Ethyl acetate , RFE, acetic ester, Acetic Ether, METHYL CARBINOL, 141-78-6

Ethyl acetate , RFE, acetic ester, Acetic Ether, METHYL CARBINOL, 141-78-6

CAS: 141-78-6

Molecular Formula: C4H8O2

Names and Identifiers

Physico-chemical Properties

Risk and Safety

Hazard Symbols	F - Flammable Xi - Irritant
Risk Codes	R11 - Highly Flammable R36 - Irritating to the eyes R66 - Repeated exposure may cause skin dryness or cracking R67 - Vapors may cause drowsiness and dizziness
Safety Description	S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges.
UN IDs	UN 1173

141-78-6 - Upstream Downstream Industry

Nature

colorless transparent liquid. Volatile. Flammable. There is fruit aroma. Water can alleviate the decomposition and acidic reaction. With chloroform, ethanol, acetone, ether phase miscibility, ImL the product 25 deg C dissolved in lOmL water. Its vapor and air to form an explosive mixture, fire, high heat caused by combustion explosion. A strong reaction with an oxidizing agent can occur.

Last Update：2024-01-02 23:10:35

Preparation Method

anhydrous ethanol, glacial acetic acid and concentrated sulfuric acid were mixed and refluxed, and after cooling, an equal volume of saturated brine was added to precipitate a crude ester.

Standard

This product is based on anhydrous, containing ethyl acetate (c 4 h 8o 2) shall not be less than 99.5% (g / g ) o

Trait

• This product is colorless and clear liquid; It is volatile, easy to burn, and has fruit aroma.
• This product is dissolved in water, and any miscible with ethanol, ether, acetone or methane.

relative density

The relative density of this product (General 0601) is 0. 898~902.

refractive index

The refractive index of this product (General 0622) is 1. 370~373.

Use

Analytical reagents. Tests for bismuth, boron, gold, iron, molybdenum, platinum, potassium, thallium. Chromatographic analysis of standards, solvents, detergents. For anhydrous sodium sulfate or anhydrous magnesium sulfate drying. Ethyl acetate can be obtained by distillation with a high efficiency fractionating column.

Differential diagnosis

1. This product produces yellow flame and acetic acid odor when burning.
2. The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).

Safety

rat oral LD50: 11.3 ml/kg. This substance may be harmful to the environment, and special attention should be paid to the water body. The eyes, nose, throat have a stimulating effect. Inhalation of high concentrations can cause a slow and progressive anesthetic effect. The containers are sealed and stored in a cool, ventilated warehouse. Keep away from fire, heat source and oxidant. The temperature should not exceed 30 ℃.

Exam

clarity and color of solution

take 1.0ml of this product, add water 1 5M l, mix well, check according to law (General rule 0901 and general rule 0902), the solution should be clear and colorless.

acidity

take 2.0ml of this product, put it in an Erlenmeyer flask, Add 10ml of neutral ethanol and 2 drops of phenolphthalein indicator solution, shake well, and add sodium hydroxide titration solution (O .lm o l/L) to pink. Consumption of sodium hydroxide titration solution (O.lmo l/L) should not exceed 0.10 ml.

easily carbonized

take 2.0ml of this product, put it in a 25ml plug Cuvette, Add 10ml sulfuric acid, plug and shake, let stand for 15 minutes, and do not develop color.

Non-volatile

take 20.0 of this product, put it in a constant weight evaporation dish, and then evaporate it on a water bath. After drying it for 1 hour at 105X, the remaining residue should not pass 0. 6mg.

moisture

should not exceed 0832 (General rule first Law 2).

Related substances

measured by gas chromatography (General 0521). Chromatographic conditions and system suitability test a capillary column with 6% cyanopropylphenyl-94% dimethylsiloxane as stationary liquid (or similar polarity), starting at 90°C for 5 minutes, the temperature was increased to 240°C at a rate of 286C per minute for 2 minutes at an inlet temperature of 260°C and a detector temperature of 280°C. Take the mixed solution of chloroform, ethyl acetate, isobutyl acetate and butyl acetate (3 : 1 : 1 : 1) as the applicable solution of the system, take 1m, inject the gas chromatograph, record the chromatogram, ethyl acetate peak tailing factor should not be greater than 1 .5, and the separation of each peak should meet the requirements.

assay

take the product 1W, injection gas chromatograph, record chromatogram. Calculated by area normalization method, the sum of the total area of each impurity peak shall not be greater than 0.2% of the area of the main peak.

Content determination

take about 1.5g of this product, precision weighing, put it in a 250ml Erlenmeyer flask, Precision Add 50ml of sodium hydroxide titration solution (0.5mol/L), heat reflux for 1 hour, cool, phenolphthalein indicator solution was added 1 drop, titrated to colorless with hydrochloric acid titration solution (0.5mol/L), and the titration result was corrected with a blank test. Each l of sodium hydroxide titration solution (0.5 mol/L) corresponds to 44. 05mg of C4H80 2.

Category

pharmaceutical excipients, solvents.

Last Update：2022-01-01 11:19:23

Storage

sealed storage.