ADVANTAME – ADVANTAM

CAS Number: 165450-17-9
EC Number (EINECS): Not assigned
Molecular Formula: C₂₀H₃₀N₂O₅
Molecular Weight: 378.47 g/mol
E Number: E969
Chemical Class: Artificial sweetener (dipeptide derivative)

SECTION 1: CHEMICAL IDENTITY AND DEFINITION

Parameter	Information
Chemical Name (IUPAC)	N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester
Other Names	Advantame, N-(3,3-Dimethylbutyl)-L-aspartyl-L-phenylalanine 1-methyl ester, Artificial Sweetener
Chemical Formula	C₂₀H₃₀N₂O₅
Molecular Weight	378.47 g/mol
CAS Number	165450-17-9
EC Number (EINECS)	Not assigned
E Number	E969 (Artificial sweetener)
Chemical Class	Artificial sweetener (dipeptide derivative)
Appearance	White, crystalline powder
Odor	Odorless
Taste	Intensely sweet
Physical State (20°C)	Solid (crystalline powder)
Source	Synthesized from aspartame and 3,3-dimethylbutyraldehyde

SECTION 2: PHYSICAL PROPERTIES

Property	Value
Appearance	White, crystalline powder
Odor	Odorless
Taste	Intensely sweet
Molecular Weight	378.47 g/mol
Melting Point	~100-110 °C (decomposes)
Density	~1.2 g/cm³
Solubility in Water	Slightly soluble
Solubility in Ethanol	Soluble
Solubility in Methanol	Soluble
Solubility in Acetone	Slightly soluble
Sweetness (Sucrose = 100)	~7,000 – 13,000 times sweeter
Caloric Value	Negligible
Log P (octanol/water)	~2.5
Hygroscopicity	Low
Stability	Stable under normal storage conditions

SECTION 3: CHEMICAL PROPERTIES

Property	Information
Chemical Formula	C₂₀H₃₀N₂O₅
Molecular Weight	378.47 g/mol
Chemical Class	Artificial sweetener (dipeptide derivative)
Structure	Derived from aspartame with 3,3-dimethylbutyl group
Precursor	Aspartame + 3,3-dimethylbutyraldehyde
SMILES	COC(=O)C(CC1=CC=C(C=C1)OC)NC(=O)C(CC2=CC=CC=C2)NC(CCC3=CC=C(C=C3)O)(C)C
InChI Key	InChIKey=JXQXZBKOWFOPKM-UHFFFAOYSA-N
Optical Activity	L-form (natural, biologically active)
Stability	Stable under normal storage conditions
Heat Stability	Stable at high temperatures (suitable for baking)
pH Stability	Stable across a wide pH range
Incompatible Materials	Strong oxidizing agents, strong acids, strong bases

Chemical Structure:

Aspartame derivative with 3,3-dimethylbutyl group
    |
N-(3,3-Dimethylbutyl)-L-aspartyl-L-phenylalanine 1-methyl ester
    |
C₂₀H₃₀N₂O₅

SECTION 4: COMPARISON WITH OTHER SWEETENERS

Property	Advantame (E969)	Aspartame (E951)	Sucralose (E955)	Neotame (E961)
Sweetness (Sucrose=100)	7,000-13,000	200	600	7,000-13,000
Calories	Negligible	~4 kcal/g	0	0
Heat Stability	High	Low	High	High
PKU Restriction	No	Yes	No	No
Metabolism	Rapidly metabolized	Hydrolyzed to amino acids	Not metabolized	Rapidly metabolized
Aftertaste	Minimal	Slight bitter	None	Minimal
Synergy	With other sweeteners	With acesulfame K	With other sweeteners	With other sweeteners
ADI (mg/kg bw/day)	5	40	15	2

SECTION 5: MECHANISM OF ACTION

Parameter	Description
Primary Function	Artificial sweetener
Taste Perception	Binds to sweet taste receptors (T1R2/T1R3) on the tongue
Receptor Affinity	High affinity; 7,000-13,000 times sweeter than sucrose
Metabolism	Rapidly metabolized in the body
Excretion	Excreted in urine and feces
Absorption	Readily absorbed from the gastrointestinal tract
Distribution	Does not accumulate in the body

SECTION 6: METABOLISM AND EXCRETION

Parameter	Description
Absorption	Rapidly absorbed from the gastrointestinal tract
Metabolism	Rapidly metabolized via hydrolysis and oxidation
Major Metabolites	Methanol, aspartic acid, phenylalanine, 3,3-dimethylbutyraldehyde
Excretion	Urine (approximately 50%) and feces (approximately 50%)
Half-Life	Short (hours)
Accumulation	Does not accumulate in the body
PKU Safety	Does not contain phenylalanine (unlike aspartame)

SECTION 7: HEALTH BENEFITS AND APPLICATIONS

Benefit	Description
Zero Calories	Negligible caloric contribution
Weight Management	Helps reduce caloric intake
Diabetes Friendly	Does not affect blood sugar levels
Dental Health	Does not promote tooth decay
Heat Stable	Suitable for baking and cooking
PKU Safe	Safe for individuals with phenylketonuria

SECTION 8: FOOD INDUSTRY APPLICATIONS (E969)

Application	Function
Carbonated Beverages	Low-calorie sweetener
Still Drinks	Artificial sweetener
Dairy Products	Yogurt, flavored milk
Confectionery	Candies, chocolates
Bakery Products	Cakes, cookies, pastries
Tabletop Sweeteners	Powder and tablet forms
Chewing Gum	Sweetener
Ice Cream	Sweetener
Sauces and Dressings	Sweetener
Pharmaceuticals	Taste masking

SECTION 9: TYPICAL USAGE LEVELS

Application	Typical Dosage (mg/kg)
Carbonated Beverages	10-30 mg/L
Still Drinks	10-30 mg/L
Dairy Products	20-100 mg/kg
Confectionery	50-200 mg/kg
Bakery Products	50-200 mg/kg
Tabletop Sweeteners	5-20 mg/serving
Chewing Gum	100-500 mg/kg

SECTION 10: QUALITY SPECIFICATIONS (FOOD GRADE)

Parameter	Specification (FCC / JECFA)
Appearance	White, crystalline powder
Identification	Positive (HPLC, IR)
Assay (HPLC)	98.0 – 102.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
pH (1% solution)	4.5 – 6.5
Specific Rotation [α]D²⁰	-40° to -50°
Heavy Metals (as Pb)	≤ 10 ppm
Lead (Pb)	≤ 2 ppm
Arsenic (As)	≤ 3 ppm
Mercury (Hg)	≤ 1 ppm
Cadmium (Cd)	≤ 1 ppm
Related Substances	≤ 1.0%
Water Content	≤ 0.5%

SECTION 11: MICROBIOLOGICAL SPECIFICATIONS

Parameter	Specification
Total Aerobic Mesophilic Bacteria	≤ 1,000 CFU/g
Yeast and Mold	≤ 100 CFU/g
Salmonella spp.	Negative in 25g
Escherichia coli	Negative in 10g

SECTION 12: STORAGE AND SHELF LIFE

Parameter	Information
Storage Conditions	Cool (15-25°C), dry, well-ventilated area
Container Requirements	Tightly closed, original packaging
Protect From	Moisture, heat, strong oxidizing agents, strong acids, strong bases
Shelf Life	24-48 months (unopened original packaging)
Stability Note	Stable under recommended conditions

SECTION 13: PACKAGING OPTIONS

Packaging Type	Quantity	Material
Aluminum foil bag	1-5 kg	Laminated aluminum
Plastic pail	20-25 kg	HDPE
Fiber drum	25-50 kg	HDPE + PE
Glass bottle	100-500 g	Amber glass
Big-Bag	500-1000 kg	Polypropylene (with PE liner)

SECTION 14: SAFETY AND HEALTH INFORMATION

GHS Classification (Bulk Powder)

Hazard Class	Category
Not classified as hazardous	-

Hazard Statements

Code	Statement
None	Not classified as hazardous

Precautionary Statements

Code	Statement
P261	Avoid breathing dust
P280	Wear protective gloves/eye protection
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing

SECTION 15: TOXICOLOGICAL INFORMATION

Parameter	Value
Oral LD50 (Rat)	> 5,000 mg/kg
ADI (Acceptable Daily Intake)	0-5 mg/kg body weight/day (JECFA)
ADI (EFSA)	0-5 mg/kg body weight/day
ADI (FDA)	0-5 mg/kg body weight/day
Carcinogenicity	Not classified
Mutagenicity	Negative in standard tests
Reproductive Toxicity	No evidence of adverse effects
PKU Safety	Safe for PKU patients (no phenylalanine)

SECTION 16: FIRST AID MEASURES

Exposure Route	Action
Inhalation	Move to fresh air. If respiratory irritation persists, seek medical attention.
Skin Contact	Wash with plenty of soap and water.
Eye Contact	Rinse immediately with plenty of water for at least 15 minutes. Seek medical attention.
Ingestion	Rinse mouth. Drink plenty of water. Seek medical attention.

SECTION 17: REGULATORY STATUS

Region / Authority	Status
European Union	Approved as E969
USA (FDA)	Approved (2014)
Turkey	Approved (Turkish Food Codex)
JECFA (FAO/WHO)	Approved; ADI: 0-5 mg/kg bw/day
EFSA	Approved; ADI: 0-5 mg/kg bw/day
Codex Alimentarius	Approved (INS 969)
FCC	Monograph available

SECTION 18: TRANSPORT INFORMATION

Parameter	Information
UN Number	Not regulated (not dangerous goods)
Hazard Class	Not applicable
Packing Group	Not applicable
ADR/RID	Not regulated
IMDG Code	Not regulated
IATA (Air)	Not regulated
Marine Pollutant	No

SECTION 19: FIRE-FIGHTING MEASURES

Parameter	Information
Fire Hazard	Combustible organic solid
Suitable Extinguishing Media	Water spray (mist), CO₂, dry chemical powder
Specific Hazards	When heated, emits CO, CO₂, nitrogen oxides
Decomposition Products	CO, CO₂, NOx
Protective Equipment	Self-contained breathing apparatus (SCBA), full protective clothing

SECTION 20: ACCIDENTAL SPILLAGE AND CLEANUP

Parameter	Information
Personal Protection	Nitrile gloves, protective goggles, dust mask (N95)
Cleaning Methods	Collect mechanically (sweep or spatula)
Environmental Precautions	Prevent entry into drains, soil, and surface waters
Waste Disposal	According to local regulations; incineration or landfilling at licensed facilities

SECTION 21: OTHER NAMES AND SYNONYMS

Type	Name
Turkish Names	Advantam, Yapay Tatlandırıcı
English Names	Advantame, N-(3,3-Dimethylbutyl)-L-aspartyl-L-phenylalanine 1-methyl ester
Chemical Names	N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester
Abbreviation	E969
CAS Number	165450-17-9

SECTION 22: FREQUENTLY ASKED QUESTIONS

Question	Answer
Is Advantame Safe?	Yes, approved by FDA, EFSA, and JECFA at ADI of 5 mg/kg bw/day.
Is Advantame PKU Safe?	Yes, does not contain phenylalanine; safe for PKU patients.
Is Advantame Heat Stable?	Yes, stable at high temperatures; suitable for baking.
Does Advantame Have Calories?	Negligible caloric value.
Is Advantame Suitable for Diabetics?	Yes, does not affect blood sugar levels.
Is Advantame Sweeter than Aspartame?	Yes, 7,000-13,000 times sweeter than sucrose; 30-60 times sweeter than aspartame.
Is Advantame Natural?	No, it is a synthetic artificial sweetener.
Where is Advantame Used?	Beverages, dairy, confectionery, bakery, tabletop sweeteners, and pharmaceuticals.

SECTION 23: SUMMARY AND CRITICAL NOTES

Product Summary

Parameter	Value
Product	Advantame
CAS Number	165450-17-9
E Number	E969
Appearance	White, crystalline powder
Molecular Weight	378.47 g/mol
Sweetness	7,000-13,000 times sucrose
Primary Function	Artificial sweetener
ADI	0-5 mg/kg body weight/day

Critical Notes

Intensely Sweet: Advantame is 7,000-13,000 times sweeter than sucrose, making it one of the most potent sweeteners available.
Heat Stable: Stable at high temperatures; suitable for baking and cooking applications.
PKU Safe: Unlike aspartame, advantame does not contain phenylalanine; safe for PKU patients.
Aspartame Derivative: Synthesized from aspartame and 3,3-dimethylbutyraldehyde.
Rapid Metabolism: Rapidly metabolized and excreted; does not accumulate in the body.
Minimal Aftertaste: Clean sweet taste with minimal aftertaste.
Synergistic Effect: Works synergistically with other sweeteners for enhanced taste profiles.
Regulatory Status: Approved by FDA, EFSA, and JECFA.
ADI: Acceptable Daily Intake is 5 mg/kg body weight/day.
Wide Applications: Used in beverages, dairy, confectionery, bakery, tabletop sweeteners, and pharmaceuticals.

IMPORTANT DECLARATION: This Technical Data Sheet (TDS) is for informational purposes only and has been prepared based on available technical data. The user is responsible for determining the product's suitability for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, use, transport, waste, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. This document does not replace medical advice.

Advantame, Advantam, Artificial Sweetener, E969, 165450-17-9

ADVANTAME – ADVANTAM

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