Alpha Lipoic Acid, DL-Thioctic Acid, Dithiooctanoic Acid, ALA, 1077-28-7

Alpha Lipoic Acid, DL-Thioctic Acid, Dithiooctanoic Acid, ALA, 1077-28-7

ALPHA LIPOIC ACID (ALA)

SECTION 1: PRODUCT IDENTITY AND CHEMICAL IDENTIFICATION

SECTION 2: CHEMICAL STRUCTURE

         O
         ‖
    HO—C—CH₂—CH₂—CH₂—CH—CH₂
                       |     \
                       S     S
                       |     |
                       CH₂—CH₂

    Alpha Lipoic Acid
    (±)-1,2-Dithiolane-3-pentanoic acid
    C₈H₁₄O₂S₂

Simplified Structure:

    HOOC—(CH₂)₄—C—CH₂—CH₂
                   \     /
                    S   S
                     \ /
                      C

    Alpha Lipoic Acid
    (Dihydrolipoic acid form: HOOC—(CH₂)₄—CH—SH
                                     |
                                    CH₂
                                     |
                                    CH₂
                                     |
                                    SH )

SECTION 3: PHYSICAL AND CHEMICAL PROPERTIES

SECTION 4: R AND S ENANTIOMERS COMPARISON

SECTION 5: BIOLOGICAL FUNCTION AND MECHANISM OF ACTION

SECTION 6: COMMERCIAL GRADES AND VARIANTS

SECTION 7: PHARMACOKINETIC PROPERTIES

SECTION 8: CLINICAL USE AND INDICATIONS

SECTION 9: QUALITY SPECIFICATIONS

SECTION 10: SAFETY PROFILE AND TOXICOLOGICAL ASSESSMENT

SECTION 11: GHS CLASSIFICATION AND LABELING

GHS Classification (in accordance with 1272/2008/EC):

Signal Word: Warning

Hazard Pictograms: GHS07 (Exclamation mark), GHS09 (Environment)

NFPA 704 Hazard Classification:

SECTION 12: PRECAUTIONARY STATEMENTS (P-CODES)

SECTION 13: FIRST AID MEASURES

SECTION 14: FIREFIGHTING MEASURES

SECTION 15: STORAGE AND SHELF LIFE

SECTION 16: PACKAGING OPTIONS

SECTION 17: TRANSPORTATION INFORMATION

SECTION 18: REGULATORY STATUS

SECTION 19: OTHER NAMES AND SYNONYMS

SECTION 20: SUMMARY TABLE

SECTION 21: CRITICAL WARNINGS AND BEST PRACTICES

CRITICAL WARNINGS:

1. Light Sensitivity: Alpha Lipoic Acid is light sensitive. Store in light-proof containers (amber glass, aluminum, HDPE).

2. Temperature Sensitivity: Melting point is 60-62°C. Melts and may degrade above 60°C.

3. Oxidation Sensitivity: Sensitive to oxygen; oxidizes from yellow to dark yellow. Antioxidant addition recommended.

4. Skin Sensitization: May cause allergic skin reactions (H317). Avoid skin contact.

5. Environmental Toxicity: Toxic to aquatic life with long-lasting effects (H411). Avoid release to the environment.

6. Drug Interactions: Potential interaction with chemotherapeutics (cisplatin, carboplatin), thyroid hormones (levothyroxine), and antidiabetic drugs.

7. High Doses: High doses (≥1800 mg/day) may cause gastrointestinal discomfort, nausea, headache.

8. Dust Explosion: Dust explosion risk; avoid dust formation and ensure adequate ventilation.

BEST PRACTICE RECOMMENDATIONS:

1. Form Selection: Use R-α-lipoic acid (pure, natural form) for applications requiring high biological activity; DL-α-lipoic acid (racemic) for common use and economical products.

2. Concentration (Cosmetic): Typical concentration 0.5-5%; Optimum concentration 1-2%; Up to 5% considered safe.

3. Formulation (Cosmetic): Dissolve in water phase or oil phase; dissolve at 40-50°C; avoid high temperatures (>60°C); stabilize at pH 4.0-6.0.

4. Antioxidant Use: Add Vitamin E (0.1-0.5%) or BHT (0.01-0.1%) to formulations; prevents oxidation and color change.

5. Chelator Use: Add EDTA (0.05-0.1%) to bind metal ions; improves stability.

6. Dosage (Oral): Diabetic neuropathy: 600-1800 mg/day; antioxidant support: 300-600 mg/day; take with meals (GI tolerance).

7. Light Protection: Use amber glass, aluminum or opaque HDPE containers; protect with UV filters.

8. Personal Protective Equipment: Nitrile or neoprene gloves (minimum 0.11 mm thickness), safety goggles, dust mask (P2 type), protective clothing.

9. Hygiene: Wash hands thoroughly after handling; Do not eat, drink or smoke when using this product.

10. Storage: Store in cool, dry, light-proof containers; Inert atmosphere (nitrogen) recommended to prevent oxidation; Shelf life 24-36 months.

LEGAL DISCLAIMER:

The information provided in this document is based on our current knowledge and experience and is presented in good faith. However, as all conditions of use are beyond our control, it does not constitute a binding specification or guarantee. This Technical Data Sheet is for informational purposes only and does not constitute medical advice. Users are responsible for testing suitability for their own applications and for complying with all local, regional, and national regulations. For complete safety, storage, use, handling, waste, and regulatory compliance information, please refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. Alpha Lipoic Acid is a dietary supplement/cosmetic ingredient; its medical use should be under the supervision of a healthcare professional.