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Tetrasodium EDTA, EDTA 4Na, Edetate Sodium, Tetra Sodium Ethylene Diamine Tetra Acetate, Trilon B, 64-02-8

Tetrasodium EDTA, EDTA 4Na, Edetate Sodium, Tetra Sodium Ethylene Diamine Tetra Acetate, Trilon B, 64-02-8

TETRASODYUM EDTA – TETRASODIUM EDTA

1. CHEMICAL IDENTITY AND DEFINITION

Parameter Information
Chemical Name (IUPAC) Ethylenediaminetetraacetic Acid Tetrasodium Salt
Other Names Tetrasodium EDTA, Edetate Sodium, EDTA 4Na, Trilon B, Komplekson 3, Chelaton 3, Ethylenediamine Tetraacetic Acid Tetrasodium Salt
Chemical Formula C₁₀H₁₂N₂Na₄O₈
Molecular Weight 380.17 g/mol
CAS Number 64-02-8
EC Number (EINECS) 200-573-9
Appearance White crystalline powder
Odor Odorless
Physical State (20°C) Solid (powder)
Chemical Class Chelating agent (aminopolycarboxylic acid salt)

2. WHAT IS TETRASODIUM EDTA?

Tetrasodium EDTA is the tetrasodium salt of ethylenediaminetetraacetic acid (EDTA). It is a versatile chelating agent with the chemical formula C₁₀H₁₂N₂Na₄O₈. It is a white crystalline powder that is soluble in water and other polar solvents. It decomposes at 150-200°C, gradually losing water of crystallization and changing color. It is widely used as a water softener, preservative, and stabilizer in various industries including water treatment, detergents, cosmetics, food, pharmaceuticals, and agriculture.

3. PHYSICAL PROPERTIES

Property Value
Appearance White crystalline powder
Chemical Formula C₁₀H₁₂N₂Na₄O₈
Molecular Weight 380.17 g/mol
CAS Number 64-02-8
EC Number 200-573-9
pH (1% Solution) ~11.3 (alkaline)
Solubility in Water Soluble
Solubility in Polar Solvents Soluble
Solubility in Alcohol Slightly soluble
Solubility in Organic Solvents Insoluble
Decomposition Temperature 150 – 200 °C
Color White
Odor Odorless

4. CHEMICAL PROPERTIES

Property Information
Chemical Formula C₁₀H₁₂N₂Na₄O₈
Molecular Weight 380.17 g/mol
CAS Number 64-02-8
EC Number 200-573-9
pH (1% Solution) ~11.3
Chelation Capacity High (tetravalent chelating agent)
Metal Ion Binding Binds Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺, Zn²⁺, Pb²⁺, etc.
Stability Stable under normal conditions
Decomposition Decomposes at 150-200°C, losing water of crystallization
Hygroscopicity Hygroscopic
Solubility in Water Freely soluble

5. CHEMICAL STRUCTURE

EDTA 4Na Structure:

              CH₂ — COONa
              |
    NaOOC — CH₂ — N — CH₂ — CH₂ — N — CH₂ — COONa
                    |               |
              CH₂ — COONa      CH₂ — COONa

Tetrasodium EDTA (EDTA 4Na):

Four sodium cations (Na⁺) are bonded to the four negatively charged oxygen atoms of the EDTA molecule. This structure allows Tetrasodium EDTA to effectively chelate metal ions.

Chelation Mechanism:

    [EDTA]⁴⁻ + M²⁺ → [EDTA-M]²⁻

(Where M²⁺ represents a divalent metal ion)

6. EDTA TYPES COMPARISON

Property EDTA (Free Acid) Disodium EDTA Tetrasodium EDTA
Formula C₁₀H₁₆N₂O₈ C₁₀H₁₄N₂Na₂O₈ C₁₀H₁₂N₂Na₄O₈
CAS 60-00-4 139-33-3 64-02-8
pH (1% Solution) ~2.5 ~4.5 ~11.3
Water Solubility Low Moderate High
Sodium Content None ~12% ~24%
Chelation Capacity High High High
Primary Use Laboratory Cosmetics, food Water treatment, industrial

7. APPLICATIONS

7.1. Water Treatment

Application Description
Water Softening Binds Ca²⁺ and Mg²⁺ ions to prevent scale formation
Scale Prevention Prevents limescale in pipes and boilers
Metal Ion Sequestration Removes heavy metal ions from water
Boiler Water Treatment Prevents scaling in industrial boilers
Cooling Water Systems Prevents scale and corrosion

7.2. Detergents and Cleaning Products

Application Description
Builder Binds metal ions to enhance cleaning efficiency
Stabilizer Prevents decomposition of bleaching agents
Water Softener Softens water in washing machines
Industrial Cleaners Removes metal deposits from surfaces

7.3. Cosmetics and Personal Care

Application Description
Preservative Prevents metal ion-catalyzed degradation
Stabilizer Stabilizes formulations
Skin Barrier Modifier Weakens natural skin barrier for deeper penetration
Shampoo Additive Prevents minerals from binding to other ingredients
Creams and Lotions Stabilizes emulsions
Conditioner Additive Prevents product degradation

7.4. Food Industry

Application Description
Preservative Prevents oxidation and color change
Stabilizer Maintains flavor, color, and texture
Color Retention Prevents discoloration of fruits and vegetables
Antioxidant Synergist Enhances antioxidant activity

7.5. Pharmaceutical Industry

Application Description
Anticoagulant Preserves blood samples
Stabilizer Stabilizes vaccines and pharmaceuticals
Antihemagglutinin Prevents blood cell clumping
Chelation Therapy Removes heavy metals from the body
Psoriasis Treatment Used as precursor in ethylimide synthesis

7.6. Agriculture

Application Description
Micronutrient Availability Increases nutrient availability to plants
Soil Conditioner Binds metals in soil
Micronutrient Fertilizers Chelates trace elements for plant uptake

7.7. Textile and Dyeing

Application Description
Dye Stabilizer Improves color fastness and brightness
Metal Ion Control Prevents metal ions from affecting dyes
Printing Used in textile printing processes

7.8. Paper Industry

Application Description
Pulp Treatment Treats steamed fibers
Whiteness Enhancement Improves paper whiteness
Scale Reduction Reduces scaling in digesters

7.9. Polymer Industry

Application Description
Polymerization Activator For butyl benzene latex
Polymerization Terminator In acrylic fiber production

8. ADVANTAGES OF TETRASODIUM EDTA

Advantage Description
High Chelation Capacity Binds a wide range of metal ions
High Water Solubility Easily dissolves in aqueous solutions
Stabilizing Effect Improves product shelf life
Versatility Applicable across multiple industries
Low Toxicity Safe for use in food and cosmetics
Cost-Effective Economical chelating agent
Alkaline pH Useful in alkaline formulations

9. SAFETY AND HEALTH INFORMATION

Parameter Value
Oral LD50 (Rat) ~1,200 mg/kg
Skin Contact May cause mild irritation
Eye Contact May cause irritation
Inhalation Dust may cause respiratory irritation
Ingestion May cause gastrointestinal discomfort
Carcinogenicity Not classified as carcinogenic
Mutagenicity Negative
Reproductive Toxicity No evidence of adverse effects

9.1. GHS CLASSIFICATION

Hazard Category Description
Eye Irritation Category 2 (H319)
Skin Irritation Category 2 (H315)

9.2. FIRST AID MEASURES

Route of Exposure Action
Inhalation Remove to fresh air. If respiratory irritation, seek medical attention.
Skin Contact Wash with plenty of soap and water.
Eye Contact Rinse thoroughly with water for at least 15 minutes. Seek medical attention.
Ingestion Rinse mouth. Drink plenty of water. Seek medical attention.

10. STORAGE AND HANDLING

Parameter Information
Storage Conditions Cool, dry, well-ventilated area
Container Requirements Tightly closed, original packaging
Protect From Moisture, strong acids, strong oxidizing agents
Shelf Life 24-36 months (with proper storage)
Hygroscopicity Hygroscopic; store in a dry environment

11. TRANSPORT INFORMATION

Parameter Information
UN Number Not regulated (not a hazardous material)
Hazard Class Not applicable
Packing Group Not applicable

12. PACKAGING OPTIONS

Packaging Type Quantity Material
Kraft Bag 25 kg Kraft + PE liner
Plastic Bucket 5-25 kg HDPE
Plastic Drum 25-50 kg HDPE
Fibre Drum 25-50 kg Fibreboard

13. REGULATORY STATUS

Region / Authority Status
European Union (REACH) Registered substance
USA (EPA TSCA) Listed on TSCA inventory
USA (FDA) Approved for food and pharmaceutical use
Turkey Registered substance

14. OTHER NAMES AND SYNONYMS

Type Name
Turkish Names Tetrasodyum EDTA, Edetat Sodyum, EDTA 4Na, Komplekson 3, Şelaton 3, Trilon B
English Names Tetrasodium EDTA, Edetate Sodium, EDTA 4Na, Trilon B
CAS Number 64-02-8
EC Number 200-573-9

15. SUMMARY AND CRITICAL WARNINGS

Product Summary

Parameter Value
Product Tetrasodium EDTA
CAS Number 64-02-8
Formula C₁₀H₁₂N₂Na₄O₈
Molecular Weight 380.17 g/mol
Appearance White crystalline powder
pH (1% Solution) ~11.3
Primary Applications Water treatment, detergents, cosmetics, food, pharmaceuticals, agriculture

CRITICAL WARNINGS

1. Alkaline pH: Tetrasodium EDTA has a high pH (~11.3). Avoid contact with skin and eyes. Use appropriate protective equipment.

2. Hygroscopicity: Tetrasodium EDTA is hygroscopic. Store in a dry environment in tightly closed containers to prevent caking.

3. Chelation: Binds metal ions (Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺, Zn²⁺, etc.). This property is beneficial but may deplete essential minerals.

4. Cosmetic Use: In cosmetics, it acts as a preservative and stabilizer. It can weaken the skin barrier for deeper penetration of other ingredients.

5. Food Use: Approved for food use as a preservative and stabilizer. Effective at low concentrations.

6. Pharmaceutical Use: Used as an anticoagulant in blood collection tubes. Also used in chelation therapy for heavy metal poisoning.

7. Water Treatment: Effective for water softening and scale prevention. Binds calcium and magnesium ions.

8. Storage: Store in a cool, dry, well-ventilated area. Protect from moisture and strong acids.

9. Compatibility: Incompatible with strong acids, strong oxidizing agents, and metal ions (will chelate).

10. Safety: Generally recognized as safe (GRAS) for food and pharmaceutical applications. Use appropriate PPE during handling.

IMPORTANT DISCLAIMER: This Technical Data Sheet (TDS) is for informational purposes only and is prepared based on available technical data. The user is responsible for determining the suitability of the product for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, use, handling, disposal, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. This document is not a substitute for professional or medical advice.

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