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Send EmailAvobenzone, Butyl Methoxydibenzoylmethane, 70356-09-1
AVOBENZONE
SECTION 1: PRODUCT IDENTITY AND CHEMICAL IDENTIFICATION
| Parameter | Information |
|---|---|
| Product Name | Avobenzone |
| INCI Name | Butyl Methoxydibenzoylmethane |
| Chemical Name (IUPAC) | 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3-dione |
| Common Names | Avobenzone, Parsol 1789, Eusolex 9020, Neo Heliopan 357, Escalol 517 |
| CAS Number | 70356-09-1 |
| EC Number (EINECS) | 274-581-6 |
| REACH Registration Number | Available (varies by manufacturer) |
| Molecular Formula | C₂₀H₂₂O₃ |
| Molecular Weight | 310.4 g/mol |
| Chemical Class | Dibenzoylmethane derivative; organic UV filter |
| Functional Group | β-diketone (keto-enol tautomerism) |
SECTION 2: CHEMICAL STRUCTURE
O O
‖ ‖
C C
/ \ / \
/ \ / \
/ \ / \
/ \ / \
/ \ / \
/ \ / \
| | | |
| CH₃ | | CH₃ |
| | | | | |
H₃CO-C-H C-H C-H C-H C-CH₃
| | | | |
| | | | |
\ / \ / /
\ / \ / /
\ / \ / /
\ / \ /
C C /
‖ ‖ /
O O /
\ /
C
‖
H
(Enol Form - Active UV Absorbing Form)
Simplified Chemical Structure:
O O
‖ ‖
Ar₁—C—CH₂—C—Ar₂
Ar₁ = 4-tert-butylphenyl group (C₆H₄-C(CH₃)₃)
Ar₂ = 4-methoxyphenyl group (C₆H₄-OCH₃)
Keto Form (Less active)
OH O
| ‖
Ar₁—C = CH—C—Ar₂
Enol Form (Active UV absorbing form)
| Parameter | Description |
|---|---|
| Molecular Formula | C₂₀H₂₂O₃ |
| Molecular Weight | 310.4 g/mol |
| Chemical Class | Dibenzoylmethane derivative |
| Functional Group | β-diketone (1,3-diketone) |
| Chromophore | Conjugated β-diketone system (responsible for UVA absorption) |
| Tautomerism | Keto-enol tautomerism; enol form is the active UV absorbing form |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=C(C=C2)OC |
| InChI | InChI=1S/C20H22O3/c1-20(2,3)15-7-5-14(6-8-15)18(21)13-19(22)16-9-11-17(23-4)12-10-16/h5-12H,13H2,1-4H3 |
| InChI Key | XNEFYCZVKIDDMS-UHFFFAOYSA-N |
| Crystal System | Monoclinic |
| Enol Form Stability | Non-polar solvents favor keto form; polar solvents stabilize enol form |
| Hydrogen Bond Donor/Acceptor | 1 donor (enol form); 3 acceptors |
| Topological Polar Surface Area (PSA) | ~46.5 Ų |
| Rotatable Bond Count | 6 |
| Steric Structure | Conjugation in β-diketone system provides UVA absorption |
SECTION 3: PHYSICAL AND CHEMICAL PROPERTIES
| Property | Value | Test Method / Note |
|---|---|---|
| Appearance | Pale yellow to light yellow crystalline powder / granules | Visual |
| Odor | Slight characteristic odor | Olfactometric |
| Molecular Weight | 310.4 g/mol | Calculated |
| Melting Point | 80 – 85 °C | DSC |
| Density (20°C) | ~1.15 g/cm³ (estimated) | - |
| Maximum Absorption Wavelength (λmax) | ~357 nm (UVA region) | UV-VIS Spectrophotometer |
| Absorption Range | 320 – 400 nm (full UVA spectrum) | UV-VIS Spectrophotometer |
| Molar Absorptivity (ε) | ~30,000 – 35,000 L·mol⁻¹·cm⁻¹ (at 357 nm) | UV-VIS Spectrophotometer |
| Solubility in Water (20°C) | Insoluble (<0.1 mg/L) | General Method |
| Solubility in Oils | Soluble in oils and organic solvents | General Method |
| Solubility in Propylene Glycol | Slightly soluble | General Method |
| Solubility in Ethanol | Soluble | General Method |
| Solubility in Isopropyl Myristate | Soluble (~10-15%) | General Method |
| Log P (Octanol/Water) | ~4.5 (lipophilic) | Calculated |
| pKa | ~7.5 (enol form) | - |
| Vapor Pressure (25°C) | Very low (<0.001 mmHg) | - |
| Flash Point | >100°C | - |
