Caffeine, Coffeine, Caffeine Anhydrous, Guaranin, Hycomine, Theine, Methyl Theo Bromine, 58-08-2

Caffeine, Coffeine, Caffeine Anhydrous, Guaranin, Hycomine, Theine, Methyl Theo Bromine, 58-08-2

Caffeine Anhydrous

Chemical and Physical Properties

• Chemical Formula: C₈H₁₀N₄O₂

• Molecular Weight: 194.19 g/mol

• CAS Number: 58-08-2

• Appearance: White crystalline powder or shiny white needles

• Taste/Odor: Bitter taste, odorless

• Density: ~1.23 g/cm³

• Melting Point: 235 °C

• Boiling Point: 178 °C

• Solubility:

  • Highly soluble in water (21,600 mg/L at 25 °C)

  • Freely soluble in pyridine, pyrrole, trichloroethylene

  • Slight solubility in petroleum ether

  • Freely soluble in tetrahydrofuran containing 4% water

• Note: Crystallizes at room temperature unless stabilized with Mono Propylene Glycol.

Other Names

• 1,3,7-Trimethylxanthine

• Guaranine

• Theine

• Methyltheobromine

• Coffeine / Koffein

• Hycomine

• Purine alkaloid

Biological and Pharmacological Properties

• Class: Methylxanthine alkaloid

• Natural Sources: Coffee, tea, guarana, cocoa, mate (found in ~60 plant species)

• Mechanism of Action: Adenosine receptor antagonist → stimulant, psychotropic, anti-inflammatory effects

• Natural Role: Acts as a natural insecticide by paralyzing insects feeding on caffeine-containing plants

Applications

• Pharmaceuticals:

  • Headache remedies, cold medicines, pain relievers

  • CNS respiratory stimulant

  • Narcolepsy treatment adjunct

• Food & Beverages:

  • Energy drinks, soft drinks, multivitamin supplements

  • Cola and other carbonated beverages

• Cosmetics:

  • Skincare (antioxidant, anti-cellulite, eye creams, body lotions)

  • Improves viscosity, hydration, and reduces swelling

• Sports Nutrition:

  • Pre-workout supplements for performance enhancement

  • Fat-burning formulations

• Industrial:

  • Natural pesticide against insects and pests

  • Used in spray formulations for breath freshening

Safety and Usage Notes

• Recommended Daily Intake: ~300 mg/day (according to health authorities)

• Excess Consumption Risks: Increased blood pressure, heartburn, dependency

• ERP/Compliance: CAS 58-08-2 must be used for identification; COA and TDS required for supplier verification.

Summary

Caffeine Anhydrous (CAS 58-08-2) is a dehydrated form of caffeine widely used in pharmaceuticals, food & beverages, cosmetics, sports nutrition, and industrial applications. It is a powerful stimulant, antioxidant, and functional additive, with both natural and synthetic production routes.