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Ethyl Hexyl Glycerin, Octoxy Glycerin, Ethylhexylglycerin, 70445-33-9

Ethyl Hexyl Glycerin, Octoxy Glycerin, Ethylhexylglycerin, 70445-33-9

ETHYLHEXYLGLYCERIN - ETİLHEKSİL GLİSERİN
3-(2-Ethylhexyloxy)-1,2-propanediol - Octoxyglycerin
CAS: 70445-33-9

Product Name Ethylhexylglycerin
CAS Number 70445-33-9
EC Number 408-080-2
Chemical Class Alkyl Glyceryl Ether
Synonyms Ethylhexylglycerin, Ethyl Hexyl Glycerin, 3-(2-Ethylhexyloxy)-1,2-propanediol, Octoxyglycerin, Batyl Alcohol

ITEM 1: PRODUCT IDENTITY AND NOMENCLATURE

Parameter Description
IUPAC Name 3-(2-Ethylhexyloxy)propane-1,2-diol
Chemical Formula C₁₁H₂₄O₃
Molecular Weight 204.306 g/mol
CAS Number 70445-33-9
EC Number 408-080-2
Synonyms Ethylhexylglycerin, Ethyl Hexyl Glycerin, 3-(2-Ethylhexyloxy)-1,2-propanediol, Octoxyglycerin, Batyl Alcohol
HS Code 2909.49.00.00.00
REACH Status Registered and compliant

Description: Ethylhexylglycerin is an alkyl glyceryl ether derived from vegetable glycerin. It is a clear, colorless to pale yellow, viscous liquid. It is widely used in cosmetic and personal care products as a preservative booster, moisturizer, emollient, and deodorant active ingredient. It is known for its low toxicity, broad pH stability, and excellent tolerance profile. Its antimicrobial activity is particularly effective against Gram-positive bacteria and synergistically enhances the efficacy of preservatives such as phenoxyethanol.

ITEM 2: CHEMICAL STRUCTURE AND MOLECULAR PROPERTIES

Parameter Description
Chemical Family Alkyl Glyceryl Ether
Structure Glycerin backbone with 2-ethylhexyl ether group
Functional Groups Two hydroxyl (-OH), one ether (-O-)
Molecular Structure HO-CH₂-CH(OH)-CH₂-O-CH₂-CH(CH₂CH₃)-CH₂CH₂CH₃
SMILES CCCCC(CC)COCC(O)CO
InChI Key VYQNWZOUAUKGHI-UHFFFAOYSA-N
Surface Activity Surface active (amphiphilic)
Source Vegetable glycerin (renewable)

Structural Formula:

text

    OH   OH
     |    |
HO-CH₂-CH-CH₂-O-CH₂-CH-CH₂-CH₂-CH₂-CH₃
                   |
                  CH₂-CH₃

Description: Ethylhexylglycerin is an alkyl glyceryl ether formed by attaching a 2-ethylhexyl ether group to a glycerin molecule. The molecule contains two hydroxyl groups (-OH) and one ether group (-O-). This structure imparts both hydrophilic (water-loving) and lipophilic (oil-loving) properties, giving it amphiphilic (surface-active) character. This amphiphilic structure enables interaction with microbial cell membranes, providing antimicrobial activity. Being derived from vegetable glycerin, it is sourced from renewable materials.

ITEM 3: PHYSICAL APPEARANCE AND FORM

Parameter Specification Test Method
Appearance Clear, colorless to pale yellow liquid Visual Inspection
Physical Form Liquid (viscous) Visual Inspection
Color Colorless to pale yellow Visual Inspection
Odor Slight characteristic Organoleptic
Clarity Clear, free from sediment Visual Inspection

Description: Ethylhexylglycerin is a clear, colorless to pale yellow, viscous liquid with a slight characteristic odor. It is supplied in high purity and contains no visible sediment or turbidity.

ITEM 4: PHYSICAL PROPERTIES

Property Specification Typical Value Test Method
Density (20°C) 0.955 – 0.965 g/cm³ 0.962 g/cm³ ASTM D4052
Refractive Index (20°C) 1.445 – 1.450 1.448 ASTM D1218
Viscosity (25°C) ~30 – 50 cP 40 cP
Melting Point ~-12 °C -12 °C DSC
Boiling Point 325 °C 325 °C
Flash Point > 100 °C > 100 °C ASTM D93
pH (1% Aqueous Solution) 5.5 – 7.0 (neutral) 6.5 pH Meter
Water Solubility Slightly soluble (~1 g/L)

Description: Ethylhexylglycerin has a density of approximately 0.962 g/cm³ at 20°C and a refractive index of 1.448. Its melting point is approximately -12°C. The boiling point is 325°C, indicating low volatility. It is slightly soluble in water (approximately 1 g/L) but readily soluble in alcohol and glycols. Its aqueous solution is neutral (pH 5.5-7.0).

