We unleash your business potential by maximize the business innovation.
Send EmailMonoethanolamine, Ethanol amine, olamine, Ethanolamine Mono ethanol amine, 141-43-5
CAS: 141-43-5
Molecular Formula: C2H7NO
Names and Identifiers
| Name | Ethanolamine |
| Synonyms | olamine H-Glycinol EthanoIamine Ethanolamine 2-Aminoethanol Monoethanolamine ETHANOLAMINE pure 2-aminoethanethiol 2-Hydroxyethylamine Ethanolamine solution 2-aminoethanol ethanolamine Ethanolamine2-Aminoethanol Ethanolamine Monoethanolamine |
| CAS | 141-43-5 |
| EINECS | 205-483-3 |
| InChI | InChI=1/C2H7NO/c3-1-2-4/h4H,1-3H2 |
| InChIKey | HZAXFHJVJLSVMW-UHFFFAOYSA-N |
Physico-chemical Properties
| Molecular Formula | C2H7NO |
| Molar Mass | 61.08 |
| Density | 1.012g/mLat 25°C(lit.) |
| Melting Point | 10-11°C(lit.) |
| Boling Point | 170°C(lit.) |
| Flash Point | 200°F |
| Water Solubility | miscible |
| Solubility | Soluble in benzene, ether, carbon tetrachloride. |
| Vapor Presure | 0.2 mm Hg ( 20 °C) |
| Vapor Density | 2.1 (vs air) |
| Appearance | Liquid |
| Specific Gravity | 1.012 |
| Color | APHA: ≤15 |
| Exposure Limit | TLV-TWA 3 ppm (～7.5 mg/m3) (ACGIH,MSHA, and OSHA); TLV-STEL 6 ppm(～15 mg/m3) (ACGIH); IDLH 1000 ppm(NIOSH). |
| Merck | 14,3727 |
| BRN | 505944 |
| pKa | 9.5(at 25℃) |
| PH | 12.1 (100g/l, H2O, 20℃) |
| Storage Condition | Store at +15°C to +25°C. |
| Stability | Stable. Flammable; incompatible with strong oxidizing agents, strong acids. Hygroscopic. |
| Sensitive | Air Sensitive & Hygroscopic |
| Explosive Limit | 3.4-27%(V) |
| Refractive Index | n20/D 1.454(lit.) |
| Physical and Chemical Properties | Character at room temperature for colorless transparent viscous liquid, hygroscopicity and ammonia odor. melting point 10.5 ℃ boiling point 170 ℃ relative density 1.0180 refractive index 1.4540 flash point 93.3 ℃ , ethanol and acetone miscible, slightly soluble in ether and carbon tetrachloride. |
| Use | It is used to remove acid gas from natural gas and petroleum gas, and to manufacture non-ionic detergents and emulsifiers. |
Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R34 - Causes burns R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R10 - Flammable R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2924 3/PG 3 |
| WGK Germany | 1 |
| RTECS | KJ5775000 |
| FLUKA BRAND F CODES | 8-10-23 |
| TSCA | Yes |
| HS Code | 29221100 |
| Hazard Class | 8 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 10.20 g/kg (Smyth) |
Upstream Downstream Industry
| Raw Materials | Ethylene Oxide Ammonia |
| Downstream Products | Piperazine hexahydrate 2-Aminoethanethiol hydrochloride Ethanolamine Furazolidone Taurine |
Nature
It is a colorless, transparent and viscous liquid at room temperature, and has hygroscopicity and ammonia odor. With water, ethanol and acetone miscible, slightly soluble in benzene, ether, carbon tetrachloride, ethanol and chloroform. With sulfuric acid, nitric acid, hydrochloric acid and other strong acid reaction. Reaction with inorganic acids and organic acids to produce esters; Flammable, in case of high temperature, open flame or contact with oxidants have the risk of combustion.
