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Ethyl Ascorbic Acid, 3-O-Ethyl Ascorbic Acid, Vitamin C Ethyl Ether, 86404-04-8

Ethyl Ascorbic Acid, 3-O-Ethyl Ascorbic Acid, Vitamin C Ethyl Ether, 86404-04-8

3-O-ETHYL ASCORBIC ACID

1. PRODUCT IDENTIFICATION

Parameter Information
Product Name 3-O-Ethyl Ascorbic Acid
CAS Number 86404-04-8
Chemical Definition Stable Vitamin C derivative
Other Names Ethyl Ascorbic Acid, 3-Ethyl Ascorbic Acid, Vitamin C Ethyl Ether
Molecular Formula C₈H₁₂O₆
Molecular Weight 204.18 g/mol
Appearance White to off-white powder

2. PHYSICAL AND CHEMICAL PROPERTIES

Property Value
Appearance White to off-white powder
Color White to slightly yellowish
Odor Odorless or characteristic slight odor
Purity ≥ 98%
Solubility in Water Soluble
Solubility in Glycol-based Solutions Soluble
Solubility in Oil Slightly soluble
pH (1% Solution) ~5.0 – 7.0
Stability Resistant to light, heat, and oxidation
Melting Point ~110 – 118 °C

3. CHEMICAL STRUCTURE

Chemical Structure:

        O
        ||
    HO — C — C — C — C — C — OH
         |   |   |   |
        OH  OH  H   OCH₂CH₃

IUPAC Name: (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-5-hydroxy-2H-furan-3-one

Chemical Class: Vitamin C derivative (ascorbic acid ether)

4. FUNCTIONAL PROPERTIES

Property Description
Stability More stable than L-ascorbic acid; resistant to light, heat, and oxidation
Skin Penetration Excellent skin penetration ability
Antioxidant Activity Strong free radical scavenging activity
Tyrosinase Inhibition Inhibits melanin synthesis
Collagen Synthesis Stimulates collagen production
Non-irritating Gentle on skin; suitable for sensitive skin

5. APPLICATIONS

5.1. Skincare and Cosmetics

Application Description
Skin Brightening Suppresses melanin synthesis; helps reduce dark spots and hyperpigmentation
Anti-Aging Neutralizes free radicals; delays skin aging
Collagen Synthesis Improves skin elasticity; reduces wrinkles
Serums Widely used in vitamin C serums
Creams and Lotions Used in moisturizing and anti-aging creams
Sunscreen Products Boosts UV protection and antioxidant defense
Eye Creams Reduces dark circles and fine lines

5.2. Recommended Usage Levels

Application Recommended Concentration
Serums 1 – 5%
Creams 0.5 – 3%
Lotions 0.5 – 2%
Sunscreens 0.5 – 2%
Eye Care Products 0.5 – 2%

6. ADVANTAGES OVER L-ASCORBIC ACID

Property 3-O-Ethyl Ascorbic Acid L-Ascorbic Acid (Vitamin C)
Stability High Low (oxidizes quickly)
Light Sensitivity Resistant Sensitive
Heat Sensitivity Resistant Sensitive
Skin Irritation Low Moderate
Skin Penetration Excellent Moderate
pH Requirement Works at neutral pH Requires acidic pH (< 3.5)
Formulation Flexibility High Limited

7. STORAGE AND STABILITY

Parameter Information
Storage Conditions Cool, dry, dark place
Recommended Temperature 2 – 8 °C (refrigerated)
Container Requirements Tightly closed, light-protected packaging
Protect From Light, heat, moisture, strong oxidizing agents
Shelf Life 24 months (in unopened packaging)
In-use Stability Should be used within 6 months after opening

8. SAFETY AND HEALTH INFORMATION

Parameter Information
Toxicity Low toxicity
Skin Contact Non-irritating (may cause sensitivity at high concentrations)
Eye Contact Avoid contact with eyes
Inhalation Avoid inhalation of dust
Ingestion Not for internal use
Carcinogenicity Not classified as carcinogenic
Mutagenicity Negative
Sensitization May cause sensitivity in some individuals (at high concentrations)

8.1. FIRST AID MEASURES

Route of Exposure Action
Skin Contact Wash with plenty of soap and water. If irritation persists, seek medical attention.
Eye Contact Rinse thoroughly with water for at least 15 minutes. Seek medical attention.
Inhalation Remove to fresh air. If respiratory irritation, seek medical attention.
Ingestion Rinse mouth. Seek medical attention.

9. HANDLING AND STORAGE RECOMMENDATIONS

Parameter Information
Handling Precautions Use in well-ventilated area. Avoid dust formation.
Personal Protective Equipment Gloves, safety goggles, dust mask (if handling powder)
Storage Area Cool, dry, dark, well-ventilated area
Incompatibilities Strong oxidizing agents, strong acids, strong bases

10. REGULATORY STATUS

Region / Authority Status
European Union (REACH) Registered substance
USA (FDA) Approved for cosmetic use
China Approved for cosmetic use
Korea Approved for cosmetic use
Japan Approved for cosmetic use

11. PACKAGING OPTIONS

Packaging Type Quantity Material
Aluminum Foil Bag 100 g – 1 kg Laminated aluminum
Plastic Bottle 100 g – 500 g HDPE
Plastic Bucket 1 – 5 kg HDPE
Fiber Drum 10 – 25 kg Fiberboard

12. OTHER NAMES AND SYNONYMS

Type Name
Turkish Names 3-O-Etil Askorbik Asit, Etil Askorbik Asit
English Names 3-O-Ethyl Ascorbic Acid, Ethyl Ascorbic Acid, Vitamin C Ethyl Ether
CAS Number 86404-04-8

13. SUMMARY AND CRITICAL WARNINGS

Parameter Value
Product 3-O-Ethyl Ascorbic Acid
CAS Number 86404-04-8
Purity ≥ 98%
Appearance White to off-white powder
Solubility Soluble in water and glycols
Primary Applications Skin brightening, anti-aging, collagen synthesis

CRITICAL WARNINGS

1. STABILITY: 3-O-Ethyl Ascorbic Acid is a stable vitamin C derivative. Unlike L-ascorbic acid, it does not oxidize quickly. However, it should still be stored in a cool, dark place.

2. REFRIGERATION: Recommended storage temperature is 2-8°C. Refrigeration is recommended for long-term storage.

3. SENSITIVITY: While generally non-irritating, high concentrations (>5%) may cause skin sensitivity in some individuals. Patch test recommended.

4. FORMULATION pH: Effective at neutral pH (5.0-7.0), unlike L-ascorbic acid which requires acidic pH.

**5. PENETRATION ENHANCEMENT: The ethoxy group improves skin penetration, making it more effective at lower concentrations.

**6. SYNERGY: Works well with other antioxidants (Vitamin E, ferulic acid) for enhanced protection.

**7. SHELF LIFE: 24 months in unopened packaging. Use within 6 months after opening.

**8. AVOID CONTAMINATION: Do not introduce moisture or contaminants into the container. Use a clean, dry spatula.

9. NOT FOR INTERNAL USE: For external (cosmetic) use only. Not intended for oral consumption.

10. MSDS: Refer to Safety Data Sheet (SDS) for complete safety information.

IMPORTANT DISCLAIMER: This Technical Data Sheet (TDS) is for informational purposes only and is prepared based on available technical data. The user is responsible for determining the suitability of the product for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, use, handling, disposal, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. This document is not a substitute for professional or medical advice.

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