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Send EmailPetroleum Jelly White, 8009-03-8
CAS: 8009-03-8
Molecular Formula: C15H15N
8009-03-8 - Names and Identifiers
8009-03-8 - Physico-chemical Properties
| Molecular Formula | C15H15N |
| Molar Mass | 209.2863 |
| Density | 0.84 |
| Melting Point | 70-80°C ((ASTM D 127)) |
| Boling Point | 322 °C |
| Flash Point | 198 °C |
| Water Solubility | Insoluble in water |
| Solubility | Practically insoluble in acetone, ethanol, hot or coldethanol (95%), glycerin, and water; soluble in benzene, carbondisulfide, chloroform, ether, hexane, and most fixed and volatileoils. |
| Appearance | Paste |
| Specific Gravity | 0.815～0.880 (60℃) |
| Color | white |
| Odor | Odorless |
| PH | pH (25℃) : 4.5～8.0 |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | n20/D 1.45 |
| MDL | MFCD00147839 .. |
| Physical and Chemical Properties | White to yellow or light amber semisolid grease. Thin layer when transparent, micro-fluorescent. Insoluble in water, practically insoluble in cold or hot ethanol and cold anhydrous ethanol. Soluble in ether, hexane and most volatile or non-volatile oil; Soluble in benzene, carbon disulfide, chloroform and turpentine. |
| Use | Raw materials for ointments and raw materials for cosmetics |
8009-03-8 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 45 - May cause cancer |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. |
| WGK Germany | 3 |
| RTECS | RV0350000 |
| HS Code | 27121000 |
8009-03-8 - Standard
A semisolid mixture of decolorized hydrocarbons obtained from petroleum by this line.
8009-03-8 - Trait
- This product is a white to yellowish uniform soft-like material; Odorless or almost odorless; It has a smooth feeling in contact with the skin; It has drawability.
- This product is slightly soluble in ether, and almost insoluble in ethanol or water.
relative density
The relative density of this product (General 0601) is 0. 815 to 0. 880 at 60°C.
melting point
The melting point of this product (General 0612) is 45~60°C.
Last Update：2022-01-01 11:21:52
8009-03-8 - Introduction
Insoluble in water, actually insoluble in glycerin, soluble in benzene, chloroform, ether, petroleum ether, carbon disulfide and oil.
Last Update：2022-10-16 17:29:02
8009-03-8 - Differential diagnosis
- take 2.0g of this product, melt, add 2 m l of water and 0. 05mol/L of iodine solution 0 .2 m l, shake, cool, the upper layer should be purple-pink or brown.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (membrane method) (General rule 0402).
8009-03-8 - Exam
cone penetration
take an appropriate amount of this product, melt at 85°C ± 2°C, according to the cone penetration method (General 0983), the cone should be 130 to 230 units.
pH
take this product 35. O g, put it in a 250ml beaker, add 100ml of water, heat it to slight boiling, stir it for 5 minutes, let it stand and let it cool, separate the water layer, add 1 drop of phenolphthalein indicator solution, which should be colorless; Add 0.10 of methyl orange indicator solution, no pink color.
Color
take this product lO .O g, put in the beaker, heat on the water bath to melt, move to the colorimetric tube, and the same volume of the control liquid (take the colorimetric copper sulfate liquid 0 .2M l and colorimetric potassium dichromate solution 7. 8 m l, mix well, take the mixture 2. 5ml, add water to 25ml) comparison, not deeper.
absorbance of impurities
take this product, add trimethylpentane to make a solution containing 0.50mg per lm l, according to UV-visible spectrophotometry (General rule 0401), at the wavelength of 290nm, absorbance should not exceed 0.50.
sulfide
take this product 3. 0G, inspection according to law (General 0803), should meet the requirements (0. 000 17%).
organic acids
take 20.0g of this product, add 1 0 0 M l of neutral dilute ethanol (neutral to phenolphthalein), stir and heat to boiling, add phenolphthalein indicator liquid lm l and sodium hydroxide titration liquid (0. Im o l/L )0 .40 m l, strong stirring, should be red.
