Calcium Pyruvate, Calcium 2-oxopropanoate, 52009-14-0

Calcium Pyruvate, Calcium 2-oxopropanoate, 52009-14-0

(CAS No. 52009-14-0)

A) Physical and Chemical Properties

• Chemical Name: Calcium 2-oxopropanoate

• Molecular Formula: C₆H₆CaO₆

• Molecular Weight: 214.19 g/mol

• Appearance: White crystalline powder

• Melting Point: >245 °C (decomposes)

• Solubility: Sparingly soluble in water (better when heated)

• LogP: -1.24

• Storage: Room temperature, dry, inert atmosphere

• pH (1% solution): ~6.5–7.5

B) Detailed Applications

• Dietary Supplement: Supports fat metabolism, energy production, and weight management

• Sports Nutrition: Enhances endurance and athletic performance

• Pharmaceuticals: Investigated for antioxidant and cardioprotective effects

• Food Additive: Found naturally in fermented foods; used for flavor enhancement

• Cosmetics: Used in anti-aging and skin-repair formulations

• Veterinary & Feed: Improves gut health and immunity in livestock

C) Synonyms

• Calcium bis(2-oxopropanoate)

• Pyruvic acid calcium salt

• Propanoic acid, 2-oxo-, calcium salt

• Calcium pyruvate anhydrous

• Kalziumpyruvat (German)

• Kalcium pyruvat (Swedish)

D) Production Method

1. Neutralization of Pyruvic Acid with Calcium Hydroxide:

2CH3COCOOH+Ca(OH)2→(CH3COCOO)2Ca+2H2O2CH₃COCOOH + Ca(OH)₂ → (CH₃COCOO)₂Ca + 2H₂O

2. Crystallization → Filtration → Vacuum drying

3. L-pyruvic acid may be sourced via microbial fermentation for higher bioavailability

E) Alternative Products

• Sodium Pyruvate – Common in cell culture

• Calcium Lactate – Cheaper calcium source, lacks pyruvate benefits

• Calcium Citrate – High bioavailability, no metabolic role

• Calcium Gluconate – Used in food and pharma

• Calcium Malate – Preferred for bone health

F) Common Names

• Energy Salt

• Fat-Burning Calcium

• Calcium Pyruvate Supplement

• Athlete’s Calcium

G) Reactions

• Acidic Conditions: Converts to pyruvic acid

• Reduction: Forms lactic acid

• Oxidative Decarboxylation: Converts to acetyl-CoA for TCA cycle

• Antioxidant Action: Scavenges ROS

• CO₂ Release: Converts to acetate under mild oxidation