Nicotinamide Riboside Chloride, Nicotinamide D-riboside, NR-CL, 23111-00-4

NICOTINAMIDE RIBOSIDE CHLORIDE (NR-CL) 

1. PRODUCT IDENTIFICATION AND CHEMICAL IDENTITY

2. CHEMICAL STRUCTURE

2.1. Molecular Structure

Nicotinamide riboside (NR) is a member of the vitamin B3 (niacin) family and is a natural precursor of nicotinamide adenine dinucleotide (NAD⁺). NR is a nucleoside formed by the combination of nicotinamide and ribose via a glycosidic bond. The chloride salt form is the most stable and widely used form of NR.

Structural Formula:

        NH₂
         |
    O=C-N
         |
         C
       /   \
      N     C
      |     |
      C - C
      |   |
      H   H
          |
    HOCH₂-O
          |
    C - C - C - CH₂OH
    |   |   |
    OH  OH  OH

Molecular Structure Properties:

2.2. Role in NAD⁺ Metabolism

3. PHYSICAL AND CHEMICAL PROPERTIES

4. STABILITY AND REACTIVITY

5. BIOLOGICAL AND FUNCTIONAL PROPERTIES

5.1. NAD⁺ Metabolism

Nicotinamide riboside (NR) is converted to NAD⁺ via the NRK (Nicotinamide Riboside Kinase) pathway, one of the main pathways for NAD⁺ synthesis in cells. Unlike NMN, this pathway provides a direct precursor for NAD⁺ synthesis.

NAD⁺ Synthesis Pathway:

NR (Nicotinamide Riboside) → NRK → NMN → NMNAT → NAD⁺

5.2. Biological Activities

5.3. Comparison with NMN

6. APPLICATION AREAS

6.1. Dietary Supplements (Most Important Application)

6.2. Neurological Health Products

6.3. Sports and Performance Nutrition

6.4. Research and Development

7. DOSAGE AND USAGE RECOMMENDATIONS

Note: Clinical studies have used 100-2000 mg/day. Medical conditions require physician consultation.

8. BIOAVAILABILITY AND METABOLISM

9. SAFETY AND TOXICOLOGY

10. GHS CLASSIFICATION

Signal Word: None

Hazard Pictograms: None

Hazard Statements: No H-codes

11. PRECAUTIONARY STATEMENTS (P-CODES)

12. FIRST AID MEASURES

13. STORAGE AND SHELF LIFE

14. PACKAGING OPTIONS

15. TRANSPORT INFORMATION

16. REGULATORY STATUS

17. ENVIRONMENTAL INFORMATION

18. OTHER NAMES AND SYNONYMS

• Nicotinamide Riboside Chloride

• NR-CL

• Niagen® (Trademark)

• Nicotinamide D-riboside

• Pyridinium, 3-(aminocarbonyl)-1-(β-D-ribofuranosyl)-, chloride

• 1-(β-D-Ribofuranosyl)nicotinamide chloride

• 3-Carbamoyl-1-β-D-ribofuranosylpyridinium chloride

19. QUICK REFERENCE TABLE

20. CRITICAL NOTICES AND BEST PRACTICES

CRITICAL NOTICES:

1. Moisture Sensitivity: NR-Chloride is hygroscopic; caking and degradation may occur in humid environments. Silica gel is recommended.

2. Light Sensitivity: Moderate-high light sensitivity. Color change and degradation may occur under UV and daylight. Must be stored in light-proof packaging.

3. Oxygen Sensitivity: Oxidation may occur with prolonged air contact. Inert gas (nitrogen) storage is recommended.

4. Solution Stability: Stable for 1 week at +4°C in aqueous solution; should not be kept at room temperature for extended periods.

5. Dosage Caution: High doses may cause gastrointestinal discomfort (nausea, diarrhea). Use within recommended dosage range.

6. Drug Interactions: Theoretically may interact with drugs affecting NAD⁺ metabolism. Clinical studies are limited.

7. Flushing Effect: NR does not cause flushing (skin redness) unlike niacin.

BEST PRACTICE RECOMMENDATIONS:

Storage:

• Store in a cool, dry, light-protected environment

• Use light-proof (aluminum foil) packaging

• Use silica gel for moisture protection

• Store under inert gas (nitrogen)

• Store at room temperature (15-25°C)

Formulation:

• Can be used in capsules, tablets, powders, or liquid formulations

• Maintains stability in acidic environments

• Has high water solubility

• Can be combined with other NAD⁺ precursors for synergistic effects

Handling:

• Use dust mask, protective goggles, and gloves

• Avoid dust formation

• Use in well-ventilated areas

• Wash hands after handling

Waste Management:

• Dispose in accordance with local regulations

• Avoid release into the environment

Dosage:

• Daily dose: 100-300 mg (general NAD⁺ support)

• High dose: 300-500 mg (anti-aging and performance)

• Medical conditions require physician consultation

LEGAL DISCLAIMER

This Technical Data Sheet (TDS) is for informational purposes only and is prepared based on available technical data. The user is solely responsible for determining the suitability of the product for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, handling, transport, waste, and regulatory compliance information, the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier must be consulted. This document does not substitute professional advice. Dosage and application conditions should be optimized through product-specific trials. Regulatory status of Nicotinamide Riboside Chloride may vary by country; verify compliance before use. For medical use, consultation with a healthcare professional is mandatory.