Methylsulfonylmethane, Methyl Sulfone, Dimethyl Sulfone, MSM, 67-71-0

METHYLSULFONYLMETHANE (MSM)

PRODUCT IDENTIFICATION INFORMATION

CHEMICAL STRUCTURE

    Methylsulfonylmethane (MSM)
    
         O
         ||
    CH₃ — S — CH₃
         ||
         O

    Dimethyl Sulfone
    (CH₃)₂SO₂

Molecular Formula: C₂H₆O₂S
SMILES: CS(=O)(=O)C
InChI: InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
Functional Groups: Sulfone group (SO₂)
Structure: Organic sulfur compound; Dimethyl sulfone

SECTION 1: CHEMICAL IDENTITY AND DEFINITION

SECTION 2: PHYSICAL AND CHEMICAL PROPERTIES

SECTION 3: CHEMICAL PROPERTIES AND REACTIVITY

SECTION 4: COMPARISON OF SULFUR COMPOUNDS

SECTION 5: PRODUCTION METHODS

Method 1: Oxidation of Dimethyl Sulfoxide (DMSO) (Most Common Method)

• Reaction: (CH₃)₂SO + [O] → (CH₃)₂SO₂

• Description: Dimethyl sulfoxide is oxidized with hydrogen peroxide or other oxidizing agents; MSM is formed; Purification and crystallization yield the product; Most common industrial production method

Method 2: Oxidation of Dimethyl Sulfide

• Reaction: (CH₃)₂S + 2[O] → (CH₃)₂SO₂

• Description: Dimethyl sulfide is oxidized with oxidizing agents; MSM is formed; Purification yields the product

Method 3: Extraction from Natural Sources

• Process: Plant sources → Extraction → Purification → MSM

• Description: MSM naturally present in some plants is obtained by extraction; Limited quantities

Method 4: Reaction of Methane with Sulfuric Acid (Industrial)

• Process: Methane + Sulfuric acid → MSM (at high temperature)

• Description: Methane gas is reacted with sulfuric acid; MSM is formed; Large-scale production

SECTION 6: FUNCTIONAL PROPERTIES AND MECHANISM OF ACTION

SECTION 7: MAIN APPLICATION AREAS

SECTION 8: QUALITY SPECIFICATIONS (PURITY GRADE)

SECTION 9: TOXICOLOGICAL PROFILE

SECTION 10: GHS CLASSIFICATION AND LABELING

GHS Classification (Compliant with CLP and UN GHS):

Note: MSM generally has a low hazard classification and is not classified as hazardous in most regions.

Signal Word: No signal word required (non-hazardous) or WARNING (optional)

Hazard Pictograms: GHS07 (optional)

Hazard Statements (H-Codes) - if classified:

SECTION 11: PRECAUTIONARY STATEMENTS (P-CODES)

SECTION 12: FIRST AID MEASURES

SECTION 13: FIREFIGHTING MEASURES

SECTION 14: STORAGE AND SHELF LIFE

SECTION 15: PACKAGING OPTIONS

SECTION 16: TRANSPORT INFORMATION

SECTION 17: REGULATORY STATUS

SECTION 18: OTHER NAMES AND SYNONYMS

SECTION 19: SUMMARY TABLE

SECTION 20: CRITICAL WARNINGS AND BEST PRACTICES

CRITICAL WARNINGS:

• Low toxicity compound. Considered safe for most applications.

• Slightly hygroscopic. Protect from moisture.

• Non-combustible but decomposes at high temperatures releasing toxic sulfur oxide fumes.

• High doses may cause stomach discomfort. Use at recommended dosages.

• For food and supplement use, purity grade (food grade) must be used.

• Keep away from strong oxidizing agents.

• Storage temperature: Store below +30°C.

• GRAS (Generally Recognized as Safe) approved by FDA.

• Supplement dosage: Typically 500-3,000 mg per day.

BEST PRACTICE RECOMMENDATIONS:

• Dietary Supplements: Use as sulfur source for joint health; Reduces osteoarthritis and rheumatoid arthritis symptoms; Used in sports supplements; Supports collagen and glucosamine synthesis.

• Skin and Hair Health: Supports keratin and collagen synthesis; Improves hair, nail, and skin health; Used as active ingredient in cosmetic products.

• Organic Synthesis: Use as intermediate in chemical synthesis; As reagent in sulfonation reactions; Use analytical grade for high-purity applications.

• Handling: Use in well-ventilated areas; Avoid dust generation; Wear protective gloves and safety goggles when handling powder.

• Personal Protective Equipment: Safety goggles, protective clothing (dust-resistant), dust mask, protective gloves (nitrile, neoprene).

• Hygiene: Wash hands thoroughly after handling; Do not eat, drink, or smoke when using.

• Storage: Store in tightly closed, properly labeled containers in dry conditions; Store below +30°C; Keep away from oxidizing agents; Moisture-proof containers recommended.

• Spill Response: Avoid dust generation; Vacuum or wet-sweep; Place in closed containers for disposal.

• Disposal: Dispose of in accordance with local, regional, and national regulations; MSM is considered non-hazardous waste.

SPECIAL NOTE ON SUPPLEMENT USE:

MSM is widely used as a dietary supplement:

• Recommended Dosage: 500-3,000 mg per day

• Duration: Effects typically begin after 2-4 weeks

• Combination: Synergistic effect with glucosamine and chondroitin

• Side Effects: Stomach discomfort at high doses; Rarely headache and fatigue

• Safety: Considered safe for long-term use

MSM vs DMSO COMPARISON:

LEGAL DISCLAIMER:

The information provided in this document is based on our current knowledge and experience and is presented in good faith. However, as all conditions of use are beyond our control, this document does not constitute a binding specification or warranty. This Technical Data Sheet is for informational purposes only. Users are responsible for testing suitability for their own applications. For complete safety, storage, handling, transportation, waste, and regulatory compliance information, please refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier.