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Send EmailZinc Lactate, Zinc L-lactate, E327, 63179-81-7, 16039-53-5
ZINC LACTATE / ZINC L-LACTATE
PRODUCT IDENTIFIER INFORMATION
| Parameter | Information |
|---|---|
| Product Name | Zinc Lactate / Zinc L-Lactate |
| Chemical Name | Zinc bis(2-hydroxypropanoate) |
| CAS Number | 16039-53-5 (Zinc Lactate) / 63179-81-7 (Zinc L-Lactate) |
| EC Number (EINECS) | 240-178-4 (16039-53-5) |
| Food Additive Code | E327 (for Lactic Acid; used as zinc salt) |
| Molecular Formula | C6H10O6Zn |
| Molecular Weight | 243.55 g/mol |
SECTION 1: CHEMICAL IDENTITY AND DESCRIPTION
| Parameter | Information |
|---|---|
| Chemical Name (IUPAC) | Zinc bis(2-hydroxypropanoate) |
| Synonyms | Zinc Lactate, Zinc DL-Lactate, Zinc L-Lactate, Lactic Acid Zinc Salt, Zinc 2-Hydroxypropanoic Acid, Zinc bis(2-Hydroxypropanoate) |
| CAS Number (Zinc Lactate) | 16039-53-5 |
| CAS Number (Zinc L-Lactate) | 63179-81-7 |
| EC Number (EINECS) | 240-178-4 |
| Food Additive Code (Lactic Acid) | E327 |
| Molecular Formula | C6H10O6Zn |
| Molecular Weight | 243.55 g/mol |
| Chemical Class | Organic acid salt (zinc salt of lactic acid) |
| Zinc Content | ~22% (mineral content) |
| Physical State (20°C) | Solid (white crystalline powder) |
| Odor | Practically odorless |
| Taste | Neutral |
SECTION 2: PHYSICAL AND CHEMICAL PROPERTIES
| Property | Value | Test Method |
|---|---|---|
| Appearance | White crystalline solid / powder | Visual |
| Odor | Practically odorless | Olfactometric |
| Taste | Neutral | Sensory |
| Molecular Weight | 243.55 g/mol | Calculated |
| Zinc Content | ~22% | AAS / Complexometric Titration |
| Melting Point | >256°C (sublimation/decomposition) | DSC |
| Density (20°C) | 1.65 g/cm3 | ASTM D4052 |
| Solubility in Water (25°C) | Slightly soluble (~5-10 g/100 mL) | Gravimetric |
| Solubility in Ethanol | Slightly soluble | General Method |
| Solubility in Ether | Insoluble | General Method |
| pH (1% solution, 25°C) | 5.5 – 7.0 (near neutral) | pH Meter |
| Hygroscopicity | Low-moderate | Visual |
| Flammability | Combustible | ASTM D93 |
| Stability | Stable under normal conditions |
SECTION 3: CHEMICAL PROPERTIES AND REACTIVITY
| Parameter | Information |
|---|---|
| Chemical Character | Organic zinc salt; antimicrobial properties |
| Stability | Stable under normal conditions |
| Decomposition Products (Heating) | Sublimes/decomposes above 256°C; CO, CO2, ZnO, lactic acid derivatives |
| Incompatible Materials | Strong oxidizing agents, strong acids |
| Reaction with Acids | Releases lactic acid with strong acids |
| Reaction with Bases | May form zinc hydroxide/oxide with strong bases |
| Hazardous Polymerization | Does not occur |
SECTION 4: PRODUCTION METHOD
| Stage | Process | Description |
|---|---|---|
| 1 | Neutralization | Lactic acid (C3H6O3) is neutralized with a high-purity zinc source (ZnO or ZnCO3) |
| 2 | Reaction | 2C3H6O3 + ZnO → Zn(C3H5O3)2 + H2O |
| 3 | Crystallization | The resulting solution undergoes crystallization |
| 4 | Drying | Crystals are dried and milled to desired particle size |
SECTION 5: ZINC LACTATE AND ZINC L-LACTATE COMPARISON
| Property | Zinc Lactate | Zinc L-Lactate |
|---|---|---|
| CAS Number | 16039-53-5 | 63179-81-7 |
| Chemical Formula | C6H10O6Zn | C6H10O6Zn |
| Molecular Weight | 243.55 g/mol | 243.55 g/mol |
