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Send EmailEthylene diamine tetra acetic acid tetrasodium salt, EDTA 4Na ,64-02-8, EDTA 2Na, EDTA-2NA,EDTA-4NA
CAS: 64-02-8
Molecular Formula: C10H12N2Na4O8
Product Attributes
Model No.: EDTA-2NA,EDTA-4NA
Classification: Sodium Organic Salt
Place Of Origin: China
Grade: Agriculture Grade, Food Grade, Industrial Grade, Reagent Grade
Product: EDTA
Other Name: Ethylene Diamine Tetraacetic Acid Disodium Salt
Grade: Industrial Grade
Model: EDTA-2NA,EDTA-4NA
CAS No.: 139-33-3
EINECS No.: 205-358-3
Application: Detergent
Packing: 25kg/pp bag or kraft bag
Appearance: White Powder
HS Code: 2922499990
Water Treatment Softener EDTA-2NA
Description Of EDTA-2NA:
EDTA disodium has three specific effects:
1. Utilize its coordination to prevent harmful reactions such as discoloration, deterioration, turbidity, and oxidation loss of vitamin C caused by metal ions.
2. As a water treatment agent, it can prevent the adverse effects of metal ions such as calcium, magnesium, iron, and manganese present in water.
3. The trace metals (such as iron and copper) in fats and oils have the effect of promoting lipid oxidation. This product can complex with trace metal ions, enhancing lipid oxidation resistance and preventing food discoloration.
Disodium ethylenediaminetetraacetic acid is widely used in beverages (excluding packaged drinking water), jam, vegetable puree (sauce), tomato sauce, compound seasoning, preserved sweet potato fruits, pickled vegetables, canned vegetables, canned nuts and seeds, and canned grains (0.25g/kg).
For example, when it is used to pickle pickled Chinese cabbage and pickled cabbage, it can make pickled Chinese cabbage even and bright, prolong its storage period, and its color fixing and fresh-keeping effect is obviously better than that of VC and phosphate; Before sterilization, add seasoning to canned vegetables and mushrooms in clear water to maintain product color, prevent boiling water from becoming turbid, and have a protective effect on color.
Specification Of Water Treatment Softener EDTA-2NA:
|
Item |
Specification |
|
Appearance |
White powder |
|
Purity,% |
99.0min |
|
Chloride(Cl) content,% |
0.05max |
|
Sulfate(SO4) content,% |
0.05max |
|
Iron(Fe) content,% |
0.001max |
|
Heavy metal(Pb),% |
0.001max |
|
Chelate value(mg CaCO3/g),% |
260min |
|
PH value |
4.0-5.0 |
Application Of EDTA-2NA For Detergent:
EDTA-2NA can be used as a heavy metal detoxification agent, complexing agent, antioxidant synergist, stabilizer, and softener; Calcium, magnesium, and other metal reagents, metal masking agents. Disodium ethylenediaminetetraacetic acid is an important complexing agent used for complexing metal ions and separating metals.
Packing Of Detergent Grade EDTA-2NA:
25kg/pp bag or kraft bag.24MT/20'FCL without pallets.
Product Attributes
Model No.: EDTA-2NA,EDTA-4NA
Classification: Sodium Organic Salt
Place Of Origin: China
Grade: Food Grade, Industrial Grade, Reagent Grade, Agriculture Grade
Product: EDTA Disodium Salt
Other Name: EDTA-2NA,EDTA-4NA
Grade: Industrial Grade
CAS No.: 139-33-3
EINECS No.: 205-358-3
MF: C10H12FeN2NaO8
Appearance: White powder
Packing: 25kg/pp bag or kraft bag
HS Code: 2922499990
Product Description
EDTA Tetrasodium Salt EDTA-4Na CAS 64-02-8
Description Of EDTA-2NA:
Disodium ethylenediamine tetraacetate, also known as EDTA-2Na, is widely used as a food additive as a stabilizer, antioxidant, preservative, and chelating agent to prevent discoloration, deterioration, turbidity, and oxidative loss of vitamins caused by metal ions.
Disodium ethylenediaminetetraacetic acid is not broken down and is excreted in the human body, which can cause calcium deficiency in the body and can also cause temporary blood pressure drop and kidney disorders. The Joint Expert Committee on Food Additives (JECFA) of the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) recommends a daily allowable intake (ADI) of 0-2.5mg/kg bw.
Specification Of EDTA Tetrasodium Salt EDTA-4Na:
|
Item |
Specification |
|
Appearance |
White powder |
|
Purity,% |
99.0min |
|
Chloride(Cl) content,% |
0.05max |
|
Sulfate(SO4) content,% |
0.05max |
|
Iron(Fe) content,% |
0.001max |
|
Heavy metal(Pb),% |
0.001max |
|
Chelate value(mg CaCO3/g),% |
260min |
|
PH value |
4.0-5.0 |
Application Of EDTA Tetrasodium Salt:
1. Preventing food discoloration: If disodium ethylenediaminetetraacetic acid is appropriately added during the process of making food, its ingredients have the effect of promoting oil oxidation and can effectively prevent food discoloration.
2. As a water treatment agent: If disodium ethylenediaminetetraacetic acid is added to daily drinking water, its composition can prevent the adverse effects of manganese ions, iron ions, and magnesium ions present in the water.