| Thermal Stability | Stable up to 120°C (short term) | - |
| Emission Maximum | ~490 nm (fluorescence) | - |
SECTION 4: FUNCTIONAL PROPERTIES AND MECHANISM OF ACTION
| Property | Description |
|---|---|
| UVA Filter | Avobenzone is one of the most commonly used organic UV filters that absorbs UVA rays (320-400 nm). Provides broad-spectrum UVA protection. |
| Energy Absorption | Through its conjugated β-diketone system, it absorbs UVA photons, raising the molecule to a higher energy excited state. |
| Energy Dissipation | The absorbed energy is dissipated as thermal energy through intramolecular vibrational and rotational movements without entering unsafe reactions. |
| Photoprotection | Absorbs UVA radiation in the upper layers of the epidermis, preventing it from reaching living cells beneath the skin. |
| Broad Spectrum Contribution | Provides UVA protection, making it a key component of broad-spectrum sunscreen formulations together with UVB filters. |
| Singlet Oxygen Quencher | Avobenzone has the ability to quench reactive oxygen species (singlet oxygen) generated during light absorption. |
| Photodegradation Stability | Degrades under light when used alone; combination with photostabilizers reduces degradation and maintains efficacy. |
| Skin Retention Time | Due to its lipophilic structure, it adheres to the stratum corneum and forms a water-resistant film. |
SECTION 5: PHOTOSTABILITY AND FORMULATION TIPS
| Parameter | Description |
|---|---|
| Photostability Issue | When used alone, Avobenzone undergoes photodegradation upon exposure to UV light; UVA protection performance decreases over time. |
| Photodegradation Mechanism | Keto-enol tautomerization upon light exposure, followed by Norrish type I reaction leading to degradation; conversion to carbonyl compounds. |
| Photodegradation Products | 4-methoxybenzaldehyde, 4-tert-butylbenzaldehyde, benzylic acid derivatives |
| Recommended Photostabilizers | Octocrylene (most common), Tinosorb S (Bemotrizinol), Tinosorb M (Bisoctrizole), Uvinul A Plus (Diethylamino Hydroxybenzoyl Hexyl Benzoate), Polysilicone-15 |
| Stabilization Ratios | Octocrylene at 1:1 to 2:1 (Avobenzone:Octocrylene); Tinosorb S: addition of 0.5-2% recommended |
| Antioxidant Use | Addition of Vitamin E (tocopherol) 0.1-1% improves photostability; Vitamin C (ascorbic acid) esters are also beneficial |
| Solvent Selection | Recommended to dissolve in the oil phase (chemically compatible oils); combination with propylene glycol and ethanol is possible |
| pH Optimization | Stability is better in pH 5-7 range (enol form is stabilized) |
| Temperature Processing | Melt and dissolve homogeneously in oil phase at 80-85°C; do not keep at high temperature for extended periods |
| Formulation System | Add to oil phase in O/W (oil-water) emulsions; also incorporated into oil phase in W/O systems |
| Film Formers | Can be used with polymers in water-resistant formulations |
SECTION 6: COMMERCIAL GRADES AND VARIANTS
| Grade / Type | Purity | Appearance | Primary Application |
|---|---|---|---|
| Cosmetic Grade | ≥99.0% | Pale yellow powder | Sunscreens, daily care products |
| Pharmaceutical Grade | ≥99.5% | Light yellow powder | Dermatological products, medical sunscreens |
| Technical Grade | ≥98.0% | Yellowish powder | Industrial applications, research |
| Micronized Grade | ≥99.0% | Micronized powder (particle size <5 μm) | High SPF formulations, transparent application |
