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Send EmailPolyoxyethylene stearate, PEGMS, PEG 200 STEARATE, Polyoxyethylene stearate, Polyethylene glycol monostearate, 9004-99-3
CAS: 9004-99-3
Molecular Formula: C34H70O9
Names and Identifiers
| Name | Polyoxyethylene stearate |
| Synonyms | PEGMS MYRJ 58 MYRJ 45 MYRJ 59 MYRJ(R) 53 MYRJ(TM) 59 MYRJ(TM) 53 MYRJ(TM) 45 PEG 200 STEARATE PEG (6) Monostearate Polyoxyethylene stearate polyoxyethylene 8 stearate Polyethylene glycol monostearate |
| CAS | 9004-99-3 |
| EINECS | 618-405-1 |
| InChI | InChI=1/C20H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)23-19-18-21/h21H,2-19H2,1H3 |
Physico-chemical Properties
| Molecular Formula | C34H70O9 |
| Molar Mass | 622.91 |
| Melting Point | 47 °C |
| Flash Point | 39 °C |
| Water Solubility | Soluble in water |
| Appearance | powder to lump |
| Color | White to Almost white |
| Storage Condition | 2-8°C，贮存于阴凉、干燥处，避免日晒、雨淋；有效贮存期12个月。按一般货物运输。 |
| MDL | MFCD00043374 |
| Physical and Chemical Properties | This product is a white waxy solid, soluble in isopropanol, mineral oil butyl stearate, glycerin, peroxyethylene, gasoline solvent, dispersed in water. |
| Use | Used in cosmetics, pharmaceutical emulsifiers, soap-based thickeners, softeners, emulsion stabilizers, etc |
Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| RTECS | MD0907300 |
| HS Code | 3907200000 |
| Toxicity | LD50 oral in rabbit: > 12mL/kg |
Standard
This product is polyethylene glycol monostearate. Molecular formula to C17H15COO(CH2CH2O)nH table, n is about 40.
Trait
Authoritative Data Verified Data
- This product is a white waxy solid, odorless.
- This product is soluble in water and ethanol, insoluble in ether and ethylene glycol.
melting point
The melting point of this product (General 0612) is 46~51°C.
acid value
The acid value of this product (General 0713) is not greater than 2.
saponification value
The saponification value of this product (General 0713) is 25~35.
hydroxyl value
The Hydroxyl value of this product (General 0713) is 22~38.
Introduction
The larger the surfactantn of Polyoxyethylene stearate is a neutral, the lower the saponification value (mgKOH/g) and the larger the HLB value. The pH of 1% aqueous solution is between 5.0 and 7.5, in which n≤ 8 is diffusive in water and has good flexibility and lubricity. It can be used as a softener for fiber processing and has good antistatic and lubricity. Use softener during fabric weaving to reduce breakage and improve fabric feel. As an emulsifier in cosmetics, the general dosage is 1-3%. It can also be used as a co-emulsifier for the emulsification of paraffin wax. Used as emulsifier in lubricating oil production. When 9 ≤n≤ 11, it diffuses in water and has good emulsification and cleaning efficiency. It is used as emulsifier in cosmetics, ointment, paste shoe polish and other products, and has thickening effect. In the textile industry, emulsifiers and oils used in synthetic fiber finishing are flexible and antistatic. Used as thickener and stabilizer in paper starch coating. Lubricant used for multiplex transmission wires in cable ducts. When 12 ≤ n≤ 25, it is soluble in a variety of solvents such as ethanol, and the water is dispersed, which is stable to a variety of electrolytes and has good emulsification, softness and antistatic properties. It is used as softener and antistatic agent in textile industry, emulsifier and solubilizer in cosmetics, food and pharmaceutical industry, and can also be used for emulsification of cardboard, construction board and waterproof wax. 40 ≤n≤ 100, soluble in water, ethanol, carbon tetrachloride, etc., with good emulsification, wetting, complexation and thickening properties. As an emulsifier, solubilizer, ointment matrix in the pharmaceutical industry, as an emulsifier and detergent in the cosmetics industry, as a softener and antistatic agent in the textile industry, and as an emulsifying additive in the food industry.
Differential diagnosis
The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
Exam
alkalinity
take 2.0g of this product, add 20ml of ethanol to dissolve, take 2ml of solution, add 0.05ml of phenolsulfonphthalein indicator solution, and do not appear red.
clarity and color of solution
take this product l. After 20ml of water is added and dissolved, the solution shall be clear and colorless (General rule 0901 and general rule 0902). In case of color development, it shall not be deeper than the yellow 6# Standard Colorimetric solution (General rule 0901).
free poly (ethylene glycol)
Take 6g of this product, weigh it accurately, put it in a 500ml separating funnel, add ethyl acetate to dissolve it, and extract it twice with gasified sodium solution (29-100), 50ml each time, combine the lower aqueous phase, extract with 50ml of ethyl acetate, separate the lower aqueous phase, extract with chloroform 2 times, 50ml each time, combine the chloroform layer, water bath evaporation, dissolve the residue with chloroform 15ml, filter, the filter was washed with a small amount of chloroform, and the filtrate was combined and evaporated to dryness until there was no smell of chloroform and ethyl acetate. The residue was dried under vacuum at 60°C for 1 hour,
Cooling, weighing, containing free polyethylene glycol is 17% to 27%.
moisture
take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed 3 .0%.
ignition residue
0841 (general).
Heavy metals
take this product 0821G, inspection according to law (General rule third law), containing heavy metals shall not exceed 10 parts per million.
fatty acid composition
take about 0.LG of this product, put it in a 25ml Erlenmeyer flask, add 2ml of 0.5mol/L sodium hydroxide methanol solution to shake to dissolve, and heat and reflux for 30 minutes, add 2ml of 14% methanol solution of boron trifluoride along the condenser tube, heat and reflux for 30 minutes, add 4ml of n-heptane along the condenser tube, heat and reflux for 5 minutes, cool, add 10ml of saturated gasification sodium solution, shake for 15 seconds, the saturated gasification sodium solution was added to the neck of the bottle, mixed well, allowed to stand and layered, and the upper layer solution was taken to be 2ml, washed with water for 3 times, 2ml each time. The upper layer solution was dried over anhydrous sodium sulfate. According to the determination by gas chromatography (General rule 0521), the capillary column with polyethylene glycol as stationary liquid is used as the chromatographic column, and the column temperature is heated according to the program, and the initial temperature is 170 ° C. For 2 minutes, the temperature is raised to 240°C at 10°C per minute for several minutes; The detector is hydrogen flame ionization detector (FID), and the temperature of the detector is 260°C; The temperature of the sample inlet is 250°C; the carrier gas was nitrogen, the flow rate was 2 ml/min, and the split ratio was 10:1. The upper layer 1M1 was injected into the gas chromatograph, and the order of peaks was methyl palmitate and methyl stearate. The resolution of methyl palmitate and methyl stearate was not less than 5.0. Based on the peak area, the content of stearic acid is not less than 40.0%, and the sum of stearic acid and palmitic acid is not less than 90.0%.
arsenic salt
take 0.67g of this product and check it according to law (General 0822 second law). The arsenic content shall not exceed 0.0003%.
Category
pharmaceutical excipients, solubilizers, emulsifiers and substrates.
Storage
sealed, stored in a cool and dry place.
Preparation method
Add 1.07mol polyethylene glycol and 0.49mol boric acid into the reaction vessel, heat to 110 ℃, vacuum to 0.67MPa, and react for 2 hours to generate borate esters. Then add p-toluenesulfonic acid as a catalyst and add 1mol of the reactant stearic acid. After reacting at 140 ℃ for 3-4 hours, take a sample and measure the acid value. The reaction ends when the acid value drops to around 10mgKOH/g. Inject the material solution into the neutralization kettle for neutralization and discharge the wastewater. Stir and shape while hot, and package after cooling to form the finished product.
Reference Information
| hydrophilic-lipophilic balance (HLB value) | 18.8 |
| identification test | solubility: soluble in ethanol, methanol, acetone, ether, ethyl acetate and dioxane; it is cloudy when dissolved in mineral oil. According to the OT-42 method. Freezing point: 27-29 ℃. According to the conventional method of measurement. Take 5% W/V) 5ml of sample solution, and add 10ml of ammonium cobaltate solution (made up of 37.5g cobalt nitrate and 150g ammonium thiocyanate to 100ml with water, freshly prepared) and 5ml of chloroform, the layers were separated after shaking; A blue color should be generated in the chloroform layer. Saponification of 100g of sample with alkali Saponification can produce about 44g of fatty acids and 59g of polyols. Take sample 20g (accurate to 0.01g), with potassium hydroxide ethanol solution (TS-190) for alkali hydrolysis, while heating reflux 2H, the amount of alkali used was more than 100% of the amount of potassium hydroxide contained relative to the calculated amount required for complete saponification of the sample. After hydrolysis, water was added and the ethanol was evaporated on a steam bath to convert the soap-like ethanol solution to an aqueous solution. The hot aqueous soap solution is acidified with sulfuric acid to free the fatty acids. The acid solution was extracted with 3 parts of petroleum ether to separate the fatty acids. The petroleum ether extract was evaporated on a steam bath and the residue was dried to constant weight under vacuum at 75 °c to recover the fatty acids. By multiplying 100/w by the weight of the recovered fatty acid, the yield of the fatty acid in the sample (where w is the weight of the sample) was G. Fatty acids can be determined by determining Physical and Chemical Constants (E. G., saponification temperature), or by gas-liquid chromatography. The aqueous polyol solution after removal of the fatty acid was neutralized to pH 7 with a potassium hydroxide solution (TS-189). After evaporation on a steam bath to a wet residue, the polyol was extracted with 3 portions of hot absolute ethanol. After distilling off the ethanol on the steam bath, the residue was dried to constant weight under vacuum at 75 °c to give the polyol fraction in the sample. The yield of the polyol obtained in 100g of the sample (where W is the weight of the sample) is obtained by multiplying/W by the weight of the recovered polyol. |
| content analysis | ethylene oxide content was determined by the OT-36 method. |
| usage limit | ADI 0~25mg/kg(FAO/WHO,2001). Safe for use in food (FDA,§ 172.834,2000). There are reports of kidney stones. |
| Use | This product is used as an emulsifier for oils and esters during liquid or paste emulsification in the production of lubricating oil. It can also be used as thickeners and stabilizers in paper powder coating, lubricants and softeners for textiles, lubricants for multiplex transmission wires in cable pipes, and lubricants for paper sizing. used in cosmetics, pharmaceutical emulsifiers, soap-based thickeners, softeners, emulsion stabilizers, etc. |
| production method | put 1.07 mol polyethylene glycol and 0.49 mol boric acid into the reaction kettle and heat to 110 °c, vacuum was applied to 0367 MPa, and the reaction was carried out for 2 h to form borate ester. P-toluenesulfonic acid was then added as a catalyst and 1 mol of stearic acid was added as a reactant. After reacting at 140 ℃ for 3~4 h, the acid value was measured by sampling, and the reaction was completed when the acid value was reduced to about 10 mgKOH/g. The feed liquid was driven into a neutralization kettle, and neutralization was performed to discharge waste water. When hot mixing molding, cooling packaging is the finished product. |