3. Improving washing quality: If disodium ethylenediaminetetraacetic acid is added to the Detergent, its composition can enhance the washing and emulsifying power of the detergent, and prevent precipitation, thereby improving the washing quality.
Packing Of EDTA-2Na:
25kg/pp bag or kraft bag.
Names and Identifiers
| Name | Ethylenediaminetetraacetic acid tetrasodium salt |
| Synonyms | EDTA-4Na EDTA 4Na EDTA.Na4.2H2O Edetate Sodium Sodium edetate EDTA Tetrasodium(Na4) tetrasodium ethylenediaminetetraacetate Ethylenediaminetetraacetic acid tetrasodium ETHYLENEDINITRILOTETRACETICACIDTETRASODIUMSALT Ethylenediaminetetraacetic acid tetrasodium salt ETHYLENE-DIAMINO-TETRA-ACETIC-ACID-TETRA-SODIUMSALT ETHYLENEDIAMINETETRAACETICACIDTETRASODIUMSALT,REAGENT ETHYLENEDIAMINETETRAACETIC ACID TETRASOD IUM SALT PURE Ethylenediaminetetraacetic acid tetrasodium salt HYDRATE ETHYLENEDIAMINETETRAACETIC ACID TETRA-SO DIUM SALT TETRAH. tetrasodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate Ethylenediamine-N,N,N',N'-tetraaceticacid,tetrasodiumsalt,tetrahydrate EDTA, tetrasodium salt, dihydrate Ethylenediamine tetraacetic acid, tetrasodium salt, dihydrate |
| CAS | 64-02-8 |
| EINECS | 200-573-9 |
| InChI | InChI=1/C6H12N2O4.4Na/c7-1-2-8(3-5(9)10)4-6(11)12;;;;/h1-4,7H2,(H,9,10)(H,11,12);;;;/q;4*+1/p-2 |
EDTA 4Na - Physico-chemical Properties
| Molecular Formula | C10H12N2Na4O8 |
| Molar Mass | 380.17 |
| Density | Apparent density: 6.9 lb/gallon |
| Melting Point | >300°C(lit.) |
| Solubility | H2O: 0.1g/mL, clear, colorless |
| Appearance | Crystalline Powder |
| Color | White |
| Storage Condition | Room Temprature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| MDL | MFCD00150025 |
| Physical and Chemical Properties | Character white crystalline powder. soluble in water and acid, insoluble in alcohol, benzene and chloroform. solubility: H2O: 0.1 M at 20 ℃, clear, colorless WGK Germany:3 |
| Use | Used as water softener, chelating agent, styrene butadiene rubber polymerization initiator, acrylic initiator, printing and dyeing auxiliary, detergent auxiliary, etc. In chemical analysis is also used for titration, can accurately titrate a variety of metal ions, widely used |
EDTA 4Na - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 2 |
| RTECS | AH5075000 |
| HS Code | 29224985 |
EDTA 4Na - Upstream Downstream Industry
EDTA 4Na - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | ethylenediaminetetraacetic acid (EDTA) contains four carboxyl groups, generally can form two salts, three salts and four salts. Common EDTA salts are disodium edetate (EDTA-2Na), tetrasodium edetate (EDTA-4Na), dipotassium edetate (EDTA-2K), and tripotassium edetate (EDTA-3K). Tetrasodium edetate (EDTA-4Na) is a small multifunctional organic molecule containing amino and carboxyl groups, which is widely used in analytical chemistry as a complexing agent. It is widely available and inexpensive. |
| Application | Tetrasodium EDTA is an important complexing agent and metal masking agent. Can be used in the textile industry dyeing, water treatment, color sensitive, pharmaceutical, daily chemical, paper and other industries, as additives, activators, water purification agents, metal ion shielding agent and styrene butadiene rubber industry activator. Dry acrylic industry offset metal interference, improve the color and brightness of the dyed fabric, can also be used in liquid detergent, improve the quality of washing, enhance the washing effect. |
| Use | used as chelating agent, styrene butadiene rubber polymerization initiator, acrylic fiber initiator, etc. used as solvent, also used in rubber, dyestuff Industry It is used as a complexing agent, synthetic rubber catalyst, and water softener for fiber refining, bleaching and dyeing industry |
| production method | is derived from the reaction of ethylenediamine with chloroacetic acid, or from the reaction of ethylenediamine with formaldehyde and sodium cyanide. |
EDTA 2Na
TDS
Table of Contents
EDTA 2Na
EDTA 2Na
synonyms:
