Ethyl Hexyl Glycerin, Octoxy Glycerin, Ethylhexylglycerin, 70445-33-9
ETHYLHEXYLGLYCERIN - ETİLHEKSİL GLİSERİN
3-(2-Ethylhexyloxy)-1,2-propanediol - Octoxyglycerin
CAS: 70445-33-9
| Product Name |
Ethylhexylglycerin |
| CAS Number |
70445-33-9 |
| EC Number |
408-080-2 |
| Chemical Class |
Alkyl Glyceryl Ether |
| Synonyms |
Ethylhexylglycerin, Ethyl Hexyl Glycerin, 3-(2-Ethylhexyloxy)-1,2-propanediol, Octoxyglycerin, Batyl Alcohol |
ITEM 1: PRODUCT IDENTITY AND NOMENCLATURE
| Parameter |
Description |
| IUPAC Name |
3-(2-Ethylhexyloxy)propane-1,2-diol |
| Chemical Formula |
C₁₁H₂₄O₃ |
| Molecular Weight |
204.306 g/mol |
| CAS Number |
70445-33-9 |
| EC Number |
408-080-2 |
| Synonyms |
Ethylhexylglycerin, Ethyl Hexyl Glycerin, 3-(2-Ethylhexyloxy)-1,2-propanediol, Octoxyglycerin, Batyl Alcohol |
| HS Code |
2909.49.00.00.00 |
| REACH Status |
Registered and compliant |
Description: Ethylhexylglycerin is an alkyl glyceryl ether derived from vegetable glycerin. It is a clear, colorless to pale yellow, viscous liquid. It is widely used in cosmetic and personal care products as a preservative booster, moisturizer, emollient, and deodorant active ingredient. It is known for its low toxicity, broad pH stability, and excellent tolerance profile. Its antimicrobial activity is particularly effective against Gram-positive bacteria and synergistically enhances the efficacy of preservatives such as phenoxyethanol.
ITEM 2: CHEMICAL STRUCTURE AND MOLECULAR PROPERTIES
| Parameter |
Description |
| Chemical Family |
Alkyl Glyceryl Ether |
| Structure |
Glycerin backbone with 2-ethylhexyl ether group |
| Functional Groups |
Two hydroxyl (-OH), one ether (-O-) |
| Molecular Structure |
HO-CH₂-CH(OH)-CH₂-O-CH₂-CH(CH₂CH₃)-CH₂CH₂CH₃ |
| SMILES |
CCCCC(CC)COCC(O)CO |
| InChI Key |
VYQNWZOUAUKGHI-UHFFFAOYSA-N |
| Surface Activity |
Surface active (amphiphilic) |
| Source |
Vegetable glycerin (renewable) |
Structural Formula:
text
OH OH
| |
HO-CH₂-CH-CH₂-O-CH₂-CH-CH₂-CH₂-CH₂-CH₃
|
CH₂-CH₃
Description: Ethylhexylglycerin is an alkyl glyceryl ether formed by attaching a 2-ethylhexyl ether group to a glycerin molecule. The molecule contains two hydroxyl groups (-OH) and one ether group (-O-). This structure imparts both hydrophilic (water-loving) and lipophilic (oil-loving) properties, giving it amphiphilic (surface-active) character. This amphiphilic structure enables interaction with microbial cell membranes, providing antimicrobial activity. Being derived from vegetable glycerin, it is sourced from renewable materials.
ITEM 3: PHYSICAL APPEARANCE AND FORM
| Parameter |
Specification |
Test Method |
| Appearance |
Clear, colorless to pale yellow liquid |
Visual Inspection |
| Physical Form |
Liquid (viscous) |
Visual Inspection |
| Color |
Colorless to pale yellow |
Visual Inspection |
| Odor |
Slight characteristic |
Organoleptic |
| Clarity |
Clear, free from sediment |
Visual Inspection |
Description: Ethylhexylglycerin is a clear, colorless to pale yellow, viscous liquid with a slight characteristic odor. It is supplied in high purity and contains no visible sediment or turbidity.
