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Send EmailE920, L-Cysteine hydrochloride anhydrous, Di-isopropyl nahpthalene, L-Cysteine HCl, 52-89-1
L-Cysteine hydrochloride anhydrous
CAS: 52-89-1
Molecular Formula: C3H8ClNO2S
Names and Identifiers
| Name | L-Cysteine hydrochloride anhydrous |
| Synonyms | L-β-mercapto H-Cys-OH.HCl L-Cysteine HCl L-Cysteine hydrochlo L-Cysteine Hcl Anhydrous L-Cysteine hydrochloride L-Cysteine HCl anhydrate Di-isopropyl nahpthalene L-Cisteine·hydrochloride L-Cysteine·hydrochloric acid L-Cysteine hydrochloride anhydrous L-(+)-α-amino-β-thiopropionic acid L-cysteine hcl cell culture tested L-Cysteine hydrochloride anhydrous, extra pure 2-(2-Methoxy Ethoxy) Acetaldehyde Dimethyl Actal (2R)-2-Amino-3-sulfanylpropanoic acid hydrochloride (2R)-2-Amino-3-mercaptopropanoic acid·hydrochloric acid |
| CAS | 52-89-1 |
| EINECS | 200-157-7 |
| InChI | InChI=1/C3H7NO2S.ClH/c4-2(1-7)3(5)6;/h2,7H,1,4H2,(H,5,6);1H/p-1 |
| InChIKey | IFQSXNOEEPCSLW-DKWTVANSSA-N |
Physico-chemical Properties
| Molecular Formula | C3H8ClNO2S |
| Molar Mass | 157.62 |
| Melting Point | 180°C |
| Boling Point | 305.8°C at 760 mmHg |
| Specific Rotation(α) | 5.5 º (c=8, 6 N HCL) |
| Flash Point | 138.7°C |
| Water Solubility | SOLUBLE |
| Solubility | H2O: 1M at20°C, clear, colorless |
| Vapor Presure | 0.000183mmHg at 25°C |
| Appearance | White Crystals |
| Color | White to light brown |
| Merck | 14,2781 |
| BRN | 3560277 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable, but light, moisture and air sensitive. Incompatible with strong oxidizing agents, some metals. |
| Sensitive | Hygroscopic |
| MDL | MFCD00064553 |
| Physical and Chemical Properties | White Crystal or crystalline powder, odor, acid, soluble in water, ammonia, acetic acid, ethanol-soluble, acetone, ethyl acetate, benzene, carbon disulfide, carbon tetrachloride. Acid stability, and in neutral or slightly alkaline solution is easy to be air oxidation into cystine, trace iron and heavy metal ions can promote oxidation. Its hydrochloride is more stable, so it is generally made into hydrochloride. L-cysteine is a sulfur-containing non-essential amino acid. In the living body, the hydroxyl oxygen atom of serine is replaced by the sulfur atom of methionine and synthesized via the thioether. L-cysteine can generate glutathione, involved in the reduction process of cells and phospholipid metabolism in the liver, can protect liver cells from damage, and can stimulate hematopoietic function, increase white blood cells, promotes the repair of skin lesions. Its mp is 175 ℃, decomposition temperature is 175 ℃, isoelectric point is 5.07, [α]25D-16.5 (H2O), [α]25D 6.5 (5mol/L, HCl). |
| Use | Widely used in cosmetics, medicine, food and other industries |
Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | HA2275000 |
| FLUKA BRAND F CODES | 3-10-23 |
| TSCA | Yes |
| HS Code | 29309013 |
| Toxicity | LD50 intraperitoneal in mouse: 1250mg/kg |
Nature
white crystals. Hygroscopic. 175~178 degrees C decomposition. Slow oxidation and decomposition in air. Soluble in water, ethanol and acetone. The aqueous solution was acidic.
Preparation Method
Cystine was dissolved in dilute hydrochloric acid, and the tin particles were added by filtration to warm reflux. Dilute the reducing solution with water, remove the remaining tin particles, saturate with hydrogen sulfide, filter, wash the residue with a small amount of water, combine the washing solution and filtrate, concentrate under reduced pressure, cool and crystallize, drying gave L-cysteine hydrochloride.