EDTA disodium salt; 139-33-3; Disodium EDTA; Ethylenediaminetetraacetic acid disodium salt; Edta disodium; Disodium ethylenediaminetetraacetate; AK164289; EDTA 2Na; Disodium ethylenediaminetetraacetic acid;Etilendiamin tetraasetik asit; etilendiamintetrasetikasit; etilen diamine asetik asit; EDTA; tetraasetik asit; tetraasetikasit; etilendiamin;edetat;1,2-Bis (N,N-dicarboxymethylamino)-ethane;3,6-Diazaoctanedioic acid, 3,6-bis(carboxymethyl)-;62: PN: US20050026181 PAGE: 33 claimed protein;Acetic acid, (ethylenedinitrilo)tetra-;Acetic acid, 2,2′,2”,2”’-(1,2-ethanediyldinitrilo)tetrakis-;Acide edetique;acido edetico;Acroma DH 700;AETHYLENDIAMIN-TETRAESSIGSAEURE;Celon A;Celon ATH;Cheelox;Chelest 3A;Chemcolox 340;Clewat TAA;Clewat TTA;Complexon II;Dissolvine E;Dissolvine Z;DOHTITE 4H, EDTA ACID;Edathamil;EDETA B;edetic acid;Edetinsaure;EDTA;EDTA (chelating agent);EDTA ACID FORM;Endrate;ETHYLENE DINITRILO TETRAACETIC ACID;Ethylenediamine Tetra-Acetic Acid;Ethylenediamine-N,N,N’,N’-tetraacetic acid;Ethylenediaminetetraacetic acid;ETHYLENEDIAMINETETRAACETIC ACID (EDTA);ETHYLENEDIAMINETETRAACETIC ACID DISODIUM SALT;Ethylenediaminetetracetic acid;ETHYLENEDINITRILOTETRAACETIC ACID;Ethylene-N,N’-biscarboxymethyl-N,N’-diglycine;Gluma Cleanser;GLYCINE, N,N’-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL));Glycine, N,N’-1,2-ethanediylbis[N-(carboxymethyl)-;Glycine, N,N’-1,2-ethanediylbis[N-(carboxymethyl)-;Glycine, N,N’-1,2-ethanediylbis[N-(carboxymethyl)-;Glycine,N,N’-1,2-ethanediylbis[N-(carboxymethyl)-,;Havidote;ICRF 185;Metaquest A;N,N’-1,2-Ethanediylbis[N-(carboxymethyl)glycine];N,N’-1,2-Ethanediyl-bis-N-(carboxymethyl)glycine;Nervanaid B acid;NSC 97243;NSC 97404;Nullapon B acid;Nullapon BF acid;Perma Kleer 50 acid;Quastal Special;Sequestrene AA;Sequestrene K 4;Sequestric acid;Sequestrol;Techrun DO;Titriplex;Titriplex II;Trilon BS;Trilon BW;Versene;WS;WS (chelating agent);YD 30;Zonon AO; Disodium dihydrogen ethylenediaminetetraacetate; 6381-92-6; ethylenediamine tetraacetic acid disodium salt; ETA Solution; Ethylenediaminetetraacetic acid disodium salt solution; Aceticacid, (ethylenedinitrilo)tetra-, disodium salt, dihydrate (8CI);Glycine,N,N’-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt, dihydrate (9CI);Disodium EDTA dihydrate;Disodium dihydrogen; ethylenediamine tetraacetatedihydrate; Disodium ethylenediaminetetraacetatedihydrate;Ethylenediaminetetraacetic acid disodium salt dihydrate;Ethylenediaminetetraacetic disodium;Edta disodium salt dihydrate; Edta 2 Na; EDTA disodium salt; 139-33-3; Disodium EDTA; Ethylenediaminetetraacetic acid disodium salt; Edta disodium; Disodium ethylenediaminetetraacetate; AK164289; EDTA 2Na; Disodium ethylenediaminetetraacetic acid; Disodium dihydrogen ethylenediaminetetraacetate; 6381-92-6; ethylenediamine tetraacetic acid disodium salt; ETA Solution; Ethylenediaminetetraacetic acid disodium salt solution; Edta 2 Na; EDTA 2NA; EDTA2NA; EDTA 2Na; edta 2na; Edta 2Na; EDTA-2Na; 2Na; edta 2na;
EDTA 2Na
Formula
C10H14N2Na2O8
CAS No. 139-33-3
EC No. 205-358-3
Synonyms INCI: Disodium EDTA ; Isodium dihydrogen ethylenediaminetetraacetate; Edetic acid disodium salt; EDTA disodium salt; (Ethylenedinitrilo)tetraacetic acid disodium salt; Disodium Edetate
Ethylenediaminetetraacetic acid disodium salt (EDTA 2Na)
EDTA 2Na (ethylenediaminetetracetic acid disodium) is a chelating agent, used to sequester and decrease the reactivity of metal ions that may be present in many industrial and personal care products.
Industrial applications:
EDTA 2Na is used in cleaners, detergent, fertilizers, fixer solution for development of colour film, water cleaner and pH modifier. It is also used in redox reaction for the polymerization of butyl benzene rubber, it is used as part of activator for the control of polymerization speed.
Personal Care:
EDTA 2Na is used in Cosmetics to increase effectiveness and improve stability of bar and solid soaps, bath preparations; creams, oils, hair care products and many other personal care formulations.
Unfortunately, EDTA 2Na is difficultly biodegradable and hazardous for water.
Connect Chemicals offer valid and effective alternatives to EDTA Na2, please see the product pages of H-Quest and GLDA, both 100% biodegradable and obtained from bio-feedstock.
Packaging & Shelf Life:
bags 25 kg net
Under proper storage conditions the shelf life is 36 months
Health & Safety:
Detailed information on the product described can be found in our relevant Health and Safety Information (Material Safety Data Sheet).
Ethylenediaminetetraacetic acid
From Wikipedia, the free encyclopedia
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This article is about the chemical. For the medication, see Sodium calcium edetate.
