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Zinc Acetate, Zinc Diacetate, 557‑34‑6

Zinc Acetate, Zinc Diacetate, 557‑34‑6

ZINC ACETATE (ZINC DIACETATE)

PRODUCT IDENTIFICATION INFORMATION

Parameter Information
Product Name Zinc Acetate
Chemical Name Zinc Acetate (Zinc Diacetate)
Synonyms (Turkish) Çinko Asetat, Çinko Diasetat, Asetik Asit Çinko Tuzu
Synonyms (English) Zinc Acetate, Zinc Diacetate, Acetic Acid Zinc Salt, Zinc(II) Acetate, Dicarbomethoxyzinc
CAS Number 557-34-6
EC Number 209-170-2
Molecular Formula Zn(CH₃COO)₂ (Anhydrous) / Zn(CH₃COO)₂·2H₂O (Dihydrate)
Molecular Weight 183.48 g/mol (Anhydrous) / 219.51 g/mol (Dihydrate)
Appearance White crystalline powder (may appear yellowish or grayish-green in some commercial forms)
Odor Slight acetic acid odor

CHEMICAL STRUCTURE

Zinc Acetate Structure:

        O     O
        ||    ||
    CH₃—C—O—Zn—O—C—CH₃

Structure Description:

  • Zinc salt of acetic acid.

  • White crystalline powder (anhydrous and dihydrate forms).

  • Water-soluble; soluble in alcohol and dilute acids.

  • Hygroscopic (absorbs moisture from air).

  • Weakly acidic salt (pKa ~4.76).

  • Stable under normal conditions; reacts with strong oxidizing agents.

SECTION 1: CHEMICAL IDENTITY AND DESCRIPTION

Parameter Information
Product Name Zinc Acetate
Chemical Name Zinc Acetate (Zinc Diacetate)
Synonyms (Turkish) Çinko Asetat, Çinko Diasetat, Asetik Asit Çinko Tuzu
Synonyms (English) Zinc Acetate, Zinc Diacetate, Acetic Acid Zinc Salt, Zinc(II) Acetate, Dicarbomethoxyzinc
CAS Number 557-34-6
EC Number 209-170-2
Molecular Formula Zn(CH₃COO)₂ (Anhydrous) / Zn(CH₃COO)₂·2H₂O (Dihydrate)
Molecular Weight 183.48 g/mol (Anhydrous) / 219.51 g/mol (Dihydrate)
Chemical Class Organic salt; Acetate; Zinc compound
Source Synthetic (reaction of zinc oxide or zinc carbonate with acetic acid)
Physical State (20°C) Solid (crystalline powder)
Odor Slight acetic acid odor
Color White (may appear yellowish or grayish-green in some commercial forms)

SECTION 2: PHYSICAL AND CHEMICAL PROPERTIES

Property Value Test Method / Note
Appearance White crystalline powder Visual
Odor Slight acetic acid odor Olfactometric
Molecular Weight 183.48 g/mol (Anhydrous); 219.51 g/mol (Dihydrate) Calculated
Density (25°C) ~1.84 g/cm³ ASTM D4052
Melting Point 83 – 86°C (Dihydrate); 237°C (Anhydrous, decomposes) DSC
Boiling Point ~908°C (decomposes)
Solubility in Water Soluble General Method
Solubility in Alcohol Soluble General Method
Solubility in Dilute Acids Soluble General Method
pH (1% Solution) ~6.0 – 7.0 (neutral to slightly acidic) pH Meter
pKa ~4.76 (acetic acid)
Hygroscopicity Hygroscopic (absorbs moisture)
Stability Stable under normal conditions; Reacts with strong oxidizing agents
Zinc Content ~35.6% (Anhydrous); ~29.8% (Dihydrate) AAS / ICP
Loss on Drying ≤ 2.0% (Anhydrous); 15.0 – 17.0% (Dihydrate) Gravimetric
Heavy Metals (as Pb) ≤ 10 ppm AAS / ICP
Arsenic (As) ≤ 2 ppm AAS / ICP
Lead (Pb) ≤ 2 ppm AAS / ICP
Iron (Fe) ≤ 10 ppm AAS / ICP
Assay (Zn(CH₃COO)₂) ≥ 98.0 – 99.5% (grade dependent) Titrimetric / ICP

SECTION 3: ZINC ACETATE vs OTHER ZINC COMPOUNDS

Property Zinc Acetate (Zn(CH₃COO)₂) Zinc Sulfate (ZnSO₄) Zinc Oxide (ZnO) Zinc Chloride (ZnCl₂) Zinc Gluconate (ZnC₁₂H₂₂O₁₄)
CAS Number 557-34-6 7733-02-0 1314-13-2 7646-85-7 4468-02-4
Molecular Weight 183.48 g/mol 161.47 g/mol 81.38 g/mol 136.30 g/mol 455.69 g/mol
Zinc Content ~35.6% ~40.5% ~80.3% ~48.0% ~14.3%
Solubility in Water Soluble High Insoluble High Soluble
pH (1% Solution) 6.0-7.0 5.0-6.5 ~7.0-8.0 4.0-5.0 ~6.0-7.0
Taste Astringent Bitter Tasteless Bitter Sweetish
Primary Use Pharmaceutical, food Fertilizer, medicine Rubber, ceramics Flux, disinfectant Dietary supplement
GRAS Status Yes (FDA) Yes (limited) Yes No Yes
Cost Moderate Low Moderate Low High

SECTION 4: MECHANISM OF ACTION

Property Description
Zinc Supplementation Provides bioavailable zinc (Zn²⁺) for nutritional purposes; Essential for immune function, wound healing, and enzyme activity; Used to treat zinc deficiency and Wilson's disease.
Antimicrobial Action Zinc ions (Zn²⁺) exhibit antimicrobial properties; Disrupts bacterial cell membranes; Inhibits bacterial growth; Used in topical formulations and mouthwashes.
Astringent Effect Zinc ions precipitate proteins on mucosal surfaces; Creates a protective film; Reduces inflammation and irritation; Used in lozenges for sore throat.
Enzyme Cofactor Zinc is an essential cofactor for many enzymes; Supports immune function and cellular metabolism; Plays a role in DNA synthesis and protein synthesis.
Wilson's Disease Treatment Chelates copper ions; Promotes copper excretion; Reduces copper accumulation in tissues; Used as a maintenance therapy.
Catalysis Acts as a catalyst in organic reactions; Used in esterification and polymerization reactions; Lewis acid catalyst.

SECTION 5: PRODUCTION PROCESS

Industrial Production Methods:

Method 1: Reaction of Zinc Oxide with Acetic Acid

Reaction: ZnO + 2CH₃COOH → Zn(CH₃COO)₂ + H₂O

Process Flow:
Zinc Oxide (ZnO) + Acetic Acid (CH₃COOH) → Reaction (Heat) → Zinc Acetate Solution → Filtration → Crystallization → Centrifugation → Drying → Milling → Final Product

Description: Zinc oxide is reacted with acetic acid in aqueous solution with heating. The zinc acetate solution is filtered, crystallized, dried, and milled to obtain the final product.

Method 2: Reaction of Zinc Carbonate with Acetic Acid

Reaction: ZnCO₃ + 2CH₃COOH → Zn(CH₃COO)₂ + CO₂ + H₂O

Description: Zinc carbonate is reacted with acetic acid. Carbon dioxide gas is released. The zinc acetate solution is processed to obtain the final product.

Method 3: Reaction of Zinc Metal with Acetic Acid

Reaction: Zn + 2CH₃COOH → Zn(CH₃COO)₂ + H₂

Description: Zinc metal is reacted with acetic acid. Hydrogen gas is released. The zinc acetate solution is processed to obtain the final product.

SECTION 6: FUNCTIONAL PROPERTIES

Property Description
Zinc Source Provides bioavailable zinc for nutritional and pharmaceutical applications; Used in dietary supplements; Used in zinc fortification of foods.
Antimicrobial Exhibits antimicrobial activity; Used in topical creams and ointments; Used in mouthwashes and dental products; Effective against bacteria and fungi.
Astringent Precipitates proteins on mucosal surfaces; Reduces inflammation; Used in throat lozenges; Used in skin care products.
Catalyst Acts as a catalyst in organic reactions; Lewis acid catalyst; Used in polymerization; Used in esterification reactions.
Copper Chelator Chelates copper ions; Used in Wilson's disease treatment; Promotes copper excretion; Reduces copper toxicity.
Food Additive (E650) Used as a flavor enhancer; Approved as food additive E650; Used in certain food products.

SECTION 7: MAIN APPLICATION AREAS

Industry / Application Function Typical Use
Pharmaceutical Zinc supplement, Wilson's disease treatment Zinc deficiency treatment; Wilson's disease maintenance therapy; Dosage: 25-150 mg/day (as elemental zinc); Oral capsules, tablets, lozenges.
Dietary Supplements Zinc source, mineral supplement Multivitamin/mineral formulations; Zinc-only supplements; Immune support products; Dosage: 10-50 mg/day (as elemental zinc).
Food Industry (E650) Flavor enhancer, nutrient fortifier Food additive E650; Zinc fortification of foods; Flavor enhancer; Dosage: As per regulatory limits.
Cosmetics & Personal Care Antimicrobial, astringent Mouthwashes; Toothpaste (antimicrobial); Throat lozenges (astringent); Topical creams; Skin care products; Dosage: 0.1-2%.
Textile Industry Dyeing aid, mordant Textile dyeing and printing; Mordant (color fixative); Limited use; Dosage: 1-5% of dye bath.
Chemical Industry Catalyst, reagent Polymer synthesis; Esterification reactions; Laboratory reagent; Organic synthesis; Catalytic applications.
Animal Nutrition Zinc source Animal feed formulations; Zinc supplementation in livestock and poultry; Dosage: 50-200 ppm.
Industrial Applications Intermediate, catalyst Polymer synthesis; Chemical processes; Coatings and adhesives; Dosage: Process specific.

SECTION 8: SAMPLE FORMULATIONS

Zinc Supplement Capsule (25 mg Elemental Zinc):

Component Amount per Capsule
Zinc Acetate Dihydrate ~70 mg (equivalent to 25 mg Zn)
Microcrystalline Cellulose As required
Magnesium Stearate 1 – 2%
Silicon Dioxide 0.5 – 1%

Instructions: Blend zinc acetate with excipients; Fill into capsules (size 0 or 00); Package in blister packs or HDPE containers; Recommended dosage: 1-2 capsules daily.

Throat Lozenges (Sore Throat Relief):

Component Amount
Zinc Acetate 5 – 15 mg
Sugar or Sweetener As required
Flavoring (Mint, Honey) As required
Binders, Lubricants As required
Base (Starch, Gum) To 100%

Instructions: Blend all ingredients; Compress into lozenges; Package in moisture-proof packaging; Recommended: dissolve slowly in mouth.

SECTION 9: QUALITY SPECIFICATIONS

Parameter Pharmaceutical Grade Food Grade (E650) Technical Grade Analytical Grade Test Method
Appearance White crystalline powder White crystalline powder White to off-white powder White crystalline powder Visual
Assay (Zn(CH₃COO)₂·2H₂O) ≥ 99.5% ≥ 98.0% ≥ 97.0% ≥ 99.5% Titrimetric / ICP
Zinc Content ~29.8% ~29.5% ~29.0% ~29.8% AAS / ICP
Loss on Drying 15.0 – 17.0% 15.0 – 17.0% ≤ 18.0% 15.0 – 17.0% Gravimetric
pH (1% Solution) 6.0 – 7.0 6.0 – 7.0 6.0 – 7.0 6.0 – 7.0 pH Meter
Heavy Metals (as Pb) ≤ 5 ppm ≤ 10 ppm ≤ 5 ppm AAS / ICP
Arsenic (As) ≤ 1 ppm ≤ 2 ppm ≤ 1 ppm AAS / ICP
Lead (Pb) ≤ 1 ppm ≤ 2 ppm ≤ 1 ppm AAS / ICP
Iron (Fe) ≤ 5 ppm ≤ 10 ppm ≤ 5 ppm AAS / ICP
Chloride (Cl) ≤ 0.01% ≤ 0.02% ≤ 0.05% ≤ 0.01% Titrimetric
Sulfate (SO₄) ≤ 0.01% ≤ 0.02% ≤ 0.05% ≤ 0.01% Gravimetric

SECTION 10: TOXICOLOGICAL PROFILE

Parameter Value
Acute Oral Toxicity (LD50, Rat) ~ 1,500 – 2,500 mg/kg (moderate toxicity)
Acute Dermal Toxicity Low toxicity; May cause mild irritation
Skin Irritation May cause irritation (H315)
Eye Irritation May cause serious eye irritation (H319)
Inhalation Toxicity May cause respiratory irritation (dust)
Chronic Toxicity No significant adverse effects at normal use levels; High doses may cause gastrointestinal discomfort
Carcinogenicity Not classified as carcinogenic
Mutagenicity Not mutagenic
Reproductive Toxicity No reproductive toxicity at normal levels
Allergenicity Low allergenicity
Environmental Toxicity May be harmful to aquatic life at high concentrations
Special Toxicity Note GRAS (Generally Recognized as Safe) by FDA for specific uses; Safe at normal use levels; Excessive intake may cause gastrointestinal irritation; Use appropriate PPE; Avoid inhalation of dust.

SECTION 11: GHS CLASSIFICATION AND LABELING

GHS Classification (in accordance with CLP and UN GHS):

Hazard Class Category H-Statement
Skin Irritation Category 2 H315
Eye Irritation Category 2 H319
Specific Target Organ Toxicity (Single) Category 3 H335

Signal Word: WARNING

Hazard Pictograms: GHS07 (Exclamation Mark)

Hazard Statements (H-Codes):

Code Statement
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

NFPA 704 Hazard Classification:

Health Flammability Reactivity Special
1 0 0 -
(Slight health hazard) (Non-flammable) (Stable) (None)

SECTION 12: PRECAUTIONARY STATEMENTS (P-CODES)

Code Statement
P264 Wash hands thoroughly after handling
P271 Use only outdoors or in a well-ventilated area
P280 Wear protective gloves/protective clothing/eye protection/face protection
P302+P352 IF ON SKIN: Wash with plenty of soap and water
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and continue rinsing
P332+P313 If skin irritation occurs: Get medical advice/attention
P337+P313 If eye irritation persists: Get medical advice/attention
P362+P364 Take off contaminated clothing and wash it before reuse
P403+P233 Store in a well-ventilated place. Keep container tightly closed
P501 Dispose of contents/container in accordance with local/regional/national/international regulations

SECTION 13: FIRST AID MEASURES

Exposure Route Action to Take
Inhalation Remove to fresh air immediately. If respiratory irritation develops, seek medical attention.
Skin Contact Wash with plenty of soap and water. Remove contaminated clothing. If irritation persists, get medical attention.
Eye Contact Rinse immediately with plenty of water for at least 15 minutes. Keep eyelids open. Remove contact lenses if present. If irritation persists, seek medical attention.
Ingestion Rinse mouth. Drink plenty of water. Seek medical attention if large quantities are ingested or if feeling unwell.

SECTION 14: FIREFIGHTING MEASURES

Parameter Information
Fire Hazard Non-flammable organic material. May burn with thick smoke at high temperatures.
Hazards Arising from Fire Thermal decomposition produces carbon monoxide, carbon dioxide, and zinc oxide fumes.
Suitable Extinguishing Media Water spray, CO₂, dry chemical powder, foam.
Unsuitable Extinguishing Media Water jet (may spread dust)
Special Protective Equipment Self-contained breathing apparatus (SCBA), full protective clothing.
Special Precautions Prevent dust from entering sewers and waterways. Avoid dust cloud formation.

SECTION 15: STORAGE AND SHELF LIFE

Parameter Information
Storage Conditions Store in a cool, dry, well-ventilated area; PROTECT FROM MOISTURE and LIGHT; Keep away from direct sunlight and high temperatures.
Container Requirements Tightly closed, moisture-proof containers (PE-lined bags, HDPE containers, aluminum foil bags).
Materials to Protect From Moisture, heat, light, strong oxidizing agents
Shelf Life 24 – 36 months (in unopened original packaging, under proper storage conditions).
Stability Note Stable under recommended storage conditions; Hygroscopic (absorbs moisture); May cake if exposed to high humidity.
Special Storage Requirements Store in a dry, cool place; Avoid exposure to air and moisture; Opened containers must be resealed immediately.

