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Send EmailCopper Gluconate, Copper D-gluconate, Cupric Gluconate, E580, 527-09-3
COPPER GLUCONATE
1. PRODUCT IDENTIFICATION
| Attribute | Description |
|---|---|
| Chemical Name | Copper(II) Gluconate |
| Synonyms | Copper D-gluconate, Cupric Gluconate |
| CAS Number | 527-09-3 |
| EINECS Number | 208-408-2 |
| Molecular Formula | C₁₂H₂₂CuO₁₄ (Anhydrous basis) |
| Molecular Weight | 453.84 g/mol |
| Food Additive Code (EU) | E 580 |
| Appearance / Physical State | Fine, slightly hygroscopic, blue or blue-green crystalline powder. |
| Odor | Odorless. |
| Taste | Slightly metallic, characteristic taste. |
2. PHYSICAL AND CHEMICAL PROPERTIES
| Parameter | Value / Range |
|---|---|
| Solubility (Water, 25°C) | Approx. 30 g/100 mL (Freely soluble) |
| Solubility (Ethanol) | Insoluble |
| Solubility (Ether, Acetone) | Practically insoluble |
| pH Value (5% Solution) | 6.0 – 7.5 |
| Melting Point / Decomposition | 155°C – 157°C (Decomposes on melting) |
| Specific Optical Rotation [α]²⁰/D | +5.0° to +9.0° (C=1, in water) |
| Bulk Density | Approx. 0.8 - 1.2 g/cm³ |
| Loss on Drying | ≤ 3.0% |
3. SPECIFICATIONS (Food and Pharmaceutical Grade)
| Analytical Parameter | Specification Limit (Typical) |
|---|---|
| Copper Content (Cu, Dried Basis) | 12.5% – 14.0% w/w |
| Appearance of Solution | Clear, free from suspended matter |
| Chloride (Cl) | ≤ 700 ppm (mg/kg) |
| Sulfate (SO₄) | ≤ 500 ppm (mg/kg) |
| Heavy Metals (as Lead Pb) | ≤ 10 ppm (mg/kg) |
| Arsenic (As) | ≤ 3 ppm (mg/kg) |
| Lead (Pb) | ≤ 2 ppm (mg/kg) |
| Cadmium (Cd) | ≤ 1 ppm (mg/kg) |
| Mercury (Hg) | ≤ 1 ppm (mg/kg) |
| Reducing Substances | ≤ 1.0% (as Dextrose) |
| Microbiological Quality | |
| Total Aerobic Microbial Count | ≤ 1000 CFU/g |
| Total Yeast and Mold Count | ≤ 100 CFU/g |
| Escherichia coli | Absent in 10 g |
| Salmonella spp. | Absent in 10 g |
4. STABILITY AND STORAGE CONDITIONS
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Stability: Stable under normal conditions. Hygroscopic nature may cause caking upon exposure to air/moisture.
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Incompatible Materials: Strong oxidizing agents, strong acids, and bases.
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Storage Temperature: Ambient temperature (15-25°C).
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Protection: Keep container tightly closed in a cool, dry, and well-ventilated area. Protect from direct sunlight and moisture.
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Shelf Life: Typically 2 years from the date of manufacture under recommended storage conditions.
5. APPLICATIONS AND USAGE
| Industry | Application Details |
|---|---|
| Food & Dietary Supplements | Trace Mineral Source (E 580): Highly bioavailable organic copper salt used to address copper deficiency. Formulated in multivitamin tablets, capsules, liquid minerals, and functional beverages. Often paired with Zinc supplements. |
| Pharmaceutical & Medical Use | Parenteral Nutrition: Added to Total Parenteral Nutrition (TPN) solutions to meet trace element requirements in patients. Dermatology: Used in topical creams and lotions for skin conditioning and mild antiseptic properties. |
| Agriculture & Animal Feed | Feed Additive: Source of copper mineral for poultry, swine, and ruminant diets. Foliar Fertilizer: Used as a chelated copper source for rapid correction of copper deficiencies in plants via foliar spray. |
| Cosmetics & Personal Care | Used in skincare formulations (particularly anti-aging and anti-acne serums) and oral care products. |
6. SAFETY AND TOXICOLOGICAL INFORMATION
| Parameter | Data / Description |
|---|---|
| Acute Toxicity (Oral, LD50) | Rat: > 2000 mg/kg body weight Mouse: Approx. 419 mg/kg (Literature values may vary). |
| Irritation / Sensitization | Skin: Not classified as irritant or sensitizer based on available data. Eyes: Dust may cause mechanical irritation. |
| Target Organ Toxicity | Liver: Chronic high-dose intake may lead to hepatic copper accumulation and hepatocellular damage. |
| Safety Warnings | Overdose Symptoms: Nausea, vomiting, epigastric pain, diarrhea, metallic taste. Interaction: High copper intake may impair Zinc absorption. |
| Precautionary Statements | P260: Do not breathe dust. P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. |
7. PACKAGING INFORMATION
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Standard Packaging:
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1 kg, 5 kg, or 10 kg Aluminum foil laminated PE bags.
