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Send EmailTetrasodium EDTA Dihydrate, Sodium edetate, Na₄EDTA, 10378-23-1
TETRASODIUM EDTA (DIHYDRATE)
SECTION 1: PRODUCT IDENTITY AND CHEMICAL IDENTIFICATION
| Parameter | Information |
|---|---|
| Product Name | Tetrasodium EDTA Dihydrate |
| Chemical Name (IUPAC) | Ethylenediaminetetraacetic acid, tetrasodium salt, dihydrate |
| Common Names | Tetrasodium EDTA, EDTA tetrasodium salt, Sodium edetate, Na₄EDTA |
| CAS Number | 10378-23-1 |
| EC Number (EINECS) | 200-573-9 (anhydrous form) |
| Molecular Formula | C₁₀H₁₂N₂Na₄O₈·2H₂O |
| Molecular Weight | 416.20 g/mol (dihydrate) |
| Chemical Class | Aminopolycarboxylic acid salt; chelating agent |
| Anhydrous Formula | C₁₀H₁₂N₂Na₄O₈ |
| Anhydrous Molecular Weight | 380.17 g/mol |
SECTION 2: CHEMICAL STRUCTURE
O O
‖ ‖
NaO—C—CH₂ CH₂—C—ONa
\ /
N—CH₂—CH₂—N
/ \
NaO—C—CH₂ CH₂—C—ONa
‖ ‖
O O
Tetrasodium EDTA Dihydrate
C₁₀H₁₂N₂Na₄O₈·2H₂O
(CH₂COONa)₂—N—CH₂—CH₂—N—(CH₂COONa)₂
· 2H₂O
| Parameter | Description |
|---|---|
| Molecular Formula | C₁₀H₁₂N₂Na₄O₈·2H₂O |
| Molecular Weight | 416.20 g/mol |
| Chemical Class | Aminopolycarboxylic acid salt |
| Functional Groups | Four carboxylate groups (COONa); two amine groups (N) |
| SMILES | C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+].O.O |
| InChI | InChI=1S/C10H16N2O8.4Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;;4*1H2/q;4*+1;;/p-4 |
| InChI Key | QJOLRRJGKOOUPD-UHFFFAOYSA-J |
| Chromophore | None (no UV absorption) |
| Crystal System | Monoclinic |
| Coordination Number | 6 (for chelation) |
| Steric Structure | Forms octahedral chelate complexes |
SECTION 3: PHYSICAL AND CHEMICAL PROPERTIES
| Property | Value | Test Method / Note |
|---|---|---|
| Appearance | White crystalline powder | Visual |
| Odor | Odorless | Olfactometric |
| Molecular Weight | 416.20 g/mol | Calculated |
| Melting Point | >150°C (decomposes) | DSC |
| Decomposition Temperature | 150-200°C (loses crystallization water) | - |
| Bulk Density (20°C) | ~0.7-0.9 g/cm³ | - |
| pH (1% solution, 25°C) | ~11.0-11.5 (alkaline) | pH Meter |
| Solubility in Water (20°C) | High (>800 g/L) | General Method |
| Solubility in Hot Water | Very high | General Method |
| Solubility in Ethanol | Slightly soluble (~5 g/L) | General Method |
| Solubility in Methanol | Slightly soluble | General Method |
| Solubility in Organic Solvents | Insoluble (generally) | General Method |
| Log P (Octanol/Water) | < -5.0 (very hydrophilic, ionic) | Calculated |
| Hygroscopicity | High (absorbs moisture) | - |
| Flash Point | >200°C | - |
| Vapor Pressure (25°C) | Very low | - |
| Thermal Stability | Stable up to 150°C; decomposes at higher temperatures | - |
| Boiling Point | Decomposes before boiling | - |
| Heat of Solution | Exothermic (releases heat when dissolved in water) | - |
| Surface Tension (0.1%) | ~55-65 mN/m | - |
| Conductivity (1% solution) | High (electrolyte) | - |
SECTION 4: FUNCTIONAL PROPERTIES AND MECHANISM OF ACTION
| Property | Description |
|---|---|
| Chelating Capacity | Binds polyvalent metal ions (Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺, Zn²⁺, Pb²⁺, Mn²⁺, Co²⁺, Ni²⁺, Cr³⁺, Cd²⁺, Hg²⁺, etc.) |
| Chelation Stoichiometry | 1 mol EDTA = 1 mol metal ion (1:1 complex) |