| Encapsulated Grade | Variable | Encapsulated particles | Advanced formulations requiring photostability |
| Liquid Dispersion | Variable | Liquid dispersion (oil-based) | Easy formulation integration |
SECTION 7: PHOTOSTABILIZER COMPARISON
| Photostabilizer | Stabilization Mechanism | Typical Ratio | Advantages | Disadvantages |
|---|---|---|---|---|
| Octocrylene | Energy transfer / UV absorption | 1:1 – 2:1 (Avo:Oct) | Most common, effective, cost-effective | Limited UVA protection; possible allergy |
| Tinosorb S (Bemotrizinol) | UV absorption + stabilization | 0.5-2% | Broad spectrum, highly effective | Higher cost; new generation |
| Tinosorb M (Bisoctrizole) | UV absorption + stabilization | 0.5-2% | Broad spectrum, physical+chemical | Difficult to disperse; opaque appearance |
| Uvinul A Plus | UV absorption + stabilization | 0.5-2% | UVA protection + stabilization | Higher cost |
| Oxybenzone | UV absorption | 1-2% | Effective stabilization | Endocrine disruptor debate; being banned |
| Vitamin E (Tocopherol) | Antioxidant (free radical scavenger) | 0.1-1% | Skin-friendly, additional benefit | Not sufficient alone |
| Ethylhexyl Triazone | UVB absorption | 0.5-2% | UVB protection + partial stabilization | UVB only; extra cost |
SECTION 8: INDUSTRY APPLICATIONS AND USAGE AREAS
| Industry / Sector | Application | Typical Ratio |
|---|---|---|
| Cosmetics | Sunscreen creams | 2-5% (max. 5% in EU) |
| Cosmetics | Daily moisturizers (with SPF) | 0.2-1% |
| Cosmetics | Foundations and BB creams | 0.5-2% |
| Cosmetics | Lip products (SPF lipsticks) | 0.5-3% |
| Cosmetics | Body lotions (with SPF) | 1-3% |
| Cosmetics | Children's sunscreens | 2-4% (with dermatological testing) |
| Cosmetics | Sports and water-resistant formulations | 3-5% (with film formers) |
| Dermatology | Medical photoprotective products | 2-5% (photodermatitis, melanoma risk) |
| Dermatology | Hypopigmentation treatments | 1-3% (adjunctive protection) |
| Color Cosmetics | SPF blushes and bronzers | 0.5-2% |
| Color Cosmetics | Eye makeup (with SPF) | 0.2-1% (eye area tolerance) |
SECTION 9: REGULATORY AND LEGISLATIVE STATUS
| Region / Authority | Status | Maximum Usage Rate | Description |
|---|---|---|---|
| European Union (EC) | Approved | 5% | Permitted UV filter under EC 1223/2009 |
| USA (FDA) | Approved | 3%* | OTC Monograph (21 CFR 352); *FDA proposed 3% limit |
| Australia (TGA) | Approved | 5% | Therapeutic Goods Administration approved |
| Canada (HC) | Approved | 5% | Health Canada approved |
| Japan (MHLW) | Approved | 5% | Under positive list |
| Turkey | Approved | 5% | Under KKDIK and Cosmetics Regulation |
| China (NMPA) | Approved | 5% | Permitted in Chinese cosmetic regulations |
| ECHA | Approved | - | Registered under REACH |
| California Prop 65 | Not Listed | - | Not listed as carcinogen or reproductive toxin |
SECTION 10: SAFETY PROFILE AND TOXICOLOGICAL ASSESSMENT
| Parameter | Value / Description |
|---|---|
| GHS Classification | Generally not classified as hazardous substance; however some classifications may exist |
| Acute Oral Toxicity (LD50, Rat) | >2000 mg/kg (low toxicity) |
| Acute Dermal Toxicity (LD50, Rabbit) | >2000 mg/kg (low toxicity) |
| Skin Irritation | May be mildly irritating (rare) |
| Eye Irritation | Mildly irritating |
| Skin Sensitization | May cause potential sensitization (rare) |
| Phototoxicity | Low phototoxic potential; however studies on photodegradation products are ongoing |
