Citrulline Malate, L-Citrulline Malate, Citruline Malate, 54940-97-5, 70796-17-7

Citrulline Malate, L-Citrulline Malate, Citruline Malate, 54940-97-5, 70796-17-7

Chemical Identity

• Name: Citrulline Malate

• Molecular Formula: C₁₀H₁₉N₃O₈

• Molecular Weight: 309.28 g/mol

• CAS Numbers: 54940-97-5; 70796-17-7

• Synonyms:

  • Stimol

  • L-Citrulline-DL-Malate

  • N5-(Aminocarbonyl)-L-Ornithine 2-hydroxybutanedioate

  • (S)-2-amino-5-ureidopentanoic acid 2-hydroxysuccinic acid salt

Physical and Chemical Properties

• Appearance: White crystalline powder

• Solubility: Soluble in water

• Density: ~1.4 g/cm³ (estimated)

• Melting Point: ~200–215 °C (decomposes upon heating)

• Storage: Keep in a dark place, inert atmosphere, at room temperature

Biological Role

• Non-essential amino acid derivative → composed of L-Citrulline and DL-Malic Acid.

• Arginine conversion: Citrulline is absorbed and converted into L-Arginine in the kidneys.

• Nitric Oxide synthesis: Supports NO production → vasodilation, improved blood flow, better oxygen delivery to muscles.

• Protein metabolism: Promotes amino acid metabolism and protein synthesis.

• Energy metabolism: Malate supports ATP production, enhancing endurance and reducing fatigue.

Applications

• Sports Nutrition:

  • Improves endurance and exercise performance.

  • Reduces fatigue and accelerates muscle recovery.

  • Commonly used in pre-workout supplements for “pump” effect.

• Pharmaceutical:

  • Supportive therapy in erectile dysfunction.

  • Used when nitric oxide deficiency leads to low blood pressure.

• Food Supplements:

  • Incorporated into functional foods and dietary supplements for energy and performance.

Safety Information

• Toxicity: Generally considered safe, non-toxic.

• Side effects: High doses may cause gastrointestinal discomfort or headache.

• Precautions: Should be avoided by pregnant/lactating women and individuals with liver, kidney, or cardiovascular conditions.

Summary

Citrulline Malate is a compound of L-Citrulline and Malic Acid that boosts nitric oxide production, improves blood flow, and enhances muscle endurance and recovery. It is widely used in sports nutrition as a performance enhancer and in medical applications as a supportive therapy for vascular health.