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Send EmailTween-60, Tween(R) 60, Emulsifier T-60, Polyoxyethylene sorbitan monostearate, 9005-67-8
CAS: 9005-67-8
Molecular Formula: C22H42O8
Names and Identifiers
| Name | Tween(R) 60 |
| Synonyms | Tween 60 Tween-61 Tween-60 Tween(R) 60 Emulsifier T-60 Emulsifier T-6l Polyoxyethylene sorbitan monostearate 1,4-anhydro-6-O-dodecanoyl-2,3-bis-O-(2-hydroxyethyl)-D-glucitol |
| CAS | 9005-67-8 |
| InChI | InChI=1/C22H42O8/c1-2-3-4-5-6-7-8-9-10-11-20(26)29-16-18(25)21-22(28-15-13-24)19(17-30-21)27-14-12-23/h18-19,21-25H,2-17H2,1H3/t18-,19+,21-,22-/m1/s1 |
Physico-chemical Properties
| Molecular Formula | C22H42O8 |
| Molar Mass | 434.564 |
| Density | 1.12g/cm3 |
| Melting Point | 45-50 °C |
| Boling Point | 583.8°C at 760 mmHg |
| Flash Point | 190.4°C |
| Water Solubility | 100 g/L |
| Solubility | Soluble in water, isopropanol and ethanol, insoluble in mineral oil and vegetable oil |
| Vapor Presure | 4.64E-16mmHg at 25°C |
| Appearance | Bright yellow liquid |
| PH | 5.5-7.7 (50g/l, H2O, 25℃) |
| Storage Condition | Store below +30°C. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.498 |
| MDL | MFCD01780110 |
| Physical and Chemical Properties | Chemical quality This product is a yellow waxy solid, soluble in water, sulfuric acid and dilute alkali, HLB value is 9.6, and has dispersion ability in the presence of some salts. |
| Use | Used as emulsifier, Defoamer, lubricant, detergent, antistatic agent |
Risk and Safety
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | WG2934000 |
| TSCA | Yes |
| HS Code | 34021300 |
| Toxicity | LD50 orally in Rabbit: > 38000 mg/kg |
Upstream Downstream Industry
| Raw Materials | Hydrogen peroxide Nitrogen ETHYLENE OXIDE Sodium ethoxide Stearic acid Sorbitol Span 60 |
| Downstream Products | Spining lubricant agent |
Standard
This strain of Sorbitan stearate and ethylene oxide polymerization of polyoxyethylene 20 Sorbitan stearate.
Trait
- This product is a milky white to yellow viscous liquid or frozen paste; Slightly odorless.
- This product is soluble in warm water, ethanol, methanol or ethyl acetate, slightly soluble in liquid paraffin.
relative density
The relative density of this product (General 0601) in 25V is 1.06~1.09.
viscosity
The kinematic viscosity of this product (General rule 0633 first method) is 300~450/s at 30°C (capillary inner diameter is or suitable capillary inner diameter).
acid value
take about 10g of this product, accurately weigh it, put it in a 250ml Erlenmeyer flask, add 50ml of neutral ethanol (neutral to phenolphthalein indicator solution) to dissolve, heat and reflux for 10 minutes, and let it cool, add phenolphthalein indicator solution 5 drops, with sodium hydroxide titration solution (0.lmol/L) titration, acid value (General 0713) should not exceed 2.0.
saponification value
The saponification value of this product (General 0713) is 45~55.
hydroxyl value
The Hydroxyl value of this product (General 0713) is 81~96.
perchlorination value
The peroxide value of this product (General rule 0713) shall not exceed 10.
Introduction
Nonionic surfactants. Gas chromatography stationary solution (maximum service temperature 160 ℃), separation and analysis of fatty acid esters, alcohols, ketones and halides.
Differential diagnosis
- take 5ml of aqueous solution (1-20) of this product, add 5ml of sodium hydroxide solution, boil for several minutes, let cool, acidify with dilute hydrochloric acid, and show milky white turbidity.