Ethylenediaminetetraacetic acid
Skeletal formula of ethylenediaminetetraacetic acid
Names
Systematic IUPAC name
2,2′,2″,2‴-(Ethane-1,2-diyldinitrilo)tetraacetic acid[1]
Other names
EthyleneDiamineTetraAcetic acid
N,N′-Ethane-1,2-diylbis[N-(carboxymethyl)glycine][1]
Diaminoethane-tetraacetic acid
Edetic acid (conjugate base edetate) (INN, USAN)
Versene
Identifiers
CAS Number
60-00-4 (free acid) ☑
6381-92-6 (dihydrate disodium salt) ☒
3D model (JSmol)
Interactive image
Abbreviations EDTA 2Na, H4EDTA
Beilstein Reference
1716295
ChEBI
CHEBI:42191 ☑
ChEMBL
ChEMBL858 ☑
ChemSpider
5826 ☑
DrugBank
DB00974 ☑
ECHA InfoCard 100.000.409
EC Number
200-449-4
Gmelin Reference
144943
KEGG
D00052 ☑
MeSH Edetic+Acid
PubChem CID
6049
RTECS number
AH4025000
UNII
9G34HU7RV0 ☑
UN number 3077
CompTox Dashboard (EPA)
DTXSID6022977 Edit this at Wikidata
InChI[show]
SMILES[show]
Properties
Chemical formula
C10H16N2O8
Molar mass 292.244 g·mol-1
Appearance Colourless crystals
Density 0.860 g cm-3 (at 20 °C)
log P -0.836
Acidity (pKa) 2.0, 2.7, 6.16, 10.26[2]
Thermochemistry
Std enthalpy of
formation (ΔfH⦵298)
-1765.4 to -1758.0 kJ mol-1
Std enthalpy of
combustion (ΔcH⦵298)
-4461.7 to -4454.5 kJ mol-1
Pharmacology
ATC code
S01XA05 (WHO) V03AB03 (WHO) (salt)
Routes of
administration
Intramuscular
Intravenous
Hazards
GHS pictograms GHS07: Harmful
GHS Signal word Warning
GHS hazard statements
H319
GHS precautionary statements
P305+351+338
NFPA 704 (fire diamond)
NFPA 704 four-colored diamond
010
Lethal dose or concentration (LD, LC):
LD50 (median dose)
1000 mg/kg (oral, rat)[3]
Related compounds
Related alkanoic acids
Daminozide
Octopine
Related compounds
Triethylenetetramine
Tetraacetylethylenediamine
PMDTA
Bis-tris propane
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Ethylenediaminetetraacetic acid (EDTA 2Na), also known by several other names, is a chemical used for both industrial and medical purposes. It was synthesized for the first time in 1935 by Ferdinand Münz.[4]
Ethylenediaminetetraacetic acid (EDTA), also known by several other names, is a chemical used for both industrial and medical purposes.
It is an aminopolycarboxylic acid and a colourless, water-soluble solid. Its conjugate base is ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate (“six-toothed”) ligand and chelating agent, i.e., its ability to “sequester” metal ions such as Ca2+ and Fe3+. After being bound by EDTA into a metal complex, metal ions remain in solution but exhibit diminished reactivity. EDTA is produced as several salts, notably disodium EDTA and calcium disodium EDTA.
Uses of EDTA
Industry
In industry, EDTA is mainly used to sequester metal ions in aqueous solution. In the textile industry, it prevents metal ion impurities from modifying colors of dyed products. In the pulp and paper industry, EDTA inhibits the ability of metal ions, especially Mn2+, from catalyzing the disproportionation of hydrogen peroxide, which is used in “chlorine-free bleaching”. In a similar manner, EDTA is added to some food as a preservative or stabilizer to prevent catalytic oxidative decoloration, which is catalyzed by metal ions. In soft drinks containing ascorbic acid and sodium benzoate, EDTA mitigates formation of benzene (a carcinogen).
The reduction of water hardness in laundry applications and the dissolution of scale in boilers both rely on EDTA and related complexants to bind Ca2+, Mg2+, as well as other metal ions. Once bound to EDTA, these metal centers tend not to form precipitates or to interfere with the action of the soaps and detergents. For similar reasons, cleaning solutions often contain EDTA.
The solubilization of ferric ions, at or below near neutral pH can be accomplished using EDTA. This property is useful in agriculture including hydroponics. However, given the pH dependence of ligand formation, EDTA is not helpful for improving Fe solubility in above neutral soils.[5] Otherwise, at near-neutral pH and above, iron(III) forms insoluble salts, which are less bioavailable to susceptible plant species. Aqueous [Fe(edta)]- is used for removing (“scrubbing”) hydrogen sulfide from gas streams. This conversion is achieved by oxidizing the hydrogen sulfide to elemental sulfur, which is non-volatile.
In this application, the ferric center is reduced to its ferrous derivative, which can then be reoxidized by air. In similar manner, nitrogen oxides are removed from gas streams using [Fe(edta)]2-. The oxidizing properties of [Fe(edta)]- are also exploited in photography, where it is used to solubilize silver particles.