| Photodegradation Products | 4-methoxybenzaldehyde, 4-tert-butylbenzaldehyde; some may have allergenic potential |
| Carcinogenicity | Not classified as carcinogenic; IARC Group 3 (Not classifiable) |
| Mutagenicity | Not mutagenic (Ames test negative) |
| Endocrine Disrupting Potential | Low to moderate; some in vitro studies show endocrine activity; however in vivo effects are low |
| Reproductive Toxicity | Reproductive toxicity not known (insufficient data) |
| Target Organ Toxicity | Not known (low potential) |
| Dermal Absorption | Low (0.5-1.5%) (human skin) |
| Systemic Exposure | Low systemic absorption with topical application; high safety margin |
| Ecotoxicity (EC50, Daphnia) | >10 mg/L (moderate toxicity) |
| Bioaccumulation Potential | Moderate (lipophilic structure) |
SECTION 11: FIRST AID MEASURES
| Route of Exposure | Action |
|---|---|
| Inhalation | If inhaled as powder, move to fresh air. Seek medical attention if respiratory symptoms persist. |
| Skin Contact | Remove contaminated clothing. Wash with plenty of soap and water. Seek medical attention if irritation occurs. |
| Eye Contact | Rinse thoroughly with plenty of water for at least 15 minutes. Keep eyelids open. Remove contact lenses if present. Seek medical attention if irritation persists. |
| Ingestion | Rinse mouth with water. Do NOT induce vomiting. Seek medical attention. |
| Note | Symptomatic treatment is administered. No specific antidote available. |
SECTION 12: STORAGE AND SHELF LIFE
| Parameter | Information |
|---|---|
| Storage Conditions | Store in a cool (<25°C), dry, dark place; protect from direct sunlight and UV sources. |
| Temperature Limits | 15-25°C (ideal); do not exceed 30°C |
| Humidity | Low humidity environment (not hygroscopic) |
| Light | Protect from UV light and direct sunlight (photodegradation) |
| Air (Oxygen) | Protect against oxidation; storage under inert atmosphere (nitrogen) recommended |
| Incompatible Materials | Strong oxidizing agents, strong acids, strong bases |
| Container Requirements | Light and moisture proof containers: Amber glass, aluminum containers, opaque HDPE containers |
| Shelf Life | 24 months (unopened original packaging, under proper storage conditions) |
| Shelf Life (After Opening) | 12 months (under proper storage conditions) |
| Signs of Degradation | Color change (turning dark yellow), odor change, clumping, crystallization |
| Stability Warning | Rapidly degrades when exposed to UV light in formulations without photostabilizers |
SECTION 13: PACKAGING OPTIONS
| Packaging Type | Quantity / Capacity | Material | Application Area |
|---|---|---|---|
| Aluminum Foil Bag | 1 kg, 5 kg, 10 kg, 25 kg | Aluminum / PE (light and moisture proof) | Cosmetic industry, research |
| Plastic Drum (HDPE) | 25 kg, 50 kg | HDPE (opaque, UV protected) | Industrial use, bulk supply |
| Amber Glass Jar | 100 g, 500 g, 1 kg | Amber glass (UV protected) | Pharmaceutical, laboratory |
| Metal Drum | 25 kg, 50 kg | Stainless steel / Lined steel | Industrial supply |
| IBC Container | 500 kg, 1000 kg | UV-protected HDPE | Large-scale industrial supply |
| Kraft Bag (PE Lined) | 10 kg, 25 kg | Kraft paper / PE liner | Economical packaging |
SECTION 14: TRANSPORTATION INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not applicable (not classified as dangerous substance) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| ADR/RID | Not classified as dangerous goods |
