Sodium Hyaluronate, Sodium Hyaluronan, HA, 9067-32-7

Sodium Hyaluronate, Sodium Hyaluronan, HA, 9067-32-7

SODIUM HYALURONATE

SECTION 1: PRODUCT IDENTITY AND CHEMICAL IDENTIFICATION

Note: Sodium Hyaluronate is the sodium salt of hyaluronic acid. Compared to hyaluronic acid, it is more stable, has better water solubility, and is more commonly used in cosmetic formulations. It can hold up to 1000 times its weight in water.

SECTION 2: SODIUM HYALURONATE vs HYALURONIC ACID

SECTION 3: MOLECULAR WEIGHT CLASSES

SECTION 4: CHEMICAL STRUCTURE

Structure Description:

    COONa              CH₂OH
      |                  |
    C—O—CH₂             C—O
    |     |             |   |
    C—OH  C—OH          C—OH C—NHCOCH₃
    |     |             |   |
    C—OH  C—H           C—OH C—H
    |     |             |   |
    C—H   C—OH          C—H  C—OH
      |    |              |    |
      C—O—C—O—CH₂—O—C—O—C—O—CH₂—O—
    
    Sodium Hyaluronate
    (C₁₄H₂₀NNaO₁₁)ₙ

Simplified Structure:

    —[D-Glucuronic Acid — N-Acetylglucosamine]—
                   |
                   n
                   |
               Sodium (Na⁺)

    Sodium Hyaluronate
    (Sodium salt of hyaluronic acid)

SECTION 5: PHYSICAL AND CHEMICAL PROPERTIES

SECTION 6: FUNCTIONAL PROPERTIES AND MECHANISM OF ACTION

SECTION 7: MOLECULAR WEIGHT MECHANISM OF ACTION

SECTION 8: APPLICATIONS AND USAGE

SECTION 9: TYPICAL FORMULATION CONCENTRATIONS

SECTION 10: QUALITY SPECIFICATIONS

SECTION 11: SAFETY AND TOXICOLOGICAL PROFILE

SECTION 12: GHS CLASSIFICATION AND LABELING

GHS Classification (in accordance with 1272/2008/EC):

Signal Word: None (Not classified as hazardous)

Hazard Pictograms: None

NFPA 704 Hazard Classification:

SECTION 13: PRECAUTIONARY STATEMENTS (P-CODES)

SECTION 14: FIRST AID MEASURES

SECTION 15: FIREFIGHTING MEASURES

SECTION 16: STORAGE AND SHELF LIFE

SECTION 17: PACKAGING OPTIONS

SECTION 18: TRANSPORTATION INFORMATION

SECTION 19: REGULATORY STATUS

SECTION 20: OTHER NAMES AND SYNONYMS

SECTION 21: SUMMARY TABLE

SECTION 22: CRITICAL WARNINGS AND BEST PRACTICES

CRITICAL WARNINGS:

1. Hygroscopicity: Absorbs moisture; store in tightly closed, dry containers. Close immediately after opening.

2. Temperature Sensitivity: High temperature causes viscosity loss; do not heat above 60°C.

3. pH Sensitivity: Stable in pH 5.5-7.5; hydrolysis begins above pH 7.5.

4. Enzyme Sensitivity: Hyaluronidase enzyme degrades HA; avoid formulations containing enzymes.

5. Microbial Contamination: Fermentation-derived products may contain endotoxins; endotoxin testing is mandatory for pharmaceutical grade.

6. Molecular Weight Selection: Choose the correct molecular weight based on application:

   • High MW (>1M Da): Surface hydration, barrier

   • Medium MW (100k-1M Da): Balanced hydration

   • Low MW (10k-100k Da): Deep anti-aging

   • Very low MW (<10k Da): Transdermal, medical

7. Dissolution: Dissolve slowly in water; avoid high-speed mixing (viscosity loss).

8. Storage: Recommended storage at 2-8°C; short-term storage at room temperature is possible.

BEST PRACTICE RECOMMENDATIONS:

1. Concentration: Creams: 0.1-0.5%; Serums: 0.5-2%; Masks: 0.5-3%.

2. Dissolution: Dissolve slowly in cold or lukewarm water (up to 40°C). Avoid high-shear mixing.

3. pH Adjustment: Optimum pH 6.0-7.5; degradation begins above pH 7.5.

4. Preservatives: Compatible with phenoxyethanol, sodium benzoate, potassium sorbate; precipitation with cationic preservatives.

5. Combination with Other Actives: Synergistic effect with vitamin C, niacinamide, ceramides, peptides.

6. Storage: Store at 2-8°C in dry, light-protected containers. Close tightly after opening.

7. Microbiological Control: Powder form should be tested for microbiological contamination (TAMC, TYMC, pathogens).

8. Quality Control: Regularly perform assay, molecular weight, pH, viscosity, endotoxin, microbiological purity tests.

9. Formulation: Add to water phase in O/W or W/O emulsions; do not add to oil phase.

10. Endotoxin Control: Endotoxin testing is mandatory for pharmaceutical and injectable applications (≤0.5 EU/mg).

LEGAL DISCLAIMER:

The information provided in this document is based on our current knowledge and experience and is presented in good faith. However, as all conditions of use are beyond our control, it does not constitute a binding specification or guarantee. This Technical Data Sheet is for informational purposes only. Users are responsible for testing suitability for their own applications and for complying with all local, regional, and national regulations. For complete safety, storage, use, handling, waste, and regulatory compliance information, please refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. Sodium Hyaluronate is a widely used ingredient in cosmetic, pharmaceutical, and medical applications; its medical use should be under the supervision of a healthcare professional.