E494,Sorbitan oleate, Sorbitan monooleate, Span-80, EmulsifierS80, 1338-43-8

E494,Sorbitan oleate, Sorbitan monooleate, Span-80, EmulsifierS80, 1338-43-8

Span-80

CAS: 1338-43-8

Molecular Formula: C24H44O6

Names and Identifiers

Physico-chemical Properties

 Risk and Safety

Upstream Downstream Industry

Nature

Amber viscous oil, insoluble in water. Soluble in general hot oil and organic solvents; With good emulsifying and dispersing power. It is a water-in-oil surfactant.

Preparation Method

Sorbitan and oleic acid were esterified.

Standard

This product is Sorbitan and oleic acid to form a mixture of esters, sorbitol dehydration, in alkaline catalyst, and oleic acid esterification prepared; or from sorbitol and oleic acid in 180 to 280*0 under the direct esterification of the system.

Trait

• This product is light yellow to yellow oily liquid, with slight abnormal odor.
• This product is insoluble in water or propylene glycol.

acid value

The acid value of this product (General Rule 0 7 1 3) is not more than 8.

saponification value

The saponification value of this product (General Rule 0 7 1 3) is 1 4 5~1 6 0 (saponification time 1 hour).

hydroxyl value

The Hydroxyl value of this product (General Rule 0 H 3) is 1 9 0~2 1 5.

iodine value

The iodine value of this product (General Rule 0 7 1 3) is 6 2~7 6.

perchlorination value

The peroxide value of this product (General Rule 0 7 1 3) is not more than 1 0.

 Introduction

Nonionic surfactants. Water/oil emulsifier. Gas chromatography stationary solution (maximum service temperature 150 ℃, solvent methanol), separation and analysis of oxygen-containing compounds. Stabilizer.

Use

used as emulsifier, thickener, dispersant and rust inhibitor. In the emulsion explosives, textile oil as emulsifier; Paint industry as dispersant; Petroleum products as rust inhibitor and solvent; Titanium dioxide as a stabilizer in the production. And widely used in medicine, food and cosmetics industry.

Differential diagnosis

take about 2g of this product, put it in a 250m l flask, add 100ml of ethanol and 3 . 5 g of potassium hydroxide, and mix well. Heat reflux for 2 hours, add about 100ml of water, transfer to a 250ml beaker while hot, evaporate on a water bath and continue to add water, continue to evaporate until no ethanol odor, finally heat 100ml of water, slowly Dropwise add sulfuric acid solution (1-2) While it is hot until the litmus paper is neutral, record the consumed volume, continue to Dropwise add sulfuric acid solution (1-2) (about 10% of the above consumed volume), the liquid in the lower layer was clarified by standing. Transfer the above solution to a 10%-ml separatory funnel, extract with n-hexane for 3 times, each time, discard the n-hexane layer, and take the aqueous layer solution to adjust the p H value to 7 with potassium hydroxide solution. 0, water bath evaporation to dryness, the residue (if necessary, the residue is triturated) plus anhydrous ethanol 150ml, stirred with a glass rod, boiled in a water bath for 3 minutes, the above solution was placed in a funnel covered with diatomaceous earth, filtered, the solution was evaporated to dryness, and the residue was dissolved with 2ml of methanol as a test solution, 4-desosorbide 25mg with sorbitol 2 5M g, add methanol lm l to dissolve, as a reference solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions each 2 ml, respectively point on the same-silica gel G thin layer plate, with acetone-glacial acetic acid (50: 1) for Development, spread out, take out, dry, spray sulfuric acid solution (1- 2) to just wet, immediately heat at 20C0C until the spots are clear, cool, immediately check, the position and color of the spots of the test solution should be the same as that of the control solution.

Exam

fatty acid composition

take this product O . l g, put in 25ml Erlenmeyer flask, add 0.2ml of 5m o l/L sodium hydroxide methanol solution, shake to dissolve, heat reflux for 30 minutes, add 2ml of 14% boron trifluoride methanol solution along the condenser, heat reflux for 30 minutes, add n-heptane 4 m l along the condenser tube, heat and reflux for 5 minutes, cool, add 10ml saturated gasification sodium solution, shake for 15 seconds, add saturated gasification sodium solution to the neck of the bottle, mix well, let stand and separate the layers, take 2ml of the upper layer, wash with water for three times, 2 m l each time, take the upper layer and dry it with anhydrous sodium sulfate, as the test solution f, the following appropriate amount of each fatty acid methyl ester reference substance was accurately weighed, and dissolved and diluted with n-heptane to prepare methyl myristate 0.5mg and methyl palmitate 1 per l of lm l. Omg, methyl palmitoleate 0.5mg: methyl stearate 0.5mg, methyl oleate 6. Omg, methyl linoleate 1. Omg, methyl linolenic acid 0.5M g of mixed control solution (1 ), take l.O m I, put in a 10ml measuring flask, dilute to the scale with n-heptane, shake, as a mixed control solution (2). According to the gas chromatography method (General rule 0521), the capillary column with polyethylene glycol as stationary liquid is used as the column, the initial temperature is 1 70V, and the temperature is raised to 230TC at the rate of 2 t per minute, the sample inlet temperature was 250 * C, the detector temperature was 250TC, and 1M1 of each of the mixed reference solution (1) and (2) was injected into the human gas chromatograph to record the chromatogram, the resolution of the fatty acid methyl ester peak of each component in the mixed control solution (1) was not less than 1 .8, the theoretical plate number according to the peak of oleic acid methyl ester is not less than 30 000, the signal to noise ratio of the minimum fatty acid methyl ester peak in the mixed reference solution (2) should be greater than 5. Take Test Solution 1 ^ 1, inject human gas chromatograph, calculate according to peak area normalization method, containing myristic acid is not more than 5 ,0%, Palmitic acid not more than 1 6 .0%, palmitoleic acid not more than 8.0%, stearic acid not more than 6 .0%, oleic acid is 65.0% ~ 8 8.0%, linoleic acid not more than 18.0%, linolenic acid not more than 4 .0%, other fatty acids not more than 4 .0%.

moisture

take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed 1 .0%.

ignition residue

The l.O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

Category

pharmaceutical excipients, emulsifiers and Defoamers.

Storage

sealed and stored in a dry place.

Reference Information