Isopropylamine, 2-Propanamine, Monoisopropylamine, IPA, MIPA, 75-31-0

📌 Isopropylamine 

1. Identity

• Chemical Name: Isopropylamine

• CAS Number: 75-31-0

• Molecular Formula: C3H9N

• Molecular Weight: 59.11 g/mol

• Synonyms: 2-Propanamine, Monoisopropylamine

2. Physical & Chemical Properties

• Appearance: Colorless liquid

• Odor: Strong ammoniacal, pungent, irritating

• Density: ~0.688 g/cm³ (20 °C)

• Boiling Point: 32–35 °C

• Melting Point: ~-101 °C

• pKa: ~10.6 (at 25 °C)

• Solubility: Miscible with water, ethanol, ether; dissolves in acetone, hydrocarbons, mineral oils

• Flash Point: −26 °F

• Vapor Pressure: ~9.2 psi (20 °C)

• Explosive Limits: 2–10.4% (v/v in air)

3. Functional Characteristics

• Primary Amine: Highly reactive, used in synthesis of intermediates

• Neutralizing Agent: Effective for acid neutralization in formulations

• Volatile & Water-Miscible: Facilitates blending in agrochemical and industrial products

4. Applications

• Agrochemicals:

  • Herbicide salts (e.g., glyphosate isopropylamine salt)

  • Pesticide intermediates

• Pharmaceuticals:

  • Intermediate in drug synthesis

• Industrial Uses:

  • Corrosion inhibitors

  • Rubber chemicals

  • Surfactants and emulsifiers

  • Solvent and catalyst in organic synthesis

5. Safety & Regulation

• Strongly irritating to eyes, skin, and respiratory tract

• TLV-TWA exposure limit: 5 ppm

• Requires PPE (gloves, goggles, respirator in high concentrations)

• Storage: Cool, ventilated area, away from heat sources

📌 Isopropylamine – Sectoral Compatibility & Alternatives

1. Identity

• Chemical Name: Isopropylamine

• CAS Number: 75-31-0

• Molecular Formula: C3H9N

• Molecular Weight: 59.11 g/mol

• Synonyms:

  • 2-Propanamine

  • Monoisopropylamine

  • Propan-2-amine

  • IPA (commercial abbreviation, note: also used for isopropyl alcohol)

  • NSC 7524

2. Sectoral Compatibility

3. Alternatives

🔹 Similar Primary Amines

• Methylamine (CH3NH2) → Smaller, highly reactive, used in pharma and pesticides.

• Ethylamine (C2H5NH2) → Applied in pesticide and pharmaceutical synthesis.

• n-Propylamine (C3H9N, straight chain) → Alternative to isopropylamine, but with different physical properties.

🔹 Functional Alternatives

• Dimethylamine (DMA) → Neutralizing agent in glyphosate and herbicide salts.

• Ethanolamine → Used in pesticide formulations and detergents.

• Diisopropylamine (DIPA) → Base and catalyst in organic synthesis.

• Triethylamine (TEA) → Common solvent and catalyst, inexpensive.

4. Advantages / Disadvantages Comparison

🎯 Summary

• Isopropylamine (75-31-0) is indispensable in agrochemicals, especially glyphosate salt production.

• In pharmaceuticals and industry, it serves as an optional intermediate or solvent.

• Alternatives include methylamine, ethylamine, n-propylamine, dimethylamine, ethanolamine, diisopropylamine, and triethylamine.

• Critical Note: For glyphosate salt production, isopropylamine is irreplaceable; alternatives lead to performance loss or different toxicity profiles.

📌 Isopropylamine

1. Main Abbreviations

• IPA → Isopropylamine ⚠️ Note: IPA is also widely used for Isopropyl Alcohol, so context is important.

• MIPA → Monoisopropylamine (alternative name, same product).

• 2-PA → 2-Propanamine (derived from IUPAC systematic name).

2. Registry Codes

• NSC 7524 → U.S. National Cancer Institute chemical code.

• EC Number: 200-860-9

• CAS Number: 75-31-0

🎯 Summary

• The most common English abbreviations are IPA, MIPA, 2-PA, NSC 7524.

• CAS 75-31-0 is the unique identifier for Isopropylamine.

• Always clarify “IPA” in documents, since it can mean Isopropyl Alcohol or Isopropylamine.