Foreign organic matter and ignition residue
take 2.0g of this product, put 5501C into a crucible with constant weight, and heat with straight fire. There should be no smell and smell, lmgCO.05%).
fixed oils, fats, and rosin
Take 10g of this product, add 50ml of 5m o l/L sodium hydroxide solution, place it in a water bath for 30 minutes, separate the water layer, and use 2 .5M o l/L sulfuric acid solution acidification, no oil or solid material.
Heavy metals
take this product l .O g, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 30 parts per million.
arsenic salt
take this product l .O g, Add 10ml of a solution of magnesium nitrate hexahydrate in ethanol (1 - 50) and hydrogen peroxide (30%)1. 5ml, burning to charring, cooling, if not completely ash, then add a certain amount of nitric acid and then charring, 550 deg C to Ash completely. Inspection according to law (General Principles 0822 first law), shall comply with the provisions (0.0002%).
polycyclic aromatic hydrocarbons
take this product l .O g, in a separatory funnel, add 50ml of n-hexane to dissolve, and add 10ml of dimethyl sulfoxide to shake, until layers are separated, add the lower layer to another separatory funnel, add 20ml of dimethyl sulfoxide and 20ml of n-hexane, shake for 1 min. After stratification, take the lower liquid, put it in a 50ml measuring flask, dilute it to the scale with dimethyl sulfoxide, shake well, and use it as a test solution. Take 10ml of dimethyl sulfoxide and 25ml of n-hexane, shake, layer, take the lower liquid as blank solution. In addition, take appropriate amount of naphthalene and use blank solution to make a solution containing 6mg per l lm as a control solution, according to UV-Vis spectrophotometry (General rule 0401), the absorbance of the test solution was measured in the range of 260 ~ 420nm, and the maximum value should not exceed the absorbance value of the control solution at the wavelength of 278mn.
8009-03-8 - Category
pharmaceutical excipients, ointment base and lubricant.
8009-03-8 - Storage
sealed and protected from light.
8009-03-8 - Reference Information
| Overview | Vaseline is an important pharmaceutical, lubricants for daily chemical, fine chemical raw materials and precision instruments. China's Vaseline products are mainly ordinary Vaseline, industrial Vaseline and medical Vaseline. Ordinary Vaseline is suitable for the preparation of all kinds of ointment and make dark rubber softening agent; Industrial Vaseline can be used for metal products and general mechanical parts of the rust, light load mechanical lubrication, leather impregnating agent, rubber softening agent. China's Vaseline products are mainly concentrated in the medical Vaseline, divided into two kinds of medicine White Vaseline and medicine yellow Vaseline. Medical Vaseline is mainly used for the preparation of ointment, skin protection cream and cosmetics raw materials, can also be used as medical equipment, precision equipment rust lubricant material. |
| Performance | white or yellowish homogeneous paste, almost odorless and tasteless, is a mixture of liquid and solid paraffin hydrocarbons. The relative density is 0.815~0.830, the viscosity is 0.01~0.02 · s (100 ℃), the flash point is greater than 190 ℃ (open), and the dropping point is about 37~54 ℃. Soluble in ether, petroleum ether, a variety of fatty oils, benzene, carbon disulfide, chloroform and turpentine, difficult to dissolve in ethanol, almost insoluble in water. It is heated to form a transparent liquid, which can fluoresce in the dark after ultraviolet irradiation. |
| Use | because Vaseline has the characteristics of colorless, odorless, chemically inert, semi-solid, lipophilic and good adhesion, it is suitable for the manufacture of hair care cream, hair conditioner, eye shadow cream, lipstick, hair wax and other substrates. Medicinal petrolatum, which can be combined with almost all drugs without changing the drug, can be used as the base of ointment and is widely used. The hydrophilic petrolatum can be prepared by adding an alcohol such as decaptanol, decapotyl alcohol, cholesterol, etc. to the petrolatum, melting at a high temperature and stirring sufficiently. The hydrophilic Petrolatum is a highly permeable and stable ointment base with little irritation. The ointment base can be used alone for dry rash, erythema, papules and other symptoms, especially for the removal of blood scab, desquamation. Vaseline can also be used as an emulsifier with cholesterol compatibility, with non-ionic, so the scope of compatibility is very wide. In addition, because of its Absorbability, it can be compatible with a liquid drug or an aqueous solution of the drug. Industrial Vaseline, used for rubber softening agent, metal device rust, rust preventive grease raw materials. |
