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Send EmailArginine, Arg, ABL2, L-Arginine, L(+)Arginine, Abelson murine leukemia viral oncogene homolog 2, 74-79-3
CAS: 74-79-3
Molecular Formula: C6H14N4O2
Names and Identifiers
| Name | L-Arginine |
| Synonyms | Arg ABL2 FLJ31718 FLJ22224 Arginine FLJ41441 H-Arg-OH L-Arginine L(+)Arginine L(+)-Arginine L-Arginine base Abelson tyrosine-protein kinase 2 2-amino-5-guanidino-pentanoic acid L-2-Amino-5-guanidinopentanoic acid ANTI-ABL2 antibody produced in mouse (S)-2-Amino-5-guanidinopentanoic acid (S)-2-amino-5-guanidino-pentanoic acid ABL2 (38-end), active, His tagged human Abelson murine leukemia viral oncogene homolog 2 (2S)-5-{[amino(iminio)methyl]amino}-2-ammoniopentanoate |
| CAS | 74-79-3 |
| EINECS | 200-811-1 |
| InChI | InChI=1/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 |
| InChIKey | ODKSFYDXXFIFQN-BYPYZUCNSA-N |
Physico-chemical Properties
| Molecular Formula | C6H14N4O2 |
| Molar Mass | 174.2 |
| Density | 1.2297 (rough estimate) |
| Melting Point | 222 °C (dec.) (lit.) |
| Boling Point | 305.18°C (rough estimate) |
| Specific Rotation(α) | 27.1 º (c=8, 6N HCl) |
| Flash Point | 201.2°C |
| JECFA Number | 1438 |
| Water Solubility | 148.7 g/L (20 ºC) |
| Solubility | H2O: 100mg/mL |
| Vapor Presure | 7.7E-08mmHg at 25°C |
| Appearance | powder |
| Color | white |
| Maximum wavelength(λmax) | ['λ: 260 nm Amax: ≤0.2', , 'λ: 280 nm Amax: ≤0.1'] |
| Merck | 14,780 |
| BRN | 1725413 |
| pKa | 1.82, 8.99, 12.5(at 25℃) |
| PH | 10.5-12.0 (25℃, 0.5M in H2O) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Air Sensitive |
| Refractive Index | 27 ° (C=8, 6mol/L HC |
| MDL | MFCD00002635 |
| Physical and Chemical Properties | Hydrochloride is white or hydrochloride nearly white crystalline powder, odorless, bitter taste. 218 C when baking, 225 C when the solid state. Melting point 235 °c (decomposition). Soluble in water, soluble in hot ethanol, insoluble in ether. |
| Use | Arginine is an essential amino acid for the growth and development of infants and young children. It is an intermediate metabolite of the ornithine cycle that promotes the conversion of ammonia to urea, thereby reducing blood ammonia levels. It is also the main component of sperm protein, which promotes sperm production and provides energy for sperm movement. In addition, intravenous arginine, can stimulate the pituitary growth hormone release, can be used for pituitary function test. |
Risk and Safety
| Risk Codes | R36 - Irritating to the eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R61 - May cause harm to the unborn child |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
| RTECS | CF1934200 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 29252000 |
| Hazard Class | IRRITANT |
| Toxicity | cyt-grh-par 100 mmol/L IJEBA6 24,460,86 |
Upstream Downstream Industry
| Raw Materials | Gelatin |
| Downstream Products | L-Arginine alpha-Ketoglutarate |
Nature
- This product is a white crystalline powder. Soluble in water (15%,21 ° C), slightly soluble in alcohol, insoluble in ether. Aqueous solution shows alkaline reaction, can absorb carbon dioxide from the air. 238 degrees C decomposition.
- arginine is a semi-essential amino acid in the human body, that is, an amino acid that is less synthesized in the human body and needs to be partially supplemented from food, but is essential for maintaining the growth and development of infants. In the body it is an intermediate metabolite of the ornithine cycle, can promote the production and excretion of urea, correct ammonia poisoning and can relieve hepatic coma. Arginine is also the main component of sperm protein, which can promote sperm production and improve sperm movement energy. Widely found in pig hair, hoof nails, blood meal, gelatin, protamine, small miscellaneous fish.
Preparation Method
- extraction method.
- fermentation method.
Introduction
A substrate for nitric oxide synthetase that is converted to citrulline and nitric oxide (NO). Insulin release is induced by a mechanism associated with nitric oxide.
Use
- amino acid drugs. For all kinds of liver coma and avoid the use of sodium glutamate and viral liver class abnormal alanine aminotransferase.
- usage and dosage of intravenous drip 15~20g per day, diluted with 5% glucose injection looml, then intravenous drip, within 4H, 0.75~1. 5g orally, 3 times a day. For male infertility oral 3 months for a course of treatment, 4g per day.
Safety
- attention should be paid to the occurrence of hyperchloremic acidosis in patients with renal dysfunction and anuria or in large doses. Too fast infusion can cause salivation, facial flushing and Vomit. Renal insufficiency or anuria with caution or disabled. Explosive liver failure, the lack of arginase, should not be used. When the liver function is not good, the enzyme activity required in the ornithine circulation is reduced, and the effect of reducing blood ammonia is not obvious.
