Chondroitin Sulphate, CSO, chondroitin sulfates, chondroitin polysulfate, chondroitin sulfuricacid, 9007-28-7

Chondroitin Sulphate, Chondroitin Sulfate, CS, 9007-28-7

Chemical Identity

• Name: Chondroitin Sulphate

• Molecular Formula: C₁₃H₂₁NO₁₅S

• Molecular Weight: 463.37 g/mol

• CAS Number: 9007-28-7

• Chemical Class: Sulfated glycosaminoglycan (GAG)

• Origin: Extracted from bovine, chicken, shark, and porcine cartilage

Physical and Chemical Properties

• Appearance: White powder at room temperature

• Odor/Taste: Odorless, tasteless

• Density: ~1.5–1.6 g/cm³

• Melting Point: 190–194 °C

• Boiling Point: Not applicable (decomposes on heating)

• Solubility:

  • Good solubility in water

  • Soluble in ethanol, ether, and acetone

• Acidity (pKa): 1.5–2.0

• Moisture Sensitivity: Strong water absorption capacity

Production Method

• Extracted from cartilage (bovine throat/nasal cartilage commonly used).

• Process involves:

  • Treatment with 2% sodium hydroxide solution

  • Trypsin digestion at 50 °C to remove proteins

  • Filtration and preparation of enzymatic hydrolysis solution (pH ~6)

  • Addition of ethanol (75% concentration) for precipitation

  • Centrifugation → yields purified Chondroitin Sulphate

Biological Role

• Structural function: Provides compressive strength and elasticity to cartilage.

• Pain relief: Reduces joint pain and improves mobility.

• Anti-inflammatory: Plays a role in reducing inflammation in joints and connective tissue.

Applications

• Pharmaceutical / Medical:

  • Used in osteoarthritis treatment (often combined with Glucosamine Sulphate)

  • Applied in myocardial ischemia, infarction, and coronary atherosclerosis therapies

  • Cataract surgery: combined with sodium ascorbate, manganese, hyaluronic acid, and collagen to protect the eye

• Biomaterials / Tissue Engineering:

  • Hydrogels, biofilms, microspheres, and micelles for biocompatible scaffolds

  • Surface modification reagent for biomedical devices

• Nutraceuticals:

  • Dietary supplements for joint health

  • Often marketed in combination with glucosamine and MSM

• Industrial / Chemical:

  • Used in anti-inflammatory and anti-rheumatic product formulations

Synonyms

• Chondroitin Sulphate

• Condroitin Sulphate

• Chondroitin Sulfate (US spelling)

• Kondroitin Sülfat

• CAS 9007-28-7

Summary

Chondroitin Sulphate is a sulfated glycosaminoglycan derived from animal cartilage. It is widely used in joint health supplements, pharmaceutical therapies (especially osteoarthritis and cardiovascular conditions), and biomaterials for tissue engineering. Its ability to reduce pain, improve mobility, and support cartilage structure makes it a key compound in both medical and nutraceutical industries.