| IMDG Code | Not marine pollutant; not classified as dangerous goods |
| IATA (Air) | Not classified as dangerous goods; can be transported by air |
| Transport Temperature | Ambient temperature; keep away from heat sources |
| Transport Precautions | Transport in light-proof, moisture-protected packaging |
| Spill Cleanup | Collect mechanically; clean with absorbent material; do not let enter water or sewers |
| Marine Pollutant | No |
SECTION 15: QUALITY CONTROL AND ANALYTICAL METHODS
| Parameter | Test Method | Specification |
|---|---|---|
| Appearance | Visual | Pale yellow to light yellow powder |
| Odor | Olfactometric | Slight characteristic odor |
| Assay (Avobenzone) | HPLC / UV-VIS | ≥99.0% (Cosmetic); ≥99.5% (Pharmaceutical) |
| Melting Point | DSC / Capillary | 80 – 85°C |
| Maximum Absorption (λmax) | UV-VIS Spectrophotometer | 356 – 358 nm |
| Molar Absorptivity (ε) | UV-VIS Spectrophotometer | ≥30,000 L·mol⁻¹·cm⁻¹ (at 357 nm) |
| Particle Size | Laser Diffraction / Sieve | As per customer specification |
| Moisture Content | Karl Fischer | ≤0.5% |
| Residue on Ignition | Gravimetric | ≤0.1% |
| Heavy Metals | ICP-MS / USP <231> | Pb <10 ppm, As <2 ppm, Hg <1 ppm |
| Impurities (HPLC) | HPLC | Single impurity ≤0.5%; Total impurities ≤1.0% |
| Photostability Test | UV Irradiation / HPLC | Degradation rate over specific time (% specification) |
| Microbiological Purity | USP <61> | TAMC ≤10² CFU/g; TYMC ≤10¹ CFU/g |
SECTION 16: QUALITY SPECIFICATIONS
| Parameter | Specification (Cosmetic) | Specification (Pharmaceutical) | Test Method |
|---|---|---|---|
| Appearance | Pale yellow powder | Light yellow powder | Visual |
| Assay (HPLC) | ≥99.0% | ≥99.5% | HPLC |
| Melting Point | 80-85°C | 81-84°C | DSC / Capillary |
| λmax | 356-358 nm | 356-358 nm | UV-VIS |
| Moisture Content | ≤0.5% | ≤0.3% | Karl Fischer |
| Residue on Ignition | ≤0.1% | ≤0.1% | Gravimetric |
| Heavy Metals (Pb) | ≤10 ppm | ≤5 ppm | ICP-MS |
| Arsenic (As) | ≤2 ppm | ≤1 ppm | ICP-MS |
| Mercury (Hg) | ≤1 ppm | ≤0.5 ppm | ICP-MS |
| Single Impurity | ≤0.5% | ≤0.3% | HPLC |
| Total Impurities | ≤1.0% | ≤0.5% | HPLC |
| Microbiological Purity | TAMC ≤10² CFU/g | TAMC ≤10¹ CFU/g | USP <61> |
SECTION 17: OTHER NAMES AND SYNONYMS
| Type | Name |
|---|---|
| INCI Name | Butyl Methoxydibenzoylmethane |
| Chemical Name | 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3-dione |
| Trade Marks | Parsol 1789, Eusolex 9020, Neo Heliopan 357, Escalol 517, Uvinul 357, Solastay |
| Pharmaceutical Names | Avobenzone USP, Avobenzone EP |
| Cosmetic Names | Butyl Methoxydibenzoylmethane, BMDBM, 4-tert-Butyl-4'-methoxydibenzoylmethane |
| Common Names | Avobenzone, BMDBM |
| CAS Number | 70356-09-1 |
| EC Number | 274-581-6 |
SECTION 18: GHS CLASSIFICATION AND LABELING
| Parameter | Information |
|---|---|
| GHS Classification | Generally not classified as hazardous substance |
| Signal Word | None (not hazardous) or Warning |
| Hazard Pictograms | None (generally) |
| Hazard Statements (H-Codes) | None (generally) or: H315 (Causes skin irritation), H319 (Causes serious eye irritation) |
| Precautionary Statements (P-Codes) | P264, P280, P302+P352, P305+P351+P338, P332+P313, P337+P313, P362+P364 |
| NFPA 704 Classification | Health: 1, Flammability: 1, Reactivity: 0 |
SECTION 19: ENVIRONMENTAL IMPACT AND DISPOSAL
| Parameter | Information |
