Sodium Pyruvate, Natrium Pyruvat, Sodium Oxopropanoate, Sodium Ketopropionate, 113-24-6

Sodium Pyruvate, Natrium Pyruvat, Sodium Oxopropanoate, Sodium Ketopropionate, 113-24-6

Sodium pyruvate (CAS No. 113-24-6) is the sodium salt of pyruvic acid, widely used in biological research, cell culture, and biochemical applications.

Chemical Identity

• IUPAC Name: Sodium 2-oxopropanoate

• Molecular Formula: C₃H₃NaO₃

• Molecular Weight: 110.04 g/mol

• Appearance: White to slightly yellow crystalline powder

• Melting Point: >300 °C

• Solubility: Highly soluble in water; very slightly soluble in ethanol

• pH (1% solution): ~7.0

• Storage: 2–8 °C, dry and sealed conditions

Applications

• Cell Culture: Supplemented in media as an energy source; supports ATP production

• Antioxidant Role: Scavenges reactive oxygen species (ROS), protecting cells from oxidative stress

• Metabolic Research: Intermediate in glycolysis, TCA cycle, and amino acid metabolism

• Microbial Growth: Used as a carbon source in bacterial and yeast cultures

• Pharmaceuticals: Investigated for neuroprotective and metabolic support roles

Safety & Handling

• Hazard Statements:

  • H317: May cause allergic skin reaction

  • H319: Causes serious eye irritation

• Precautions: Use gloves and eye protection; avoid inhalation of dust

• WGK (Germany): 1 (low hazard to water)

Sodium Pyruvate

Other Names: Sodium 2-oxopropanoate, Pyruvic acid sodium salt Chemical Formula: C₃H₃NaO₃ Molecular Weight: 110.04 g/mol Appearance: White to slightly yellow crystalline powder Solubility: Freely soluble in water; very slightly soluble in alcohol pH (1% aqueous): ~7.0 Storage: Store tightly sealed at 2–8 °C in a dry environment

Production Method

Sodium pyruvate is industrially synthesized by neutralizing pyruvic acid with sodium hydroxide:

CH3COCOOH+NaOH→CH3COCOONa+H2OCH_3COCOOH + NaOH \rightarrow CH_3COCOONa + H_2O

This process can involve intermediate steps starting from tartaric acid or via decarboxylation of oxaloacetate, followed by purification and crystallization. Final drying is typically done under vacuum.

Applications

• Cell Culture: Acts as a metabolic energy source and supports cell viability

• Antioxidant Action: Scavenges reactive oxygen species (e.g. H₂O₂), protecting cells from oxidative damage

• Pharmaceutical Research: Explored for neuroprotective properties, especially in ischemia or hypoxia models

• Biotech and Microbiology: Serves as a carbon source for microbial and yeast cultures

• Cosmetics: Used in formulations for anti-aging and skin-brightening effects

• Food Applications: Naturally found in fermented products; contributes to flavor

Reactions and Biochemical Roles

• Converts to lactic acid under anaerobic conditions

• Participates in transamination reactions forming alanine

• Enters the TCA cycle via acetyl-CoA after oxidative decarboxylation

• May transform back into pyruvic acid in acidic conditions

Possible Substitutes

Depending on the intended use:

• Lactic Acid – for acidification or energy roles in biological contexts

• Acetic Acid – simpler carbon donor but lacks antioxidant function

• D-Glucose – primary energy source in media, but doesn’t buffer oxidative stress

• Glutamine or Alanine – alternative metabolic energy/amino acid sources

• Calcium Pyruvate – sometimes used in food and supplement applications

Sodium Pyruvate (CAS No. 113-24-6) that you can include in your product listing or documentation:

• Pyruvic acid sodium salt

• Sodium 2-oxopropanoate

• 2-Oxopropanoic acid sodium salt

• α-Ketopropionic acid sodium salt

• Propanoic acid, 2-oxo-, sodium salt

• Natriumpyruvat (German)

• Natrium-2-oxopropanoat

• Sodium α-ketopropionate

• Sodium pyruvate-1-13C / -2-13C / -13C₃ (isotopically labeled forms)