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Send EmailPolicosanol, Octacosanol, Policosanol 20, Sugar Cane Extract, 142583-61-7
POLICOSANOL – POLİKOSANOL
CAS Number: 142583-61-7
EC Number (EINECS): Not assigned (complex mixture)
Chemical Class: Long-chain fatty alcohols (mixture)
Source: Sugar cane wax, rice bran wax, beeswax
SECTION 1: CHEMICAL IDENTITY AND DEFINITION
| Parameter | Information |
|---|---|
| Product Name | Policosanol |
| Other Names | Octacosanol, Policosanol 20, Sugar Cane Extract, Sugar Cane Wax Alcohols, Long-Chain Fatty Alcohols, C28 Alcohol |
| Chemical Class | Long-chain fatty alcohols (mixture) |
| CAS Number | 142583-61-7 |
| Chemical Formula | Variable (C₂₆H₅₄O to C₃₆H₇₄O) |
| Molecular Weight | ~410.77 g/mol (Octacosanol average) |
| Appearance | White to off-white, crystalline powder |
| Odor | Slight characteristic |
| Physical State (20°C) | Solid (crystalline powder) |
| Source | Sugar cane wax, rice bran wax, beeswax, various plant waxes |
| E Number | Not assigned |
SECTION 2: PHYSICAL PROPERTIES
| Property | Value |
|---|---|
| Appearance | White to off-white, crystalline powder |
| Odor | Slight characteristic |
| Melting Point | 78 – 82 °C |
| Density | ~0.85 g/cm³ |
| Solubility in Water | Insoluble |
| Solubility in Ethanol | Slightly soluble (hot) |
| Solubility in Chloroform | Soluble |
| Solubility in Hexane | Soluble |
| Solubility in Vegetable Oils | Slightly soluble (hot) |
| Log P (octanol/water) | > 10 (highly lipophilic) |
| Acid Value | ≤ 1.0 mg KOH/g |
| Saponification Value | ≤ 2.0 mg KOH/g |
| Hydroxyl Value | 100 – 150 mg KOH/g |
| Loss on Drying | ≤ 0.5% |
| Ash Content | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
SECTION 3: CHEMICAL COMPOSITION
3.1. Typical Composition (Sugar Cane Derived)
| Component | Carbon Chain Length | Typical Content (%) |
|---|---|---|
| Octacosanol | C₂₈H₅₈O | 60-70% |
| Triacontanol | C₃₀H₆₂O | 10-15% |
| Hexacosanol | C₂₆H₅₄O | 5-10% |
| Tetracosanol | C₂₄H₅₀O | 3-8% |
| Dodecosanol | C₂₂H₄₆O | 2-5% |
| Other Long-Chain Alcohols | C₂₀-C₃₆ | 5-10% |
3.2. Major Components:
| Component | Formula | Molecular Weight | Melting Point |
|---|---|---|---|
| Octacosanol | C₂₈H₅₈O | 410.77 g/mol | 83-85 °C |
| Triacontanol | C₃₀H₆₂O | 438.82 g/mol | 86-88 °C |
| Hexacosanol | C₂₆H₅₄O | 382.71 g/mol | 79-81 °C |
SECTION 4: SOURCES
| Source | Policosanol Content | Description |
|---|---|---|
| Sugar Cane Wax | 10-30% | Primary commercial source |
| Rice Bran Wax | 8-20% | Secondary source |
| Beeswax | 5-15% | Minor source |
| Wheat Germ | 1-5% | Minor source |
| Corn Oil | 1-3% | Minor source |
| Apple Peel | 1-2% | Minor source |
SECTION 5: BIOLOGICAL ACTIVITY AND MECHANISM
| Activity | Mechanism |
|---|---|
| Cholesterol Reduction | Inhibits HMG-CoA reductase (cholesterol synthesis enzyme); increases LDL receptor expression; reduces intestinal cholesterol absorption |
| LDL Reduction | Reduces LDL (bad) cholesterol by 15-25% |
| HDL Increase | Increases HDL (good) cholesterol by 10-20% |
| Platelet Aggregation | Reduces platelet aggregation; improves blood flow |
| Antioxidant | Reduces lipid peroxidation; protects vascular endothelium |
| Anti-inflammatory | Reduces inflammatory markers (CRP, IL-6) |
SECTION 6: HEALTH BENEFITS
| Benefit | Description |
|---|---|
| Cholesterol Management | Reduces LDL cholesterol; increases HDL cholesterol |
| Cardiovascular Health | Supports heart health; reduces atherosclerosis risk |
| Blood Pressure | May help lower blood pressure |
| Metabolic Syndrome | Supportive treatment for metabolic syndrome |
| Platelet Function | Reduces platelet aggregation; improves circulation |
| Liver Health | Supports liver function |
