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Send EmailZINC PYRITHIONE, Zinc Omadine, ZPT, zincpolyanemine, Pyrithione zincique, 13463-41-7
Zinc pyrithione
1-hydroxypyridine-2-thione zinc
CAS: 13463-41-7
Molecular Formula: C10H8N2O2S2Zn
Names and Identifiers
| Name | 1-hydroxypyridine-2-thione zinc |
| Synonyms | ZPT Zinc Omadine Omadine Zinc Pyrithione Zinc ZINC PYRITHIONE zincpolyanemine Pyrithione zincique zinc 2-pyridinethiol-1-oxide Mercaptopyridinenoxidezincsalt 1-HYDROXYPYRIDINE-2-THIONE ZINC 1-hydroxypyridine-2-thione zinc 2-Mercaptopyridine N-oxide zinc salt 1-HYDROXY-2-PYRIDINE THIONE, ZN SALT zinc bis(2-thioxopyridin-1(2H)-olate) zinc bis(pyridine-2-thiol) di-1-oxide zinc bis(pyridine-2-thiolate 1-oxide) Bis[(1-oxylatopyridinium-2-yl)thio]zinc Bis[(1-oxylatopyridinium)-2-ylthio] zinc Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt zinc bis(1,2-dihydro-2-thioxo-1-pyridyl) dioxide Bis(2-pyridylthio) Zinc 1,1'-Dioxide1-Hydroxypyridine-2-thione Zinc Salt2-Pyridinethiol 1-Oxide Zinc SaltZinc Pyrithione |
| CAS | 13463-41-7 |
| EINECS | 236-671-3 |
| InChI | InChI=1/2C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4H;/q2*-1;+2 |
| InChIKey | OTPSWLRZXRHDNX-UHFFFAOYSA-L |
Physico-chemical Properties
| Molecular Formula | C10H8N2O2S2Zn |
| Molar Mass | 317.7 |
| Density | 1.782 g/cm3(Temp: 25 °C) |
| Melting Point | approximate 240℃ |
| Boling Point | 253.8°C at 760 mmHg |
| Flash Point | 107.3°C |
| Water Solubility | Insoluble ( |
| Solubility | almost transparency in Pyridine |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | Light brown particles |
| Color | White to Orange to Green |
| Merck | 14,7994 |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00067336 |
| Physical and Chemical Properties |
water-soluble Insoluble (<0.1g/100 mL at 21°C), off-white powder |
| Use | In cosmetics as anti-dandruff agents and fungicides, widely used in the preparation of anti-dandruff shampoo. Mainly used in cosmetics, shampoo, skin care, but also for adhesives, coatings, paints and so on. |
Risk and Safety
| Risk Codes | R24/25 - R26 - Very Toxic by inhalation R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R23 - Toxic by inhalation R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste. S39 - Wear eye / face protection. |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | ZH0950000 |
| HS Code | 29333990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 177mg/kg |
Reference Information
| LogP | 0.9 at 25℃ and pH7.5-7.7 |
| surface tension | 73mN/m at 7.22mg/L and 20 ℃ |
| product description | zinc pyrithione is also known as zinc pyrithione, zinc pyrithione, and zinc omedine. this zinc complex was synthesized as early as 2030s and used as an antifungal or antibacterial agent for external use. White to yellow crystalline powder at room temperature. Slightly characteristic smell. Insoluble in water. Zinc pyrithione forms insoluble precipitates with cationic and nonionic surfactants, which are unstable to light and oxidants, and unstable to acids and bases at higher temperatures. It is not compatible with EDTA, and non-ionic surfactants will partially inactivate it. In the presence of heavy metals, chelation or dechelation will occur, and these chelates are hardly soluble in water. EEC and GB7916-87 stipulate that the maximum allowable concentration mass fraction of zinc pyrithione in cosmetics is 0.5%, which is only used in products cleaned after use. For a period of use, the concentration of 250~1000 mg/kg (active substance) can be used for gel, cream, emulsion, powder and dandruff shampoo, as well as for deodorization and disinfection products. |
| traits | zinc pyrithione is a white non-precipitating emulsion. |
| use | zinc pyrithione is used for shampoo dandruff, which can inhibit the growth of gram-positive and negative bacteria and mold. Can effectively care for hair, delay hair aging, control the generation of white hair and hair loss. Zinc pyrithione ZPT has a strong killing power on fungi and bacteria, and can effectively kill dandruff-producing fungi and play a role in dandruff removal. As a long-standing dandruff remover, zinc pyrithione ZPT is widely known in the shampoo industry and used by many well-known brands. Zinc pyrithione ZPT is also used as a cosmetic preservation agent, oil, pulp, paint, fungicide, and is also widely used. It has strong killing power to fungi and bacteria, and can effectively kill dandruff-producing fungi and play a role in removing dandruff. As an anti-dandruff agent and fungicide in cosmetics, it is widely used to prepare dandruff shampoo. Mainly used for cosmetics, shampoo, skin care, can also be used for adhesives, coatings, paints, etc. personal care products; used as anti-dandruff agents and fungicides in cosmetics, widely used to prepare dandruff shampoo used for dandruff shampoo, can inhibit the growth of gram-positive and negative bacteria and mold. Can effectively care for hair, delay hair aging, control the generation of white hair and hair loss. In addition, it is also used as a cosmetic preservation agent, oil agent, paint biocide; as a fungicide for coatings and plastics and other products, it is also widely used. Broad-spectrum fungicides and pollution-free marine biocides |
| CAS Number | 13463-41-7 |
| Chem/IUPAC Name: | Pyridine-2-thiol-1-oxide, zinc complex (2:1) |
| EINECS/ELINCS No: | 236-671-3 |
| COSING REF No: | 38974 |
Zinc Pyrithione is a compound commonly used in cosmetics and personal care products for its antifungal and antibacterial properties. It is an active ingredient designed to treat dandruff, seborrheic dermatitis, and various fungal infections of the skin and scalp. Zinc Pyrithione works by inhibiting the growth of fungi and bacteria that contribute to these conditions, helping to reduce flakiness, itching, and irritation. Additionally, it aids in controlling sebum production, contributing to a healthier scalp environment. The chemical formula of Zinc Pyrithione is C10H8N2O2S2Zn.
What is ZINC PYRITHIONE used for?
Zinc Pyrithione is a beneficial compound owing to its antimicrobial properties and finds extensive application in personal care products and cosmetics. Primarily utilized in cleansing formulations like shampoos and soap, this ingredient effectively targets dandruff, seborrheic dermatitis, and fungal skin infections by inhibiting the growth of fungi and bacteria responsible for these conditions. It also alleviates symptoms like itching, flaking, and redness on the scalp and skin. Zinc Pyrithione’s ability to regulate microbial balance and control sebum production makes it an essential ingredient in products designed to promote scalp and skin health, offering consumers relief from common dermatological issues with proven efficacy.
Origin
Zinc Pyrithione is synthesized through a multistep chemical process. Initially, 2-mercaptopyridine-N-oxide reacts with sodium hydroxide to form sodium pyrithione. This compound undergoes a double displacement reaction with zinc sulfate, yielding Zinc Pyrithione precipitate. The product is then filtered, washed, and dried to obtain a fine powder.
What does ZINC PYRITHIONE do in a formulation?
- Antidandruff
- Antimicrobial
- Hair conditioning
- Preservative
Safety profile
While generally safe for topical use, Zinc Pyrithione may cause mild side effects such as skin irritation, redness, or dryness, especially in individuals with sensitive skin. Prolonged or excessive use can exacerbate these symptoms. Additionally, some people may experience allergic reactions characterized by itching or swelling. It is advisable to perform a patch test before widespread application and discontinue use if adverse reactions occur.
ZINC PYRITHIONE Alternatives
KETOCONAZOLE, SELENIUM SULFIDE
Technical profile
| Property | Values |
| Boiling Point | 350.20°C |
| Melting Point | 240°C |
| Solubility | Soluble in water |
| Viscosity | Low to moderate |