ITEM 5: THERMAL PROPERTIES

Property Specification / Value Test Method
Melting Point ~-12 °C DSC
Boiling Point 325 °C
Flash Point > 100 °C ASTM D93
Thermal Stability Stable up to 150°C

Description: Ethylhexylglycerin has a low melting point of approximately -12°C and remains liquid over a wide temperature range. Its boiling point is 325°C, indicating very low volatility. The flash point is above 100°C. It is thermally stable up to 150°C, which is sufficient for most cosmetic processing conditions.

ITEM 6: SOLUBILITY AND MISCIBILITY

Solvent / Medium Solubility / Miscibility
Water Slightly soluble (~1 g/L)
Ethanol Completely miscible
Methanol Completely miscible
Isopropanol Completely miscible
Propylene Glycol Completely miscible
Glycerin Completely miscible
Acetone Completely miscible
Ethyl Acetate Completely miscible
Oils (Vegetable/Mineral) Completely miscible
Silicone Oils Completely miscible

Description: Ethylhexylglycerin is slightly soluble in water but completely miscible with most organic solvents including ethanol, methanol, isopropanol, propylene glycol, glycerin, acetone, ethyl acetate, oils, and silicone oils. This broad solubility profile makes it easy to incorporate into a wide range of cosmetic formulations.

ITEM 7: PURITY AND ANALYTICAL SPECIFICATIONS

Parameter Specification Typical Value Test Method
Purity (GC) ≥ 98.0% 99.0% GC
Water Content (Karl Fischer) ≤ 0.50% 0.10% Karl Fischer
Color (APHA) ≤ 50 20 ASTM D1209
Density (20°C) 0.955 – 0.965 g/cm³ 0.962 ASTM D4052
Refractive Index (20°C) 1.445 – 1.450 1.448 ASTM D1218
Acid Value (mg KOH/g) ≤ 0.50 0.10 Titration
Heavy Metals (Pb) ≤ 10 ppm <5 ppm ICP-MS
Arsenic (As) ≤ 2 ppm <1 ppm ICP-MS
Appearance Clear liquid Passes Visual

Description: Ethylhexylglycerin is supplied in high purity (≥98.0%). Low water content and acid value indicate high quality and product stability. Heavy metal content is strictly controlled to ensure safety for cosmetic applications.

ITEM 8: COSMETIC APPLICATIONS (PRESERVATIVE BOOSTER)

Application Function / Benefit
Preservative Booster Enhances the efficacy of primary preservatives
Preservative Synergist Improves broad-spectrum activity of preservative systems
Deodorant Active Prevents body odor, antibacterial effect
Moisturizer Humectant, skin conditioning
Emollient Softens and smooths the skin
Wetting Agent Wetting properties in formulations
Surfactant Mild surface-active effect

Preservative Synergy:

Preservative Synergy Effect
Phenoxyethanol Excellent synergy, broad-spectrum activity
Sorbic Acid Good synergy
Benzoic Acid Good synergy
Salicylic Acid Good synergy
Parabens Good synergy
Isothiazolinones Moderate synergy

Description: Ethylhexylglycerin is used in cosmetic formulations as a preservative booster. It is particularly effective in synergy with phenoxyethanol. It exhibits antibacterial, antifungal, and mild antiviral activity. Its surface-active properties allow it to affect the surface tension of microbial cell membranes, enhancing the efficacy of preservative systems.

ITEM 9: DEODORANT AND ODOR CONTROL APPLICATIONS

Application Function / Benefit
Deodorants Prevents body odor, antibacterial effect
Antiperspirants Odor control, antibacterial
Body Sprays Odor control, freshness
Foot Care Products Prevents foot odor
Personal Care Products Odor control, freshness
Creams and Lotions Prevents odor formation

Mechanism of Action:

Parameter Description
Active Ingredient Ethylhexylglycerin
Mechanism of Action Affects cell membrane of Gram-positive bacteria; prevents odor formation
Target Microorganisms Corynebacterium, Staphylococcus, other odor-causing bacteria
Activity Spectrum Particularly effective against Gram-positive bacteria
Duration Long-lasting odor control

Description: Ethylhexylglycerin provides deodorant efficacy by inhibiting the growth of odor-causing bacteria (particularly Gram-positive bacteria). It is a preferred ingredient in aluminum-free natural deodorant formulations. It prevents odors caused by bacteria, yeast, and fungi on the skin.

ITEM 10: MOISTURIZING AND SKIN CARE APPLICATIONS

Application Function / Benefit
Moisturizing Creams Humectant, skin conditioning
Body Lotions Moisturizing, skin conditioning
Facial Creams Moisturizing, emollient
Hand and Foot Care Moisturizing, protective
Sunscreens Moisturizing, preservative booster
Baby Care Products Mild moisturizer, skin-friendly
Sensitive Skin Products Mild, non-irritating

Description: In skin care products, Ethylhexylglycerin functions as a moisturizer and emollient. Being a glycerin derivative, it attracts and retains moisture in the skin. It also helps extend product shelf life and contributes to preventing unpleasant odors that may develop over time.