EDTA was used in the separation of the lanthanide metals by ion-exchange chromatography. Perfected by F.H. Spedding et al. in 1954, the method relies on the steady increase in stability constant of the lanthanide EDTA complexes with atomic number. Using sulfonated polystyrene beads and copper(II) as a retaining ion, EDTA causes the lanthanides to migrate down the column of resin while separating into bands of pure lanthanide. The lanthanides elute in order of decreasing atomic number. Due to the expense of this method, relative to counter-current solvent extraction, ion-exchange is now used only to obtain the highest purities of lanthanide (typically greater than 4N, 99.99%).
Cosmetic
In shampoos, cleaners, and other personal care products, EDTA salts are used as a sequestering agent to improve their stability in air.
Medicine
Main article: Sodium calcium edetate
A specific salt of EDTA, known as sodium calcium edetate, is used to bind metal ions in the practice of chelation therapy, e.g., for treating mercury and lead poisoning. It is used in a similar manner to remove excess iron from the body. This therapy is used to treat the complication of repeated blood transfusions, as would be applied to treat thalassaemia.
Dentists and endodontists use EDTA solutions to remove inorganic debris (smear layer) and lubricate the canals in endodontics. This procedure helps prepare root canals for obturation. Furthermore, EDTA solutions with the addition of a surfactant loosen up calcifications inside a root canal and allow instrumentation (canals shaping) and facilitate apical advancement of a file in a tight/calcified root canal towards the apex.
It serves as a preservative (usually to enhance the action of another preservative such as benzalkonium chloride or thiomersal) in ocular preparations and eyedrops.
In evaluating kidney function, the complex [Cr(edta)]- is administered intravenously and its filtration into the urine is monitored. This method is useful for evaluating glomerular filtration rate.
EDTA is used extensively in the analysis of blood. It is an anticoagulant for blood samples for CBC/FBEs.
EDTA is a slime dispersant, and has been found to be highly effective in reducing bacterial growth during implantation of intraocular lenses (IOLs).
EDTA 2Na is an aminopolycarboxylic acid and a colorless, water-soluble solid.EDTA 2Nas conjugate base is ethylenediaminetetraacetate. EDTA 2Na is widely used to dissolve limescale. EDTA 2Na’s usefulness arises because of its role as a hexadentate (“six-toothed”) ligand and chelating agent, i.e., its ability to sequester metal ions such as Ca2+ and Fe3+. After being bound by EDTA 2Na into a metal complex, metal ions remain in solution but exhibit diminished reactivity. EDTA 2Na is produced as several salts, notably disodium EDTA 2Na, calcium disodium EDTA 2Na, and tetrasodium EDTA 2Na (typically as the hydrate).
Uses
Industry
In industry, EDTA 2Na is mainly used to sequester metal ions in aqueous solution. In the textile industry, it prevents metal ion impurities from modifying colors of dyed products. In the pulp and paper industry, EDTA 2Na inhibits the ability of metal ions, especially Mn2+, from catalyzing the disproportionation of hydrogen peroxide, which is used in chlorine-free bleaching. In a similar manner, EDTA 2Na is added to some food as a preservative or stabilizer to prevent catalytic oxidative decoloration, which is catalyzed by metal ions.In soft drinks containing ascorbic acid and sodium benzoate, EDTA 2Na mitigates formation of benzene (a carcinogen).
The reduction of water hardness in laundry applications and the dissolution of scale in boilers both rely on EDTA 2Na and related complexants to bind Ca2+, Mg2+, as well as other metal ions. Once bound to EDTA 2Na, these metal centers tend not to form precipitates or to interfere with the action of the soaps and detergents. For similar reasons, cleaning solutions often contain EDTA 2Na. In a similar manner EDTA 2Na is used in the cement industry for the determination of free lime and free magnesia in cement and clinkers.
The solubilization of Fe3+ ions at or below near neutral pH can be accomplished using EDTA 2Na. This property is useful in agriculture including hydroponics. However, given the pH dependence of ligand formation, EDTA 2Na is not helpful for improving iron solubility in above neutral soils.[8] Otherwise, at near-neutral pH and above, iron(III) forms insoluble salts, which are les bioavailable to susceptible plant species. Aqueous [Fe(EDTA 2Na)]- is used for removing (“scrubbing”) hydrogen sulfide from gas streams. This conversion is achieved by oxidizing the hydrogen sulfide to elemental sulfur, which is non-volatile:
2 [Fe(EDTA)]- + H2S → 2 [Fe(EDTA)]2- + S + 2 H+
In this application, the iron(III) center is reduced to its iron(II) derivative, which can then be reoxidized by air. In similar manner, nitrogen oxides are removed from gas streams using [Fe(edta)]2-. The oxidizing properties of [Fe(edta)]- are also exploited in photography, where it is used to solubilize silver particles.[9]
EDTA 2Na was used in separation of the lanthanide metals by ion-exchange chromatography. Perfected by F. H. Spedding et al. in 1954,[citation needed] the method relies on the steady increase in stability constant of the lanthanide EDTA 2Na complexes with atomic number. Using sulfonated polystyrene beads and Cu2+ as a retaining ion, EDTA 2Na causes the lanthanides to migrate down the column of resin while separating into bands of pure lanthanides. The lanthanides elute in order of decreasing atomic number. Due to the expense of this method, relative to countercurrent solvent extraction, ion exchange is now used only to obtain the highest purities of lanthanides (typically greater than 99.99%).[citation needed]
Medicine
Main article: Sodium calcium edetate
A specific salt of EDTA 2Na, known as sodium calcium edetate, is used to bind metal ions in the practice of chelation therapy, such as for treating mercury and lead poisoning.It is used in a similar manner to remove excess iron from the body. This therapy is used to treat the complication of repeated blood transfusions, as would be applied to treat thalassaemia.
