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Send EmailCreatine, Amidino Sarcosine, Methyl Glycosyl Amine, 57-00-1
Creatine (N-Amidino Sarcosine) – Product Profile
Chemical Identity
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Molecular Formula: C₄H₉N₃O₂
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Molecular Weight: 131.13 g/mol
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Chemical Name: N-Amidino Sarcosine
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CAS Number: 57-00-1
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Appearance: Fine crystalline powder
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Density: 1.33 g/cm³ (25 °C)
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Melting Point: ~255 °C
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Solubility: Poorly soluble in water (13.3 mg/L at 18 °C), soluble in glacial acetic acid
Biological Role
Creatine is synthesized in the liver, kidneys, and pancreas of vertebrates and stored mainly in skeletal muscle (about 95%). It plays a critical role in ATP regeneration, supporting short bursts of high-intensity activity. It also contributes to protein synthesis and has potential neuroprotective effects.
Production
Commercial creatine monohydrate is produced by reacting sarcosine with cyanamide under heat and pressure in the presence of catalysts. The product is crystallized, purified by centrifugation, dried, and milled to a fine powder (200 mesh) for improved solubility.
Applications
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Sports Nutrition: Pre-workout supplements, bodybuilding, muscle volumization, endurance support.
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Pharmaceuticals: Used in formulations for myocardial dysfunction, septic shock, heart disease, respiratory insufficiency, ALS therapy, and growth hormone-related drugs.
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Functional Foods: Anti-aging supplements, recovery products.
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Research: Studied for neuroprotective and metabolic effects.
Synonyms
Creatine, N-Methyl-N-Guanidylglycine, N-Amidino Sarcosine, Methylglycosylamine, Creatine Monohydrate, Alpha-Methylguanidino Acetic Acid, N-(Aminoiminomethyl)-N-methyl-glycine.
Creatine – Sectoral Suitability Table
| Sector | Application Purpose | Suitability | Notes / Considerations |
|---|---|---|---|
| Sports Nutrition & Supplements | Energy storage, ATP regeneration, performance enhancement, muscle volumization | High suitability | Most common use; typically in monohydrate form; labeling and dosage warnings required |
| Functional Food Additives | Energy support, anti-aging, recovery | Moderate suitability | Must comply with food regulations; health claims restricted |
| Pharmaceuticals / Clinical Research | Heart disease, respiratory insufficiency, ALS therapy, neuroprotection | Limited suitability | Requires GMP-grade purity and regulatory approval |
| Animal Nutrition | Experimental performance and endurance support | Low suitability | Not widely used; lacks regulatory framework |
| Industrial Chemicals / R&D | Amino acid derivative for synthesis and laboratory research | Moderate suitability | Mainly for R&D purposes; limited commercial use outside sports nutrition |
| Cosmetics | Anti-aging and recovery potential | Limited suitability | Still experimental; not common in mainstream cosmetic formulations |
Summary: Creatine is primarily positioned in sports nutrition, with secondary potential in pharmaceuticals and functional foods. Its widespread commercial form is Creatine Monohydrate, valued for its role in muscle energy metabolism and performance enhancement.