SECTION 16: PACKAGING OPTIONS

Packaging Type Quantity Material
Aluminum Foil Bag 100 g, 500 g, 1 kg, 5 kg Aluminum foil laminated bag (moisture and light-proof)
PE-Lined Paper Bag 5 kg, 10 kg, 20 kg, 25 kg PE-lined kraft paper bag (moisture-proof)
Plastic Drum 10 kg, 25 kg HDPE / Polypropylene (moisture-proof)
Fiber Drum 20 kg, 25 kg PE-lined fiberboard drum
FIBC / Big Bag 500 kg, 1000 kg PE-lined, moisture-resistant PP woven bag

SECTION 17: TRANSPORT INFORMATION

Parameter Information
UN Number Not regulated (non-hazardous)
Hazard Class Not applicable
Packing Group Not applicable
ADR/RID Not regulated
IMDG Code Not regulated (non-hazardous)
IATA (Air) Not regulated (non-hazardous)
Marine Pollutant No
Transport Temperature Ambient temperature; Protect from moisture and heat.

SECTION 18: REGULATORY STATUS

Region / Authority Status
European Union Approved for food and pharmaceutical use; REACH registered; Food additive E650 (flavor enhancer).
USA (TSCA) Listed (TSCA Inventory)
USA (FDA) GRAS (Generally Recognized as Safe) ; 21 CFR 175.105; 21 CFR 310.545; 21 CFR 582.8; Approved for food contact and pharmaceutical use.
Turkey Approved for food, pharmaceutical, and industrial use; Ministry of Agriculture and Health approvals required; KKDIK regulation compliance required.
EFSA Approved as food additive; Safe for use.
JECFA Approved; Specifications included.
IARC Not classified (non-carcinogenic)
NTP Not listed
OSHA Regulated as nuisance dust/irritant
California (Prop 65) Not listed
Halal Yes (with certification)
Kosher Yes (with certification)
Vegan Yes (synthetic, no animal ingredients)

SECTION 19: OTHER NAMES AND SYNONYMS

Type Name
Turkish Names Çinko Asetat, Çinko Diasetat, Asetik Asit Çinko Tuzu
English Names Zinc Acetate, Zinc Diacetate, Acetic Acid Zinc Salt, Zinc(II) Acetate, Dicarbomethoxyzinc
CAS Number 557-34-6
EC Number 209-170-2
HS Code 2915.29

SECTION 20: SUMMARY TABLE

Parameter Value
Product Zinc Acetate (Zinc Diacetate)
CAS Number 557-34-6
Molecular Formula Zn(CH₃COO)₂ (Anhydrous); Zn(CH₃COO)₂·2H₂O (Dihydrate)
Molecular Weight 183.48 g/mol (Anhydrous); 219.51 g/mol (Dihydrate)
Appearance White crystalline powder
Density (25°C) ~1.84 g/cm³
Melting Point 83-86°C (Dihydrate)
Solubility in Water Soluble
Zinc Content ~35.6% (Anhydrous); ~29.8% (Dihydrate)
Primary Functions Zinc supplement, antimicrobial, catalyst, food additive
Main Application Areas Pharmaceutical, dietary supplements, food (E650), cosmetics, textiles, chemicals, animal nutrition
Shelf Life 24 – 36 months
GHS Signal Word WARNING
UN Number Not regulated
Special Properties Bioavailable zinc source; Hygroscopic; GRAS; FDA approved; Food additive E650; Antimicrobial properties; Vegan; Halal.

SECTION 21: CRITICAL WARNINGS AND BEST PRACTICES

CRITICAL WARNINGS:

  • GRAS Status: FDA GRAS; EFSA approved; Safe for food, pharmaceutical, and cosmetic use.

  • Zinc Source: Provides bioavailable zinc for nutritional and pharmaceutical applications.

  • Hygroscopic: Absorbs moisture from air; Store in tightly closed containers.

  • Skin and Eye Irritant: Causes skin and eye irritation (H315, H319); Use appropriate PPE.

  • Non-Flammable: Stable and non-combustible.

  • Wilson's Disease: Used as maintenance therapy for Wilson's disease (copper chelation).

  • Food Additive: E650 approved as a flavor enhancer.