|---|---|
| Biodegradability | Limited; slowly biodegradable |
| Aquatic Toxicity (EC50) | >10 mg/L (Daphnia magna) - moderate toxicity |
| Aquatic Toxicity (LC50) | >10 mg/L (fish) - moderate toxicity |
| Soil Mobility | Moderate; adsorbs to soil due to lipophilic structure |
| Bioaccumulation Potential | Moderate (log P ~4.5) |
| Persistence | Moderate; may persist in the environment |
| Disposal Method | Dispose of in accordance with local, regional, and national regulations |
| Incineration | Controlled incineration facilities; energy recovery possible |
| Sewer Discharge | Do not discharge into sewers, water resources, or soil |
| Environmental Precautions | Prevent environmental spread during spills; collect with absorbent material |
| Ecotoxicity Note | May pose potential risk to aquatic ecosystems; should be used with care |
SECTION 20: FREQUENTLY ASKED QUESTIONS
| Question | Answer |
|---|---|
| Q1: What is Avobenzone and what does it do? | Avobenzone is an organic UV filter that absorbs UVA rays (320-400 nm). It is used in sunscreen products to provide broad-spectrum UVA protection. |
| Q2: Why does Avobenzone require a photostabilizer? | Avobenzone undergoes photodegradation when exposed to UV light alone, and its UVA protection performance decreases over time. It must be used together with stabilizers such as Octocrylene and Tinosorb S. |
| Q3: Is Avobenzone safe? | It is generally considered safe for topical use. It is approved by FDA and EU cosmetic regulations. However, it may cause sensitivity (allergy) in some individuals; photodegradation products are potential allergens. |
| Q4: In which products is Avobenzone used? | It is used in sunscreens, daily moisturizers, foundations, BB creams, lip products, children's sunscreens, and dermatological products. |
| Q5: Does Avobenzone leave a white residue on the skin? | No. Avobenzone is a chemical (organic) UV filter and does not leave a white residue like physical filters (zinc oxide, titanium dioxide). Provides transparent application. |
| Q6: What is the difference between Avobenzone and Oxybenzone? | Avobenzone provides UVA protection, while Oxybenzone provides UVB and short UVA protection. Oxybenzone receives more criticism due to endocrine disruptor potential debates. |
| Q7: Why is Avobenzone limited to 5% in sunscreens? | The EU cosmetics regulation (EC 1223/2009) sets the maximum usage rate of Avobenzone at 5%. The FDA recommends a 3% limit. These limits are based on safety assessments. |
| Q8: How should products containing Avobenzone be stored? | Store in a cool (<25°C), dry, dark place, protected from direct sunlight and UV sources. Should be stored in light-proof containers (amber glass or opaque). |
| Q9: Are Avobenzone's photodegradation products harmful? | Photodegradation products include 4-methoxybenzaldehyde and 4-tert-butylbenzaldehyde. Some may have allergenic potential. However, the use of photostabilizers significantly reduces this degradation. |
| Q10: Is Avobenzone soluble in water? | No, Avobenzone is not soluble in water. It is a lipophilic (oil-soluble) compound and is added to formulations by dissolving in the oil phase. |
SECTION 21: QUICK REFERENCE TABLE
| Property | Value |
|---|---|
| CAS Number | 70356-09-1 |
| INCI Name | Butyl Methoxydibenzoylmethane |
| Molecular Formula | C₂₀H₂₂O₃ |
| Molecular Weight | 310.4 g/mol |
| Appearance | Pale yellow crystalline powder / granules |
| Melting Point | 80 – 85°C |
| λmax (UV Absorption) | ~357 nm (UVA) |
| Water Solubility | Insoluble |
| Log P | ~4.5 (lipophilic) |
| Primary Function | UVA filter (320-400 nm) |
| Maximum Usage Rate (EU) | 5% |
| Maximum Usage Rate (FDA) | 3% (recommended) |
| Photostability | Low (alone); requires stabilizer |
| Shelf Life | 24 months (proper storage) |
| Storage | Cool (<25°C), dry, dark |
| GHS Classification | Generally not hazardous |
| Main Applications | Sunscreens, dermatological products, cosmetics |
SECTION 22: CRITICAL WARNINGS AND BEST PRACTICES
CRITICAL WARNINGS:
Photostability is critical: Avobenzone degrades rapidly under UV light when used alone. Photostabilizers (Octocrylene, Tinosorb S, Uvinul A Plus, etc.) MUST be used in formulations.
Follow maximum usage rates: Do not exceed 5% in EU, 3% (recommended) in FDA.
Store protected from light: Avobenzone is light-sensitive. Store in amber glass, aluminum, or opaque containers away from direct sunlight and UV sources.
Avoid high temperatures: Do not keep above melting point (~80-85°C) for extended periods; thermal degradation may occur.
pH optimization: Stability is better in pH 5-7 range; avoid highly acidic or basic environments.
Add antioxidants: Antioxidants such as Vitamin E (tocopherol) improve photostability and prevent oxidation.
Sensitization potential: May cause skin sensitivity (allergy) in rare cases. Patch testing should be performed for sensitive skin.
Follow regulations: Use in accordance with the cosmetic regulations of the country where the product is sold (EU, FDA, Turkey, etc.).
BEST PRACTICE RECOMMENDATIONS:
Photostabilization: Combine with Octocrylene at a 1:1 to 2:1 (Avobenzone:Octocrylene) ratio. Addition of Tinosorb S or Uvinul A Plus improves stability.
Oil Phase Addition: Dissolve Avobenzone homogeneously in the oil phase at 80-85°C. Do not add directly to the water phase.
Antioxidant Use: Add 0.1-1% Vitamin E (Tocopherol) to formulations; this improves photostability and oxidation resistance.
UV-Protected Packaging: Use amber glass, aluminum, or UV-protected opaque HDPE containers. Package under inert atmosphere (nitrogen) if possible.
pH Control: Keep formulation pH in the 5-7 range. Degradation accelerates at pH values above 7.
Chelator Use: Chelators such as EDTA bind metal ions and reduce photodegradation.
SPF Evaluation: Perform SPF and UVA-PF (PPD) tests on formulations with photostabilizers; photostability affects the stability of the protection factor over time.
Microbiological Control: Avobenzone powder should be controlled for microbiological purity (TAMC, TYMC, pathogens).
Storage: Maintain temperature control and light protection throughout shelf life. Regularly monitor storage areas.
Spill Cleanup: Do not raise dust during spills; use HEPA-filtered vacuum or wet cleaning. Prevent entry into water and sewers.
LEGAL DISCLAIMER:
The information provided in this document is based on our current knowledge and experience and is presented in good faith; however, it does not constitute a binding specification or guarantee as all conditions of use are beyond our control. This Technical Data Sheet is for informational purposes only. Users are responsible for testing suitability for their own applications. For complete safety, storage, use, handling, waste, and regulatory compliance information, please refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier.