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Sodium Gluconate, Monosodium Gluconate, Sodium D-Gluconate, E576, 527-07-1

Sodium Gluconate, Monosodium Gluconate, Sodium D-Gluconate, E576, 527-07-1

SODIUM GLUCONATE 

1. PRODUCT IDENTIFICATION AND CHEMICAL IDENTITY

Property Description
Product Name Sodium Gluconate
Chemical Name (IUPAC) D-Gluconic Acid Monosodium Salt
Molecular Formula C₆H₁₁NaO₇
Molecular Weight 218.14 g/mol
CAS Number 527-07-1
EINECS Number 208-407-7
E Number (Food) E576
Other Names Monosodium Gluconate, Sodium D-Gluconate, D-Gluconate Sodium Salt, Monosodium D-Gluconate
Product Type Organic Sodium Salt / Chelating Agent

2. CHEMICAL STRUCTURE

2.1. Molecular Structure

Sodium gluconate is the monosodium salt of D-gluconic acid. It is formed by the oxidation of glucose to gluconic acid, followed by replacement of the hydrogen in the carboxyl group with sodium. The molecule has a six-carbon chain containing five hydroxyl groups (-OH) and one carboxylate group (-COONa).

Structural Formula:

        COONa
         |
    HO — C — H
         |
    H — C — OH
         |
    HO — C — H
         |
    H — C — OH
         |
        CH₂OH

Molecular Structure Properties:

Property Description
Functional Groups 5 hydroxyl groups (-OH), 1 carboxylate group (-COONa)
Chirality 4 chiral centers
Chelating Structure Multiple hydroxyl and carboxyl groups chelate metal ions
Optical Activity Optically active

3. TYPICAL PHYSICAL AND CHEMICAL PROPERTIES

Parameter Specification / Typical Value
Physical Appearance White crystalline powder or free-flowing granules
Odor Odorless
Molecular Weight 218.14 g/mol
Density ~1.80 g/cm³ (20°C)
Melting Point 175 – 180 °C (Decomposition begins)
Boiling Point Not applicable (Decomposes when heated)
Solubility (Water, 25°C) 59 g / 100 ml water (Very soluble)
Solubility (Ethanol) Slightly soluble
pH (10% Aqueous Solution) 6.5 – 7.5
Biodegradability Readily biodegradable (>98%, OECD 301E)
Chelation Capacity High (Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺)
Alkaline Stability Stable at high pH (pH > 12)

4. CHEMICAL ANALYSIS SPECIFICATIONS

The following values are typical for industrial and food grades:

Analysis Parameter Standard Value Unit
Purity (Dry Basis) ≥ 98.0 – 99.5 %
Loss on Drying ≤ 1.0 %
Reducing Sugars (Glucose) ≤ 1.0 %
Chloride (Cl⁻) ≤ 0.05 %
Sulfate (SO₄²⁻) ≤ 0.05 %
Lead (Pb) ≤ 2.0 ppm
Arsenic (As) ≤ 1.0 ppm
Heavy Metals (as Pb) ≤ 10 ppm
Iron (Fe) ≤ 10 ppm
pH (10% solution) 6.5 – 7.5 -

5. PRODUCTION METHOD

Sodium gluconate is produced by two main methods:

5.1. Chemical Synthesis Method

Step Description
1. Gluconic Acid Production Calcium Gluconate is reacted with Sulfuric Acid to obtain Gluconic Acid solution
2. Neutralization Gluconic acid is neutralized with Sodium Carbonate (Na₂CO₃) or Sodium Hydroxide (NaOH)
3. Filtration Precipitates are filtered out
4. Drying Dried in spray dryer or vacuum dryer

5.2. Biotechnological (Fermentation) Method

Step Description
1. Fermentation Controlled fermentation of glucose with microorganisms such as Aspergillus niger
2. Neutralization Gluconic acid formed is neutralized with sodium hydroxide
3. Purification Decolorization with activated carbon and filtration
4. Crystallization Purification by crystallization
5. Drying Drying and milling

6. MECHANISM AND FUNCTIONAL PROPERTIES

6.1. Chelation Mechanism

Sodium gluconate forms stable complexes with metal ions through its multiple hydroxyl and carboxyl groups. This property makes it a strong chelating agent.

General Chelation Reaction:

Sodium Gluconate + Mⁿ⁺ → [Gluconate-M] complex + nNa⁺
(M: Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺, Pb²⁺, etc.)
Metal Ion Chelation Stability (Log K)
Ca²⁺ ~2.0
Mg²⁺ ~1.8
Fe³⁺ ~8.0
Cu²⁺ ~6.0
Pb²⁺ ~4.5

6.2. Alkaline Stability

Sodium gluconate remains stable even in high pH (pH > 12) environments. This is a significant advantage over other chelating agents such as EDTA.

6.3. Biodegradability

Sodium gluconate is >98% biodegradable according to OECD 301E testing. This makes it an environmentally friendly product.