| Stability Constants (log K) | • Ca²⁺: 10.7 • Mg²⁺: 8.7 • Fe³⁺: 25.1 • Cu²⁺: 18.8 • Zn²⁺: 16.5 • Pb²⁺: 18.0 • Mn²⁺: 13.9 |
| Coordination Geometry | Octahedral (6 coordination sites) |
| Water Solubility | Tetrasodium salt is the most water-soluble form of EDTA. |
| Alkalinity | Forms strongly alkaline solution (pH ~11-11.5). |
| Synergistic Effect | When used with antioxidants (e.g., BHA, BHT, Vitamin E), oxidation prevention effect increases. |
| Stabilizer Effect | Extends product shelf life; prevents metal-induced degradation (color, odor, taste changes). |
| Hydrolysis Resistance | Stable in pH 4-11 range. Precipitates in acidic environments (pH <4). |
| Biodegradability | Limited biodegradability (~50-80% in OECD 301 tests) |
SECTION 5: COMMERCIAL GRADES AND VARIANTS
| Grade / Type | Purity | Appearance | pH (1%) | Primary Application |
|---|---|---|---|---|
| Technical Grade | ≥99.0% | White powder | 11.0-11.5 | Detergents, textile, paper, water treatment, industrial cleaners |
| Cosmetic Grade | ≥99.5% | White crystalline powder | 11.0-11.3 | Cosmetics and personal care (preservative, stabilizer) |
| Food Grade | ≥99.5% | White crystalline powder | 11.0-11.5 | Food additive (E386) - preservative, stabilizer |
| Pharmaceutical Grade | ≥99.5% | White crystalline powder | 11.0-11.3 | Pharmaceuticals (anticoagulant, chelation therapy, stabilizer) |
| Analytical Grade | ≥99.8% | White crystalline powder | 11.0-11.3 | Laboratory (titration, complexometry, R&D) |
| GMP Grade | ≥99.5% | White crystalline powder | 11.0-11.3 | Pharmaceutical manufacturing (strict quality control) |
| Micronized Grade | ≥99.0% | Micronized powder | 11.0-11.5 | Fast solubility applications |
SECTION 6: CHELATION PERFORMANCE AND METAL BINDING CAPACITY
| Metal Ion | Stability Constant (log K) | Max Binding Capacity (mg metal/g EDTA) | pH Range | Application |
|---|---|---|---|---|
| Ca²⁺ | 10.7 | 100.3 | 7-11 | Water softening, scale prevention |
| Mg²⁺ | 8.7 | 60.9 | 8-11 | Water softening, detergents |
| Fe³⁺ | 25.1 | 139.7 | 1-11 | Iron stabilization, corrosion prevention |
| Cu²⁺ | 18.8 | 159.0 | 2-11 | Copper stabilization, antioxidant synergist |
| Zn²⁺ | 16.5 | 163.5 | 4-11 | Zinc stabilization, fertilizers |
| Pb²⁺ | 18.0 | 518.0 | 4-11 | Lead chelation, heavy metal detox |
| Mn²⁺ | 13.9 | 137.4 | 5-11 | Manganese stabilization |
| Co²⁺ | 16.3 | 147.4 | 4-11 | Cobalt stabilization |
| Ni²⁺ | 18.6 | 146.8 | 4-11 | Nickel stabilization |
| Cd²⁺ | 16.4 | 281.2 | 4-11 | Cadmium chelation |
| Hg²⁺ | 21.5 | 501.6 | 3-11 | Mercury chelation |
| Al³⁺ | 16.1 | 67.5 | 2-11 | Aluminum stabilization |
Stoichiometry Calculation:
1 mol Tetrasodium EDTA (416.20 g) = 1 mol metal ion
Theoretical chelation capacity (for Ca²⁺): 416.20 g EDTA = 40.08 g Ca²⁺
Ca²⁺ binding capacity: ~96.3 mg Ca²⁺ / g EDTA
SECTION 7: APPLICATIONS AND INDUSTRY USAGE
| Industry / Sector | Application | Function | Typical Concentration |
|---|---|---|---|
| Cosmetics & Personal Care | Preservative system | Prevents product degradation by binding metal ions | 0.05-0.5% |
| Cosmetics & Personal Care | Shampoo and cream stabilizer | pH and viscosity stability | 0.05-0.5% |
| Cosmetics & Personal Care | Toners and lotions | Hardness stabilization | 0.05-0.2% |
| Detergents & Cleaning | Water softener | Binds Ca²⁺, Mg²⁺ to improve detergent efficacy | 1-10% |