Dentists and endodontists use EDTA 2Na solutions to remove inorganic debris (smear layer) and lubricate the root canals in endodontics. This procedure helps prepare root canals for obturation. Furthermore, EDTA 2Na solutions with the addition of a surfactant loosen up calcifications inside a root canal and allow instrumentation (canal shaping) and facilitate apical advancement of a file in a tight or calcified root canal towards the apex.
It serves as a preservative (usually to enhance the action of another preservative such as benzalkonium chloride or thiomersal) in ocular preparations and eyedrops.
In evaluating kidney function, the chromium(III) complex [Cr(edta)]- (as radioactive chromium-51 (51Cr)) is administered intravenously and its filtration into the urine is monitored. This method is useful for evaluating glomerular filtration rate (GFR) in nuclear medicine.
EDTA 2Na is used extensively in the analysis of blood. It is an anticoagulant for blood samples for CBC/FBEs, where the EDTA 2Na chelates the calcium present in the blood specimen, arresting the coagulation process and preserving blood cell morphology.[12] Tubes containing EDTA 2Na are marked with lavender or pink tops.[13] EDTA 2Na is also in tan top tubes for lead testing and can be used in royal blue top tubes for trace metal testing.
EDTA 2Na is a slime dispersant, and has been found to be highly effective in reducing bacterial growth during implantation of intraocular lenses (IOLs).
Alternative medicine
Some alternative practitioners believe EDTA 2Na acts as an antioxidant, preventing free radicals from injuring blood vessel walls, therefore reducing atherosclerosis.[citation needed] These ideas are unsupported by scientific studies, and seem to contradict some currently accepted principles. The U.S. FDA has not approved it for the treatment of atherosclerosis.
Cosmetics
In shampoos, cleaners, and other personal care products, EDTA 2Na salts are used as a sequestering agent to improve their stability in air.
Laboratory applications
In the laboratory, EDTA 2Na is widely used for scavenging metal ions: In biochemistry and molecular biology, ion depletion is commonly used to deactivate metal-dependent enzymes, either as an assay for their reactivity or to suppress damage to DNA, proteins, and polysaccharides.EDTA 2Na also acts as a selective inhibitor against dNTP hydrolyzing enzymes (Taq polymerase, dUTPase, MutT),[19] liver arginase[20] and horseradish peroxidase independently of metal ion chelation. These findings urge the rethinking of the utilization of EDTA 2Na as a biochemically inactive metal ion scavenger in enzymatic experiments. In analytical chemistry, EDTA 2Na is used in complexometric titrations and analysis of water hardness or as a masking agent to sequester metal ions that would interfere with the analyses.
EDTA 2Na finds many specialized uses in the biomedical labs, such as in veterinary ophthalmology as an anticollagenase to prevent the worsening of corneal ulcers in animals. In tissue culture EDTA 2Na is used as a chelating agent that binds to calcium and prevents joining of cadherins between cells, preventing clumping of cells grown in liquid suspension, or detaching adherent cells for passaging. In histopathology, EDTA 2Na can be used as a decalcifying agent making it possible to cut sections using a microtome once the tissue sample is demineralised. EDTA 2Na is also known to inhibit a range of metallopeptidases, the method of inhibition occurs via the chelation of the metal ion required for catalytic activity.EDTA 2Na can also be used to test for bioavailability of heavy metals in sediments. However, it may influence the bioavailability of metals in solution, which may pose concerns regarding its effects in the environment, especially given its widespread uses and applications.
Side effects
EDTA 2Na exhibits low acute toxicity with LD50 (rat) of 2.0 g/kg to 2.2 g/kg.[9] It has been found to be both cytotoxic and weakly genotoxic in laboratory animals. Oral exposures have been noted to cause reproductive and developmental effects.The same study also found that both dermal exposure to EDTA 2Na in most cosmetic formulations and inhalation exposure to EDTA 2Na in aerosolized cosmetic formulations would produce exposure levels below those seen to be toxic in oral dosing studies.
Synthesis
The compound was first described in 1935 by Ferdinand Münz, who prepared the compound from ethylenediamine and chloroacetic acid.[23] Today, EDTA 2Na is mainly synthesised from ethylenediamine (1,2-diaminoethane), formaldehyde, and sodium cyanide.[24] This route yields the tetrasodium EDTA 2Na, which is converted in a subsequent step into the acid forms:
H2NCH2CH2NH2 + 4 CH2O + 4 NaCN + 4 H2O → (NaO2CCH2)2NCH2CH2N(CH2CO2Na)2 + 4 NH3
(NaO2CCH2)2NCH2CH2N(CH2CO2Na)2 + 4 HCl → (HO2CCH2)2NCH2CH2N(CH2CO2H)2 + 4 NaCl
This process is used to produce about 80,000 tonnes of EDTA 2Na each year. Impurities cogenerated by this route include glycine and nitrilotriacetic acid; they arise from reactions of the ammonia coproduct.[9]
Nomenclature
To describe EDTA 2Na and its various protonated forms, chemists distinguish between EDTA 2Na4-, the conjugate base that is the ligand, and H4EDTA 2Na, the precursor to that ligand. At very low pH (very acidic conditions) the fully protonated H6EDTA2+ form predominates, whereas at very high pH or very basic condition, the fully deprotonated EDTA4- form is prevalent. In this article, the term EDTA is used to mean H4-xEDTAx-, whereas in its complexes EDTA4- stands for the tetraanion ligand.