ITEM 4: PHYSICAL PROPERTIES
| Property |
Specification |
Typical Value |
Test Method |
| Density (20°C) |
0.955 – 0.965 g/cm³ |
0.962 g/cm³ |
ASTM D4052 |
| Refractive Index (20°C) |
1.445 – 1.450 |
1.448 |
ASTM D1218 |
| Viscosity (25°C) |
~30 – 50 cP |
40 cP |
– |
| Melting Point |
~-12 °C |
-12 °C |
DSC |
| Boiling Point |
325 °C |
325 °C |
– |
| Flash Point |
> 100 °C |
> 100 °C |
ASTM D93 |
| pH (1% Aqueous Solution) |
5.5 – 7.0 (neutral) |
6.5 |
pH Meter |
| Water Solubility |
Slightly soluble (~1 g/L) |
– |
– |
Description: Ethylhexylglycerin has a density of approximately 0.962 g/cm³ at 20°C and a refractive index of 1.448. Its melting point is approximately -12°C. The boiling point is 325°C, indicating low volatility. It is slightly soluble in water (approximately 1 g/L) but readily soluble in alcohol and glycols. Its aqueous solution is neutral (pH 5.5-7.0).
ITEM 5: THERMAL PROPERTIES
| Property |
Specification / Value |
Test Method |
| Melting Point |
~-12 °C |
DSC |
| Boiling Point |
325 °C |
– |
| Flash Point |
> 100 °C |
ASTM D93 |
| Thermal Stability |
Stable up to 150°C |
– |
Description: Ethylhexylglycerin has a low melting point of approximately -12°C and remains liquid over a wide temperature range. Its boiling point is 325°C, indicating very low volatility. The flash point is above 100°C. It is thermally stable up to 150°C, which is sufficient for most cosmetic processing conditions.
ITEM 6: SOLUBILITY AND MISCIBILITY
| Solvent / Medium |
Solubility / Miscibility |
| Water |
Slightly soluble (~1 g/L) |
| Ethanol |
Completely miscible |
| Methanol |
Completely miscible |
| Isopropanol |
Completely miscible |
| Propylene Glycol |
Completely miscible |
| Glycerin |
Completely miscible |
| Acetone |
Completely miscible |
| Ethyl Acetate |
Completely miscible |
| Oils (Vegetable/Mineral) |
Completely miscible |
| Silicone Oils |
Completely miscible |
Description: Ethylhexylglycerin is slightly soluble in water but completely miscible with most organic solvents including ethanol, methanol, isopropanol, propylene glycol, glycerin, acetone, ethyl acetate, oils, and silicone oils. This broad solubility profile makes it easy to incorporate into a wide range of cosmetic formulations.
ITEM 7: PURITY AND ANALYTICAL SPECIFICATIONS
| Parameter |
Specification |
Typical Value |
Test Method |
| Purity (GC) |
≥ 98.0% |
99.0% |
GC |
| Water Content (Karl Fischer) |
≤ 0.50% |
0.10% |
Karl Fischer |
| Color (APHA) |
≤ 50 |
20 |
ASTM D1209 |
| Density (20°C) |
0.955 – 0.965 g/cm³ |
0.962 |
ASTM D4052 |
| Refractive Index (20°C) |
1.445 – 1.450 |
1.448 |
ASTM D1218 |
| Acid Value (mg KOH/g) |
≤ 0.50 |
0.10 |
Titration |
| Heavy Metals (Pb) |
≤ 10 ppm |
<5 ppm |
ICP-MS |
| Arsenic (As) |
≤ 2 ppm |
<1 ppm |
ICP-MS |
| Appearance |
Clear liquid |
Passes |
Visual |
Description: Ethylhexylglycerin is supplied in high purity (≥98.0%). Low water content and acid value indicate high quality and product stability. Heavy metal content is strictly controlled to ensure safety for cosmetic applications.
ITEM 8: COSMETIC APPLICATIONS (PRESERVATIVE BOOSTER)
| Application |
Function / Benefit |
| Preservative Booster |
Enhances the efficacy of primary preservatives |
| Preservative Synergist |
Improves broad-spectrum activity of preservative systems |
| Deodorant Active |
Prevents body odor, antibacterial effect |
| Moisturizer |
Humectant, skin conditioning |
| Emollient |
Softens and smooths the skin |
| Wetting Agent |
Wetting properties in formulations |
| Surfactant |
Mild surface-active effect |
Preservative Synergy:
| Preservative |
Synergy Effect |
| Phenoxyethanol |
Excellent synergy, broad-spectrum activity |
| Sorbic Acid |
Good synergy |
| Benzoic Acid |
Good synergy |
| Salicylic Acid |
Good synergy |
| Parabens |
Good synergy |
| Isothiazolinones |
Moderate synergy |
Description: Ethylhexylglycerin is used in cosmetic formulations as a preservative booster. It is particularly effective in synergy with phenoxyethanol. It exhibits antibacterial, antifungal, and mild antiviral activity. Its surface-active properties allow it to affect the surface tension of microbial cell membranes, enhancing the efficacy of preservative systems.