| Detergents & Cleaning | Bleach stabilizer | Hydrogen peroxide stabilization | 0.5-2% |
| Detergents & Cleaning | Industrial cleaners | Metal oxide and scale remover | 1-15% |
| Water Treatment | Scale prevention | Binds Ca²⁺, Mg²⁺ to prevent scale formation | 1-5% |
| Water Treatment | Metal ion sequestration | Binds heavy metal ions | 1-10% |
| Water Treatment | Boiler and cooling water systems | Corrosion prevention, scale remover | 1-5% |
| Food Industry | Preservative | Prevents metal-induced oxidation | 0.005-0.05% |
| Food Industry | Color and flavor stabilizer | Prevents metal-induced color/flavor degradation | 0.005-0.05% |
| Food Industry | Antioxidant synergist | Prevents oxidation with antioxidants | 0.005-0.05% |
| Pharmaceutical Industry | Anticoagulant | Prevents blood clotting (in vitro) | 0.1-0.5% |
| Pharmaceutical Industry | Stabilizer | Prevents metal-induced drug degradation | 0.05-0.5% |
| Pharmaceutical Industry | Chelation therapy (Pb, Hg, Cd) | Heavy metal poisoning treatment | Variable |
| Agriculture | Micronutrient fertilizers (chelating agent) | Fe, Zn, Mn, Cu chelates | 1-10% |
| Agriculture | Soil conditioner | Balances metal ions in soil | Variable |
| Textile Industry | Dye stabilizer | Binds metal ions for dye homogeneity | 0.1-1% |
| Textile Industry | Whiteness enhancer | Binds metal ions to increase brightness | 0.1-1% |
| Paper Industry | Scale reducer | Binds metal ions in cellulose | 0.1-1% |
| Photography | Processing solution stabilizer | Binds metal ions for film quality | Variable |
| Petroleum Industry | Drilling mud stabilizer | Controls metal ions | Variable |
SECTION 8: FOOD ADDITIVE USE (E386)
| Parameter | Information |
|---|---|
| E Number | E386 |
| Function | • Preservative (antioxidant synergist) • Stabilizer • Sequestrant (chelating agent) |
| Food Applications | • Canned foods • Brines and pickles • Mayonnaise and sauces • Beverages (concentrates) • Processed meat products • Frozen foods • Instant soups and sauces |
| Typical Concentration | 0.005-0.05% (50-500 ppm) |
| ADI (Acceptable Daily Intake) | 0-2.5 mg/kg body weight (JECFA) |
| Tolerance Limits (EU) | Generally limited by GMP (Good Manufacturing Practice) |
| Tolerance Limits (FDA) | Permitted under 21 CFR 172.135, 21 CFR 173.320 |
SECTION 9: PHARMACOPOEIA COMPLIANCE
| Pharmacopoeia | Standard | Specifications |
|---|---|---|
| USP (United States Pharmacopeia) | Edetate Sodium (Tetrasodium EDTA) | White powder; pH 11.0-11.8 (1%); soluble in water; 98-102% by titration; tested as dihydrate |
| EP (European Pharmacopoeia) | Tetrasodium Edetate Dihydrate | Similar to USP standards; additional purity and microbiological tests |
| JP (Japanese Pharmacopoeia) | Tetrasodium Edetate Dihydrate | Specific quality requirements for Asian market |
| BP (British Pharmacopoeia) | Tetrasodium Edetate Dihydrate | British Pharmacopoeia standards |
| FCC (Food Chemicals Codex) | Tetrasodium EDTA | Food additive specifications (E386) |
| Microbiological Limits | USP <61> | TAMC <10² CFU/g; TYMC <10¹ CFU/g |
| Heavy Metal Limits | USP <231> | Pb <10 ppm, As <2 ppm, Hg <1 ppm |
SECTION 10: SAFETY PROFILE AND TOXICOLOGICAL ASSESSMENT
| Parameter | Value / Description |
|---|---|
| GHS Classification | Skin Irritant Category 2; Eye Irritant Category 2A |
