Camphor, Synthetic Camphor, Technic, Pharma Grade, 76-22-2 

Camphor, Synthetic Camphor, CAMPHOR TECH. GRADE, CAMPHOR SQUARES SYNTHETIC TECHNICAL, Camphor Natural,Tablet, bornan-2-one, antitussive, analgesic, antidiarrheal. 76-22-2 

bornan-2-one

CAS: 76-22-2

Molecular Formula: C10H16O

Names and Identifiers

Physico-chemical Properties

Risk and Safety

Upstream Downstream Industry

Nature

colorless or white crystals, granular or easily broken blocks. Flammable. Toxic. There is a pungent aroma. Volatilize slowly at room temperature. Micro-soluble in water, soluble in ethanol, ether, chloroform, carbon disulfide, solvent naphtha and volatile or non-volatile oils. Density: 0.99g/m3. Melting point 179.75 °c. Boiling Point 204 °c (sublimation). Flash point (closed cup) 65.6 °c. Spontaneous ignition point 466. The explosion limit in air is 0.6% ~ 3.5%. Chemical stability. Camphoric acid is generated during mild oxidation. Borneol was generated during reduction.

Preparation Method

1. camphor oil purification method camphor root, dry, branch cut into wood chips for steam distillation to obtain camphor oil, vacuum distillation, freezing, centrifugation, sublimation, preparation of refined products.
2. synthesis of turpentine as raw material, from which the extraction of pinene, by isomerization of pinene. Then it is esterified with acetic acid to produce isobornyl acetate, and then hydrolyzed by saponification to obtain isoborneol. Finally, it is dehydrogenated, distilled and sublimed to obtain synthetic camphor.

Use

This product is used in the pharmaceutical industry to prepare anti-cavity drugs for cardiotonic agents, stimulants, coolants, antipruritic agents, clothes and books. Plasticizers which are also used in the preparation of esters and ethers of celluloid and cellulose. This plasticizer can improve the transparency and toughness of polyvinyl chloride. It is also used for the preparation of fireworks, pesticides, explosive stabilizers and paints.

Safety

• This product has moderate toxicity, and its vapor can kill insects, sparrows and other birds, at a concentration of 200 x 10-6 (1. 3mg/L) under the steam, the mice inhaled 5~10 minutes will jump restless, Dyspnea, dizziness, intense spasm, then stop breathing and death. It can damage the heart function of rabbits, and its toxicity is much greater than that of chloroform. Camphor vapor on the human body can also cause heart dysfunction, will make people appear lethargy, Dyspnea, the muscle paralysis and death. The lowest lethal dose of subcutaneous injection in rats was 2.2g/kg. The maximum allowable concentration in the workplace is 2mg/m3.
• production equipment should be sealed to prevent leakage, and operators should wear protective masks. Good ventilation was maintained at the production site. It is packed in plastic bag, carton, or linen bag or wooden box. 25kg or 50kg per bag. Store in a cool, ventilated place, away from fire. During the transport to fire, heat.

Compound camphor tincture

This product contains morphine (C17H19N03) per lml should be 0.425 ~ 0.575mg.

prescription

camphor 3G
Opium Tincture
Benzoic acid 5G
Star anise oil 3ml
Ethanol (56%) appropriate amount
Made up to 1000ml

preparation method

add benzoic acid, camphor and star anise oil, add 56% ethanol to dissolve, slowly add the appropriate amount of Opium Tincture and 56% ethanol, make the whole amount to 1000ml, stir and filter to obtain.

trait

This product is yellow-brown liquid; There are camphor and star anise oil aroma.

identification

take 2ml of this product, add ammonia solution to adjust the pH value to about 9; Add chloroform-Isopropanol (3:1) to extract 2 times, each time the amount of 20ml, combined extract, filtered through anhydrous sodium sulfate, the filtrate was evaporated to dryness under reduced pressure, and the residue was dissolved by adding 0.3ml of methanol as a test solution. An appropriate amount of morphine control was taken, dissolved and diluted with methanol to prepare a solution containing about 1 mg per 1 ml, as a control solution. According to the thin layer chromatography (General 0502) test, take the above two Solutions 10 u1, respectively, on the same silica gel G thin layer plate, with ethyl acetate-methanol-concentrated ammonia solution (17:2:1) for the development of the agent, expand, dry, spray with dilute bismuth potassium iodide solution. The spot position and color of the test solution should be consistent with the spot position and color of the morphine control solution.

examination

• the amount of ethanol should be 52% to 60% (General 0711 gas chromatography).
• others should comply with the relevant provisions under tincture (General rule 0120).

Content determination

• measured by high performance liquid chromatography (General 0512).
• chromatographic conditions and system suitability test using octyl silane bonded silica gel as filler; 0.05mol/L potassium dihydrogen phosphate solution -0.0025mol/L sodium heptane sulfonate aqueous solution-acetonitrile (2:2:1) as mobile phase; The detection wavelength was 220nm. The number of theoretical plates was not less than 1000 based on the morphine peak.
• suitability test of solid phase extraction column system a silica gel bonded with a Eighteen alkyl silane was used as a filler; The same treatment conditions and elution conditions in the measurement method were tested. Accurately measure 1ml of 5% acetic acid solution containing 0.25mg morphine reference substance per 1ml, set on the treated same-phase extraction column, elute with the same method, and collect the eluate with 5ml measuring flask to the scale, shake well as a system-suitable solution. The suitable solution of the system and the reference solution under the content determination item are respectively 10 u1 and injected into the human liquid chromatograph to record the chromatogram.
• one homogenous extraction column was used for the determination, washed with methanol water (3:1)l5ml and water 5ml successively, and then with ammonia solution with pH value of about 9 (the water was suitable for children, the ammonia test solution was added dropwise until the pH value was 9) and the effluent was flushed until the pH value of the effluent was about 9, which was to be used. Take 1 bottle of this product, ultrasonic 10 minutes, take out and shake; Precision take 5ml, put the grinding mouth conical flask, steam dry, precision plus 5% acetic acid solution 10ml, ultrasonic 10 minutes to dissolve morphine, take out, cool and filter; Take 1ml of the continuous filtrate accurately, place it on the above solid phase column, and add appropriate amount of ammonia test solution Dropwise to make the pH value of the solution in the column about 9. Take the same volume of continued filtrate before sample, to determine the amount of dropping ammonia solution), shake, after the solvent drops, rinse with about 20ml of water, elute with 5% acetic acid solution containing 20% methanol, collect the eluate with 5ml measuring flask to the scale, shake well, precisely take LOL and inject it into human liquid chromatograph, record chromatogram; Take morphine reference substance, add 5% acetic acid solution containing 20% methanol to dissolve and quantitatively dilute to make a solution containing about 0.05mg morphine per 1ml. According to the external standard method, the peak area of morphine was calculated.

category

antitussive, analgesic, antidiarrheal.

storage

shade, seal, and store in a cool and dry place.

Reference Information