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Send EmailCitric acid monohydrate, Citric acid Mono, Citric acid hydrate, Hydrous citric acid, CITRIC ACID H2O, HYDROXY TRICARBALLYLIC ACID MONOHYDRATE, 5949-29-1
Citric acid monohydrate
CAS: 5949-29-1
Molecular Formula: C6H10O8
Names and Identifiers
| Name | Citric acid monohydrate |
| Synonyms | citric CITRIC ACID H2O Citricacidhydrate Citric acid Mono Hydrous citric acid Citric acid hydrate Citronensαure-hydrat Citric acid Monohydride Citric acid monohydrate Citric acid, monohydrate Citric Acid Monohydrate BP HYDROXYTRICARBALLYLIC ACID MONOHYDRATE BETA-HYDROXY-TRICARBOXYLIC ACID MONOHYDRATE citric acid free acid monohydrate*crystalline 2,3-propanetricarboxylicacid,2-hydroxy-monohydrate 1,2,3-Propanetricarboxylicacid,2-hydroxy-,monohydrate 2-Hydroxy-1,2,3,propane-tricarboxylic acid, monohydrate 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monohydrate |
| CAS | 5949-29-1 |
| EINECS | 200-662-2 |
| InChI | InChI=1/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2 |
| InChIKey | YASYEJJMZJALEJ-UHFFFAOYSA-N |
Physico-chemical Properties
| Molecular Formula | C6H10O8 |
| Molar Mass | 210.1388 |
| Density | 0.791g/mLat 25°C(lit.) |
| Melting Point | -94°C(lit.) |
| Boling Point | 56°C760mm Hg(lit.) |
| Flash Point | 1°F |
| Water Solubility | 1630 g/L (20 oC) ;H2O: soluble 54% (w/w) at 10°C (Citric acid in water) |
| Solubility | Soluble in methanol and water |
| Vapor Presure | 184 mm Hg ( 20 °C) |
| Vapor Density | 2 (vs air) |
| Appearance | White crystal or powder |
| Specific Gravity | 0.810 (20/4℃) |
| Color | White |
| Merck | 14,2326 |
| BRN | 4018641 |
| pKa | 3.138, 4.76, 6.401 |
| PH | 1.85 (50g/l, H2O, 25℃) |
| Storage Condition | no restrictions. |
| Stability | Stable. Incompatible with oxidizing agents, bases, reducing agents, nitrates. |
| Sensitive | Hygroscopic |
| Refractive Index | n20/D 1.359(lit.) |
| MDL | MFCD00149972 |
| Physical and Chemical Properties | Density 1.54 melting point 135-152°C flash point 173.9°C water-soluble 1630g/L (20°C) |
| Use | It is mainly used as a sour agent for food, and is also used for the preparation of pharmaceutical coolants, detergent additives, etc. |
Risk and Safety
| Risk Codes | R11 - Highly Flammable R36 - Irritating to the eyes R66 - Repeated exposure may cause skin dryness or cracking R67 - Vapors may cause drowsiness and dizziness R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R37/38 - Irritating to respiratory system and skin. |
| Safety Description | S9 - Keep container in a well-ventilated place. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1090 3/PG 2 |
| WGK Germany | 1 |
| RTECS | AL3150000 |
| TSCA | Yes |
| HS Code | 29181400 |
| Toxicity | LD50 orally in Rabbit: 3000 mg/kg |
Upstream Downstream Industry
| Raw Materials | Sulfuric acid Sodium hydroxide Calcium carbonate Hydrochloric acid |
Nature
colorless orthogonal columnar crystals or white crystalline particles. It is easily weathered in dry air and easily caked in humid air. Soluble in water and ethanol, slightly soluble in ether.
Preparation Method
with sugar solution as raw material, with Aspergillus niger fermentation, separation, purification. Or from fruit containing citric acid, such as lemon juice (available citric acid 5% ~ 8%), pineapple waste extract directly.
Standard
This product is 2-hydroxypropane-1, 2, 3-tricarboxylic acid monohydrate. The content of C6H80 7 shall not be less than 99.5% calculated as anhydrous.
Trait
- This product is colorless translucent crystals, white particles or white crystalline powder; Odorless, extremely sour; Slightly weathered in dry air; Acidic reaction in aqueous solution.
- This product is easily soluble in water, soluble in ethanol, and slightly soluble in ether.
Introduction
Verification of bismuth, nitrite, oxygen and water, determination of aluminum, copper, mercury, nickel, oxygen and thorium, as a multivalent chelating agent, remove trace metals, prepare a buffer solution, and determine blood potassium.
Use
A reagent for measuring bismuth, aluminum, copper, mercury, nickel, nitrite, nitrous acid, and the like. For the preparation of buffer, preparation of biological medium, alkali poisoning antidote. Together with picric acid, it is used for the determination of proteins in urine.
Differential diagnosis
Authoritative Data Verified Data
- this product in 105X: Drying for 2 hours, the infrared absorption spectrum should be consistent with the control spectrum (Spectrum set 263 figure).
- This product shows the identification reaction of citrate (General rule 0301).
Safety
rats were injected intraperitoneally with LD50:975mg/kg.