| Signal Word | Warning |
| Hazard Pictograms | GHS07 (Exclamation mark) |
| Hazard Statements (H-Codes) | H315 (Causes skin irritation), H319 (Causes serious eye irritation) |
| Precautionary Statements (P-Codes) | P264, P280, P302+P352, P305+P351+P338, P332+P313, P337+P313, P362+P364, P501 |
| Acute Oral Toxicity (LD50, Rat) | ~1,200-1,500 mg/kg (low toxicity) |
| Acute Dermal Toxicity (LD50, Rabbit) | >2000 mg/kg (low toxicity) |
| Acute Inhalation Toxicity | Low toxicity; dust inhalation may cause irritation |
| Skin Irritation | Mild irritant (Category 2) |
| Eye Irritation | Mild-moderate irritant (Category 2A) |
| Skin Sensitization | Non-sensitizing |
| Carcinogenicity | Not classified as carcinogenic; IARC Group 3 (Not classifiable) |
| Mutagenicity | Not mutagenic (AMES test negative) |
| Reproductive Toxicity | Not toxic at low doses; limited effects at high doses |
| Target Organs | Skin, eyes, respiratory tract (dust) |
| NOAEL (Rat, 90 days) | ~500 mg/kg/day |
| Dermal Absorption | Very low (ionic, high molecular weight) |
| Systemic Exposure | Low; toxicological risk is low |
| Ecotoxicity (EC50, Daphnia) | >100 mg/L (low toxicity) |
| Bioaccumulation Potential | Low (hydrophilic, ionic) |
SECTION 11: FIRST AID MEASURES
| Route of Exposure | Action |
|---|---|
| Inhalation | If inhaled as powder, move to fresh air. Seek medical attention if respiratory irritation or symptoms persist. |
| Skin Contact | Remove contaminated clothing. Wash with plenty of soap and water. Seek medical attention if irritation develops or persists. |
| Eye Contact | Rinse thoroughly with plenty of water for at least 15 minutes. Keep eyelids open. Remove contact lenses if present. Seek medical attention if irritation persists. |
| Ingestion | Rinse mouth with water. Do NOT induce vomiting. Drink 1-2 glasses of water. Seek medical attention. |
| Note | Symptomatic treatment is administered. No specific antidote available. |
SECTION 12: STORAGE AND SHELF LIFE
| Parameter | Information |
|---|---|
| Storage Conditions | Store in a cool (<25°C), dry, well-ventilated area; protect from moisture, strong acids, and oxidizing agents. |
| Temperature Limits | 15-25°C (ideal); do not exceed 30°C |
| Humidity | Low humidity environment (highly hygroscopic - absorbs moisture) |
| Light | Not sensitive to light (light-proof containers not required) |
| Oxygen | Stable against oxidation; keep containers tightly closed |
| Incompatible Materials | Strong acids (precipitation), strong oxidizing agents, metal ions (forms chelates) |
| Container Requirements | Moisture-proof containers: HDPE drums, aluminum bags, fiber drums (PE lined) |
| Shelf Life | 24-36 months (unopened original packaging, under proper storage conditions) |
| Shelf Life (After Opening) | 12-24 months (under proper storage conditions; protected from moisture) |
| Signs of Degradation | Caking, odor change, decreased solubility, color change (yellowish) |
| Stability Warning | May cake under high humidity and heat (hygroscopic structure). Keep containers tightly closed after opening. |
SECTION 13: PACKAGING OPTIONS
| Packaging Type | Quantity / Capacity | Material | Application Area |
|---|---|---|---|
| Kraft Bag (PE Lined) | 10 kg, 25 kg | Kraft paper / PE liner (moisture barrier) | Detergent, textile, water treatment, industrial |