  • Dosage: Recommended daily intake: 10-50 mg/day (as elemental zinc); Medical supervision recommended for therapeutic use.

  • Excessive Intake: High doses may cause gastrointestinal irritation; Follow recommended dosage.

BEST PRACTICE RECOMMENDATIONS:

  • Pharmaceutical: Use as zinc supplement and Wilson's disease treatment; Dosage: 25-150 mg/day (as elemental zinc); Oral capsules, tablets, lozenges; Pharmaceutical grade required; Follow USP/EP specifications.

  • Dietary Supplements: Use as zinc source; Dosage: 10-50 mg/day (as elemental zinc); Multivitamin/mineral formulations; Zinc-only supplements; Food-grade material required.

  • Food Industry (E650): Use as flavor enhancer; Dosage: As per regulatory limits; Follow food additive regulations; Use food-grade material.

  • Cosmetics: Use as antimicrobial and astringent; Dosage: 0.1-2%; Mouthwashes, toothpaste, throat lozenges; Topical creams.

  • Textile: Use as dyeing aid and mordant; Dosage: 1-5% of dye bath; Limited use; Test compatibility.

  • Chemical Industry: Use as catalyst and reagent; Polymer synthesis; Esterification reactions; Laboratory applications; Follow safety protocols.

  • Handling: Use in well-ventilated areas; Avoid dust formation; Use dust masks when handling powder; Use gloves and safety goggles; Avoid contact with eyes and skin.

  • Personal Protective Equipment: Dust mask (N95/FFP2) if dust is generated, safety goggles, chemical-resistant gloves, protective clothing.

  • Hygiene: Wash hands thoroughly after handling; Do not eat, drink, or smoke while using; Remove contaminated clothing and wash before reuse.

  • Storage: Store in tightly closed, moisture-proof containers; Store in cool, dry, well-ventilated area; Protect from moisture and heat; Opened containers must be resealed immediately; Shelf life: 24-36 months under proper conditions.

  • Spill Management: Sweep or vacuum (HEPA) and place in suitable sealed container; Avoid dust formation; Do not allow entry into drains or waterways.

  • Disposal: Dispose of in accordance with local, regional, and national regulations; Non-hazardous waste; Can be incinerated in compliance with regulations.

DETECTION METHODS:

Method Description Advantages Disadvantages
AAS / ICP Zinc determination High sensitivity, accurate, specific High cost, requires expertise
Titrimetric (Complexometric) EDTA titration Simple, accurate, standard method Requires indicator
Titrimetric (Acid-Base) Neutralization with standard base Simple Not specific for zinc
FTIR Functional group identification Fast, non-destructive Requires reference spectra
Gravimetric Zinc determination by precipitation Standard method Time-consuming
pH Meter pH of solution Simple, rapid Indicative only

ZINC ACETATE vs ALTERNATIVES COMPARISON:

Product Chemical Name / E Code Application Strength Weakness Status
Zinc Acetate (E650) Zn(CH₃COO)₂ Pharmaceutical, food, supplements Bioavailable, GRAS, antimicrobial Moderate zinc content Widely approved
Zinc Sulfate ZnSO₄ Fertilizer, medicine High zinc content, cheap Bitter taste, GI irritation Widely approved
Zinc Oxide ZnO Rubber, ceramics, sunscreen Very high zinc content Insoluble Widely approved
Zinc Gluconate ZnC₁₂H₂₂O₁₄ Supplements, lozenges Well-tolerated, good taste Low zinc content, expensive Widely approved
Zinc Citrate Zn₃(C₆H₅O₇)₂ Supplements, toothpaste Good zinc source, good taste Moderate zinc content Widely approved
Zinc Chloride ZnCl₂ Flux, disinfectant Soluble, high zinc content Corrosive Widely approved

LEGAL DISCLAIMER:
The information provided in this document is based on our current knowledge and experience and is presented in good faith. However, as all conditions of use are beyond our control, it does not constitute a binding specification or warranty. This Technical Data Sheet is for informational purposes only. Users are responsible for testing the suitability for their own applications and for complying with all local, regional, and national regulations. For complete safety, storage, use, handling, waste, and regulatory compliance information, please refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier.

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