Potassium Pyruvate, Potassium Oxopropanoate, Kalium Oxopropanoat, 4151-33-1

Potassium Pyruvate, Potassium Oxopropanoate, Kalium Oxopropanoat, 4151-33-1

(CAS No. 4151-33-1)

A) Physical and Chemical Properties

• Chemical Name: Potassium 2-oxopropanoate

• Molecular Formula: C₃H₃KO₃

• Molecular Weight: 126.15 g/mol

• Appearance: White to off-white crystalline powder

• Melting Point: >175 °C (decomposes)

• Solubility: Slightly soluble in water and methanol

• Stability: Hygroscopic; store under inert atmosphere

• LogP: ~ -1.24

• Storage: Room temperature, dry, sealed container

B) Detailed Applications

• Cell Culture: Energy source to enhance cell viability

• Antioxidant: Scavenges ROS, protects against oxidative stress

• Pharmaceuticals: Investigated for neuroprotective and metabolic support

• Cosmetics: Used in UV-protective and anti-aging formulations

• Nutritional Supplements: Supports energy metabolism and endurance

• Biochemical Research: Substrate in glycolysis and TCA cycle studies

C) Synonyms

• Potassium 2-oxopropanoate

• Pyruvic Acid Potassium Salt

• Propanoic acid, 2-oxo-, potassium salt

• Kalium-2-oxopropanoat (German)

• Potassiumpyruvate

• Potassium pyruvate (1:1)

D) Production Method

1. Neutralization of Pyruvic Acid with Potassium Hydroxide:

CH3COCOOH+KOH→CH3COCOOK+H2OCH₃COCOOH + KOH → CH₃COCOOK + H₂O

2. Crystallization and vacuum drying

3. Pyruvic acid may be sourced from microbial fermentation

E) Alternative Products

• Sodium Pyruvate: Common but lacks potassium supplementation

• Calcium Pyruvate: Used in sports nutrition

• Lactic Acid Derivatives: Alternative carbon sources

• Acetic Acid Derivatives: Simpler acids with limited bioactivity

F) Common Names

• Potassium Salt of Pyruvate

• Energy Salt (in supplements)

• Muscle Support Salt (marketing term)

G) Reactions

• Acidic Conditions: Converts back to pyruvic acid

• Reduction: Forms lactic acid

• Transamination: Precursor to alanine

• Oxidative Decarboxylation: Forms acetyl-CoA for TCA cycle

• UV Protection: Acts as a radical scavenger in skincare