| Isomer | DL-mixture (racemic) or unspecified | Specific L-isomer |
| Bioavailability | High | Higher (specific L-isomer) |
| Appearance | White crystalline solid | White crystalline solid |
| Melting Point | >256°C | >256°C |
| Solubility in Water | Slightly soluble | Slightly soluble |
| Primary Use | Supplement, oral care, pharmaceutical | Supplement (high bioavailability), pharmaceutical |
SECTION 6: ZINC SALTS COMPARISON
| Property | Zinc Lactate | Zinc Sulfate | Zinc Gluconate | Zinc Citrate | Zinc Oxide |
|---|---|---|---|---|---|
| CAS Number | 16039-53-5 | 7733-02-0 | 4468-02-4 | 546-46-3 | 1314-13-2 |
| Molecular Formula | C6H10O6Zn | ZnSO4·7H2O | C12H22O14Zn | C12H10O14Zn3 | ZnO |
| Zinc Content | ~22% | ~22% | ~14% | ~31% | ~80% |
| Bioavailability | High | Moderate | High | Moderate-High | Low-Moderate |
| Taste | Neutral | Metallic/bitter | Slightly sweet | Neutral | Tasteless |
| Gastric Irritation | Low | High | Low | Low | Moderate |
| Solubility in Water | Slight | Very high | High | Moderate | Insoluble |
| Primary Use | Supplement, oral care | Supplement, agriculture | Supplement, lozenges | Supplement | Cream, ointment, sunscreen |
SECTION 7: FUNCTIONAL PROPERTIES AND MECHANISM OF ACTION
| Property | Description |
|---|---|
| Zinc Supplementation | Highly bioavailable organic zinc source; essential for protein synthesis, wound healing, normal tissue function |
| Antimicrobial / Anti-plaque | Inhibits microbial growth in the oral cavity; prevents dental plaque and tartar formation |
| Malodor Control | Neutralizes volatile sulfur compounds (VSCs) responsible for bad breath |
| Sebum Regulation | Regulates sebum secretion from sebaceous glands; moisturizes and protects skin |
| Muscle and Nerve Function | Essential for muscle contraction and maintaining body's alkaline balance |
| Phosphorus Metabolism | Plays important role in phosphorus digestion and metabolism |
| Enzyme Cofactor | Structural and functional component of over 300 enzymes |
SECTION 8: PRIMARY APPLICATION AREAS
| Sector | Application | Typical Usage / Dosage |
|---|---|---|
| Dietary Supplement | Zinc source in tablet and capsule manufacturing | 15-50 mg Zn/day |
| Pharmaceutical | Zinc deficiency treatment; dietary supplement | 15-50 mg Zn/day |
| Oral Care - Toothpaste | Tartar prevention, anti-plaque | 0.5-2.0% |
| Oral Care - Mouthwash | Malodor control, antimicrobial (with KOH) | 0.1-1.0% |
| Oral Care - Oral Rinse | Inhibition of dental calculus and halitosis | 0.1-0.5% |
| Personal Care | Skin moisturizer, sebum-regulating formulations | 0.1-1.0% |
| Agriculture | Fertilizer to meet zinc requirements of plants | Variable |
| Animal Feed | Zinc source in animal nutrition | Variable |
SECTION 9: QUALITY SPECIFICATIONS (FOOD/PHARMACEUTICAL GRADE)
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | White crystalline powder | Visual |
| Odor | Practically odorless | Olfactometric |
| Purity (C6H10O6Zn, Dry Basis) | 98.0 – 102.0% | Complexometric Titration (EDTA) |
| Zinc Content (Zn) | 21.5 – 22.5% | AAS / Complexometric Titration |
| Loss on Drying (105°C, 2 hours) | ≤ 1.0% | Gravimetric |
| pH (1% solution, 25°C) | 5.5 – 7.0 | pH Meter |
| Water Insoluble Matter | ≤ 0.1% | Gravimetric |
| Chloride (Cl-) | ≤ 0.05% | Argentometric |
| Sulfate (SO4 2-) | ≤ 0.05% | Turbidimetric |
| Heavy Metals (as Pb) | ≤ 20 ppm | ICP-MS / USP <231> |
| Lead (Pb) | ≤ 3 ppm | ICP-MS |
| Arsenic (As) | ≤ 3 ppm | ICP-MS |
| Mercury (Hg) | ≤ 1 ppm | ICP-MS |
| Cadmium (Cd) | ≤ 1 ppm | ICP-MS |
| Iron (Fe) | ≤ 50 ppm | AAS / Colorimetric |
| Total Microbial Count | ≤ 1,000 CFU/g | USP <61> |
| Yeast and Mold | ≤ 100 CFU/g | USP <61> |
| E. coli | Negative in 10g | USP <62> |
| Salmonella spp. | Negative in 25g | USP <62> |
SECTION 10: TOXICOLOGICAL PROFILE
| Parameter | Value |
|---|---|
| Acute Oral Toxicity (LD50, Rat) | > 5,000 mg/kg (low toxicity) |
| Acute Dermal Toxicity (LD50, Rabbit) | > 2,000 mg/kg |
| Skin Irritation | Mild irritant |
| Eye Irritation | Mild-moderate irritant |
| Respiratory Irritation | Inhalation of dust may cause mechanical irritation |
| Skin Sensitization | Not sensitizing |
| Carcinogenicity | Not classified |
| Mutagenicity | Negative in in vitro tests |
| Reproductive Toxicity | No known adverse effects |
| Chronic Toxicity | Gastrointestinal discomfort at high doses; copper deficiency |
| Tolerable Upper Intake Level (UL) | 40 mg Zn/day for adults |
| GRAS Status | Recognized as GRAS by FDA |
SECTION 11: GHS CLASSIFICATION AND LABELING
GHS Classification (compliant with 1272/2008/EC):
| Hazard Class | Category | H-Statement |
|---|---|---|
| Not classified | - | Not classified as hazardous according to current regulations |
Signal Word: No signal word (not classified as hazardous)
Hazard Pictograms: No pictograms required
Precautionary Statements (P-Codes):
| Code | Statement |
|---|---|
| P261 | Avoid breathing dust |
| P280 | Wear protective gloves/eye protection |
| P305+P351+P338 | IF IN EYES: Rinse cautiously with water for several minutes |
SECTION 12: FIRST AID MEASURES
| Exposure Route | Action to Take |
|---|---|
| Inhalation | Move to fresh air. Seek medical attention if respiratory irritation persists. |
| Skin Contact | Wash with plenty of water and soap. Seek medical attention if irritation persists. |
| Eye Contact | Rinse immediately with plenty of water for at least 15 minutes. Remove contact lenses if present. Seek medical attention if irritation persists. |
| Ingestion | Rinse mouth with water. Drink plenty of water. Seek medical attention if you feel unwell. |
SECTION 13: FIREFIGHTING MEASURES
| Parameter | Information |
|---|---|
| Fire Hazard | Combustible |
| Hazards During Fire | Releases CO, CO2, ZnO particulates when heated or burned |
| Suitable Extinguishing Media | Water mist (fog), CO2, dry chemical powder, foam |
| Special Protective Equipment | Self-contained breathing apparatus (SCBA), full protective clothing |
SECTION 14: STORAGE AND SHELF LIFE
| Parameter | Information |
|---|---|
| Storage Conditions | Cool (15-25°C), dry, well-ventilated area; light-protective packaging |
| Container Requirements | Tightly closed, moisture-proof containers |
| Keep Away From | Moisture, direct sunlight, strong oxidizing agents, strong acids |
| Shelf Life | 36 months (unopened original packaging under appropriate storage conditions) |
| Stability Note | Stable under normal conditions; low-moderate hygroscopicity |
SECTION 15: PACKAGING OPTIONS
| Packaging Type | Quantity | Material |
|---|---|---|
| Aluminum foil pouch (moisture-proof) | 1 kg | Laminated aluminum |
| Aluminum foil pouch (moisture-proof) | 5 kg | Laminated aluminum |
| Kraft bag with PE inner liner | 25 kg | Kraft paper + PE |