Exam
clarity and color of solution
take this product 2. 0g, Add 10ml of water to dissolve, and check according to law (General rule 0901 and general rule 0902, first method), the solution should be clear and colorless; If color development occurs, it shall not be deeper in comparison with the yellow No. 2 or yellow-green No. 2 Standard Colorimetric solution (General rule 0901 method 1).
chloride
take lO.Og of this product and check it according to law (General rule 0801). Compared with the control solution made of 5. 0ml of standard sodium chloride solution, it should not be more concentrated (0. 0005%).
sulfate
take this product l .O g, check according to law (General rule 0802), compared with the standard potassium sulfate solution 1. 5ml made of the control solution, should not be more concentrated (0. 015%).
oxalate
after 10ml of water is added to dissolve l .O g of this product, ammonia test solution is added for neutralization, and 2ml of vaporized calcium test solution is added. Place at room temperature for 30 minutes without producing turbidity.
easily carbonized
take this product l.O g, in a colorimetric tube, add 95%(g/g) sulfuric acid 1 0 m l, heat at 90°C 1°C, immediately cool, such as color, compared with the control solution (0.9 of vaporized cobalt solution for color comparison, 8.9 of potassium dichromate solution for color comparison and 0. 2M l mixing) comparison, not deeper.
moisture
take this product, according to the water determination method (General rule 0832 first method 1), the water content is divided into 7 .5% ~ 9 .0%.
ignition residue
not over 0841 (general rule).
calcium salt
take l.O g of this product, add 10M l of water to dissolve, add ammonia test solution to neutralize, add several drops of ammonium oxalate test solution, and do not produce turbidity.
Iron Salt
take this product l.O g, check according to law (General rule 0807), after extraction with n-butanol, with standard iron solution 1. 0M l compared with the control solution made by the same method, not deeper (0. 001%).
Heavy metals
take this product 4 .0g, add 10M l of water to dissolve, add 1 drop of phenolphthalein indicator solution, add appropriate amount of ammonia test solution to the solution to show pink, add acetate buffer (ph3.5) the amount of 2m l and water shall be adjusted to 2 5 m l, which shall be checked according to law (through the first method of 0821), and the heavy metal content shall not exceed 5 parts per million.
arsenic salt
take 2.0g of this product, add water 23M l to dissolve, add hydrochloric acid 5ml, check according to law (General rule 0822 first law), should meet the requirements (0. 0001%).
Content determination
take about 1.5g of this product, weigh it accurately, add 40ml of water to dissolve, add 3 drops of phenolphthalein indicator solution, and titrate with sodium hydroxide titration solution (lm o l/L). Each lm l sodium hydroxide titration solution (lm o l/ L) corresponds to 64.04mg of Hs O7.
Category
pharmaceutical excipients, p H value regulator, stabilizer and acidifier.
Storage
sealed storage.
Reference Information
| Introduction | citric acid monohydrate is colorless crystal or white crystalline powder with a density of 1.54. Melting point 135-152 °c. Flash point 173.9 °c. Water soluble 1630g/L (20 degrees C). |
| properties | colorless crystalline or white crystalline powder. |
| Use | citric acid monohydrate is mainly used in food and beverage industry as acidulant, flavoring agent, preservative and antistaling agent. Also in the chemical industry, cosmetics industry and washing industry used as antioxidants, plasticizers, detergents mainly used as food acid, also used in the preparation of pharmaceutical cooling agent, determination of bismuth, nitrite, oxygen and water, determination of aluminum, copper, mercury, nickel, oxygen and thorium, used as sequestering agent to remove trace metals, preparation of buffer solution, determination of serum potassium. |
| production method | 1. Starch or sugar (such as sugar cane molasses) as raw material, prepared by fermentation. Sweet potato flour Disinfection fermentation↓ Aspergillus niger 26 ℃ filter mycelial washing filtrate heating → lime milk precipitation → Sulfuric acid neutralization → decolorization → resin exchange → crystallization → Citric Acid 2. First, 12%-16% of the sweet potato powder was sterilized, and then the pre-cultured Aspergillus niger Silk was inoculated for fermentation. In the fermentation process, ammonia water was added, and after 2-3 days of fermentation at 26 ℃, the mycelium was separated from the fermentation broth, and the water after washing the mycelium was added to the fermentation broth. Then heated to 90 ° C, with lime milk precipitation of citric acid, calcium citrate obtained with a slight excess of sulfuric acid decomposition of citric acid, filtration, filtrate with activated carbon decolorization, and then through the ion exchange resin to remove impurities, concentrated under reduced pressure of 60~70 ℃, cooled to not less than 36 6 ℃ conversion temperature, adding seed crystal, crystallization, cold air drying, can prepare citric acid product. 3. With sugar solution as raw material, with Aspergillus niger fermentation, separation, purification. Or from fruit containing citric acid, such as lemon juice (available citric acid 5% ~ 8%), pineapple waste extract directly. Starch-based raw materials such as dried potato, corn, etc. by Aspergillus niger fermentation, and then separated and purified to produce pure products. 5. This product is mainly produced by fermentation. Its raw materials can be molasses, sucrose, sweet potato and petroleum hydrocarbons and other carbohydrates. According to the fermentation method can be divided into two categories of surface fermentation and submerged fermentation, surface fermentation is the early production method, with some Penicillium or Aspergillus niger as the strain; Submerged fermentation method also with Aspergillus niger as the strain, in the process of fermentation, small spherical filamentous aggregates are formed, and the growing and thin filamentous cells should be avoided. The fermentation condition is that the pH value is 1.5~2.8, and at the same time, the sterile air should be introduced with stirring, after completion of fermentation, the filamentous cells and residual solid dregs were removed by filtration, and the filtrate was neutralized with calcium carbonate to obtain calcium citrate, and then neutralized with concentrated sulfuric acid to obtain crude citric acid, which was refined by ion exchange resin, concentration and crystallization gave the final product. |