- Take 2ml of the aqueous solution (1-20) of this product and add 0.5ml of bromine test solution dropwise. The bromine test solution will not fade.
- take 6ml of this product, add 4ml of water and mix well to form a gel.
- take 10ml of aqueous solution (L-0) of this product, add 5ml of cobalt ammonium thiocyanate solution (take 17.4g of ammonium thiocyanate and 2.8g of cobalt nitrate, add water to dissolve 100ml), mix well, add 5ml of chloroform, after shaking and mixing and standing, the chloroform layer was blue.
Exam
pH
take 0.50g of this product, Add 10ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 4.0~7.5.
Color
take 10ml of this product, and compare it with the same volume of control solution (take 8.0 ml of potassium dichromate solution for color comparison and 0.8ml of cobalt chloride solution for color comparison, add water to 10ml), and not be deeper.
ethylene glycol and diethylene glycol
take about 4g of this product, precision weighing, 100ml measuring flask, precision plus internal standard solution (take 1, 3-butanediol appropriate amount, prepare a solution containing about 4mg per 1 ml of acetone) 1 ml, dilute to the scale with acetone, shake well, and use as a test solution; Take ethylene glycol and diethylene glycol, each about 40mg, precision weighing, in the same 100ml measuring flask, dilute to the scale with acetone, shake well, take 10ml and put it in another 100ml measuring flask, add lml of internal standard solution, dilute to the scale with acetone, shake well as a control solution. Test according to Gas chromatography (General 0521). With 50% phenyl 50% methyl polysiloxane as stationary liquid (column length 30m, inner diameter 0.53, membrane thickness 1.Oum), the initial temperature is 40°C, and the temperature is raised to 60°C at a rate of 1CTC per minute, after 5 minutes, the temperature was raised to 170°C at a rate of 10°C per minute and then to 280°C at a rate of 15°C per minute for 60 minutes (adjustable on a case by case basis). The inlet temperature was 270°C and the detector temperature was 290°C. Take the reference solution as the system suitability test solution, the separation degree between peaks shall not be less than 2.0, and the tailing factor of each peak shall meet the requirements. 1ul of test solution and 1ul of reference solution were injected separately, and the chromatogram was recorded. According to the internal standard method based on peak area, ethylene glycol and diethylene glycol shall not exceed 0.01%.
ethylene oxide and dioxane
take this product about lg, precision weighing, top empty bottle, precision plus ultrapure water 1.0ml, sealed, shake, as a test solution; take an appropriate amount of ethylene oxide reference stock solution, put it in a measuring flask, and add the treated polyethylene glycol 400 (rotary evaporation at 60°C,1.5 ~ 2.5kpa for 6 hours to remove volatile components) A solution containing about 1ug per 1 ml was prepared as an ethylene oxide control solution by dissolution and dilution. Separately take the right amount of dioxane, precision weighing, made of water containing about 10ug per lml of the solution, as dioxane
Control solution. Take about 1g of this product, precision weighing, top empty bottle, precision plus ethylene oxide reference solution and dioxane reference solution of 0.5, sealed, shake. As a control solution. Add 0.001% ml of newly prepared 0.5 acetaldehyde solution and ml of dioxane control solution to the headspace bottle, seal and shake. As a system suitability test solution. Test according to Gas chromatography (General 0521). With polydimethylsiloxane as the stationary liquid, the initial temperature is 35°C, the temperature is maintained for 5 minutes, the temperature is raised to 180°C at a rate of 5°C per minute, and then the temperature is raised to 230°C at a rate of 30°C per minute, maintain 5 minutes (can be adjusted according to the specific situation). The inlet temperature was 150°C and the detector temperature was 250°C. The Headspace equilibrium temperature is 70°C, and the equilibrium time is 45 minutes. The system suitability test solution is sampled in the headspace, the flow rate is 2.5ml per minute, and the split ratio is 1:20. Adjust the sensitivity of the instrument so that the peak height of ethylene oxide peak and acetaldehyde peak is 15% of the full scale, the separation degree of acetaldehyde peak and ethylene oxide peak is not less than 2.0, and the height of dioxane peak should be at least 5 times of the baseline noise. The test solution and the reference solution were respectively injected in Headspace, and the injection was repeated for at least 3 times. The relative standard deviation of the peak area of ethylene oxide should not exceed 15%, and the relative standard deviation of the peak area of dioxane should not exceed 10%. Calculated by Standard addition method, the content of ethylene oxide shall not exceed 0.0001%, and the content of dioxane shall not exceed 0.001%.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 3.0%.
