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Send EmailTriethanolamine, TEA, 102-71-6
CAS: 102-71-6
Molecular Formula: C6H15NO3102-71-6 -
Names and Identifiers
| Name | Triethanolamine |
| Synonyms | TEA Alkano Daltogen trolamine Alkanolamine alkanolamine244 Triethanolamine Alkanolamine 244 Tris(2-hydroxyethyl)amine 1,1',1''-nitrilotriethanol 2,2',2''-nitrilotriethanol Ethanol, 2,2',2''-nitrilotri- Ethanol, 2,2',2''-nitrilotris- 2,2',2''-3-hydroxy-triethylamine Triethanolamine (2-Hydroxyethyl)amine 2-[Bis-(2-hydroxy-ethyl)-amino]-ethanol |
| CAS | 102-71-6 |
| EINECS | 203-049-8 |
| InChI | InChI=1/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2 |
| InChIKey | GSEJCLTVZPLZKY-UHFFFAOYSA-N |
102-71-6 - Physico-chemical Properties
| Molecular Formula | C6H15NO3 |
| Molar Mass | 149.19 |
| Density | 1.124 g/mL at 25 °C (lit.) |
| Melting Point | 17.9-21 °C (lit.) |
| Boling Point | 190-193 °C/5 mmHg (lit.) |
| Flash Point | 365°F |
| Water Solubility | soluble |
| Solubility | H2O: 1M, clear, colorless |
| Vapor Presure | 0.01 mm Hg ( 20 °C) |
| Vapor Density | 5.14 (vs air) |
| Appearance | Oily Liquid |
| Specific Gravity | 1.125 (20/20℃) |
| Color | Clear colorless to slightly yellow |
| Odor | Mild ammoniacal. |
| Exposure Limit | ACGIH: TWA 5 mg/m3 |
| Maximum wavelength(λmax) | ['λ: 280 nm Amax: 0.1'] |
| Merck | 14,9665 |
| BRN | 1699263 |
| pKa | 7.8(at 25℃) |
| PH | 10.5-11.5 (25℃, 1M in H2O) |
| Storage Condition | Store at RT. |
| Sensitive | Air Sensitive & Hygroscopic |
| Explosive Limit | 3.6-7.2%(V) |
| Refractive Index | n20/D 1.485(lit.) |
| Physical and Chemical Properties | It is a colorless transparent viscous liquid at room temperature. Hygroscopicity and ammonia odor, alkaline, irritating. Melting point 21.2 ℃, boiling point 360℃, flash point 193 ℃, relative density (d420)1.1242, refractive index (nD20)1.4852. Miscible in water, ethanol and acetone, slightly soluble in ether, benzene and carbon tetrachloride. |
| Use | It is used as an additive in the polymerization of nitrile rubber, a concrete Accelerator, an oil emulsifier, and also used for cyanide-free electroplating. |
102-71-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| RTECS | KL9275000 |
| FLUKA BRAND F CODES | 3-10-23 |
| TSCA | Yes |
| HS Code | 29321900 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
102-71-6 - Upstream Downstream Industry
| Raw Materials | Ammonium hydroxide Nitrogen Ammonia Propylene oxide Ethylene Oxide 4-(2,6-Dimethylheptyl)phenol(O and P) Ammonia |
| Downstream Products | Dodecyldimethylbenzylammonium chloride |
102-71-6 - Nature
It is a colorless, transparent, viscous liquid with a slight ammonia odor at room temperature. It is hygroscopic and can absorb moisture and carbon dioxide in the air. Can be mixed with water and alcohol, soluble in chloroform, micro benzene and ether. The pH of the 0. 1moI/L solution was 10.5. In case of high heat, open flame or contact with oxidant, there is a risk of combustion. Its aqueous solution is corrosive.
102-71-6 - Preparation Method
see monoethanolamine.
102-71-6 - Standard
This product is 2 ,2 2 "-nitrogen three ethanol, from ethylene oxide ammonia solution and purified by separation. The total alkali content shall be 99. 0~103 in terms of c 6 h 15n o 3 calculated as anhydrous.
102-71-6 - Trait
- This product is a colorless to yellowish viscous clear liquid.