Coordination chemistry principles
Metal-EDTA chelate as found in Co(III) complexes.
Structure of [Fe(EDTA)(H2O)]-, showing that the EDTA4- ligand does not fully encapsulate Fe(III), which is seven-coordinate.
In coordination chemistry, EDTA4- is a member of the aminopolycarboxylic acid family of ligands. EDTA4- usually binds to a metal cation through its two amines and four carboxylates. Many of the resulting coordination compounds adopt octahedral geometry. Although of little consequence for its applications, these octahedral complexes are chiral. The cobalt(III) anion [Co(EDTA)]- has been resolved into enantiomers.[26] Many complexes of EDTA4- adopt more complex structures due to either the formation of an additional bond to water, i.e. seven-coordinate complexes, or the displacement of one carboxylate arm by water. The iron(III) complex of EDTA 2Na is seven-coordinate. Early work on the development of EDTA 2Na was undertaken by Gerold Schwarzenbach in the 1940s. EDTA 2Na forms especially strong complexes with Mn(II), Cu(II), Fe(III), Pb(II) and Co(III).
Several features of EDTA 2Na’s complexes are relevant to its applications. First, because of its high denticity, this ligand has a high affinity for metal cations
[Fe(H2O)6]3+ + H4EDTA ⇌ [Fe(EDTA)]- + 6 H2O + 4 H+ Keq = 1025.1
Written in this way, the equilibrium quotient shows that metal ions compete with protons for binding to EDTA. Because metal ions are extensively enveloped by EDTA 2Na, their catalytic properties are often suppressed. Finally, since complexes of EDTA4- are anionic, they tend to be highly soluble in water. For this reason, EDTA 2Na is able to dissolve deposits of metal oxides and carbonates.
The pKa values of free EDTA 2Na are 0, 1.5, 2, 2.66 (deprotonation of the four carboxyl groups) and 6.16, 10.24 (deprotonation of the two amino groups).
Environmental fate
Abiotic degradation
EDTA 2Na is in such widespread use that questions have been raised whether it is a persistent organic pollutant. While EDTA 2Na serves many positive functions in different industrial, pharmaceutical and other avenues, the longevity of EDTA 2Na can pose serious issues in the environment. The degradation of EDTA 2Na is slow. EDTA 2Na mainly occurs abiotically in the presence of sunlight.[31]
The most important process for the elimination of EDTA 2Na from surface waters is direct photolysis at wavelengths below 400 nm.[32] Depending on the light conditions, the photolysis half-lives of iron(III) EDTA 2Na in surface waters can range as low as 11.3 minutes up to more than 100 hours.[33] Degradation of FeEDTA, but not EDTA 2Na itself, produces iron complexes of the triacetate (ED3A), diacetate (EDDA), and monoacetate (EDMA) – 92% of EDDA and EDMA biodegrades in 20 hours while ED3A displays significantly higher resistance. Many environmentally-abundant EDTA 2Na species (such as Mg2+ and Ca2+) are more persistent.
Biodegradation
In many industrial wastewater treatment plants, EDTA 2Na elimination can be achieved at about 80% using microorganisms.[34] Resulting byproducts are ED3A and iminodiacetic acid (IDA) – suggesting that both the backbone and acetyl groups were attacked. Some microorganisms have even been discovered to form nitrates out of EDTA 2Na, but they function optimally at moderately alkaline conditions of pH 9.0-9.5.
Several bacterial strains isolated from sewage treatment plants efficiently degrade EDTA 2Na. Specific strains include Agrobacterium radiobacter ATCC 55002[36] and the sub-branches of Proteobacteria like BNC1, BNC2, and strain DSM 9103.[38] The three strains share similar properties of aerobic respiration and are classified as gram-negative bacteria. Unlike photolysis, the chelated species is not exclusive to iron(III) in order to be degraded. Rather, each strain uniquely consumes varying metal-EDTA 2Na complexes through several enzymatic pathways. Agrobacterium radiobacter only degrades Fe(III) EDTA 2Na while BNC1 and DSM 9103 are not capable of degrading iron(III) EDTA 2Na and are more suited for calcium, barium, magnesium and manganese(II) complexes. EDTA 2Na complexes require dissociation before degradation.
Alternatives to EDTA 2Na
Interest in environmental safety has raised concerns about biodegradability of aminopolycarboxylates such as EDTA 2Na. These concerns incentivize the investigation of alternative aminopolycarboxylates.[31] Candidate chelating agents include nitrilotriacetic acid (NTA), iminodisuccinic acid (IDS), polyaspartic acid, S,S-ethylenediamine-N,N′-disuccinic acid (EDDS), methylglycinediacetic acid (MGDA), and L-Glutamic acid N,N-diacetic acid, tetrasodium salt (GLDA).