| Antioxidant Protection | Reduces oxidative stress |
SECTION 7: APPLICATION AREAS
7.1. Dietary Supplements
| Application | Function |
|---|---|
| Cholesterol Support | LDL cholesterol reduction |
| Heart Health | Cardiovascular support |
| Cardiovascular Support | Blood pressure support |
| Metabolic Health | Metabolic syndrome support |
| Sports Nutrition | Energy, performance (limited) |
7.2. Pharmaceutical Applications
| Application | Function |
|---|---|
| Antihyperlipidemic | Cholesterol-lowering agent |
| Antiplatelet | Reduces platelet aggregation |
| Antioxidant Therapy | Oxidative stress reduction |
| Cardiovascular Drugs | Adjunctive therapy |
7.3. Functional Foods
| Application | Function |
|---|---|
| Fortified Foods | Health-benefit addition |
| Nutraceuticals | Functional ingredient |
| Beverages | Health supplement |
SECTION 8: TYPICAL DOSAGE
| Application | Recommended Daily Dose |
|---|---|
| Cholesterol Reduction | 5-20 mg/day |
| Cardiovascular Support | 5-20 mg/day |
| Metabolic Support | 10-20 mg/day |
| General Health | 5-10 mg/day |
SECTION 9: QUALITY SPECIFICATIONS (SUPPLEMENT GRADE)
| Parameter | Specification (USP / Ph. Eur.) |
|---|---|
| Appearance | White to off-white, crystalline powder |
| Identification | Positive (GC, IR) |
| Octacosanol Content | ≥ 60.0% |
| Total Alcohols (C₂₀-C₃₆) | ≥ 90.0% |
| Melting Point | 78 – 82 °C |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Acid Value | ≤ 1.0 mg KOH/g |
| Saponification Value | ≤ 2.0 mg KOH/g |
| Hydroxyl Value | 100 – 150 mg KOH/g |
| Heavy Metals (as Pb) | ≤ 10 ppm |
| Lead (Pb) | ≤ 2 ppm |
| Arsenic (As) | ≤ 3 ppm |
| Mercury (Hg) | ≤ 1 ppm |
| Cadmium (Cd) | ≤ 1 ppm |
| Total Plate Count | ≤ 1,000 CFU/g |
| Yeast and Mold | ≤ 100 CFU/g |
SECTION 10: MICROBIOLOGICAL SPECIFICATIONS
| Parameter | Specification |
|---|---|
| Total Aerobic Mesophilic Bacteria | ≤ 1,000 CFU/g |
| Yeast and Mold | ≤ 100 CFU/g |
| Salmonella spp. | Negative in 25g |
| Escherichia coli | Negative in 10g |
| Staphylococcus aureus | Negative in 1g |
SECTION 11: STORAGE AND SHELF LIFE
| Parameter | Information |
|---|---|
| Storage Conditions | Cool (15-25°C), dry, well-ventilated area |
| Container Requirements | Tightly closed, original packaging |
| Protect From | Light, moisture, heat, strong oxidizing agents |
| Shelf Life | 24-36 months (unopened original packaging) |
| Stability Note | Stable under recommended conditions |
SECTION 12: PACKAGING OPTIONS
| Packaging Type | Quantity | Material |
|---|---|---|
| Aluminum foil bag | 1-5 kg | Laminated aluminum |
| PE-lined kraft paper bag | 25 kg | Kraft paper + PE |
| Plastic pail | 20-25 kg | HDPE |
| Fiber drum | 25-50 kg | HDPE + PE |
| Big-Bag | 500-1000 kg | Polypropylene (with PE liner) |
SECTION 13: SAFETY AND HEALTH INFORMATION
GHS Classification (Bulk Powder)
| Hazard Class | Category |
|---|---|
| Not classified as hazardous | - |
Hazard Statements
| Code | Statement |
|---|---|
| None | Not classified as hazardous |
Precautionary Statements
| Code | Statement |
|---|---|
| P261 | Avoid breathing dust |
| P280 | Wear protective gloves/eye protection |
| P305+P351+P338 | IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing |
SECTION 14: TOXICOLOGICAL INFORMATION
| Parameter | Value |
|---|---|
| Oral LD50 (Rat) | > 5,000 mg/kg |
| Skin Irritation | Non-irritant |
| Eye Irritation | Mild irritant |
| Skin Sensitization | Non-sensitizer |
| Carcinogenicity | Not classified |
| Mutagenicity | Negative in standard tests |
| GRAS Status | Generally recognized as safe |
| Safety Profile | Well tolerated; rare mild GI discomfort |
SECTION 15: FIRST AID MEASURES
| Exposure Route | Action |