Preparation Method
The preparation of ethanolamine by ethylene oxide ammoniation process, can be divided into two kinds of continuous and batch method, at the same time can get monoethanolamine, Diethanolamine and triethanolamine three products. The yield of the three products is typically adjusted by varying the ratio of the amount of ammonia to the amount of ethylene oxide material. In the continuous production process, after the raw material ammonia and ethylene oxide are reacted in the tubular reactor, and then deammoniation, dehydration and vacuum rectification are carried out in the deammoniation column, dehydration column and distillation column to obtain monoethanolamine, diethanolamine and triethanolamine finished products.
Use
monoethanolamine is an important corrosion inhibitor for boiler water treatment, Automotive Engine Coolants, drilling and cutting oils, and other lubricating oils. However, monoethanolamine should not be used in combination with nitrite corrosion inhibitor to prevent the formation of nitrosamine carcinogens.
Safety
low toxicity, rat oral LD50: 10.20g/kg. Ethanol amine vapor on the human eye and respiratory tract has a strong stimulating effect, if the wrong food will produce serious toxic reactions. The operation process should be protected. If contact with the skin, eyes should be immediately with flowing water rinse. Should be stored in a cool, dry, well-ventilated non-combustible material warehouse, away from the fire, heat sources, to prevent direct sunlight. It cannot be stored and transported together with acids and oxidants.
Properties
| Henry's Law Constant | 1.61(x 10-10 atm?m3/mol) at 20 °C (Bone et al., 1983) |
| LogP | -2.3--1.91 at 25℃ |
| uses | ethanolamine is used to prepare various pharmaceutical compounds and inhibitors. Substituted carboxyl compounds were synthesized from ethanolamine with strong anti-tumor activity. It is also used to synthesize aminoquinolones with anti-plasmodium activity. Used as gas chromatography stationary liquid and solvent GB 2760-96 is a processing aid for the food industry that is allowed to be used. monoethanolamine is mainly used as plasticizer, vulcanizing agent, accelerator and foaming agent of synthetic resin and rubber, as well as intermediate of pesticide, medicine and dye. It is also a raw material for synthetic detergents and emulsifiers for cosmetics. Textile industry as printing and dyeing whitening agent, antistatic agent, mothproof agent, detergent. It can also be used as carbon dioxide absorbent, ink additive and petroleum additive. Monoethanolamine is widely used as a purification liquid for extracting acidic components from various gases (such as natural gas). Piperazine hexahydrate can be prepared by cyclization and neutralization of monoethanolamine hydrochloride. Monoethanolamine hydrochloride is chlorinated by sulfoxide chloride and then replaced by sodium thiosulfate to produce β-aminoethyl thiosulfate. This is a dye intermediate used to produce polycondensation turquoise blue 13G. The reaction of monoethanolamine and carbon disulfide can produce intermediate thiazoline, which is used in rubber and pharmaceutical industries. Ethanolamine is also known as 2-aminoethanol, 2-hydroxyethylamine and monoethanolamine. Ethanolamine is an intermediate for the preparation of the carbamate insecticide dioxygen. It is also widely used as a purification liquid for extracting acidic components from various gases (such as natural gas). Alkyl alcohol amides produced from ethanolamine with fatty acids are effective foam synergists. Ethanolamine is also an intermediate of emulsifier, used in the textile industry as an antistatic agent, mothproof agent, and detergent. Piperazine hexahydrate can be prepared by cyclization and neutralization of ethanolamine hydrochloride. Piperazine can be used as an enteric repellent in the form of phosphate or citrate. It is used to remove acid gases in natural gas and petroleum gas, and to produce non-ionic detergents, emulsifiers and other solvents. Organic synthesis to remove carbon dioxide and hydrogen sulfide from the gas. Gas chromatography stationary solution (maximum service temperature 50 ℃, solvent is ether), used to separate low carbon alcohols, pyridine and their derivatives. |
| toxicity | LD50700mg/kg (mouse, oral). LD502100 (rat, oral). |
| Production method | Ethanolamine can be prepared by the reaction of ammonia and ethylene oxide. Ethylene oxide, ammonia solution and circulating ammonia enter the reactor made of stainless steel together with a cooling device, the reaction temperature is 30~40 ℃, and the reaction pressure is 0.7 ~ 3MPa. The reaction product enters the deamination tower, and the removed ammonia returns to the ammonia absorber to prepare ammonia solution. The bottom product of the tower is evaporated, concentrated and dried and dehydrated to obtain crude ethanolamine. The purity of monoethanolamine, diethanolamine and triethanolamine were 98% ~ 99%, the conversion rate of ethylene oxide was close to 100%, and the yield of ethanolamine was about 95%. In addition, a small amount of by-product polyether is produced, and a small amount of carbon dioxide in the raw material can reduce the generation of by-products. Ethanolamine is often present in phospholipids and often coexists with choline, so it is also called cholamine. Ethanolamine is also found in serum protein rot fermentation broth. In industry, ethanolamine can be prepared by the reaction of ammonia and ethylene oxide. The ethylene oxide and ammonia water are sent to the reactor, and the condensation reaction is carried out at the reaction temperature of 30-40 ℃ and the reaction pressure of 70.9-304kPa to form a mixture of 1. 2. triethanolamine. After dehydration and concentration at 90-120 ℃, the mixture is sent to three vacuum distillation columns for vacuum distillation, and the fractions are cut according to different boiling points, and the finished products of monoethanolamine, diethanolamine and triethanolamine with purity up to 99% can be obtained. In the reaction process, if the proportion of ethylene oxide is increased, the proportion of 2. triethanolamine formation is increased, which can improve the yield of 2. triethanolamine. it is formed by condensation of ethylene oxide and ammonia water at 30-40 ℃ and 70.1-304kPa. it is a mixed solution of mono-and 2. triethanolamine, dehydrated and concentrated at 90-120 ℃, and then distilled under reduced pressure in a rectification tower to intercept the fraction at 168-174 ℃. |
| category | flammable liquid |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 1720 mg/kg; Oral-mouse LD50: 700 mg/kg |
| stimulation data | skin-rabbit 505 mg moderate; Eye-rabbit 760 micrograms severe |
| explosive hazard characteristics | blastable when mixed with air |
| flammability hazard characteristics | combustible in case of open flame, high temperature and strong oxidant; It reacts with strong acid to release heat. Combustion emits toxic nitrogen oxides and ammonia smoke |
| storage and transportation characteristics | complete packaging, light and light; warehouse ventilation, away from open flames, high temperature, separate from oxidant and strong acid |
| fire extinguishing agent | foam, carbon dioxide, dry powder, mist water |
| occupational standard | TLV-TWA 3 PPM (6 mg/m3); STEL 6 PPM (15 mg/m3) |
| spontaneous combustion temperature | 410°C |
| immediate life-threatening and health concentration | 30 ppm |
Introduction
Ethanolamine is an organic compound, also known as 2-aminoethanol. It is a colorless to light yellow liquid with an ammonia odor. Ethanolamine is an important chemical raw material widely used in the preparation of surfactants, emulsifiers, lubricant additives, and so on.
Nature:
-Appearance: colorless to light yellow liquid
-Solubility: easily soluble in water and alcohol solvents
-Property: It has alkalinity and can react with acids to form salts
Usage:
-Used as raw material for preparing lubricant additives
-Used as a substitute for ammonia and ethylene glycol, applied in the production of coatings, resins, and adhesives
-Used as a buffer and reagent in biochemical research
Method:
-Ethanolamine can be prepared by reacting ammonia and ethane oxide
-Or obtained through alcohol amine reaction
Security:
-Long term exposure to non ventilated conditions may lead to symptoms such as headache, dizziness, nausea, vomiting, etc
-Appropriate protective measures should be taken, such as wearing gloves, breathable clothing, and eye protection, to reduce exposure risks