Introduction
Strong acid taste, odorless, only trace sulfite smell. It is an amino acid used by various tissue cells to defend against harmful substances and increase vitality in animals and plants. It is also one of more than 20 amino acids that make up proteins, and it is the only amino acid with active sulfhydryl (-SH).
Use
for biochemical studies. Determination of calcium and magnesium in iron and steel raw materials. The reducing agent of hemolysin was determined. For the treatment of acrylonitrile and aromatic poisoning, prevention of radiation injury, treatment of bronchitis and phlegm. Also used in cosmetics, to prevent aging, as a food additive, promote fermentation, maintain the flavor.
Reference Information
| properties | l cysteine hydrochloride is colorless to white crystal or crystalline powder, with slight special smell and sour taste, melting point 175 ℃ (decomposition). Soluble in water, the aqueous solution is acidic, the pH value of 1% solution is about 1.7, and the pH value of 0.1% solution is about 2.4. It can also be soluble in alcohol, ammonia and acetic acid, but insoluble in ether, acetone, benzene, etc. It has the characteristics of reducing, anti-oxidation and preventing non-enzymatic browning. |
| preparation method | hydrolyze hair with hydrochloric acid, distill under reduced pressure, distill hydrochloric acid, then decolorize, filter, take filtrate and add ammonia to neutralize L-cystine crude crystal, then dissolve and neutralize it with ammonia water, recrystallize, then dissolve it with hydrochloric acid and electrolytically reduce, concentrate, cool, crystallize and dry. |
| use | is used to treat radioactive drug poisoning, heavy metal poisoning, toxic hepatitis, serum sickness, etc., and can prevent liver necrosis. Used as a component of cosmetics perm, sunscreen, hair growth perfume, hair nourishing essence; can be used as a food additive to prevent vitamin C oxidation and discoloration; used in bread to promote gluten protein formation and fermentation, mold, etc. Widely used in cosmetics, medicine, food and other industries used in medicine, food and other used in biochemical research, used as a reducing agent for the determination of hemolysin, used as an antidote in medicine. Pharmaceuticals, food. It is used to treat radioactive drug poisoning, heavy metal poisoning, toxic hepatitis, serum sickness, etc., and can prevent liver necrosis. Used as a component of cosmetics perm, sunscreen, hair growth perfume, hair nourishing essence; can be used as a food additive to prevent vitamin C oxidation and discoloration; used in bread to promote gluten protein formation and fermentation, mold, etc. NMDA glutamatergic receptor agonists are also AMPA glutamatergic receptor agonists at high concentrations. |
| production method | L-cystine is used as raw material, reduced with stannous chloride in hydrochloric acid medium, and then crystallized and refined. method 1. hydrolysis-electrolysis method uses pig hair and hair as raw materials to separate cystine from cystine by hydrolysis and adjusting the isoelectric point of cystine, and then electrolytically reduce cystine to obtain cysteine. Hydrolysis separates cystine pig hair and hair [HCl, 117 ℃, 7h]→ [acid hydrolysis] hydrolysate [NaOH, pH4.8]→ [neutralization] L-cystine (crude) electrolytic reduction in two separate pools, one pool is filled with 1mol/L HCl inserted into an ink rod, connected to the positive electrode of the power supply, this pool is the anode, and the other pool is filled with cystine hydrochloric acid solution (cystine: concentrated HCl: water = 1:1:4), insert the lead plate, connect the negative pole of the power supply, this pool is the cathode. Add salt bridge connection between the two pools. Turn on the power supply to adjust the current 5A and carry out electrolysis. Electrolysis is completed for about 6-7h. Take the electrolyte and add pyridine a little drop, no turbidity indicates that the electrolysis is completed. L-cystine [HCl]→ [electrolytic reduction] L-cysteine hydrochloride [decolorization, concentration, crystallization] → L-cysteine hydrochloride crystallization decolorization, concentration, crystallization electrolysis is completed, cut off the power supply, add 10g/L(1%) activated carbon according to the feeding amount, heat to 70 ℃, and keep the temperature for half an hour. Filter to get the filtrate. And concentrate it under reduced pressure until there is crystallization, stir to completely precipitate the crystallization, filter to take the crystallization, wash with 95% ethanol, and dry in vacuum below 60 ℃ to obtain L-cysteine hydrochloride without crystal water. Methods 2. enzymatic hydrolysis of DL-2-aminodihydrothiazolin-4-carboxylic acid (DL-ATC) |
