Citrulline Malate, L-Citrulline Malate, L-Citrulline DL-Malate, 54940-97-5, 70796-17-7

Citrulline Malate, L-Citrulline Malate, L-Citrulline DL-Malate, 54940-97-5, 70796-17-7

L-CITRULLINE MALATE

PRODUCT IDENTIFICATION INFORMATION

CHEMICAL STRUCTURE

L-Citrulline Malate Structure:

L-Citrulline:                    Malic Acid:
        O                              O
        ||                             ||
    HO—C—NH—(CH₂)₃—CH—COOH       HO—C—CH₂—CH—COOH
                     |                    |
                    NH₂                   OH

     (L-Citrulline) + (Malic Acid) → L-Citrulline Malate (Salt)

Structure Description:

• Salt formed by combining L-Citrulline (an amino acid) with DL-Malic Acid.

• L-Citrulline is a non-essential amino acid derivative.

• Malic acid is a key intermediate in the citric acid cycle (energy production).

• The malate component enhances energy metabolism and ATP production.

• Stable, water-soluble form.

SECTION 1: CHEMICAL IDENTITY AND DESCRIPTION

SECTION 2: PHYSICAL AND CHEMICAL PROPERTIES

SECTION 3: L-CITRULLINE vs L-CITRULLINE MALATE

SECTION 4: MECHANISM OF ACTION

SECTION 5: PRODUCTION PROCESS

Industrial Production Method:

Process Flow:
L-Arginine (Raw Material) → Enzymatic Conversion → L-Citrulline → Reaction with DL-Malic Acid → Crystallization → Purification → Drying → Milling → Final Product

Step-by-Step Description:

1. Raw Material: L-Arginine is used as the starting material.

2. Enzymatic Conversion: L-Arginine is converted to L-Citrulline using the enzyme arginase (or via bacterial fermentation).

3. Reaction with Malic Acid: L-Citrulline is reacted with DL-Malic Acid in aqueous solution to form the salt (L-Citrulline Malate).

4. Crystallization: The product is crystallized from the solution.

5. Purification: Crystals are purified to remove impurities.

6. Drying: Purified crystals are dried to achieve the desired moisture content.

7. Milling: Dried product is milled to achieve the desired particle size.

8. Final Product: White crystalline powder is obtained.

Natural Source: L-Citrulline is naturally found in watermelon (Citrullus vulgaris), but industrial production is mostly via enzymatic synthesis.

SECTION 6: FUNCTIONAL PROPERTIES

SECTION 7: MAIN APPLICATION AREAS

SECTION 8: SAMPLE FORMULATIONS

Pre-Workout Powder (Performance Blend):

Instructions: Blend all ingredients; Package in sealed containers; Recommended consumption: 30-45 minutes before exercise.

Capsule Formulation (Performance Support):

Instructions: Mix active ingredient with excipients; Fill into capsules (size 00 or 0); Package in blister packs or HDPE containers.

SECTION 9: QUALITY SPECIFICATIONS

SECTION 10: TOXICOLOGICAL PROFILE

SECTION 11: GHS CLASSIFICATION AND LABELING

GHS Classification (in accordance with CLP and UN GHS):

Signal Word: None (Not classified as hazardous)

Hazard Pictograms: None

NFPA 704 Hazard Classification:

SECTION 12: PRECAUTIONARY STATEMENTS (P-CODES)

SECTION 13: FIRST AID MEASURES

SECTION 14: FIREFIGHTING MEASURES

SECTION 15: STORAGE AND SHELF LIFE

SECTION 16: PACKAGING OPTIONS

SECTION 17: TRANSPORT INFORMATION

SECTION 18: REGULATORY STATUS

SECTION 19: OTHER NAMES AND SYNONYMS

SECTION 20: SUMMARY TABLE

SECTION 21: CRITICAL WARNINGS AND BEST PRACTICES

CRITICAL WARNINGS:

• GRAS Status: FDA GRAS for dietary supplement use; Safe at recommended dosages.

• Low Toxicity: LD50 > 5,000 mg/kg; Non-toxic at normal use levels.

• Mild Side Effects: High doses (>10 g/day) may cause gastrointestinal discomfort (nausea, stomach upset).

• Hygroscopic: Absorbs moisture from air; Store in tightly closed containers.

• Not a Drug: A dietary supplement ingredient; Not a drug for treating erectile dysfunction (adjunct support only).

• Consult Physician: For individuals with liver/kidney disease; For use in pregnancy/breastfeeding (consult doctor); For children without medical supervision.

• Blood Pressure: May lower blood pressure; Caution if taking antihypertensive medications.

• Natural Occurrence: Found naturally in watermelon; Safe for consumption.

BEST PRACTICE RECOMMENDATIONS:

• Sports Nutrition: Use as pre-workout ingredient; Recommended dosage: 1,000 – 6,000 mg/day; Combine with L-Arginine for enhanced effects; Add to pre-workout blends, sports drinks, capsules, or powders.

• Dietary Supplements: Use as nitric oxide booster; Dosage: 1,000 – 3,000 mg/day; For capsules, tablets, or powder formulations.

• Pharmaceutical Support: Use as adjunct therapy for erectile dysfunction (with medical supervision); Dosage: 1,000 – 3,000 mg/day; For blood pressure regulation and cardiovascular health.

• Functional Foods: Add to energy drinks, sports nutrition bars, and functional beverages; Dosage: 1,000 – 2,000 mg per serving.

• Handling: Use in well-ventilated areas; Avoid dust formation; Use dust masks when handling powder; Use gloves and safety goggles.

• Personal Protective Equipment: Dust mask (N95/FFP2) if dust is generated, safety goggles, chemical-resistant gloves, protective clothing.

• Hygiene: Wash hands thoroughly after handling; Do not eat, drink, or smoke while using.

• Storage: Store in tightly closed, moisture-proof containers; Store in cool, dry, well-ventilated area; Protect from moisture and heat; Opened containers must be resealed immediately; Shelf life: 24-48 months under proper conditions.

• Spill Management: Sweep or vacuum (HEPA) and place in suitable sealed container; Avoid dust formation; Do not allow entry into drains or waterways.

• Disposal: Dispose of in accordance with local, regional, and national regulations; Non-hazardous waste; Can be incinerated in compliance with regulations.

DETECTION METHODS:

L-CITRULLINE MALATE vs ALTERNATIVES COMPARISON:

LEGAL DISCLAIMER:
The information provided in this document is based on our current knowledge and experience and is presented in good faith. However, as all conditions of use are beyond our control, it does not constitute a binding specification or warranty. This Technical Data Sheet is for informational purposes only. Users are responsible for testing the suitability for their own applications and for complying with all local, regional, and national regulations. For complete safety, storage, use, handling, waste, and regulatory compliance information, please refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. L-Citrulline Malate is a dietary supplement ingredient; consult a healthcare professional before use, especially if you have pre-existing medical conditions.