- This product is easily dissolved in water or ethanol, and is dissolved in methane.
relative density
The relative density of this product (General 0601) is 1. 120~130.
refractive index
The refractive index of this product (General 0622) is 1.482~1.485.
102-71-6 - Use
as a corrosion inhibitor, triethanolamine is an important corrosion inhibitor component for boiler water treatment, automobile engine coolant, drilling and cutting oil. It can also be used for surfactants, textile products, waxes, polishing agents, herbicides, petroleum demulsifiers, cosmetics, cement additives, cutting oils, etc.
102-71-6 - Differential diagnosis
- take lm l of this product and add 0.3M l of copper sulfate test solution, which shows blue color. Then 2. 5ml of sodium hydroxide solution was added, and the blue color did not disappear after heating to boiling.
- take 1ml of this product and 0.3m l of gassed cobalt solution, which should be dark red.
- take the lm l of this product and put it in a test tube, slowly heating, and the generated gas can make the wet red litmus test paper turn blue.
- the sample solution lm l under the item of related substances was accurately measured, placed in a 200ml measuring flask, diluted with water to the scale, and shaken to serve as the sample solution. Accurately measure the reference solution (l ) lm l under the item of related substances, put it in a 200ml measuring flask, dilute it to the scale with water, shake it well, and use it as a reference solution. According to the chromatographic condition test under the item of related substances, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the triethanolamine reference solution.
102-71-6 - Safety
triethanolamine is irritating to the eyes, but weaker than monoethanolamine and less irritating to the skin. Should be stored in a cool, dry, well-ventilated non-combustible material warehouse, away from the fire, heat sources, to prevent direct sunlight. To be separated from the acid, oxidant storage and transportation.
102-71-6 - Exam
clarity and color of solution
take 12g of this product, put it in a 20ml measuring flask, add water to dilute it to the scale, and check it according to law (General Rule 0 90 1 and general rule 0902). The solution should be clear and colorless; If it is colored, compared with the orange-yellow No. 1 Standard Colorimetric solution (General 0901), it should not be deeper.
Related substances
take about 10g of this product, precision weighing, put it in 100ml measuring flask, precision plus internal standard solution (take about 5g of 3-aminopropanol, put it in 100ml measuring flask, add water to dissolve and dilute to the scale, shake U m l, add water to dissolve and dilute to the scale, shake, as a test solution; Take triethanolamine control about l. In a 10ml measuring flask, add water to dissolve and dilute to the scale, shake well and use it as a reference solution (1). O g, diethanolamine about 5. 0g with triethanolamine control about l.O g, each precision weighing, put in 100ml measuring flask, add water to dissolve and dilute to the scale, shake, take lm l accurately, put in 100ml measuring flask, precision Add internal standard solution lm l, dilute to the scale with water, shake, as a reference solution (2). According to the test of gas chromatography (General 0521), (5%) diphenyl-(9 5%) polydimethylsiloxane was used as the stationary phase; The initial temperature was 60°C, the temperature was increased to 230X at a rate of 30°C per minute for 10 minutes; The inlet temperature was 2 6 0 1 and the detector temperature was 290. The resolution between monoethanolamine peak and internal standard peak should be more than 2 .0. Accurately take the sample solution and the reference solution (2); 1 ^ 1, respectively inject human gas chromatography, record the chromatogram; According to the internal standard method to calculate the peak area ratio, the ratio of monoethanolamine peak area to internal standard Peak area in the test solution shall not be greater than that in the control solution (2) (0_1%), the ratio of the diethanolamine peak area to the internal standard Peak area in the test solution shall not be greater than the ratio of the diethanolamine peak area to the internal standard Peak area in the control solution (2) (0_ 5% ), the ratio of the sum of the peak areas of other impurities in the test solution to the peak area of the internal standard shall not be greater than 10 times (1.0%) of the ratio of the main peak area to the peak area of the internal standard in the reference solution (2), any area of the main peak of triethanolamine in the test solution chromatogram is less than 0. 5 times the impurity peak is negligible.
moisture
take about l g of this product, according to the determination method of moisture (General rule 0832 first method 1), the water content shall not exceed 1 .0%. Ignition residue shall not exceed 0.1% (General rule 0841).
