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Send EmailEthylene Glycol Monoacetate, 2-Hydroxyethyl Acetate, Glycol Monoacetate, Ethylene Glycol Acetate, EGMA, 542-59-6
Product Name: Ethylene Glycol Monoacetate (EGMA)
Chemical Name: 2-Hydroxyethyl Acetate
CAS No: 542-59-6
EC No (EINECS): 208-821-2
Chemical Formula: C₄H₈O₃
Molecular Weight: 104.11 g/mol
REACH Status: Registered
| Parameter | Description |
|---|---|
| Chemical Name (IUPAC) | 2-Hydroxyethyl acetate |
| Other Names | Ethylene Glycol Monoacetate, EGMA, Ethylene Glycol Monoacetate, 2-Hydroxyethyl Acetate, Glycol Monoacetate, Acetic Acid 2-Hydroxyethyl Ester |
| CAS Number | 542-59-6 |
| EC Number (EINECS) | 208-821-2 |
| Molecular Formula | C₄H₈O₃ |
| Molecular Weight | 104.11 g/mol |
| Chemical Class | Ester, alcohol-ester, glycol monoester |
| Appearance | Colorless, clear liquid |
| Odor | Mild characteristic, ester-like |
| Taste | Not determined as technical product |
| REACH Status | Registered |
CHEMICAL STRUCTURE AND DESCRIPTION:
Ethylene Glycol Monoacetate (EGMA) is a glycol monoester formed by partial esterification of ethylene glycol with acetic acid. Its structure contains both an ester (-COO-) group and a hydroxyl (-OH) group. This structure gives EGMA both ester and alcohol reactivity.
Structural Formula (Open Structure):
CH₃-COO-CH₂-CH₂-OH
(2-Hydroxyethyl Acetate)
These structural features:
Give EGMA ester and alcohol functionality.
Enable its use as an intermediate in organic syntheses.
Allow it to enter crosslinking reactions in resin and polymer systems due to its hydroxyl group.
Show solvent and plasticizer properties due to its ester group.
EGMA is a glycol monoester used as an organic synthesis intermediate and as an intermediate in chemical production processes. Its use as a solvent is limited; however, it is an important building block in chemical reactions.
| Property | Value |
|---|---|
| Molecular Formula | C₄H₈O₃ |
| Molecular Weight | 104.11 g/mol |
| Appearance | Colorless, clear liquid |
| Odor | Mild characteristic, ester-like |
| Density (20 °C) | 1.110 g/cm³ |
| Refractive Index (n20D) | 1.420 |
| Boiling Point (760 mmHg) | 179.1–182.6 °C |
| Flash Point (Closed Cup) | 103 °C |
| Vapor Pressure | Very low (<0.1 mmHg at 20 °C) |
| Solubility | Miscible with water and most organic solvents |
| Stability | Stable under recommended storage conditions |
| pH (aqueous solution) | Near neutral |
| Volatility | Low |
| Hygroscopicity | May absorb slight moisture; store in dry conditions |
| Acidity (CH₃COOH) | ≤0.03% (Test result: 0.01%) |
| Water Content | ≤0.10% (Test result: 0.05%) |
| Color (Pt-Co) | ≤15 (Test result: 7) |
| Purity (GC) | ≥99.0% |
EGMA is a colorless, clear liquid. Its density is 1.110 g/cm³ (20 °C), refractive index 1.420. Its boiling point is in the range of 179.1–182.6 °C. Its flash point is 103 °C (closed cup). It is miscible with water and most organic solvents. It has low volatility and good chemical stability.
| Solvent | Solubility | Conditions |
|---|---|---|
| Water | Miscible | 20 °C |
| Methanol | Miscible | - |
| Ethanol | Miscible | - |
| Isopropanol | Miscible | - |
| Acetone | Miscible | - |
| Ethyl acetate | Miscible | - |
| Ether | Miscible | - |
| Toluene | Miscible | - |
| Xylene | Miscible | - |
| Glycols | Miscible | - |
EGMA is miscible with a wide range of polar and non-polar solvents. It is completely miscible with water. This property makes it useful in various formulations.
