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Send EmailVitamin D3, Cholecalciferol, Calciol, Colecalciferol, E671, 67-97-0
Vitamin D3 (Cholecalciferol)
Chemical Properties
| Property | Value |
|---|---|
| CAS Number | 67-97-0 |
| Molecular Formula | C27H44O |
| Molecular Weight | 384.638 g/mol |
| Density | 1.0 ± 0.1 g/cm³ |
| Boiling Point | 496.4 ± 24.0 °C (760 mmHg) |
Biological Role and Importance
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Fat-soluble vitamin → Better absorbed when taken with dietary fat.
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Calcium & phosphorus absorption → Essential for bone and muscle health.
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Immune support → Strengthens the body’s defense against infections.
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Cardiovascular & mental health → May reduce heart disease risk and stabilize mood.
Deficiency Symptoms
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Fatigue, weakness
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Muscle pain and difficulty walking
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Insomnia, depression
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Hair loss, headaches
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Cold intolerance, excessive sweating
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Tingling in hands/feet, dark circles under eyes
Reference Range: 20–50 ng/mL Deficiency Threshold: < 12 ng/mL
Health Benefits
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Strengthens bones, reduces osteoporosis risk
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Prevents rickets in children
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Supports immune system regulation
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Helps lower blood pressure and improve insulin control
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Potential anticancer effects
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May reduce risk of multiple sclerosis (MS)
Natural Sources
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Animal-based foods: Beef liver, cod liver oil, salmon, tuna, sardines, trout
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Dairy products: Cheese, milk, butter
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Egg yolk
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Sunlight exposure → Skin synthesis
Usage and Side Effects
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Intake methods: Food, sunlight, or supplements under medical supervision
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Absorption: Enhanced when consumed with fat-containing meals
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Overdose risks: Nausea, vomiting, constipation, weight loss, kidney problems, irregular heartbeat
Vitamin D3 (Cholecalciferol) – Sectoral Suitability Table
| Sector / Application | Suitability | Typical Usage Ratios | Notes / Compliance |
|---|---|---|---|
| Food & Nutrition | ✅ Highly suitable | Infant formula: 200–400 IU per serving; Fortified dairy: 100–200 IU per 100 mL | Requires full documentation (EU EFSA, FDA GRAS). Oil powder forms preferred for infant formula. |
| Animal Nutrition | ✅ Suitable | Poultry feed: 1,000–2,000 IU/kg; Aquaculture feed: 500–1,000 IU/kg | Must comply with feed additive regulations. Often blended with Vitamin A & E. |
| Pharmaceuticals | ✅ Essential | Tablets/capsules: 400–2,000 IU/day; Injectable forms vary | GMP compliance mandatory. Used in osteoporosis, rickets, immune support. |
| Cosmetics | ⚠️ Limited | Trace levels (<0.1%) in creams/lotions | Claimed for skin health, but regulatory limits apply. |
| Chemical/Industrial | ❌ Not suitable | – | No industrial chemical applications; strictly nutritional/medical. |
Other Names / Synonyms
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Vitamin D3
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Cholecalciferol
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Calciol
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Colecalciferol
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Activated 7-dehydrocholesterol derivative