Heavy metals
take this product l.O g, add water 0821 to dissolve, check according to law (general principles the first law), containing heavy metals shall not exceed 10 parts per million.
102-71-6 - Content determination
take about 1.2g of this product, weigh it accurately, put it in a 2 50 ml Erlenmeyer flask, Add 75ml of fresh boiling cold water, and add methyl red indicator solution 0 .3M l, titrated with hydrochloric acid titrant (1 M o l/L) to the microscopic red color of the solution and held for 30 seconds without fading. Each lm l hydrochloric acid titration solution (lm o l/L) corresponds to 149. 2 m g of CsH 15N 0 3.
102-71-6 - Category
pharmaceutical excipients, emulsifiers and p H value regulator.
102-71-6 - Storage
light shielding, sealed storage.
102-71-6 - Reference Information
| pH range of acid-base indicator discoloration | 7.3 - 8.3 |
| LogP | -2.3 at 25℃ |
| (IARC) carcinogen classification | 3 (Vol. 77) 2000 |
| Overview | triethanolamine triethanolamine also known as trihydroxyethylamine, aminotriethanol. Colorless oily liquid, ammonia odor, easy to absorb water, open air and in the light to become brown. At low temperature, it is a colorless or light yellow cubic crystal. The melting point is 21.2 ℃, the boiling point is 335.4 ℃, 277 ℃(19.950kPa), 206~207 ℃(1.995kPa), the relative density is 1.1242, the refractive index is 1.4852. Kb = 2.5 x 10-10. 0.1mol/L aqueous solution pH was 10.5. Miscible with water, methanol and acetone. Soluble in benzene, ether, micro-soluble carbon tetrachloride, n-heptane. Strong bases, combined with protons, can be used for condensation reactions. In analytical chemistry, triethanolamine can be used as a stationary liquid for gas-liquid chromatography (the highest temperature is 75 ℃, and the solvent is methanol and ethanol) for separating pyridine and methyl substituents. In the analysis of Complexometric titration, can be used as a masking agent for interfering ions, such as in the solution of pH = 10, using EDTA titration of magnesium, zinc, cadmium, calcium, nickel plasma, the titanium, aluminum, iron, tin plasma can be masked with the reagent. In addition, with hydrochloric acid can also be prepared into a certain pH buffer solution. triethanolamine is mainly used in the manufacture of surfactants, liquid detergents, cosmetics, etc. It is one of the components of cutting fluid and antifreeze. In the polymerization of nitrile rubber as an activator, natural rubber and synthetic rubber vulcanization activator. Can also be used as oil, wax, pesticide and other emulsifiers, cosmetics moisturizing agent, stabilizer, textile softener, lubricating oil anti-corrosion additives. Triethanolamine can absorb gases such as carbon dioxide and hydrogen sulfide, and can remove acid gas in the purification of industrial gases such as coke oven gas. EDTA titration method is commonly used as a masking agent. The allowable concentration in air is 3 μg/g. |
| external use in dermatology | at present, the external use of biafen, a drug commonly used in dermatology departments of many hospitals to treat burns and skin wounds, is mainly composed of triethanolamine, triethanolamine can play a dual role of cleaning and drainage through the principle of penetration and capillary action, can increase the skin blood flow rate, help discharge exudate, and can also change the ratio between interleukin I and interleukin VI, stimulates fibroblast proliferation, increases collagen synthesis. Clinical for the treatment of radiation therapy caused by secondary erythema, I, II degree burn and not yet infected skin trauma. (1) skin damage caused by radiotherapy: it is recommended to apply 2~3 times a day, with equal intervals for each application, and gently massage to make skin absorption. (2) second degree burns and other skin wounds: after cleaning the wound, apply a thick layer of drug on the surface of the wound, and repeat the application to make the wound have a sufficient amount of drug. If necessary, please use wet compress. Do not use dry absorbent compress. (3) I Degree Burn: apply a thick layer until the skin no longer absorb the drug, and gently massage. 2-4 times a day. |
