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Taurine, Tauric Acid, Amino Ethane Sulfonic Acid, Aminoethanesulfonic Acid, Amino Ethyl Sulfonate, 107-35-7

Taurine, Tauric Acid, Amino Ethane Sulfonic Acid, Aminoethanesulfonic Acid, Amino Ethyl Sulfonate, 107-35-7

Product Name: Taurine
Chemical Name: 2-Aminoethanesulfonic acid
Version: 1.0
Issue Date: [Current Date]

1. CHEMICAL IDENTITY

Parameter Value
Molecular Formula C₂H₇NO₃S
Molecular Weight 125.15 g/mol
Chemical Name Taurine
IUPAC Name 2-Aminoethanesulfonic acid
CAS Number 107-35-7
EINECS Number 203-483-8
Natural Source Sulfur amino acid derived from methionine and cysteine metabolism; found free in animal tissues

2. PHYSICAL AND CHEMICAL PROPERTIES

Parameter Value
Appearance White or colorless crystalline powder
Taste/Odor Slightly acidic taste, odorless
Melting Point >300 °C (approx. 325–328 °C)
Density ~1.7 g/cm³
Solubility in Water 65 g/L (23–25 °C)
Solubility in Organics Insoluble in ethanol, ether, acetone
pH (0.5 M aqueous solution) 4.5 – 6.0
Stability Hygroscopic; stable for 36 months in closed packaging under dry conditions
Incompatibilities Strong oxidizing agents

3. MANUFACTURING METHODS

A. Chemical Synthesis (Industrial)

  1. Ethylene oxide + sodium bisulfite → intermediates

  2. Addition of liquid ammonia and sulfuric acid to obtain taurine

  3. Crystallization, centrifugation, drying, and purification

B. Natural Extraction

  • Sources: Fish, seafood (squid, mussels, shrimp), mammalian organs (liver, heart, brain)

  • Historical: First isolated from gallstones (bezoar)

4. BIOLOGICAL FUNCTIONS

Function Mechanism / Role
Osmoregulation Maintains intracellular fluid balance
Antioxidant Reduces free radicals, protects cells
Cardiovascular Regulates blood pressure, antiarrhythmic effect
Nervous System Brain development, neurotransmission, calming effect
Eye Health High concentration in retina, supports visual function
Liver & Bile Conjugates with bile acids, facilitates lipid digestion

5. APPLICATIONS

Pharmaceutical / Medical

  • Retinal degeneration treatment

  • Prevention of dilated cardiomyopathy in cats (mandatory additive)

  • Adjunctive therapy for Parkinson's and neurological disorders

  • Metabolic syndrome treatment (obesity, cholesterol, insulin resistance, hypertension)

  • Periodontal diseases, alopecia treatment

  • Excipient in pharmaceutical formulations (tablets, capsules, eye drops)

Sports Nutrition

  • Performance enhancer with caffeine in energy drinks

  • Fatigue management and endurance support

Cosmetics

  • Enhances cell membrane vitality → skin care creams

  • Anti-aging and skin rejuvenation products

Veterinary / Animal Nutrition

  • Mandatory supplement for cats (cannot synthesize taurine endogenously)

  • Added to dog, bird, and other animal feeds

Food / Nutraceuticals

  • Functional beverages, dairy products, infant formulas

  • Usage limits (China, EU): 0.1 – 0.5 g/kg

6. RISK AND SAFETY INFORMATION

Parameter Value / Description
Acute toxicity (LD50, oral, rabbit) >5000 mg/kg (low toxicity)
Risk Codes R36/37/38 – Irritant to eyes, respiratory system, and skin
Safety Precautions Use protective clothing and gloves. In case of eye contact, rinse thoroughly with plenty of water.
Storage Opaque, closed packaging in a dry, cool environment
Shelf Life 36 months under proper storage conditions

7. REGULATORY INFORMATION (Summary)

Region Status
USA (FDA) Generally Recognized as Safe (GRAS) for energy drinks and supplements
European Union Permitted in food supplements and infant formulas; subject to maximum levels
Turkey (Ministry of Agriculture and Forestry) Permitted as food and feed additive; subject to dietary supplement regulations

Note: Country-specific regulations must be verified prior to use.

8. SUMMARY AND DISCLAIMER

Summary:
Taurine is a sulfur-containing amino sulfonic acid that does not participate in protein synthesis but is critical for homeostasis, cardiovascular health, nervous system function, eye health, and metabolism. It has a wide range of applications from sports nutrition and pharmaceuticals to cosmetics and veterinary feeds.

1. Sectoral Suitability Table

Taurine is used across a wide range of industries due to its functional properties.

Sector Suitability Typical Application Remarks
Food & Beverage High Energy drinks, functional beverages, infant formula, dairy products Approved as a food additive and flavoring agent in the EU, China, and Australia
Nutraceuticals / Supplements High Dietary supplements (capsules, tablets, powder forms) One of the fastest-growing segments
Pharmaceuticals High Eye drops, cardiovascular drugs, neurological treatments Requires pharmaceutical grade purity
Veterinary / Animal Nutrition High Mandatory additive in cat food, dog and bird food Vital for heart and retinal health in cats (cannot synthesize endogenously)
Cosmetics Medium Skin care creams, anti-aging products Used to enhance cell membrane vitality
Sports Nutrition High Performance enhancers, fatigue management supplements Often combined with caffeine

Market Note: The global taurine market was valued at approximately $520-550 million in 2024 and is expected to reach $840-950 million by 2032-2033, growing at a CAGR of ~6-7%.

2. Usage Rates and Maximum Limits

Usage rates vary depending on the application and country-specific regulations.

Application Area Typical Usage / Maximum Limit Notes
Energy Drinks 200 - 400 mg / 100 mL (Turkey, typical) Varies by country; some have no defined maximum
Infant Formula 0.1 - 0.5 g / kg (EU, China) Added for brain and eye development
Dairy Products Maximum 0.5 g / kg (China) Used in functional products
Dietary Supplements 500 - 2000 mg daily (common range) Consumed in capsule, tablet, or powder form
Cat Food (Dry) Minimum 1000 mg / kg (typical requirement) Mandatory and vital for feline health

Important Regulatory Note:

  • In Australia and China, taurine is used under GMP (Good Manufacturing Practices) following the "minimum required amount" principle.

  • In China, its use is prohibited in certain basic food categories such as pasteurized milk, fresh fruits/vegetables, and some infant foods.

3. Other Names and Identifiers

Taurine is known by various chemical and trade names.

Category Name / Identifier
IUPAC Name 2-Aminoethanesulfonic acid
Other Chemical Names 2-Ethanesulfonic acid, Aminoethylsulfonic acid, Beta-Aminoethylsulfonate, Tauric acid
Trade Names TATU, TURIN (specific brands)
CAS Number 107-35-7
EINECS Number 203-483-8
FEMA Number 3813 (as a flavoring agent)

4. Alternatives to Taurine

Taurine has a unique molecular structure (sulfonic acid) and functions. No single compound perfectly mimics all its effects, but for specific applications, some ingredients can be considered.

Compound Mechanism / Application Comparison to Taurine
Beta-Alanine Uses the same taurine transporter (TauT) and can lower intracellular taurine levels. Used in sports nutrition to increase muscle buffering capacity. Different: Reduces taurine levels. Preferred for increasing muscle carnosine and buffering lactic acid during high-intensity exercise.
GABA (Gamma-aminobutyric acid) Acts as an inhibitory neurotransmitter in the central nervous system. Calming and anti-anxiety effects. Different: Shares some calming effects on the nervous system but lacks taurine's cellular functions (osmoregulation, antioxidant).
Glycine The simplest amino acid. Can conjugate with bile acids (like taurine) and has antioxidant properties. Similarity: Can partially substitute for taurine in bile salt formation. Difference: Not as potent as a cell protectant or osmolyte.
Creatine Plays a role in energy metabolism. Draws water into muscle cells and improves high-intensity exercise performance. Different: Often used alongside taurine in energy drinks, but has a completely different mechanism of action (energy buffering).
Inositol Found in cell membranes and involved in signal transmission. Often used together with taurine in energy drinks. Different: Does not perform taurine's core functions such as osmoregulation (cell volume regulation).

Summary Table of Alternatives

Alternative Best For Key Difference from Taurine
Beta-Alanine Sports performance (buffering capacity) Lowers taurine levels; different mechanism
GABA Calming / nervous system support No cellular protection or osmoregulation
Glycine Bile acid conjugation (partial) Less potent as an antioxidant/osmolyte
Creatine Energy metabolism / muscle volume Completely different mechanism
Inositol Cell signaling Does not regulate cell volume

Conclusion: If a specific function of taurine is targeted (e.g., cellular protection, osmoregulation), there is no complete substitute. However, for certain applications (e.g., sports supplements or nervous system support), compounds like Beta-Alanine or GABA may provide similar benefits through different mechanisms.

5. Regulatory Status by Region (Quick Reference)

Region Status for Taurine
USA (FDA) Generally Recognized as Safe (GRAS) for energy drinks and supplements
European Union (EFSA) Permitted in food supplements and infant formulas; subject to maximum levels
China Permitted with limits (0.1-0.5 g/kg); prohibited in certain basic foods
Australia Permitted as a flavoring substance and nutritional supplement under GMP
Turkey Permitted as a food and feed additive; subject to dietary supplement regulations

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