Iminodisuccinic acid (IDS)
Commercially used since 1998, iminodisuccinic acid (IDS) biodegrades by about 80% after only 7 days. IDS binds to calcium exceptionally well and forms stable compounds with other heavy metal ions. In addition to having a lower toxicity after chelation, IDS is degraded by Agrobacterium tumefaciens (BY6), which can be harvested on a large scale. The enzymes involved, IDS epimerase and C-N lyase, do not require any cofactors.
Polyaspartic acid
Polyaspartic acid, like IDS, binds to calcium and other heavy metal ions. It has many practical applications including corrosion inhibitors, wastewater additives, and agricultural polymers. A Polyaspartic acid-based laundry detergent was the first laundry detergent in the world to receive the EU flower ecolabel.
S,S-Ethylenediamine-N,N′-disuccinic acid (EDDS)
The S,S isomer of EDTA 2Na, ethylenediamine-N,N′-disuccinic acid (EDDS) is readily biodegradable and exhibits a high rate biodegradation.
Methylglycinediacetic acid (MGDA)
Trisodium dicarboxymethyl alaninate, also known as methylglycinediacetic acid (MGDA), has a high rate of biodegradation at over 68%, but unlike many other chelating agents can degrade without the assistance of adapted bacteria. Additionally, unlike EDDS or IDS, MGDA can withstand higher temperatures while maintaining a high stability as well as the entire pH range.[citation needed] MGDA has been shown to be an effective chelating agent, with a capacity for mobilization comparable with that of Nitrilotriacetic acid (NTA), with application to water for industrial use and for the removal of calcium oxalate from urine from patients with kidney stones.
Methods of detection and analysis
The most sensitive method of detecting and measuring EDTA 2Na in biological samples is selected reaction monitoring capillary electrophoresis mass spectrometry (SRM-CE/MS), which has a detection limit of 7.3 ng/mL in human plasma and a quantitation limit of 15 ng/mL.[45] This method works with sample volumes as small as 7-8 nL.[45]
EDTA 2Na has also been measured in non-alcoholic beverages using high performance liquid chromatography (HPLC) at a level of 2.0 μg/mL.
EDTA 2Na 2Na
( Ethylenediaminetetraacetic Acid, disodium Salt / EDTA 2Na 2Na )
Molecular Formula C10H14N2O8Na2王2H2O
Molecular Weight 372.2
CAS No 6381-92-6
Physical Properties
Appearance ……………. White Crystalline Powder
Bulk Density ………….. approx. 0.63g/cm3
Solubility in Water …. 10.8g/100m坐 at 22◥C
23.6g/100m坐 at 80◥C
Specification
Purity ……………….. 98% up
pH of 5% aqueous solution ………….. 4.4 ~ 4.7
Chelating Value (as mg CaCO3/g) … 260 up
Environmental Aspects
Biodegradability ……….. difficult
C.O.D. ……………………. approx. 560mg/g
Application
in the detergent industry as stabilizer
in the chemical industry as metal carrier in redox system
in the cosmetic industry as stabilizer for preparation
in the printing industry to control hardness and as stabilizer
Packing
20kgs net in multiply paper bag with value and inside polyethylene bag
16MT/FCL with Pallet
17MT/FCL without Pallet
Storage
Store on a dry place
Opened bags must be closed again properly.
Safety Precautions in Handling
do not inhale or ingest, avoid contacting with the skin and protest the eye from splashes.
Wear safety goggles, glovers and a mask of there is a risk of repeated contact.
Wash thoroughly after handling
First-aid Measures
Skin contact : wash with plenty of water
Splashes in the eyes: wash with water at low pressure then with a neutral solution of boric acid. Consult an ophthalmologist.
Ingestion : make the victim vomit if he/she is conscious and consult a doctor if necessary
Disodium EDTA 2Na, 99% – EDTA 2Na
Ethylene diamine tetraacetic acid disodium salt (EDTA 2NA)
EDTA-4NA2_img2Molecular fomula: C10H14N2O8Na2•2H2O
Molecular weight: M=372.24
CAS No. : 6381-92-6
Properties: white crystal powder soluble in water, and a variety of metal ion chelation.
Disodium EDTA 2Na Chelation binds to metal ions which inactivates them.
The binding of metal ions helps prevent the deterioration of cosmetics and personal care products.
It also helps to maintain clarity, protect fragrance compounds, and prevent rancidity.
By binding with metal ions, EDTA 2NA prevents metals from being deposited onto hair and skin.
Specifications ;
Test Item
Standard Specification
Quality Standard
Q/24SJK01-2009
Purity : 99% Min.
Chloride(Cl)% : 0.01% Max.
Sulfate(SO4)% : 0.05% Max.
Metal chelate(Pb)% : 0.001% Max.
Iron(Fe)% : 0.001% Max.
Chelate: mgCaCO3/g : 256 Min.
pH Value : 4.0-5.0
Appearance
White Crystalline Powder
Packing: 25KG/bag , or according to the customers’ requirements
Storage: Stored in the dry and ventilated inside storeroom, prevent direct sunlight, slightly pile and put down.
Applications :
Cosmetics
Personal care (soap, shampoo)
Oil industry (anti-caking agent)
Food additives
Textile Manufacture