ITEM 9: DEODORANT AND ODOR CONTROL APPLICATIONS
| Application |
Function / Benefit |
| Deodorants |
Prevents body odor, antibacterial effect |
| Antiperspirants |
Odor control, antibacterial |
| Body Sprays |
Odor control, freshness |
| Foot Care Products |
Prevents foot odor |
| Personal Care Products |
Odor control, freshness |
| Creams and Lotions |
Prevents odor formation |
Mechanism of Action:
| Parameter |
Description |
| Active Ingredient |
Ethylhexylglycerin |
| Mechanism of Action |
Affects cell membrane of Gram-positive bacteria; prevents odor formation |
| Target Microorganisms |
Corynebacterium, Staphylococcus, other odor-causing bacteria |
| Activity Spectrum |
Particularly effective against Gram-positive bacteria |
| Duration |
Long-lasting odor control |
Description: Ethylhexylglycerin provides deodorant efficacy by inhibiting the growth of odor-causing bacteria (particularly Gram-positive bacteria). It is a preferred ingredient in aluminum-free natural deodorant formulations. It prevents odors caused by bacteria, yeast, and fungi on the skin.
ITEM 10: MOISTURIZING AND SKIN CARE APPLICATIONS
| Application |
Function / Benefit |
| Moisturizing Creams |
Humectant, skin conditioning |
| Body Lotions |
Moisturizing, skin conditioning |
| Facial Creams |
Moisturizing, emollient |
| Hand and Foot Care |
Moisturizing, protective |
| Sunscreens |
Moisturizing, preservative booster |
| Baby Care Products |
Mild moisturizer, skin-friendly |
| Sensitive Skin Products |
Mild, non-irritating |
Description: In skin care products, Ethylhexylglycerin functions as a moisturizer and emollient. Being a glycerin derivative, it attracts and retains moisture in the skin. It also helps extend product shelf life and contributes to preventing unpleasant odors that may develop over time.
ITEM 11: SHAMPOO AND HAIR CARE APPLICATIONS
| Application |
Function / Benefit |
| Shampoos |
Preservative booster, moisturizer |
| Conditioners |
Moisturizing, emollient |
| Hair Masks |
Moisturizing, preservative |
| Hair Care Products |
Prevents microbial growth |
Description: In shampoos and hair care products, Ethylhexylglycerin is used as a preservative booster and moisturizer. It helps prevent microbial growth and extends product shelf life. It also contributes to preventing bacteria and fungus-related issues on the scalp.
ITEM 12: SUNSCREEN APPLICATIONS
| Application |
Function / Benefit |
| Sunscreens |
Preservative booster, moisturizer |
| UV Protection Products |
Antimicrobial protection, moisturizing |
Description: In sunscreen formulations, Ethylhexylglycerin is used as a preservative booster. It helps prevent microbial growth and extends product shelf life. Its moisturizing properties also enhance skin comfort.
