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Send EmailSalcaprozate Sodium, SNAC, 203787-91-1
Technical Specifications
| Property | Description |
|---|---|
| Chemical Name | Salcaprozate Sodium |
| CAS Number | 203787-91-1 |
| Molecular Formula | C₁₅H₂₀NNaO₄ |
| Molecular Weight | 303.33 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 183–185 °C |
| Solubility | ~33 mg/mL in water; slightly soluble in DMSO and methanol |
| Stability | Hygroscopic; store in sealed containers |
| Storage Conditions | Room temperature, dry and airtight |
Applications
SNAC is primarily used as an oral absorption enhancer for drugs that are poorly absorbed through the gastrointestinal tract:
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Peptide and protein-based drugs (e.g., insulin, heparin, vitamin B12)
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GLP-1 agonists like oral semaglutide for type 2 diabetes
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Pharmaceutical formulations as an excipient
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Medical foods (recognized as GRAS by the FDA)
✅ Suitability Table
| Use Case | Formulation Type | Suitability |
|---|---|---|
| Oral peptide delivery | Tablet / capsule | ✅ High |
| Injection alternative | Oral formulation | ✅ High |
| Vitamin B12 enhancement | Oral solution/tablet | ✅ Moderate |
| Medical food additive | Powder / liquid | ✅ Safe |
| General excipient use | Pharmaceutical base | ✅ Industrial |
Synonyms and Alternate Names
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SNAC (abbreviation)
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Salcaprozate Sodium
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Sodium 8-(2-hydroxybenzamido)octanoate
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Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt
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Sometimes referenced under excipient codes or internal formulation IDs
Usage Recommendations
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Dosage: Depends on the active ingredient; typically used in milligram quantities
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Formulation: Incorporated into tablets or capsules alongside the active drug
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Combination: May be paired with protease inhibitors to enhance effect
Precautions
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High doses (e.g., 2000 mg/kg/day) in animal studies showed some adverse effects, though not conclusively linked to SNAC
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Hygroscopic nature: Must be protected from moisture
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Gastrointestinal sensitivity: Rare cases of mild stomach discomfort or electrolyte imbalance
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Drug interactions: Should be evaluated when used with other permeation enhancers
SNAC is a transformative excipient in pharmaceutical science, enabling oral delivery of biologics that were previously injectable-only.