- under shading, sealed and preserved.
Reference Information
| FEMA | 3819 | L-ARGININE |
| pH range of acid-base indicator discoloration | 10.5 - 12 |
| essential amino acids | L-arginine is a coding amino acid in protein synthesis, which belongs to one of the 8 essential amino acids in human body. The body needs it to perform multiple functions. For example, it stimulates the body to release specific chemicals such as insulin and human growth hormone. This amino acid also helps to remove ammonia from the body and promotes wound healing. It is also required for the production of sarcosine by the human body. Nitric oxide is produced when L-arginine is broken down, thus dilating vascular disease and increasing blood flow. Normally, the body itself produces enough L-arginine. But in case of deficiency, it can be supplemented by eating foods rich in arginine. L-arginine can be found in any protein-containing food, such as meat, poultry, cheese products, fish, etc. Arginine-rich foods include almonds, walnuts, dried sunflower kernels, dark chocolate, chickpeas, melon, peanuts, green lentils, hazelnuts, Brazil nuts, red meat (moderate), cashew nuts, salmon, pistachio, soy and walnut. This year, many people have taken L-arginine supplements to treat certain diseases, such as congestive heart failure and cystitis. Although there are many benefits, but there are also some potential side effects, such as Abdominal Pain, Diarrhea, gout and abdominal distension, and may increase the severity of herpes outbreaks and strengthen the effect of antihypertensive drugs, causes a decrease in blood pressure beyond the expected range, causing dizziness and fainting in hypertensive patients. |
| identification test | take 0.1% ml of sample solution and add 1 ml of ninhydrin test solution (TS-250), which should be reddish purple. |
| content analysis | accurately weigh about 200mg of sample, dissolve in 3ml formic acid and 50ml glacial acetic acid, two drops of crystal violet test solution (TS-74) were added and titrated with 0.1mol/L perchloric acid to the green end point, or the blue color completely disappeared. Perchloric acid corresponds to 8.710mg of L-arginine (C6H14N4O2) per Ml of 0.1mol/L. |
| toxicity | can be used safely in foods (FDA § 172.320,2000). |
| usage limit | accounts for 6.6% of the total protein in food (FDA § 172.320,2000). FEMA(mg/kg): baked products, breakfast cereals, 20~100; Non-alcoholic beverages, alcoholic beverages, 3~30; Cheese, sauce, meat products, nut products, poultry products, 15~100; Gum, candy, frosting, gelatin and pudding, soft candy, sugar substitute, sweet sauce, 3~15; Condiment 2~25; Egg products, milk substitute, other cereals, 5~10; Fats, cold drinks, fruit ice, dairy products, 5~15; Fish products 15~30; Hard Candy 1~20; Instant coffee and tea 10~100; Jam, jelly, processed fruits, 2~15; Processed vegetables 3~5; Rehydrated vegetables 5~25; Spices 10~250; Snack food 15~250; Soup 5~250. |
| Use | used in biochemical studies, various types of hepatic coma and viral liver alanine aminotransferase abnormalities. nutritional supplements; Flavoring agents. Special flavor substances can be obtained by heating reaction with sugar (amino-carbonyl reaction). GB 2760-2001 provides for the permitted use of food flavors. An important component of amino acid infusion and comprehensive amino acid preparation. amino acid drugs. used as pharmaceutical raw materials and food additives arginine is an essential amino acid for maintaining the growth and development of infants. It is an intermediate metabolite of the ornithine cycle that promotes the conversion of ammonia to urea, thereby reducing blood ammonia levels. It is also the main component of sperm protein, which promotes sperm production and provides energy for sperm movement. In addition, intravenous arginine, can stimulate the pituitary growth hormone release, can be used for pituitary function test. nutritional supplements; Flavoring agents. Special flavor substances can be obtained by heating reaction with sugar (amino-carbonyl reaction). GB 2760-2001 provides for the permitted use of food flavors. An important component of amino acid infusion and comprehensive amino acid preparation. The substrate of nitric oxide synthase can be converted to citrulline and NO. Insulin secretion is induced by a NO-dependent mechanism. |
| production method | with gelatin or pig hair, pig blood powder as raw materials, after hydrolysis, the acid hydrochloride is extracted from the hydrolysate (see 03400) and the hydrochloric acid is removed to obtain the final product. From protein (e. G., gelatin) hydrolysates by ion exchange resin or barium hydroxide separation. It is usually made into hydrochloride, but it is also stable in the Free State, so there are also free products for sale. It can also be obtained by fermentation using sugars as raw materials. with gelatin as raw material, after hydrochloric acid hydrolysis and condensation with benzaldehyde, benzylidene arginine was obtained, which was purified by hydrochloric acid hydrolysis, activated carbon treatment and column chromatography. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | Reference range: intraperitoneal-rat LD50: 3793 mg/kg |
| flammability hazard characteristics | flammability; Toxic NOx smoke from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
| Occupational Standard | SEL 10 mg/m3 |