7. MAIN FUNCTIONAL PROPERTIES AND APPLICATIONS

7.1. Construction and Building Chemicals Industry

Application Function Details
Concrete Admixture Set retarder 0.05-0.30% of cement weight; extends setting time in summer
Water Reducer Plasticizer Low dosages (0.05%) show water-reducing effect
High Performance Concrete Dispersant Dispersant in superplasticizer systems
Gypsum and Plaster Set regulator Extends workability time in gypsum-based products

Typical Usage Rates:

Application Dosage
Set Retarder 0.15 – 0.30% of cement weight
Water Reducer 0.05 – 0.10% of cement weight
Gypsum Additive 0.05 – 0.20% of gypsum weight

7.2. Industrial Water Treatment

Application Function Details
Cooling Towers Scale inhibitor Binds Ca/Mg ions in circulating water
Corrosion Inhibitor Metal protection Prevents iron and copper corrosion
Boiler Water Scale inhibitor Prevents scale formation in boilers
Closed Loop Systems Stabilizer More stable at high alkali pH than EDTA

Typical Usage Rates:

Application Dosage
Cooling Towers 10 – 50 ppm (mg/L)
Boiler Water 5 – 20 ppm
Closed Loop Systems 20 – 100 ppm

7.3. Industrial Cleaning and Metal Surface Treatment

Application Function Details
Alkaline Cleaners Chelating agent Used with caustic soda; binds ions removed from metal surfaces
Bottle Washing Descaling agent In beer and soft drink bottle washing baths
Metal Cleaning Surface polishing Prevents re-contamination of metal surfaces
Electroplating Bath stabilizer Stabilizes metal ions in plating baths
Descaling Scale remover Scale removal in industrial equipment

Typical Usage Rates:

Application Dosage
Light Soils / Hard Water 2 – 5% (total solution)
Heavy Soils / Descaling 5 – 10% (total solution)
Bottle Washing (High Hardness) 10 – 12% (total solution)

7.4. Food Industry (Additive E576)

Application Function Details
Bitterness Masker Taste correction Suppresses the metallic bitter taste of sweeteners like Stevia
Stabilizer Texture preservation Used in dairy products and confectionery
Chelating Agent Metal binding Binds metal ions in food products
Acidity Regulator pH control pH adjustment in various food products

Typical Usage Rates:

Application Dosage
Bitterness Masking 1 – 3% of sweetener weight
Dairy Products/Cheese 0.1 – 0.5% of total mass
Confectionery/Jelly 0.2 – 1.0%

7.5. Textile and Dyeing

Application Function Details
Water Hardness Remover Sequesterant Binds hardness ions in dyeing baths
Color Enhancer Color uniformity Ensures more vivid and uniform colors in dye baths
Printing Paste Stabilizer Viscosity modifier in textile printing pastes

Typical Usage Rates:

Application Dosage
Dyeing Bath 0.5 – 2.0 g/L

7.6. Other Applications

Sector Application Function
Pharmaceutical Excipient Binder in tablet formulations
Cosmetics Chelating agent Metal ion binding in formulations
Detergents Auxiliary agent In phosphate-free detergent formulations
Agriculture Micronutrient chelator Chelation of plant nutrients
Oil & Gas Drilling mud Viscosity control in drilling fluids

8. SECTOR USAGE SUMMARY TABLE

Sector Application Dosage Function
Construction Concrete admixture 0.05-0.30% Set retarder, water reducer
Water Treatment Cooling tower 10-50 ppm Scale inhibitor, corrosion inhibitor
Cleaning Alkaline cleaner 2-12% Chelating agent, descaling
Food Food additive 0.1-3% Bitterness masker, stabilizer
Textile Dyeing 0.5-2 g/L Water hardness remover, color enhancer
Cosmetics Formulation Variable Chelating agent
Pharmaceutical Excipient Variable Binder, stabilizer

9. ALTERNATIVE CHEMICALS AND COMPARISON

Alternative Chemical Strength Weakness Compared to Sodium Gluconate
EDTA Very strong chelation, low dosage Not biodegradable; performance decreases at high alkali pH Advantage: Biodegradable, alkali stable
Sodium Glucoheptonate Stronger chelation than gluconate Higher cost Advantage: More economical
Sodium Citrate Common in food industry, inexpensive Lower chelation capacity in alkaline conditions Advantage: Alkaline stability
STPP (Sodium Tripolyphosphate) Effective in detergent sector Eutrophication risk (phosphate pollution) Advantage: Phosphate-free, eco-friendly
Lignosulfonates Very cheap in construction Limited chelation; may entrain air in concrete Advantage: Chelation capacity
Phosphonates (ATMP, HEDP) Strong scale inhibition Not biodegradable Advantage: Biodegradable

10. TOXICOLOGICAL PROFILE

Parameter Value
Acute Oral Toxicity (LD50, Rat) > 5,000 mg/kg (low toxicity)
Acute Dermal Toxicity > 2,000 mg/kg
Skin Irritation Not an irritant
Eye Irritation Mild irritant
Inhalation Dust may cause respiratory irritation
Carcinogenicity Not classified as a carcinogen
Mutagenicity Not mutagenic
ADI (Acceptable Daily Intake) Not specified (safe)
FDA Status GRAS (Generally Recognized as Safe)
EU Approval Approved as food additive E576