| HDPE Pail | 5 kg, 10 kg, 25 kg, 50 kg | HDPE (moisture-proof) | Cosmetic, food, pharmaceutical |
| Plastic Drum | 25 kg, 50 kg | HDPE (opaque, moisture barrier) | Industrial bulk supply |
| Fiber Drum | 25 kg, 50 kg | Fiber / PE liner | Industrial supply |
| Aluminum Foil Bag | 1 kg, 5 kg, 10 kg, 25 kg | Aluminum / PE (moisture-proof) | High purity, cosmetic, pharmaceutical |
| IBC Container | 500 kg, 1000 kg | UV-protected HDPE / Metal | Large-scale industrial supply |
| Amber Glass Jar | 100 g, 500 g, 1 kg | Amber glass (UV protected) | Analytical standards, R&D |
SECTION 14: TRANSPORTATION INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not applicable (not classified as dangerous substance) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| ADR/RID | Not classified as dangerous goods |
| IMDG Code | Not marine pollutant; not classified as dangerous goods |
| IATA (Air) | Not classified as dangerous goods; can be transported by air |
| Transport Temperature | Ambient temperature; protect from moisture |
| Transport Precautions | Keep away from strong acids and oxidizing agents; protect from moisture |
| Spill Cleanup | Collect mechanically; clean with absorbent material; avoid dust generation |
| Marine Pollutant | No |
SECTION 15: QUALITY CONTROL AND ANALYTICAL METHODS
| Parameter | Test Method | Specification |
|---|---|---|
| Appearance | Visual | White crystalline powder |
| Odor | Olfactometric | Odorless |
| Assay (Tetrasodium EDTA) | Titration (Zn standard) | ≥99.0% (Technical); ≥99.5% (Pharm./Food) |
| pH (1% solution, 25°C) | pH Meter | 11.0-11.5 |
| Water Content | Karl Fischer | ≤5.0% (as dihydrate) |
| Residue on Ignition | Gravimetric | ≤0.5% |
| Chloride (Cl) | Turbidimetric | ≤0.05% |
| Sulfate (SO₄) | Turbidimetric | ≤0.1% |
| Water Insoluble Matter | Gravimetric | ≤0.1% |
| Heavy Metals (Pb) | ICP-MS / USP <231> | ≤10 ppm |
| Arsenic (As) | ICP-MS | ≤2 ppm |
| Iron (Fe) | ICP-MS | ≤5 ppm |
| Nitrilotriacetic Acid (NTA) | HPLC | ≤0.5% |
| Sodium (Na) | AAS / ICP | 20.5-21.5% |
| Particle Size | Laser Diffraction / Sieve | As per customer specification |
| Microbiological Purity | USP <61> | TAMC ≤10² CFU/g; TYMC ≤10¹ CFU/g |
SECTION 16: QUALITY SPECIFICATIONS
| Parameter | Specification (Technical) | Specification (Pharmaceutical) | Specification (Food) | Test Method |
|---|---|---|---|---|
| Appearance | White powder | White crystalline powder | White powder | Visual |
| Assay | ≥99.0% | ≥99.5% | ≥99.5% | Titration |
| pH (1%) | 11.0-11.5 | 11.0-11.3 | 11.0-11.5 | pH Meter |
| Water Content | ≤5.0% | ≤5.0% | ≤5.0% | Karl Fischer |
| Residue on Ignition | ≤0.5% | ≤0.5% | ≤0.5% | Gravimetric |
| Heavy Metals (Pb) | ≤10 ppm | ≤10 ppm | ≤5 ppm | ICP-MS |
| Arsenic (As) | ≤2 ppm | ≤2 ppm | ≤1 ppm | ICP-MS |
| Iron (Fe) | ≤10 ppm | ≤5 ppm | ≤5 ppm | ICP-MS |
| NTA | ≤0.5% | ≤0.3% | ≤0.5% | HPLC |
| Microbiological Purity | - | TAMC ≤10² CFU/g | TAMC ≤10² CFU/g | USP <61> |
SECTION 17: OTHER NAMES AND SYNONYMS
| Type | Name |
|---|---|
| Chemical Name (IUPAC) | Ethylenediaminetetraacetic acid, tetrasodium salt, dihydrate |
| Common Names | Tetrasodium EDTA, EDTA tetrasodium salt, Sodium edetate, Na₄EDTA |
| Pharmaceutical Names | Tetrasodium Edetate Dihydrate, Edetate Sodium (USP) |
| Food Additive | E386 |
| Trade Marks | Trilon B, Sequestrene 30, Versene 100, Dissolvine D, EDTA 4Na |
| FCC Name | Tetrasodium EDTA |
| CAS Number | 10378-23-1 |
| EC Number | 200-573-9 (anhydrous form) |
| PubChem CID | 19829939 |
SECTION 18: GHS CLASSIFICATION AND LABELING
| Parameter | Information |
|---|---|
| GHS Classification | Skin Irritant Category 2; Eye Irritant Category 2A |
| Signal Word | Warning |
| Hazard Pictograms | GHS07 (Exclamation mark) |
| Hazard Statements (H-Codes) | H315 (Causes skin irritation), H319 (Causes serious eye irritation) |
| Precautionary Statements (P-Codes) | P264, P280, P302+P352, P305+P351+P338, P332+P313, P337+P313, P362+P364, P501 |
| NFPA 704 Classification | Health: 1, Flammability: 0, Reactivity: 0 |
SECTION 19: ENVIRONMENTAL IMPACT AND DISPOSAL
| Parameter | Information |
|---|---|
| Biodegradability | Limited-Moderate (~50-80%, OECD 301B) |
| Aquatic Toxicity (EC50) | >100 mg/L (Daphnia magna) - low toxicity |
| Aquatic Toxicity (LC50) | >100 mg/L (fish) - low toxicity |
| Soil Mobility | High (hydrophilic, ionic) |
| Bioaccumulation Potential | Very low (hydrophilic, ionic) |
| Persistence | Moderate; limited biodegradability |
| Disposal Method | Dispose of in accordance with local, regional, and national regulations |
| Incineration | Controlled incineration facilities; energy recovery possible |
| Sewer Discharge | Do not discharge into sewers or water resources |
| Environmental Precautions | Prevent environmental spread during spills; collect with absorbent material |
| Ecotoxicity Note | May reduce bioavailability by binding heavy metals; low risk in aquatic environments |
SECTION 20: FREQUENTLY ASKED QUESTIONS
| Question | Answer |
|---|---|
| Q1: What is Tetrasodium EDTA? | Tetrasodium EDTA is the tetrasodium salt of ethylenediaminetetraacetic acid (EDTA). It is a powerful chelating agent that binds polyvalent metal ions. |
| Q2: What is Tetrasodium EDTA used for? | It is used for water softening, in detergents, as a preservative/stabilizer in cosmetics, as a food additive, in pharmaceuticals as an anticoagulant and for chelation therapy. |
| Q3: Is Tetrasodium EDTA safe? | It has low toxicity. It is approved by FDA, EU, and other regulatory bodies for cosmetic, food, and pharmaceutical applications. May cause skin and eye irritation. |
| Q4: What is the pH of Tetrasodium EDTA? | The pH of a 1% aqueous solution is 11.0-11.5 (strongly alkaline). |
| Q5: Is Tetrasodium EDTA soluble in water? | Yes, it has very high water solubility (>800 g/L). |
| Q6: What is the difference between Tetrasodium EDTA and Disodium EDTA? | Tetrasodium EDTA (pH 11-11.5) is the fully neutralized form and works at pH 10-12. Disodium EDTA (pH 4-5) is partially neutralized and works in acidic pH. |
| Q7: Is Tetrasodium EDTA used in food? | Yes, as food additive E386. Used in canned foods, sauces, mayonnaise, beverages, and processed meat products as a preservative and stabilizer. |
| Q8: Is Tetrasodium EDTA harmful to skin? | It may cause skin irritation (Category 2). Typical use levels in cosmetic formulations (0.05-0.5%) are safe and well tolerated. |
| Q9: What is the shelf life of Tetrasodium EDTA? | 24-36 months under proper storage conditions (cool, dry, airtight container). |