ITEM 11: SHAMPOO AND HAIR CARE APPLICATIONS

Application Function / Benefit
Shampoos Preservative booster, moisturizer
Conditioners Moisturizing, emollient
Hair Masks Moisturizing, preservative
Hair Care Products Prevents microbial growth

Description: In shampoos and hair care products, Ethylhexylglycerin is used as a preservative booster and moisturizer. It helps prevent microbial growth and extends product shelf life. It also contributes to preventing bacteria and fungus-related issues on the scalp.

ITEM 12: SUNSCREEN APPLICATIONS

Application Function / Benefit
Sunscreens Preservative booster, moisturizer
UV Protection Products Antimicrobial protection, moisturizing

Description: In sunscreen formulations, Ethylhexylglycerin is used as a preservative booster. It helps prevent microbial growth and extends product shelf life. Its moisturizing properties also enhance skin comfort.

ITEM 13: SECTOR COMPATIBILITY MATRIX

Industry Suitability Application Notes
Cosmetics Excellent Preservative booster, moisturizer, deodorant Primary use
Personal Care Excellent Shampoos, creams, lotions, sunscreens Widespread use
Deodorants Excellent Natural deodorant, odor control Specialized use
Baby Care Good Mild preservative, moisturizer Skin-friendly
Pharmaceuticals Good Topical formulations Excipient

ITEM 14: REGULATORY STATUS

Region Status
USA FDA approved for cosmetic use
European Union Approved (Cosmetics Regulation)
Japan Approved
China Approved
REACH (EU) Registered and compliant
TSCA (USA) Listed
EINECS (EU) 408-080-2
ECOCERT Approved (for natural cosmetics)
COSMOS Approved (for natural cosmetics)
NATURE Approved (for natural cosmetics)
Halal Available upon request
Kosher Available upon request
Vegan Suitable

ITEM 15: SAFETY AND TOXICOLOGICAL PROFILE

Parameter Description
Acute Oral Toxicity (LD50) > 2000 mg/kg (low toxicity)
Acute Dermal Toxicity Low
Skin Irritation Non-irritating (at recommended levels)
Eye Irritation Mild irritant
Skin Sensitization Non-sensitizing
Carcinogenicity Not classified
Mutagenicity Not classified
Reproductive Toxicity Not classified
Biodegradability Readily biodegradable
Ecotoxicity Low toxicity

Description: Ethylhexylglycerin has a low toxicity profile (LD50 > 2000 mg/kg). At recommended usage levels, it is non-irritating to the skin and non-sensitizing. It may cause mild eye irritation. It is not classified as a carcinogen, mutagen, or reproductive toxicant. It is readily biodegradable and has low ecotoxicity.

ITEM 16: HANDLING AND PERSONAL PROTECTIVE EQUIPMENT (PPE)

Parameter Recommendation
Ventilation Adequate general ventilation
Gloves Nitrile gloves (for prolonged contact)
Eye Protection Safety goggles
Skin Contact Wash with soap and water
Eye Contact Rinse with plenty of water for 15 minutes
Ingestion Rinse mouth; seek medical attention

ITEM 17: STORAGE AND SHELF LIFE

Parameter Description
Storage Temperature 15 – 30°C
Storage Conditions Cool, dry, well-ventilated area
Light Protect from direct sunlight
Moisture Keep away from moisture
Materials to Avoid Strong oxidizers, acids, bases
Packaging Materials Stainless steel, HDPE, glass
Shelf Life 24 months (unopened, recommended conditions)
Signs of Degradation Discoloration, odor change, turbidity

ITEM 18: SPILL CLEANUP AND DISPOSAL

Parameter Description
Small Spills Absorb with inert material (sand, vermiculite)
Large Spills Dike, absorb with inert material, collect in suitable containers
Do Not Discharge to sewers or water sources
Waste Disposal Dispose according to local regulations
Environmental Classification Not classified as hazardous

ITEM 19: PACKAGING INFORMATION

Parameter Description
Standard Packaging 200 kg steel drums
Bulk Packaging 1000 kg IBC
Small Packaging 25 L jerrycans, 1 L laboratory bottles
Packaging Materials Steel, HDPE, glass

ITEM 20: SYNONYMS AND ALIASES

Name Description
Ethylhexylglycerin Most common name
Ethyl Hexyl Glycerin Chemical name
3-(2-Ethylhexyloxy)-1,2-propanediol IUPAC name
Octoxyglycerin Chemical name
Batyl Alcohol Historical name
EHG Abbreviation

QUALITY AND CERTIFICATION SUMMARY

Certificate / Standard Status
ISO 9001:2015 Certified manufacturing sites
REACH (EC 1907/2006) Registered and compliant
FDA 21 CFR Approved for cosmetic use
EU Cosmetics Regulation Permitted
ECOCERT / COSMOS Approved
Halal Available upon request
Kosher Available upon request
Vegan Suitable

Disclaimer: This Technical Data Sheet provides typical values for reference purposes only. All values are based on standard laboratory measurements and do not constitute a binding specification. For binding properties, please request the Certificate of Analysis (COA) for each specific batch. The user is solely responsible for determining product suitability for their intended application and for compliance with all applicable regulations. Safety Data Sheet (SDS) must be requested from the supplier before use.

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