| Property | Description |
|---|---|
| Chemical Class | Ester, alcohol-ester |
| Reactivity | Hydrolysis, transesterification, esterification, urethane formation |
| Hydrolytic Stability | Moderate; may hydrolyze under acidic/basic conditions |
| Thermal Stability | Good |
| Oxidation Resistance | Moderate |
| Polymerization | Does not undergo hazardous spontaneous polymerization |
| Compatibility | Carboxylic acids, anhydrides, isocyanates, esters |
| Substances to Avoid | Strong oxidizing agents, strong acids, strong bases |
| Hazardous Decomposition Products | Carbon monoxide (CO), carbon dioxide (CO₂), acetic acid vapor |
Thanks to the hydroxyl group in its structure, EGMA can undergo esterification, transesterification, and urethane formation reactions. The ester group is prone to hydrolysis and transesterification. EGMA is generally used as a chemical intermediate; its use as a solvent is limited.
| Parameter | Specification |
|---|---|
| Purity (GC) | ≥ 99.0% |
| Appearance | Colorless, clear liquid |
| Color (Pt-Co) | ≤ 15 (Test result: 7) |
| Water Content | ≤ 0.10% (Test result: 0.05%) |
| Acidity (CH₃COOH) | ≤ 0.03% (Test result: 0.01%) |
| Density (20 °C) | 1.105–1.115 g/cm³ |
| Refractive Index (20 °C) | 1.418–1.422 |
| Boiling Range | 179–183 °C |
| Flash Point | ≥ 103 °C |
| Heavy Metals | ≤ 10 ppm |
| Shelf Life | 24 months (under proper storage) |
EGMA is produced in technical grade with high purity. In industrial applications, batch-to-batch consistency, color stability, and low impurity content are important.
| Application | Description |
|---|---|
| Ester Synthesis | Reacts with carboxylic acids to form diesters |
| Polymer Intermediate | Building block in polyester and polyurethane production |
| Resin Modification | Modifier in alkyd and polyester resins |
| Pharmaceutical Intermediate | Intermediate in drug synthesis |
EGMA is an important intermediate in organic syntheses. It is used particularly in the production of diesters and polyesters.
| Application | Description |
|---|---|
| Coatings | Limited solvent use |
| Inks | Solvent and viscosity modifier |
| Cleaners | Solvent in industrial cleaners |
| Adhesives | Solvent and flow modifier |
The use of EGMA as a solvent is limited; however, it can act as a solvent or co-solvent in certain formulations.
| Application | Description |
|---|---|
| Polymer Production | Intermediate in polyester, polyurethane, and alkyd resins |
| Plasticizer Production | Ester derivatives used as plasticizers |
| Pharmaceutical Synthesis | Used in the synthesis of drug intermediates |
| Agricultural Chemicals | Intermediate in pesticide and herbicide synthesis |
EGMA is used as an important intermediate in chemical production processes.
| Application | Description |
|---|---|
| Cosmetics | Solvent and moisturizer in some cosmetic products |
| Textiles | Used in textile processing solutions |
| Leather Processing | Intermediate in leather processing chemicals |
| Property | Description |
|---|---|
| Structural Class | Ester, alcohol-ester |
| Functional Groups | Ester (-COO-) and hydroxyl (-OH) |
| Amphiphilic Character | Both hydrophilic and lipophilic |
| Solvency Power | Moderate |
| Evaporation Profile | Low, controlled |
| Water Miscibility | Completely miscible |
| Polarity | Medium polarity |
| Polymer Contribution | Intermediate, modifier |
The structure of EGMA containing both ester and hydroxyl groups makes it suitable for various chemical reactions.
| Application | Description |
|---|---|
| Esterification | Forms diesters with carboxylic acids |
| Transesterification | Used in ester exchange reactions |
| Hydrolysis | Hydrolyzes under acidic/basic conditions |
| Urethane Formation | Reacts with isocyanates |
| Polymerization | Used in polyester and polyurethane production |
| Solvent Formulation | Limited solvent applications |
| Parameter | Value |
|---|---|
| GHS Classification | Not classified as a hazardous substance |
| Oral LD50 (Rat) | > 2000 mg/kg (estimated) |
| Dermal LD50 (Rabbit) | > 2000 mg/kg (estimated) |
| Skin Irritation | May be mildly irritating |
| Eye Irritation | May be mildly irritating |
| Respiratory Irritation | Vapor inhalation may cause mild irritation |
| Skin Sensitization | Not expected |
| Mutagenicity | Not classified |
| Carcinogenicity | Not classified |
| Bioaccumulation | Not likely |
| WGK Germany | 1 (slightly hazardous to water) |
EGMA is a chemical with low toxicity. It may cause mild irritation on contact with eyes and skin. Vapor inhalation may cause mild respiratory discomfort. It is not classified as a hazardous substance, but appropriate PPE should be used in industrial handling.
