
| Carcinogenicity | Not classified |
| Mutagenicity | Negative in standard tests |
| Target Organs | Skin, eyes, respiratory system |
SECTION 12: FIRST AID MEASURES
| Exposure Route | Action |
|---|---|
| Inhalation | Move to fresh air. If respiratory irritation persists, seek medical attention. |
| Skin Contact | Wash with plenty of soap and water. Remove contaminated clothing. |
| Eye Contact | Rinse immediately with plenty of water for at least 15 minutes. Seek medical attention. |
| Ingestion | Rinse mouth. Drink plenty of water. Seek medical attention. |
SECTION 13: REGULATORY STATUS
| Region / Authority | Status |
|---|---|
| European Union | REACH registered |
| USA (FDA) | GRAS for certain food applications |
| Turkey | Registered; subject to KKDİK regulations |
SECTION 14: TRANSPORT INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not regulated (not dangerous goods) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| ADR/RID | Not regulated |
| IMDG Code | Not regulated |
| IATA (Air) | Not regulated |
| Marine Pollutant | No |
SECTION 15: FIRE-FIGHTING MEASURES
| Parameter | Information |
|---|---|
| Fire Hazard | Combustible organic solid |
| Suitable Extinguishing Media | Water spray (mist), CO₂, dry chemical powder, alcohol-resistant foam |
| Specific Hazards | When heated, emits toxic fumes (ammonia, nitrogen oxides) |
| Decomposition Products | NH₃, NOx, CO, CO₂ |
| Protective Equipment | Self-contained breathing apparatus (SCBA), full protective clothing |
SECTION 16: ACCIDENTAL SPILLAGE AND CLEANUP
| Parameter | Information |
|---|---|
| Personal Protection | Nitrile gloves, protective goggles, dust mask (N95) |
| Cleaning Methods | Collect mechanically (sweep or spatula) |
| Environmental Precautions | Prevent entry into drains, soil, and surface waters |
| Waste Disposal | According to local regulations; incineration or landfilling at licensed facilities |
SECTION 17: OTHER NAMES AND SYNONYMS
| Type | Name |
|---|---|
| Turkish Names | Amonyum Asetat, Amonyum Etanoat |
| English Names | Ammonium Acetate, Ammonium Ethanoate |
| Chemical Names | Acetic Acid Ammonium Salt |
| CAS Number | 631-61-8 |
| EC Number | 211-162-9 |
SECTION 18: SUMMARY AND CRITICAL NOTES
Product Summary
| Parameter | Value |
|---|---|
| Product | Ammonium Acetate |
| CAS Number | 631-61-8 |
| Appearance | White, hygroscopic crystalline solid |
| Molecular Weight | 77.08 g/mol |
| Primary Function | Buffer, laboratory reagent, preservative |
| pH (5% solution) | 6.0 – 7.5 |
Critical Notes
-
Buffer Applications: Widely used as a volatile buffer in HPLC, LC-MS, and biochemical applications.
-
Highly Soluble: Very high solubility in water (~1,480 g/L).
-
Hygroscopic: Highly hygroscopic; must be stored in airtight containers.
-
Neutral pH: 5% solution has pH 6.0-7.5; acts as a neutral buffer.
-
Thermal Decomposition: Decomposes to acetamide when heated above 117°C.
-
Volatile Buffer: Used in mass spectrometry due to its volatility.
-
Food Additive: Used as a preservative and acidity regulator in certain foods.
-
DNA/RNA Precipitation: Used in nucleic acid extraction protocols.
-
High Purity: Analytical grade available for laboratory use.
-
Regulatory Status: REACH registered and FDA GRAS for certain applications.
IMPORTANT DECLARATION: This Technical Data Sheet (TDS) is for informational purposes only and has been prepared based on available technical data. The user is responsible for determining the product's suitability for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, use, transport, waste, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier.