| Q10: Why is Tetrasodium EDTA used in detergents? | It binds Ca²⁺ and Mg²⁺ ions in hard water, improving detergent performance, foam formation, and preventing scale formation. |
SECTION 21: QUICK REFERENCE TABLE
| Property | Value |
|---|---|
| CAS Number | 10378-23-1 |
| EC Number | 200-573-9 |
| Molecular Formula | C₁₀H₁₂N₂Na₄O₈·2H₂O |
| Molecular Weight | 416.20 g/mol |
| Appearance | White crystalline powder |
| pH (1% solution) | 11.0-11.5 |
| Water Solubility | High (>800 g/L) |
| Primary Function | Chelating agent (metal ion binding) |
| Main Applications | Cosmetics, detergents, water treatment, food, pharmaceuticals |
| Chelation Capacity (Ca²⁺) | ~96.3 mg Ca²⁺/g EDTA |
| Shelf Life | 24-36 months |
| Storage | Cool (<25°C), dry, airtight |
| GHS Classification | Irritant (GHS07) |
| FDA Status | Approved for food and pharmaceutical use |
| EU (REACH) | Registered substance |
SECTION 22: CRITICAL WARNINGS AND BEST PRACTICES
CRITICAL WARNINGS:
Hygroscopic nature: Tetrasodium EDTA absorbs moisture. Keep containers tightly closed after opening and store in low-humidity environments.
Alkaline pH: 1% solution pH is 11-11.5. Precipitation may occur in acidic environments (pH <4).
Incompatibility: Do not contact with strong acids (precipitation); keep away from strong oxidizing agents.
Metal chelation: Do not store in metal containers (may corrode). Prefer HDPE or glass containers.
Dust control: Avoid dust inhalation; use appropriate respiratory protection in dust-generating areas.
Skin/eye irritation: Avoid skin and eye contact; wash with plenty of water if contact occurs.
Biodegradability: Limited biodegradability; do not discharge into the environment uncontrolled.
BEST PRACTICE RECOMMENDATIONS:
Formulation: Dissolve in water; solubility increases at 60-80°C. Use in slightly alkaline conditions for pH adjustment.
Correct concentration: Determine appropriate concentration based on application:
Cosmetics: 0.05-0.5%
Detergents: 1-10%
Food: 0.005-0.05%
Water treatment: 1-5%
pH control: Highest chelation efficiency at pH 10-12. Precipitation occurs below pH 4.
Metal ion selection: Choose the correct EDTA form (tetrasodium, disodium, calcium, etc.) based on target metal ion.
Stability studies: Test product stability during long-term storage; evaluate effects of moisture and temperature.
Quality control: Regularly perform assay (titration), pH, water content, heavy metals, NTA, and microbiological purity tests.
Microbiological contamination: Test powder form for microbiological contamination (TAMC, TYMC, pathogens).
Waste management: Do not discharge into the environment; dispose of in accordance with local regulations.
Personnel training: Train employees on dust control, PPE use, and emergency procedures.
Spill cleanup: Avoid dust generation; use HEPA-filtered vacuum or wet cleaning.
LEGAL DISCLAIMER:
The information provided in this document is based on our current knowledge and experience and is presented in good faith; however, it does not constitute a binding specification or guarantee as all conditions of use are beyond our control. This Technical Data Sheet is for informational purposes only. Users are responsible for testing suitability for their own applications. For complete safety, storage, use, handling, waste, and regulatory compliance information, please refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier.