ZINC PYRITHIONE, Zinc Omadine, Zinc Polyanemine, Pyrithione Zincique, ZPT, 13463-41-7

🧪 Zinc Pyrithione – Technical Profile

Chemical Name: Zinc Pyrithione Synonyms:

• Zinc Omadine

• ZPT

• Pyrithione Zinc

• Zinc Polyanemine

• Pyrithione Zincique

• Bis[(pyridine-1-oxide)-2-yl]thio]zinc

• CAS Number: 13463-41-7

• Molecular Formula: C₁₀H₈N₂O₂S₂Zn

• Molar Mass: 317.7 g/mol

• Appearance: White to yellow crystalline powder

• Odor: Mild, characteristic

• Melting Point: ~240 °C (decomposes)

• Density: 1.78 g/cm³

• Solubility:

• Water: Very low (8 ppm at pH 7)

• Ethanol: ~100 mg/kg

• PEG-400: ~2000 mg/kg

• pH Range: Optimal between 4.5–9.5

🧫 Functional Properties

• Fungistatic: Inhibits fungal cell division

• Bacteriostatic: Prevents bacterial proliferation

• Broad-Spectrum Antimicrobial: Effective against Streptococcus, Staphylococcus, Malassezia spp.

• Algaecide: Used in marine coatings to prevent biofouling

🏭 Industrial Applications

⚠️ Safety & Regulatory

• GHS Classification:

  • Signal Word: Danger

  • Hazard Statements: H301 (Toxic if swallowed), H318 (Eye damage), H330 (Fatal if inhaled), H410 (Very toxic to aquatic life)

• UN Code: UN 2811 – Toxic substances

• WGK (Germany): 3 – Severe water hazard

• FDA / EU Use: Previously allowed in cosmetics; now restricted in some regions due to toxicity concerns

• REACH: Subject to authorization in EU (as of 2022)

📦 Packaging & Storage

• Packaging: HDPE drums or foil-lined bags (25 kg)

• Storage: Cool, dry, well-ventilated area; protect from light and oxidizers

• Shelf Life: 24 months under recommended conditions

🧴 Zinc Pyrithione (ZPT) – Detailed Usage Overview

1. Cosmetics & Personal Care

• Shampoos (Anti-Dandruff): ZPT is widely used as an active ingredient in anti-dandruff shampoos due to its antifungal action against Malassezia species. Typical concentration ranges from 0.3% to 2%. It helps reduce scalp flaking, itching, and microbial imbalance.

• Skin Creams & Lotions: Used in formulations targeting seborrheic dermatitis, eczema, and acne. Its antimicrobial properties help reduce inflammation and skin irritation.

• Liquid Soaps & Cleansers: Acts as an antibacterial agent in hygiene products, especially in hand soaps and body washes.

2. Paints & Coatings

• Exterior Wall Paints: Prevents mold, mildew, and algae growth on painted surfaces. It inhibits biofilm formation, extending surface cleanliness and durability.

• Marine Coatings: Used in antifouling paints to prevent microbial adhesion on submerged surfaces such as ship hulls.

• Wood & Metal Finishes: Provides antimicrobial protection in humid environments, enhancing product longevity.

3. Textile & Fiber Processing

• Antimicrobial Finishing: Applied to fabrics to inhibit bacterial growth, especially in medical textiles, sportswear, and undergarments.

• Dye Bath Additive: Helps prevent microbial contamination during dyeing processes.

4. Water Treatment & Industrial Hygiene

• Closed-Loop Systems: Used as a biocide in cooling towers, HVAC systems, and industrial water circuits to prevent biofilm formation.

• CIP Cleaning Systems: Added to cleaning solutions in food and pharmaceutical facilities for microbial control.

5. Plastics & Polymers

• Antimicrobial Masterbatch: Incorporated into PVC, PE, and PP polymers to prevent microbial growth. Common in medical packaging, kitchenware, and hygienic surfaces.

6. Agrochemicals

• Fungicide Co-Active: Used in crop protection formulations to inhibit fungal growth on leaves and stems. Enhances adhesion and surface coverage.

• Soil & Greenhouse Applications: Helps regulate microbial balance and suppress pathogenic organisms.

7. Veterinary & Pet Care

• Pet Shampoos: Acts as an antifungal agent for treating skin infections in animals.

• Topical Sprays & Lotions: Used in formulations for skin health and microbial control in pets.

✅ Zinc Pyrithione (ZPT) – Compatibility Table

Zinc pyrithione

Zinc Pyrithione is a compound commonly used in cosmetics and personal care products for its antifungal and antibacterial properties. It is an active ingredient designed to treat dandruff, seborrheic dermatitis, and various fungal infections of the skin and scalp. Zinc Pyrithione works by inhibiting the growth of fungi and bacteria that contribute to these conditions, helping to reduce flakiness, itching, and irritation. Additionally, it aids in controlling sebum production, contributing to a healthier scalp environment. The chemical formula of Zinc Pyrithione is C₁₀H₈N_2O2S₂Zn.

What is ZINC PYRITHIONE used for?

Zinc Pyrithione is a beneficial compound owing to its antimicrobial properties and finds extensive application in personal care products and cosmetics. Primarily utilized in cleansing formulations like shampoos and soap, this ingredient effectively targets dandruff, seborrheic dermatitis, and fungal skin infections by inhibiting the growth of fungi and bacteria responsible for these conditions. It also alleviates symptoms like itching, flaking, and redness on the scalp and skin. Zinc Pyrithione’s ability to regulate microbial balance and control sebum production makes it an essential ingredient in products designed to promote scalp and skin health, offering consumers relief from common dermatological issues with proven efficacy.

Origin

Zinc Pyrithione is synthesized through a multistep chemical process. Initially, 2-mercaptopyridine-N-oxide reacts with sodium hydroxide to form sodium pyrithione. This compound undergoes a double displacement reaction with zinc sulfate, yielding Zinc Pyrithione precipitate. The product is then filtered, washed, and dried to obtain a fine powder.

What does ZINC PYRITHIONE do in a formulation?

• Antidandruff
• Antimicrobial
• Hair conditioning
• Preservative

Safety profile

While generally safe for topical use, Zinc Pyrithione may cause mild side effects such as skin irritation, redness, or dryness, especially in individuals with sensitive skin. Prolonged or excessive use can exacerbate these symptoms. Additionally, some people may experience allergic reactions characterized by itching or swelling. It is advisable to perform a patch test before widespread application and discontinue use if adverse reactions occur.

ZINC PYRITHIONE Alternatives

KETOCONAZOLE, SELENIUM SULFIDE

Technical profile

Documents

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• Betakim Zinc Pyrithione (ZPT)_TDS.docx
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