| method | 1. Acid-clay method acid-clay method is a traditional production method of Vaseline, is still in use at home and abroad. In this process, sulfuric acid with a concentration of more than 98% is added to about 60% of the raw material in a reaction kettle and the raw materials are mixed, the reaction temperature is maintained at 70 ℃, and the acid residue is separated after the reaction, the acid residue was further removed by dilution with alcohol. The acid-treated oil was decolorized by adding clay to another clay refining tank at about 140 ° C., and then the product was filtered. Acid-clay method is characterized by good quality products can be prepared, the amount of polycyclic aromatic hydrocarbons can reach the level of pharmaceutical grade, other relevant indicators can also meet the Pharmacopoeia quality indicators, this is the reason why this conventional process can persist for a long time. The main disadvantage of refining Vaseline by acid-clay method is that the yield of the target product is too low (about 50%) and a large amount of acid residue is produced, which is difficult to use, seriously polluting the environment and the production cost is very high. Aluminum trichloride method in China, aluminum trichloride method was used to replace acid-clay method to produce Vaseline in 60 s. The process is as follows: after the raw material is dehydrated, it reacts with aluminum trichloride in the reaction kettle, and the reaction temperature is 130 to 140. After the reaction, the oil is further neutralized and precipitated with an alkali solution in the neutralization tank. After slag removal, the oil is purified by Clay adsorption in The decolorizing tank at a reaction temperature of about 120 ° C., and the purified oil by filtration is commercial Vaseline. The yield of Vaseline prepared by aluminum trichloride method is higher than that of acid-clay method, and the consumption index is decreased, but the quality is slightly worse than that of Vaseline prepared by acid-clay method; compared with the quality level of Vaseline prepared by aluminum trichloride method and high pressure hydrogenation, there is a big gap in color, transparency and polycyclic aromatic hydrocarbon content. The hydrogenation of petrolatum is a new process for the production of petrolatum, which is generally carried out at 10, 20 or 30MPa and low liquid hourly space velocity. In this process, unwanted components in the raw material are converted into effective components after reaction, so that a product yield close to 100% can be obtained. However, the aluminum trichloride method or the acid-clay law turns the useless component into the waste residue, removes the effective component from the slag, and reduces the product yield. Due to the product yield, the refining depth of the aluminum chloride method or the acid-clay method is also limited, which limits the further improvement of the product quality. Therefore, the hydrogenation method for producing Vaseline is superior to the acid-clay method and the aluminum trichloride method in terms of product yield or quality. (2015-12-28) |
| identification test | solubility insoluble in water, soluble in carbon dioxide, soluble in ether and hexane (OT-42). |
| toxicity | can be used safely in foods (FDA,§ 172.880,2000). ADI is not specified (FAO/WHO,2001). |
| usage limit | Baked Goods 0.15%; Candy 0.2%; Dehydrated fruits and vegetables 0.02%; Solid protein 0.1%(FDA,§ 172.880,2000). |
| Use | Defoamer; Lubricant; Release agent; Protective coating. used in medicine, can also be used for sealing and lubrication, also used in skin care cream, wax hair cream, lipstick and other cosmetic products used for mechanical equipment, metal articles and parts of anti-corrosion, can also be used as grease in the mechanical wear-reducing parts where the temperature is not high and the load is not high raw materials for ointment and cosmetics raw materials suitable for the preparation of medical ointment and skin protection ointment it is suitable for use as an excipient for the preparation of pharmaceutical ointment and skin protection ointment, and can be used for precision instruments and medical equipment and other high-grade products of anti-corrosion, can also be used for high-grade cosmetics and other daily necessities of ingredients. |
| production method | Semi-solid mixture of petroleum residual oil refined with sulfuric acid and clay. |