ignition residue
This product l.O g, inspection according to law (General 0841), residue shall not exceed 0.25%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take this product l.Og, put in a Kjeldahl Flask, add 5ml of sulfuric acid, digest with small fire to carbonize, control the temperature not to exceed 120°C (sulfuric acid can be added if necessary, the total amount is not more than 10ml), carefully add concentrated hydrogen peroxide solution Dropwise, once the reaction is stopped, continue heating, and add concentrated hydrogen peroxide solution Dropwise until the solution is colorless, cool, add 10ml of water, evaporate until thick smoke occurs to remove hydrogen peroxide, add hydrochloric acid 5ml and water appropriate amount, according to the law inspection (General Principles 0822 The first law), should comply with the provisions (not over 0.0002%).
fatty acids
make up about 0.lg of this product, put it in a 50ml Erlenmeyer flask, add 2ml of 2% sodium hydroxide methanol solution, heat and reflux in a 65°C water bath for 30 minutes, and let it cool, add 2ml of 14% methanol solution of boron trifluoride, heat and reflux in water bath for 30 minutes, cool, add 4ml of n-heptane, continue heating and reflux in water bath for 5 minutes, cool, add 10ml of saturated sodium chloride solution, shake, the mixture was allowed to stand to separate into layers, and the upper layer was taken and washed 3 times with 4ml of water each time. The upper layer was dried over anhydrous sodium sulfate and used as a test solution. Test by gas chromatography (General 0521). A quartz capillary column (0.32mm x 30m, membrane thickness 0.50um) with polyethylene glycol 20m as stationary liquid was used as the column, the initial temperature was 90°C, and the temperature was raised to 160°C at a rate of 20°C per minute for 1 minute, the temperature was then raised to 220°C at a rate of every minute for 20 minutes; The inlet temperature was 250°C for the detector. Weigh appropriate amount of methyl stearate and methyl palmitate respectively, add n-heptane to dissolve and make solution containing about 1 mg per 1 ml, take 1ul injection gas chromatograph, record chromatogram, the number of theoretical plates shall not be less than 10000 calculated by methyl stearate peak, and the separation degree of methyl stearate peak and methyl palmitate peak shall meet the requirements. Take the sample solution 1u1 and inject it into the gas chromatograph, record the chromatogram, and calculate according to the area normalization method, the stearic acid content should be 40.0% ~ 60.0%, and the sum of stearic acid and palmitic acid should not be less than 90.0%.
Category
pharmaceutical excipients, solubilizers and emulsifiers.
Storage
light shielding, sealed storage.
Preparation method
Add 330kg emulsifier S-60 to the reaction kettle, heat and melt it, stir it, and add a catalyst amount of sodium hydroxide solution. Vacuum and reduce pressure for dehydration, replace the air in the kettle with nitrogen, raise the temperature to 140 ℃, and then start adding 700kg of ethylene oxide. Control the reaction temperature between 160~180 ℃. After the epoxy ethane is added to the proportion, the feed liquid is fed into a neutralization kettle, and the pH value is adjusted to around 2 with glacial acetic acid. Finally, an appropriate amount of hydrogen peroxide is used for decolorization, and the packaging is cooled to obtain the finished product.
