Poly Ethylene Glycol, PEG 300, PEG 400, PEG 600, PEG 1000, PEG 1500, PEG 4000, PEG 6000, PEG 8000, 25322-68-3

Poly Ethylene Glycol, PEG 300, PEG 400, PEG 600, PEG 1000, PEG 1500, PEG 4000, PEG 6000, PEG 8000, 25322-68-3

PEG 300,400,600,1000,1500,4000,6000,8000 -->CAS: 25322-68-3

Molecular Formula: N/A PEG 300,400,600,1000,1500,4000,6000,8000 

Names and Identifiers

Physico-chemical Properties

Risk and Safety

Upstream Downstream Industry

Nature

This product is white granular. Soluble in water, soluble in some organic solvents. The solution has high viscosity at low concentration, and can be processed by calendering, extrusion, casting, etc. It is a thermoplastic resin with good compatibility with other resins. Resistant to bacterial erosion, moisture absorption in the atmosphere is weak.

Preparation Method

ethylene oxide was self-polymerized under the catalysis of aluminum isopropoxide.

Standard

This product is a mixture of ethylene oxide and water polycondensation. The molecular formula is expressed as ho(ch2ch2o)nh, where n represents the average number of oxyethylene groups.

Trait

• This product is a colorless or almost colorless viscous liquid, or a translucent waxy soft object; Slightly odorless.
• This product is soluble in water or ethanol, insoluble in ether.

freezing point

The freezing point of this product (General rule 0613) is 33~38°C.

viscosity

take 25.0g of this product, put it in a 50ml measuring flask, add water to dissolve it and dilute it to the scale, shake it well, and use a pinch viscometer with a capillary inner diameter of 0.8mm, the kinematic viscosity at 0633 is 401 to 8.5/s when measured according to law (General Principles 11.0, first method).

Introduction

Gas chromatography stationary solution (maximum service temperature 200 ℃, solvent acetone, chloroform, dichloromethane), separation and analysis of alcohols, ketones, aldehydes and other oxygenates.

Differential diagnosis

1. take 10% g of this product, add 5ml of dilute hydrochloric acid and 1 ml of barium chloride solution, shake and filter; Add 1 ml of phosphomolybdic acid solution to the filtrate to produce yellow-green precipitate.
2. take 0.lg of this product, put it in a test tube, add 0.lg of potassium thiocyanate and 0.lg of cobalt nitrate, mix it, add 5ml of methylene chloride, and the solution is blue.

Use

poly (ethylene oxide) resins are high molecular weight homopolymers of ethylene oxide via heterogeneously catalyzed ring-opening polymerization. Usually can be divided into the relative molecular mass of 2 × 1 04 above and tens of thousands of above, the former is called polyethylene glycol, the latter is called polyethylene oxide. Polyethylene oxide with flocculation, thickening, slow release, lubrication, dispersion, retention, water retention and other properties, suitable for medicine, fertilizer, paper, ceramics, detergents, cosmetics, heat treatment, water treatment, fire, oil exploitation and other industries, the product is non-toxic and non-irritating, and will not remain, deposit or breed volatile matter in the process of product generation. As a papermaking additive, the retention rate of the filler and the fine fiber can be improved, and the dispersant is particularly suitable for the long fiber, and the beating time can be shortened.

Safety

The skin, eye irritation is very small, oral is difficult to be absorbed by the gastrointestinal tract, low toxicity. Injection of an aqueous solution of 5% by mass of polyethylene oxide into the eyes of rabbits caused only mild burning. Polyethylene oxide had little effect on the death rate of fish, crab, sea anemone, shrimp or algae. Its resin and aqueous solution are low toxicity, use and handling are very safe. The US Food and Drug Administration (FDA) has approved polyethylene oxide aqueous solution resins for use as direct additives for specialty food packaging and beer.

Exam

average molecular weight

take this product about 3.0G, precision weighing, dry 250ml plug Erlenmeyer flask, precision plus phthalic anhydride pyridine solution (take phthalic anhydride 14g, dissolve in anhydrous pyridine 100ml, place overnight, (Ready use) 25ml, shake well, add a small amount of anhydrous pyridine to the edge of the mouth of the conical flask, place it in a boiling water bath, heat it for 30-60 minutes, take it out for cooling, and add sodium hydroxide titration solution (0.5mol/L) accurately. 50ml, with phenol pyridine solution (1-100) as an indicator, with sodium hydroxide titration solution (0.5mol/L) titration to red, and the results of the titration with blank test correction. The product of the test quantity (g) and 4000, divided by the volume (ml) of the consumed sodium hydroxide titration solution (0.5mol/L), that is, the average molecular weight of the sample, should be 900 to 1100.

acidity

take l.Og of this product, add water to dissolve 20ml, and then determine it according to law (General rule 0631). The pH value should be 4.0~7.0.

clarity and color of solution

Take 5.0g of this product, add 50ml of water to dissolve, check according to law (General rule 0901 and general rule 0902), the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 2 Turbidity standard solution (General rule 0902 first method); If it is colored, it should not be deeper compared with yellow No. 2 Standard Colorimetric solution (General rule 0901 first method).

ethylene glycol, diethylene glycol and triethylene glycol from ethylene glycol, diethylene glycol and triethylene glycol

Each 400mg of the control was placed in a 100ml measuring flask, diluted to the scale with absolute ethanol, and shaken to serve as a control stock solution. Take the internal standard substance 1, 3-butanediol 400mg, put it in a 100ml measuring flask, dilute it to the scale with absolute ethanol, shake it well, and use it as an internal standard stock solution, take 1.0ml of the control stock solution and 4.0 ml of the internal standard stock solution, put them in a measuring flask, dilute them to the scale with absolute ethanol, shake them well, and use them as the control solution, add 1.0ml of human internal standard stock solution to a 100ml measuring flask, dilute to the scale with absolute ethanol, and shake to form a test solution. The above solution was taken and silicone was used as the stationary phase. The initial temperature was 600°C, maintained for 5 minutes, ramped up to 170°C at a rate of 2°C per minute, maintained for 5 minutes, and then ramped up to 280°C at a rate of 15°C per minute for 50 minutes. The inlet temperature was 270°C and the detector temperature was 290°C. The carrier gas is high purity N2. The gas is H2. The auxiliary gas is compressed air. The column flow was 4.0 ml/min. Calculated according to internal standard method, containing ethylene glycol, diethylene glycol and triethylene glycol shall not exceed 0.1%.

ethylene oxide and dioxane

take this product lg, precision weighing, top empty bottle, Precision Plus 1.0 pure water, sealed, shake, as a test solution. Measure 30ul of ethylene oxide (equivalent to 0.25g ethylene oxide) into a 400 volumetric flask containing 50ml of treated polyethylene glycol 1.5 (rotary evaporation at 60°C, to 2.5kPa for 6 hours to remove volatiles), add the same solvent to dilute to the scale, shake well, as the stock solution of ethylene oxide reference, weigh the stock solution of 1g cold ethylene oxide reference, in a 50ml measuring flask containing 40ml of treated polyethylene glycol 400, dilute to the mark with the same solvent. Weigh 10G, put it in a 50ml measuring flask containing 30ml of water, and dilute it with water to the mark. Take 10 m l for precision measurement, put it in 50ml measuring flask, dilute it to the scale with water, shake it well, and use it as the reference solution of ethylene oxide. The appropriate amount of dioxane was accurately determined, and a solution containing 0.1 mg per 1ml of water was prepared as a dioxane control solution. Weigh lg of this product accurately, place it in the top empty bottle, add 0.5m ethylene oxide reference solution and 0.5ml dioxane reference solution, seal and shake, and use as the reference solution. Take 0.001% ml of ethylene oxide control solution in the top empty bottle and add the freshly prepared acetaldehyde solution 0.1ml and 0.1ml of the two testis six ring control solution, sealed, shake, as the system suitability test solution, according to the gas chromatography (General 0521) test, with polydimethylsiloxane as the fixing liquid, starting at 35°C for 5 minutes, ramping up to 180°C at a rate of 5°C per minute, then ramping up to 230°C at a rate of 30°C per minute, maintain 5 minutes (can be adjusted according to the specific situation). The inlet temperature was 150°C, the detector temperature was 250°C, the headspace bottle equilibrium temperature was 70°C, and the equilibrium time was 45 minutes. Take the system suitability test solution for Headspace sampling, adjust the detector sensitivity so that the peak height of ethylene oxide peak and acetaldehyde peak is about 15% of the full scale, and the separation degree between acetaldehyde peak and ethylene oxide peak is not less than 2.0, the peak height of dioxane should be more than 5 times of the baseline noise, and the test solution and the reference solution should be respectively injected in the headspace, and the sample should be repeated for at least 3 times.
of the peak area of ethylene oxide The relative standard deviation shall not exceed 15%, and the relative standard deviation of the peak area of dioxane shall not exceed 10%. According to the standard plus person method, ethylene oxide shall not exceed 0.0001% and dioxane shall not exceed 0.001%.

formaldehyde

take this product lg, precision weighing, add 0.0.25ml of 6% sodium chromotropic solution, after cooling in ice water, add 5ml of sulfuric acid, shake well, stand for 15 minutes, slowly and quantitatively transfer to a 25ml measuring flask containing 10ml of water, and let it cool, slowly add water to the scale, shake, as a test solution. In addition, 0.81g of formaldehyde was weighed accurately, placed in a 100ml measuring flask, diluted to the scale with water, and then lml was weighed accurately, placed in a 100ml measuring flask, diluted to the scale with water; Then, lml was weighed accurately, from "join 0. Starting from 0.25ml of 6% sodium chromotropic solution, the same method was used as the control solution. The above two solutions were taken and the absorbance was measured at a wavelength of 0401 nm by UV-Vis spectrophotometry (general), and corrected with the blank solution operated in the same way. The absorbance of the test solution shall not be greater than that of the control solution (0.003%).

moisture

take 2.0g of this product, according to the determination method of moisture (General rule 0832 first method 1), the water content shall not exceed 1 .0%.

burning residue

not more than 0.1% (General rule 0841).

Heavy metals

take 4.0g of this product, add 5ml of hydrochloric acid solution (9-1000) and an appropriate amount of water, dissolve it, adjust the pH value to 3.0~4.0 with dilute acetic acid or ammonia test solution, and dilute it to 25ml with water, inspection according to law (General Principles 0821, law I), containing heavy metals shall not exceed 5 parts per million.

Category

pharmaceutical excipients, soft matrix and lubricants.

Storage

sealed storage.

Reference Information