11. GHS CLASSIFICATION

Hazard Class Category H-Statement
Not classified as hazardous

Signal Word: None

Hazard Pictograms: None

Hazard Statements: No H-codes

12. FIRST AID MEASURES

Route of Exposure Action to Be Taken
Inhalation Move to fresh air. If symptoms persist, seek medical attention
Skin Contact Wash with plenty of soap and water
Eye Contact Rinse thoroughly with plenty of water for at least 15 minutes. If irritation persists, seek medical attention
Ingestion Rinse mouth. Drink plenty of water. Do not induce vomiting. Seek medical attention

13. STORAGE AND SHELF LIFE

Parameter Detail
Storage Conditions Store in a cool, dry, well-ventilated area away from moisture and direct sunlight
Container Requirements Keep in closed packaging; PE-lined containers
Materials to Avoid Moisture, high temperature, strong oxidizers
Shelf Life 24 months in original unopened packaging under proper storage conditions
After Opening Keep tightly closed to protect from moisture

14. PACKAGING OPTIONS

Packaging Type Quantity Material
Kraft Bag 25 kg PE-lined kraft paper bag
Fiber Drum 50 kg PE-lined fiber drum
Big-Bag 500 kg, 1000 kg PE-lined PP woven bag
Small Containers 1 kg, 5 kg, 10 kg HDPE containers

15. TRANSPORT INFORMATION

Parameter Information
UN Number Not applicable (not dangerous goods)
Hazard Class Not applicable
Packing Group Not applicable
ADR/RID Not regulated
IMDG Not regulated
IATA Not regulated

16. REGULATORY STATUS

Region / Authority Status
USA (FDA) GRAS; 21 CFR 184.1318
European Union Approved as food additive (E576); (EC) No 1333/2008
Turkey Approved as food additive (Turkish Food Codex)
Codex Alimentarius INS No. 576
JECFA Evaluated; safe
REACH Registered

17. ENVIRONMENTAL INFORMATION

Parameter Information
Biodegradability Readily biodegradable (>98%, OECD 301E)
Aquatic Toxicity Low toxicity
Bioaccumulation Not expected
Eutrophication Risk Phosphate-free; does not cause eutrophication
Waste Disposal Dispose in accordance with local regulations

18. OTHER NAMES AND SYNONYMS

  • Sodium Gluconate

  • Monosodium Gluconate

  • D-Gluconic Acid, Sodium Salt

  • Sodium D-Gluconate

  • E576

  • Sodium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate (IUPAC)

  • Monosodium D-Gluconate

  • Gluconic Acid Sodium Salt

19. QUICK REFERENCE TABLE

Property Value
CAS Number 527-07-1
EINECS Number 208-407-7
E Number E576
Molecular Formula C₆H₁₁NaO₇
Molecular Weight 218.14 g/mol
Appearance White crystalline powder or granules
Solubility (Water, 25°C) 59 g/100 ml
pH (10% solution) 6.5 – 7.5
Biodegradability >98%
FDA Status GRAS
GHS Signal Word None
UN Number Not applicable
Shelf Life 24 months

20. CRITICAL NOTICES AND BEST PRACTICES

CRITICAL NOTICES:

  1. Moisture Sensitivity: Sodium gluconate is sensitive to moisture. Caking may occur if the packaging is opened and exposed to moisture. Store in a dry environment.

  2. Alkaline Stability: Sodium gluconate remains stable even at high pH (pH > 12). This is a significant advantage over other chelating agents such as EDTA.

  3. Biodegradability: When chosen as an alternative to EDTA, its biodegradability is its greatest advantage.

  4. Dosage Optimization: Optimum dosage for each application should be determined through trial runs. Overdosing may cause economic inefficiency and unwanted side effects.

  5. Food Applications: Approved as food additive E576. It is GRAS and safe.

  6. Phosphate-Free Alternative: Preferred as a phosphate-free alternative, especially in detergent and water treatment applications.

BEST PRACTICE RECOMMENDATIONS:

Concrete Applications:

  • Use at 0.05-0.30% of cement weight

  • Prefer 0.15-0.30% in summer or for long transport distances

  • Can be used with superplasticizers

Cleaning Applications:

  • Use with caustic soda

  • Adjust dosage according to water hardness

  • More effective at higher temperatures

Storage:

  • Store in a cool, dry, well-ventilated area

  • Protect from direct sunlight

  • Keep tightly closed in original packaging

Handling:

  • Use dust mask and protective goggles

  • Avoid dust formation

  • Use in well-ventilated areas

Waste Management:

  • Dispose in accordance with local regulations

  • Can be disposed of with normal waste due to being eco-friendly and biodegradable

LEGAL DISCLAIMER

This Technical Data Sheet (TDS) is for informational purposes only and is prepared based on available technical data. The user is solely responsible for determining the suitability of the product for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, handling, transport, waste, and regulatory compliance information, the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier must be consulted. This document does not substitute professional advice. Dosage and application conditions should be optimized through product-specific trials.

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