| Early strength agent | triethanolamine is a commonly used early strength agent in China's cement industry, the role of early strength agent is to accelerate the hydration process of cement in the presence of liquid phase in concrete, improve the early strength, although triethanolamine does not change the hydration products of cement, however, it can strengthen the activity of colloid generated by cement hydration, generate pressure on the surrounding, block the capillary channel, and intensify the adsorption, wetting and particle dispersion, to promote the formation of calcium sulphoaluminate hydrate reaction between C3A and gypsum, can improve the concrete density, impermeability and frost resistance, the role of early strength and improve the strength. When used in combination with inorganic salt materials, due to the hydration of cement itself and the reaction of inorganic salt and cement, it can play a catalytic role, so that the early strength effect is particularly significant. |
| Use | GB 2760-96 provides that the permitted use of food processing aids is limited to GMP. used as a detergent for removing carbon dioxide or hydrogen sulfide from a gas. Esters of triethanolamine and higher fatty acids are widely used as detergents, emulsifiers, humectants and lubricants, and also in the formulation of cosmetic balms. Triethanolamine is also used as a preservative and water repellent, Analytical reagents and solvents. As an activator in the polymerization of nitrile rubber, it can also be used as an emulsifier, stabilizer and softener for oils and waxes under acidic conditions. It is one of the components of synthetic fiber spinning finish. It is used as an additive in the polymerization of nitrile rubber, a concrete Accelerator, an oil emulsifier, and also used for cyanide-free electroplating gas chromatography stationary liquid (the highest temperature is 75 ℃, the solvent is methanol, ethanol), separation and analysis of oxygen-containing, nitrogen-containing compounds and aqueous samples. Complexing agents. Metal masking agents. Platinum and palladium were titrated. Colorimetric Determination of manganese. Determination of tin, antimony and manganese. Absorption of carbon dioxide and carbon disulfide and other alkaline gases. Emulsifiers. Solvent. Corrosion inhibitors. gas chromatography stationary liquid (the highest temperature is 75 ° C., the solvent is methanol, ethanol), separation and analysis of oxygen-containing, nitrogen-containing compounds and aqueous samples. Complexing agent, metal masking agent, titration of palladium and platinum, Colorimetric Determination of manganese, determination of tin, antimony. Absorbs odors such as carbon dioxide and carbon disulfide. Emulsifiers, solvents, corrosion inhibitors. |
| production method | ethylene oxide and ammonia water are fed into the reactor at a reaction temperature of 30-40 ℃ and a reaction pressure of 70.9-304kPa, after dehydration and concentration at 90-120 ° C., the mixture of mono-, di-and triethanolamine is produced by condensation reaction and sent to three vacuum distillation columns for vacuum distillation, and fractions are cut off according to different boiling points, A final product of monoethanolamine, Diethanolamine and triethanolamine with a purity of 99% is obtained. In the reaction process, if the proportion of ethylene oxide is increased, the proportion of di-and triethanolamine is increased, and the yield of di-and triethanolamine can be increased. It is obtained by condensation reaction of ethylene oxide and ammonia water at 30-40 ° C. Under a pressure of 71-304 kPa, wherein the molar concentration ratio of ethylene oxide to ammonia is about 2.0. After the reaction, the reaction mixture was subjected to vacuum distillation in a rectification column, and a fraction in the vicinity of 360 ° C. Was obtained. |
| category | flammable liquid |
| toxicity grade | low toxicity |
| Acute toxicity | oral-rat LD50: 8000 mg/kg; Oral-mouse LD50: 5846 mg/kg |
| stimulation data | Skin-rabbits 560 mg/24 h mild; eye-rabbit 20 mg severe |
| flammability hazard characteristics | flammable in open flame, high temperature, strong oxidant; combustion emission toxic nitrogen oxide smoke |
| storage and transportation characteristics | The package is complete, light and light unloading; The warehouse is ventilated, away from open flame, high temperature, acid, separate storage of copper and aluminum |
| fire extinguishing agent | foam, dry powder, carbon dioxide, sand |
| Occupational Standard | TWA 5 mg/m3; Tel 10 mg/m3 |
| spontaneous combustion temperature | 600 ° F. |