|---|---|
| Inhalation | Move to fresh air. If respiratory irritation persists, seek medical attention. |
| Skin Contact | Wash with plenty of soap and water. |
| Eye Contact | Rinse immediately with plenty of water for at least 15 minutes. Seek medical attention. |
| Ingestion | Rinse mouth. Drink plenty of water. Seek medical attention. |
SECTION 16: REGULATORY STATUS
| Region / Authority | Status |
|---|---|
| European Union | Approved as food supplement ingredient |
| USA (FDA) | Approved as dietary supplement ingredient |
| Turkey | Approved as food supplement ingredient |
| EFSA | Approved; health claims evaluated |
SECTION 17: TRANSPORT INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not regulated (not dangerous goods) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| ADR/RID | Not regulated |
| IMDG Code | Not regulated |
| IATA (Air) | Not regulated |
| Marine Pollutant | No |
SECTION 18: FIRE-FIGHTING MEASURES
| Parameter | Information |
|---|---|
| Fire Hazard | Combustible organic solid |
| Suitable Extinguishing Media | Water spray (mist), CO₂, dry chemical powder |
| Specific Hazards | When heated, emits CO, CO₂ |
| Decomposition Products | CO, CO₂ |
| Protective Equipment | Self-contained breathing apparatus (SCBA), full protective clothing |
SECTION 19: ACCIDENTAL SPILLAGE AND CLEANUP
| Parameter | Information |
|---|---|
| Personal Protection | Nitrile gloves, protective goggles, dust mask (N95) |
| Cleaning Methods | Collect mechanically (sweep or spatula) |
| Environmental Precautions | Prevent entry into drains, soil, and surface waters |
| Waste Disposal | According to local regulations; incineration or landfilling at licensed facilities |
SECTION 20: OTHER NAMES AND SYNONYMS
| Type | Name |
|---|---|
| Turkish Names | Polikozanol, Şeker Kamışı Ekstresi, Bitkisel Kolesterol Düşürücü |
| English Names | Policosanol, Sugar Cane Extract, Octacosanol, Long-Chain Fatty Alcohols |
| Chemical Names | Policosanol (C₂₀-C₃₆ fatty alcohols), Octacosanol (primary component) |
| Abbreviation | PCN |
| CAS Number | 142583-61-7 |
SECTION 21: SUMMARY AND CRITICAL NOTES
Product Summary
| Parameter | Value |
|---|---|
| Product | Policosanol |
| CAS Number | 142583-61-7 |
| Appearance | White to off-white, crystalline powder |
| Melting Point | 78-82 °C |
| Primary Function | Cholesterol reduction, cardiovascular support |
| GRAS | Yes |
Critical Notes
-
Cholesterol Reduction: Policosanol reduces LDL cholesterol (15-25%) and increases HDL cholesterol (10-20%).
-
Mechanism: Inhibits HMG-CoA reductase; increases LDL receptor expression; reduces intestinal cholesterol absorption.
-
Sugar Cane Source: Primary source is sugar cane wax; also derived from rice bran wax and beeswax.
-
Octacosanol: Primary active component (C₂₈H₅₈O) comprising 60-70% of the mixture.
-
Mixed Composition: Complex mixture of long-chain alcohols (C₂₀-C₃₆) with varying chain lengths.
-
Insoluble in Water: Highly lipophilic; requires oil-based formulations for bioavailability.
-
Safety: Generally recognized as safe; well tolerated at recommended doses.
-
Dosage: Typical dosage 5-20 mg/day for cholesterol reduction.
-
Natural Source: Derived from natural plant waxes; sustainable source.
-
Regulatory Status: Approved as food supplement ingredient in major markets.
IMPORTANT DECLARATION: This Technical Data Sheet (TDS) is for informational purposes only and has been prepared based on available technical data. The user is responsible for determining the product's suitability for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, use, transport, waste, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. This document does not replace medical advice.
