Panthenol, DL-Panthenol, DL-Pantothenyl Alcohol, 16485-10-2

Panthenol, DL-Panthenol, DL-Pantothenyl Alcohol, 16485-10-2

PANTHENOL (DL-PANTHENOL / DEXPANTHENOL)

CAS 16485-10-2 (DL) | CAS 81-13-0 (D) | C₉H₁₉NO₄

SECTION 1: PRODUCT IDENTITY AND DEFINITION

Description: Panthenol is the alcohol form of vitamin B5 (pantothenic acid) and is also known as provitamin B5. In the body, it is converted to pantothenic acid and serves as a precursor to coenzyme A. There are two forms: DL-Panthenol (racemic mixture, optically inactive) and Dexpanthenol (optically active D-form). Dexpanthenol is the biologically active form and can be converted to pantothenic acid. Panthenol is widely used in the cosmetic, pharmaceutical, and food industries for its moisturizing, soothing, skin-regenerating, and hair care properties.

SECTION 2: SYNONYMS AND OTHER NAMES

SECTION 3: CHEMICAL STRUCTURE AND PROPERTIES

Structural Formula (Dexpanthenol / D-Panthenol):

text

          OH
          |
    HOCH₂ - C - CHOH - CONH - CH₂ - CH₂ - CH₂OH
          |
         CH₃

    (R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide

Description: Dexpanthenol is the alcohol analog of pantothenic acid (vitamin B5). It is formed by the reaction of D-pantolactone with 3-aminopropanol. The molecule contains a primary alcohol, a secondary alcohol, and an amide group. The optically active D-isomer is the biologically active form. DL-Panthenol is an equal (1:1) mixture of D and L isomers and has approximately half the biological activity of the D-form.

SECTION 4: PHYSICAL PROPERTIES

SECTION 5: BIOLOGICAL FUNCTION AND MECHANISM

Mechanism of Action:

1. Panthenol is rapidly oxidized to pantothenic acid upon application to skin or hair

2. Pantothenic acid is used in coenzyme A (CoA) synthesis

3. Coenzyme A plays a critical role in energy metabolism and fatty acid synthesis

4. Supports cell proliferation and tissue regeneration

5. Improves skin barrier function and reduces transepidermal water loss (TEWL)

SECTION 6: COSMETIC AND PERSONAL CARE APPLICATIONS

Formulation Recommendations:

• Panthenol is readily soluble in the water phase and easily incorporated into formulations

• Suitable for hot or cold processes (stable up to 80°C)

• Prolonged heating may cause racemization (loss of D-form activity)

• Stable in pH range 4.0 – 9.0

• Compatible with most cosmetic ingredients

• Due to its hygroscopic nature, protect from moisture

SECTION 7: PHARMACEUTICAL APPLICATIONS

Pharmaceutical Formulation Tips:

• Dexpanthenol (D-form) is preferred for pharmaceutical applications

• Biologically active form

• Sterilization: Can be sterilized by autoclaving or filtration

• pH: Optimal stability at 4.0 – 7.0

• Should be protected from light

SECTION 8: FOOD APPLICATIONS (Nutritional Supplements)

Food Usage Limits:

• FDA (GRAS): Subject to GMP limits (FDA § 182.5580)

• ADI (Acceptable Daily Intake): Not specified (safe)

• As nutritional supplement: 5-10 mg/day (adult)

SECTION 9: DL-PANTHENOL vs DEXPANTHENOL COMPARISON

SECTION 10: REGULATORY STATUS

Important Regulatory Notes:

• Panthenol is considered safe in cosmetics worldwide

• Dexpanthenol has USP/EP pharmacopoeia monographs

• GRAS (Generally Recognized as Safe) as a food additive

SECTION 11: SAFETY AND TOXICOLOGICAL PROFILE

GHS Classification (DL-Panthenol):

• Xn – Harmful (R36/37/38, R41, R48, R20/21/22)

Safety Recommendations:

• S26: In case of eye contact, rinse with plenty of water and seek medical advice

• S37: Wear suitable gloves

• S22: Do not breathe dust

• S45: In case of accident, seek medical advice

SECTION 12: STORAGE AND SHELF LIFE

Special Storage Notes:

• Prolonged heating may cause racemization in D-panthenol (conversion to DL-form)

• Avoid prolonged heating in aqueous solutions

• Dexpanthenol may crystallize during long-term low-temperature storage

SECTION 13: IDENTIFICATION TESTS

SECTION 14: QUALITY CERTIFICATES AND STANDARDS

SECTION 15: DISCLAIMER AND LEGAL NOTICE

DISCLAIMER (LEGAL NOTICE): This Technical Data Sheet (TDS) is for informational purposes only and does not constitute a binding specification. The values stated herein are based on typical laboratory results. The user is solely responsible for determining the suitability of the product for the intended application and for ensuring compliance with all local regulations. A current Safety Data Sheet (SDS) and Certificate of Analysis (COA) should be requested prior to use. Allergic reactions are rare but possible in sensitive individuals; suitability tests should be conducted. This document does not grant any license or patent rights for use of the product.