| PP woven bag with PE inner liner | 25 kg | PP woven + PE |
| Fiber drum | 25-50 kg | Fiberboard + PE |
SECTION 16: TRANSPORTATION INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not regulated (not hazardous) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| ADR/RID | Not regulated |
| IMDG Code | Not regulated |
| IATA (Air) | Not regulated |
| Marine Pollutant | No |
| Transport Temperature | Ambient (15-25°C) |
SECTION 17: REGULATORY STATUS
| Region / Authority | Status |
|---|---|
| European Union | Approved as zinc source in food supplements (EC 1170/2009, 2002/46/EC) |
| USA (FDA) | GRAS; approved as dietary supplement and food additive (21 CFR 182.5227) |
| USP-NF | Official monograph available (USP Zinc Lactate) |
| JECFA (FAO/WHO) | Evaluated as food additive |
| Turkey | Zinc source under Turkish Food Codex Supplement Regulation |
| Halal | Available |
| Kosher | Available |
| Vegetarian/Vegan | Suitable |
SECTION 18: OTHER NAMES AND SYNONYMS
| Type | Name |
|---|---|
| Common Names | Zinc Lactate, Zinc DL-Lactate, Zinc L-Lactate, Lactic Acid Zinc Salt |
| Chemical Names | Zinc bis(2-hydroxypropanoate), Zinc 2-Hydroxypropanoic Acid |
| CAS Number (DL) | 16039-53-5 |
| CAS Number (L) | 63179-81-7 |
| EC Number | 240-178-4 |
SECTION 19: SUMMARY TABLE
| Parameter | Value |
|---|---|
| Product | Zinc Lactate / Zinc L-Lactate |
| CAS Number | 16039-53-5 / 63179-81-7 |
| Molecular Formula | C6H10O6Zn |
| Molecular Weight | 243.55 g/mol |
| Appearance | White crystalline powder |
| Zinc Content | ~22% |
| pH (1% solution) | 5.5 – 7.0 |
| Melting Point | >256°C |
| Primary Function | Zinc supplementation, antimicrobial, oral care |
| Shelf Life | 36 months |
| GHS Signal Word | Not classified (non-hazardous) |
SECTION 20: CRITICAL WARNINGS AND BEST PRACTICES
CRITICAL WARNINGS:
-
Zinc Toxicity: Excessive zinc intake (above 40 mg/day) may cause copper deficiency, impaired immune function, and gastrointestinal discomfort. Do not exceed recommended daily dose.
-
Combustible: Has combustible properties; keep away from heat and ignition sources.
-
Drug Interactions: Zinc may reduce absorption of tetracycline antibiotics and quinolones; should be taken at least 2 hours apart from these medications.
-
Hygroscopicity: Low-moderate moisture absorption; store in tightly closed containers.
BEST PRACTICE RECOMMENDATIONS:
-
Dosage: Daily 15-50 mg elemental zinc for adults; upper limit 40 mg/day.
-
Oral Care Formulations: Use at 0.5-2.0% in toothpaste, 0.1-1.0% in mouthwash.
-
Solution Preparation: Slightly soluble in water; use warm water to increase solubility.
-
Storage: Protect from moisture; store in airtight containers after opening.
-
L-Lactate Preference: Prefer Zinc L-Lactate (CAS 63179-81-7) for higher bioavailability.
LEGAL DISCLAIMER:
The information provided in this document is presented in good faith based on our current knowledge and experience; however, since all usage conditions are beyond our control, it does not constitute a binding specification or warranty. This Technical Data Sheet is for informational purposes only and does not constitute medical advice. Users are obligated to test the suitability for their own applications. For complete safety, storage, handling, transportation, disposal, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. This product is not intended to diagnose, treat, cure, or prevent any disease.