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25 kg Kraft paper bags or food-grade fiber drums.
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Custom packaging options available upon request.
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DISCLAIMER: The information provided in this Technical Data Sheet is based on current knowledge and experience and is intended for general product description purposes only. It is the user's responsibility to conduct their own tests to determine suitability for a specific application and compliance with final product specifications. The information provided does not constitute a legally binding specification or warranty.
INDUSTRY APPLICABILITY TABLE
| Industry | Purpose / Application | Regulatory / Standard Reference |
|---|---|---|
| Food & Dietary Supplements | Trace mineral source, fortification agent. Multivitamins, mineral premixes, sports drinks. | Turkish Food Codex (E 580), FCC (Food Chemicals Codex), USP |
| Pharmaceutical & Medical | Parenteral nutrition solutions (TPN), oral copper deficiency treatment, topical dermatological preparations. | USP, EP (European Pharmacopoeia), BP |
| Animal Feed & Veterinary | Growth promoter and immune support trace element additive in premixes and complete feed. | EU Feed Additives Regulation (3b409), FDA 21 CFR 582.5260 |
| Cosmetics & Personal Care | Skin care products (anti-aging serums), hair care products, deodorants, oral care products. | Cosmetics Regulation (INCI Name: Copper Gluconate) |
| Agriculture & Fertilizer | Chelated micronutrient. Foliar fertilizer, drip irrigation fertilizer, seed coating. | Fertilizer Regulations (Chelated Trace Element) |
| Industrial Applications | Passivation in metal surface treatment, additive in certain paint pigments, odorless algicide formulations. | Relevant industrial purity standards |
USAGE DOSAGE RECIPES (TYPICAL INCLUSION RATES)
The values below represent typical application rates. Adjustments based on final product specifications and local legal regulations are mandatory.
| Application Area | Detailed Description | Typical Usage Amount |
|---|---|---|
| Human Dietary Supplements | Daily oral intake via tablets, capsules, or liquid forms. | Adults: 0.5 mg - 2.0 mg Copper / Day *(For Copper Gluconate at 14% purity, this corresponds to approx. 3.5 mg - 14 mg of powder.)* Tolerable Upper Intake Level (UL): 10 mg/day (US Institute of Medicine) |
| Parenteral Nutrition (TPN) | Amount added to intravenous nutrition solutions. | Adults: 0.3 mg - 0.5 mg Copper / Day Pediatric: 20 mcg Copper / kg / Day |
| Animal Feed (Complete Feed) | Amount of pure Copper added per metric ton of complete feed in feed mills. | Poultry (Broiler): 8 - 25 g/ton Swine (Growing): 6 - 170 g/ton (Therapeutic doses are higher) Cattle (Beef): 10 - 35 g/ton |
| Agriculture (Foliar Spray) | Amount of Copper Gluconate mixed per 100 Liters of water. | Deficiency Correction: 50 - 150 g / 100 L water Preventive Application: 20 - 50 g / 100 L water |
| Cosmetic Products | Concentration in the final product formulation. | Face Cream / Serum: 0.05% - 0.5% (w/w) Deodorant / Foot Care: 0.2% - 1.0% (w/w) |
ALTERNATIVE NAMES AND IDENTIFIERS
Copper Gluconate may be referred to by the following names depending on the context and regulation:
| Category | Name / Identifier |
|---|---|
| Systematic Chemical Name | Bis(D-gluconato-κO1,κO2)copper |
| International Synonyms | Copper Gluconate, Cupric Gluconate, Copper(II) D-gluconate |
| Food Additive Code (EU) | E 580 |
| Cosmetic INCI Name | COPPER GLUCONATE |
| Animal Feed Category | Trace Element Compounds - Copper (3b409) |
| Pharmacopoeial Names | Cupri Gluconas (Latin), Copper Gluconate USP |
| CAS Number | 527-09-3 |
| EC / EINECS Number | 208-408-2 |
| UNII (FDA Unique Ingredient Identifier) | RV823G6G67 |
| DSSTox (EPA) Substance ID | DTXSID6034494 |
| Common Trade Chelate Class | Copper Gluconate Complex / Copper Chelate |