| Parameter | Information |
|---|---|
| UN Number | Not applicable (not a hazardous substance) |
| Hazard Class | Not a hazardous substance |
| Packing Group | Not applicable |
| Proper Shipping Name | Ethylene Glycol Monoacetate (EGMA) |
| Marine Pollutant | No |
| ADR/RID Label | Not applicable |
EGMA is not classified as a hazardous substance. There are no special restrictions for its transport by sea, land, or air.
| Region | Status |
|---|---|
| EU | REACH registered |
| USA (TSCA) | Listed |
| EINECS | 208-821-2 |
| Turkey (KKDİK) | Should be evaluated within compliance and registration requirements |
| Food Contact | Not suitable for technical grade; special grade required for food contact |
| Hazardous Substance | No |
| Parameter | Information |
|---|---|
| Storage Conditions | Cool, dry, well-ventilated area |
| Temperature | 15–25 °C (ideal); should not exceed 40 °C |
| Container Requirements | Tightly closed container |
| Moisture Control | Dry environment to prevent moisture absorption |
| Substances to Avoid | Strong oxidizing agents, direct sunlight, ignition sources |
| Shelf Life | 24 months (under proper storage) |
| Handling Notes | Avoid breathing vapor; use PPE |
| Packaging Options | 220 kg iron drum; custom packaging upon request |
Handling Notes:
Avoid breathing vapor.
Use appropriate personal protective equipment (gloves, goggles, mask).
Avoid contact with skin and eyes.
Keep away from ignition sources.
| Parameter | Information |
|---|---|
| Fire Hazard | Combustible liquid; vapor/air mixture may be flammable |
| Flash Point | 103 °C (closed cup) |
| Extinguishing Media | Water spray, foam, CO₂, dry chemical powder |
| Special Hazards | Thermal decomposition may release CO, CO₂, and acetic acid vapor |
| Protective Equipment | Self-contained breathing apparatus (SCBA), full protective clothing |
EGMA is a combustible liquid. In case of fire, appropriate extinguishing media should be used, and firefighting personnel should wear protective equipment.
| Parameter | Information |
|---|---|
| Personal Protection | Respirator, protective goggles, gloves, protective clothing |
| Ventilation | Ventilate the area |
| Containment | Contain the spill |
| Cleaning Methods | Absorb with inert material; place in suitable disposal container |
| Environmental Precautions | Prevent entry into drains, sewers, and water sources |
| Waste Disposal | Dispose of according to local regulations |
In case of a spill, clean up while preventing vapor formation. Dispose of waste properly. Prevent environmental release.
| Exposure Route | Action |
|---|---|
| Inhalation | Move the person to fresh air. Seek medical attention if irritation persists. |
| Skin Contact | Wash with plenty of water and soap. Remove contaminated clothing. |
| Eye Contact | Rinse with plenty of water for at least 15 minutes. Seek medical attention if irritation persists. |
| Ingestion | Rinse mouth with water. Drink plenty of water. Do not induce vomiting. Seek medical attention. |
| Raw Material | Description |
|---|---|
| Ethylene Glycol | Precursor in EGMA synthesis |
| Acetic Acid | Used in esterification reaction |
| Catalyst | Acidic catalysts (sulfuric acid, p-toluenesulfonic acid) |
| By-Product | Application |
|---|---|
| Ethylene Glycol Diacetate | Solvent, plasticizer |
| Polyester Resins | Coatings, adhesives |
| Polyurethanes | Adhesives, elastomers |
| Pharmaceutical Intermediates | Drug synthesis |
| Industry | Application Area | Example Use | Suitability |
|---|---|---|---|
| Chemistry | Organic synthesis intermediate | Ester and polymer synthesis | High |
| Coatings | Solvent (limited) | Inks, adhesives | Moderate |
| Pharmaceuticals | Intermediate | Drug synthesis | Suitable |
| Agriculture | Intermediate | Pesticide synthesis | Suitable |
| Textiles | Processing solution | Textile processing | Limited |
| Cosmetics | Solvent/moisturizer | Some cosmetic products | Limited |
EGMA can undergo many chemical reactions due to both its hydroxyl and ester groups:
| Reaction | Description |
|---|---|
| Esterification | Forms diesters with carboxylic acids |
| Transesterification | Reacts with esters to perform ester exchange |
| Hydrolysis | Hydrolyzes under acidic/basic conditions |
| Urethane Formation | Forms polyurethanes with isocyanates |
| Etherification | Can form ether bonds under suitable conditions |
EGMA derivatives are widely used in coatings, adhesives, polymer systems, and pharmaceutical products.
| Compound | Description |
|---|---|
| Ethylene Glycol Diacetate | Diester derivative of EGMA; solvent and plasticizer |
| Ethylene Glycol | Intermediate in EGMA production |
| Acetic Acid | Raw material in EGMA production |
| Propylene Glycol Monoacetate | Similar glycol monoester |
| Diethylene Glycol Monoacetate | Similar glycol monoester |
SUMMARY:
Ethylene Glycol Monoacetate (EGMA) is a colorless, clear liquid with the formula C₄H₈O₃ and CAS number 542-59-6. It is a glycol monoester containing both an ester and a hydroxyl group. It is used as an organic synthesis intermediate and as an intermediate in chemical production processes. Its use as a solvent is limited. It has low toxicity and is not classified as a hazardous substance. It should be stored in a cool, dry, and well-ventilated area in tightly closed containers.
Key Properties:
| Property | Value |
|---|---|
| Appearance | Colorless, clear liquid |
| Chemical Formula | C₄H₈O₃ |
| Molecular Weight | 104.11 g/mol |
| CAS Number | 542-59-6 |
| Density (20 °C) | 1.110 g/cm³ |
| Refractive Index (n20D) | 1.420 |
| Boiling Point | 179.1–182.6 °C |
| Flash Point | 103 °C (closed cup) |
| Purity (GC) | ≥ 99.0% |
| Chemical Class | Ester, alcohol-ester |
| Primary Use | Organic synthesis intermediate, chemical intermediate |
Main Applications:
| Industry | Applications |
|---|---|
| Chemistry | Organic synthesis intermediate, polymer production |
| Coatings | Limited solvent use |
| Pharmaceuticals | Intermediate |
| Agriculture | Intermediate |
| Textiles | Processing solutions |
| Cosmetics | Solvent/moisturizer in some products |
Key Safety Points:
LOW TOXICITY: Not a hazardous substance; LD50 > 2000 mg/kg (estimated)
MILD IRRITATION: May cause mild irritation to eyes and skin
VAPOR CONTROL: Inhalation of vapor should be avoided
STORAGE: Cool, dry, well-ventilated; should not exceed 40 °C
PPE RECOMMENDED: Gloves, protective goggles, respirator
INCOMPATIBLE: Strong oxidizing agents, ignition sources
CRITICAL WARNINGS:
EGMA is a glycol monoester containing both an ester and a hydroxyl group. This structure gives it dual functionality.
It is used as an intermediate in organic syntheses; it is particularly important in diester and polyester production.
Its use as a solvent is limited; however, it can act as a solvent or co-solvent in certain formulations.
It is used as an intermediate in chemical production processes.
It is a combustible liquid; it should be kept away from ignition sources.
It is not classified as a hazardous substance; however, appropriate PPE should be used in industrial handling.
Vapor inhalation may mildly irritate the respiratory tract; good ventilation should be provided.
It should be stored in tightly closed containers to prevent moisture absorption.
Important Statement: This Technical Data Sheet (TDS) is for informational purposes only. The information provided is based on available data and is believed to be accurate. However, the user is solely responsible for determining the suitability of the product for their own specific applications and for complying with all applicable regulations and safety requirements. For complete safety, use, storage, and regulatory compliance information, always refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. Users are obligated to test the product in their own processes and applications. All local, national, and international regulations must be followed when working with EGMA.