ITEM 13: SECTOR COMPATIBILITY MATRIX
| Industry |
Suitability |
Application |
Notes |
| Cosmetics |
Excellent |
Preservative booster, moisturizer, deodorant |
Primary use |
| Personal Care |
Excellent |
Shampoos, creams, lotions, sunscreens |
Widespread use |
| Deodorants |
Excellent |
Natural deodorant, odor control |
Specialized use |
| Baby Care |
Good |
Mild preservative, moisturizer |
Skin-friendly |
| Pharmaceuticals |
Good |
Topical formulations |
Excipient |
ITEM 14: REGULATORY STATUS
| Region |
Status |
| USA |
FDA approved for cosmetic use |
| European Union |
Approved (Cosmetics Regulation) |
| Japan |
Approved |
| China |
Approved |
| REACH (EU) |
Registered and compliant |
| TSCA (USA) |
Listed |
| EINECS (EU) |
408-080-2 |
| ECOCERT |
Approved (for natural cosmetics) |
| COSMOS |
Approved (for natural cosmetics) |
| NATURE |
Approved (for natural cosmetics) |
| Halal |
Available upon request |
| Kosher |
Available upon request |
| Vegan |
Suitable |
ITEM 15: SAFETY AND TOXICOLOGICAL PROFILE
| Parameter |
Description |
| Acute Oral Toxicity (LD50) |
> 2000 mg/kg (low toxicity) |
| Acute Dermal Toxicity |
Low |
| Skin Irritation |
Non-irritating (at recommended levels) |
| Eye Irritation |
Mild irritant |
| Skin Sensitization |
Non-sensitizing |
| Carcinogenicity |
Not classified |
| Mutagenicity |
Not classified |
| Reproductive Toxicity |
Not classified |
| Biodegradability |
Readily biodegradable |
| Ecotoxicity |
Low toxicity |
Description: Ethylhexylglycerin has a low toxicity profile (LD50 > 2000 mg/kg). At recommended usage levels, it is non-irritating to the skin and non-sensitizing. It may cause mild eye irritation. It is not classified as a carcinogen, mutagen, or reproductive toxicant. It is readily biodegradable and has low ecotoxicity.
ITEM 16: HANDLING AND PERSONAL PROTECTIVE EQUIPMENT (PPE)
| Parameter |
Recommendation |
| Ventilation |
Adequate general ventilation |
| Gloves |
Nitrile gloves (for prolonged contact) |
| Eye Protection |
Safety goggles |
| Skin Contact |
Wash with soap and water |
| Eye Contact |
Rinse with plenty of water for 15 minutes |
| Ingestion |
Rinse mouth; seek medical attention |
ITEM 17: STORAGE AND SHELF LIFE
| Parameter |
Description |
| Storage Temperature |
15 – 30°C |
| Storage Conditions |
Cool, dry, well-ventilated area |
| Light |
Protect from direct sunlight |
| Moisture |
Keep away from moisture |
| Materials to Avoid |
Strong oxidizers, acids, bases |
| Packaging Materials |
Stainless steel, HDPE, glass |
| Shelf Life |
24 months (unopened, recommended conditions) |
| Signs of Degradation |
Discoloration, odor change, turbidity |
ITEM 18: SPILL CLEANUP AND DISPOSAL
| Parameter |
Description |
| Small Spills |
Absorb with inert material (sand, vermiculite) |
| Large Spills |
Dike, absorb with inert material, collect in suitable containers |
| Do Not |
Discharge to sewers or water sources |
| Waste Disposal |
Dispose according to local regulations |
| Environmental Classification |
Not classified as hazardous |
ITEM 19: PACKAGING INFORMATION
| Parameter |
Description |
| Standard Packaging |
200 kg steel drums |
| Bulk Packaging |
1000 kg IBC |
| Small Packaging |
25 L jerrycans, 1 L laboratory bottles |
| Packaging Materials |
Steel, HDPE, glass |
ITEM 20: SYNONYMS AND ALIASES
| Name |
Description |
| Ethylhexylglycerin |
Most common name |
| Ethyl Hexyl Glycerin |
Chemical name |
| 3-(2-Ethylhexyloxy)-1,2-propanediol |
IUPAC name |
| Octoxyglycerin |
Chemical name |
| Batyl Alcohol |
Historical name |
| EHG |
Abbreviation |
QUALITY AND CERTIFICATION SUMMARY
| Certificate / Standard |
Status |
| ISO 9001:2015 |
Certified manufacturing sites |
| REACH (EC 1907/2006) |
Registered and compliant |
| FDA 21 CFR |
Approved for cosmetic use |
| EU Cosmetics Regulation |
Permitted |
| ECOCERT / COSMOS |
Approved |
| Halal |
Available upon request |
| Kosher |
Available upon request |
| Vegan |
Suitable |
Disclaimer: This Technical Data Sheet provides typical values for reference purposes only. All values are based on standard laboratory measurements and do not constitute a binding specification. For binding properties, please request the Certificate of Analysis (COA) for each specific batch. The user is solely responsible for determining product suitability for their intended application and for compliance with all applicable regulations. Safety Data Sheet (SDS) must be requested from the supplier before use.