Butylated Hydroxyanisole, Butyl Hydroxy Anisole, E320, BHA, 25013-16-5

Butylated Hydroxyanisole, Butyl Hydroxy Anisole, E320, BHA, 25013-16-5

BUTYLATED HYDROXYANISOLE (BHA - E320)

PRODUCT IDENTIFICATION INFORMATION

CHEMICAL STRUCTURE

BHA (Mixture of 2- and 3-tert-butyl-4-methoxyphenol)

Dominant Isomer (3-tert-butyl-4-hydroxyanisole - approximately 90%):

              OCH₃
                |
        OH      |
         |      |
    (CH₃)₃C—C₆H₃—C—H
                |
                H

Structure Description:

• Monohydric phenolic antioxidant.

• Mixture of 2-tert-butyl-4-methoxyphenol and 3-tert-butyl-4-methoxyphenol.

• Approximate isomer ratio: 90% 3-tert-butyl isomer and 10% 2-tert-butyl isomer.

• Exhibits free radical scavenging and stabilizing properties.

SECTION 1: CHEMICAL IDENTITY AND DESCRIPTION

SECTION 2: PHYSICAL AND CHEMICAL PROPERTIES

SECTION 3: BHA (E320) vs OTHER SYNTHETIC ANTIOXIDANTS

SECTION 4: MECHANISM OF ACTION

SECTION 5: PRODUCTION PROCESS

Method 1: tert-Butylation of p-Methoxyphenol

Reaction: p-Methoxyphenol + Isobutylene / tert-Butyl alcohol → BHA (2- and 3-isomer mixture)

Description: p-Methoxyphenol is reacted with isobutylene or tert-butyl alcohol in the presence of an acid catalyst (sulfuric acid or phosphoric acid); The reaction yields a mixture of 2-tert-butyl and 3-tert-butyl isomers (10:90 ratio); The product is purified by distillation and crystallization.

Method 2: Alkylation of Hydroquinone Methyl Ether

Process: Hydroquinone → Methylation → p-Methoxyphenol → Alkylation → BHA

Description: Hydroquinone methyl ether is alkylated with tert-butyl alcohol or isobutylene; Acid catalyst is used; Isomer mixture is obtained; Purification yields a white to pale yellow crystalline product.

SECTION 6: FUNCTIONAL PROPERTIES

SECTION 7: MAIN APPLICATION AREAS

SECTION 8: SAMPLE FORMULATIONS

Oil Antioxidant Blend:

Instructions: Dissolve BHA in oil with gentle heating (40-50°C); Add citric acid and/or BHT for synergistic effect; Protect from light and heat.

Cosmetic Cream (100 g):

Instructions: Dissolve BHA in oil phase; Emulsify with water phase; Cool with mixing.

SECTION 9: QUALITY SPECIFICATIONS

SECTION 10: TOXICOLOGICAL PROFILE

SECTION 11: GHS CLASSIFICATION AND LABELING

GHS Classification (in accordance with CLP and UN GHS):

Signal Word: WARNING

Hazard Pictograms: GHS07 (Exclamation Mark)

Hazard Statements (H-Codes):

NFPA 704 Hazard Classification:

SECTION 12: PRECAUTIONARY STATEMENTS (P-CODES)

SECTION 13: FIRST AID MEASURES

SECTION 14: FIREFIGHTING MEASURES

SECTION 15: STORAGE AND SHELF LIFE

SECTION 16: PACKAGING OPTIONS

SECTION 17: TRANSPORT INFORMATION

SECTION 18: REGULATORY STATUS

SECTION 19: OTHER NAMES AND SYNONYMS

SECTION 20: SUMMARY TABLE

SECTION 21: CRITICAL WARNINGS AND BEST PRACTICES

CRITICAL WARNINGS:

• CARCINOGENIC CONCERN: The U.S. National Institutes of Health (NIH/NTP) reports that BHA has carcinogenic findings in experimental animals and states that it may be a human carcinogen. Classified as IARC Group 2B (possibly carcinogenic to humans).

• Listed as a carcinogen on the California Prop 65 list.

• Causes skin irritation (H315) and serious eye irritation (H319). Wear protective equipment.

• May cause respiratory irritation (H335). Avoid inhalation of dust.

• Sensitive to light, heat, and oxidizing agents.

• Combustible – keep away from open flames and high heat.

• Use as a food additive is restricted or banned in the EU. Completely banned in some countries.

• Not recommended for use in children's foods.

• Caution for pregnant/nursing women.

• Exhibits synergistic effects with other antioxidants (BHT, ascorbic acid, citric acid).

BEST PRACTICE RECOMMENDATIONS:

• Food Industry (E320): Use as antioxidant in fats and oils; Edible oils, margarine, meat products, snack foods; Adjust usage levels according to national regulations (typically maximum 200 mg/kg fat) ; Dissolve in oil with gentle heating; Combine with BHT, ascorbic acid, or citric acid for synergistic effect.

• Cosmetics: Use as antioxidant; Creams, lotions, makeup products; Dosage 0.01-0.1%; Dissolve in oil phase; Extends shelf life; Prevents oxidation.

• Pharmaceutical: Use as stabilizer and antioxidant; Vitamin D3, isotretinoin, lovastatin, simvastatin containing drugs; Dosage 0.01-0.1%; Stabilizes active ingredients; Creams, gels, capsules, tablets.

• Animal Feed: Use as antioxidant; Dosage 50-150 mg/kg feed; Subject to regulatory control; Check regional regulations.

• Industrial: Use as stabilizer; Rubber, petroleum products, biodiesel; Dosage 0.1-0.5%; Improves fuel quality in biodiesel production.

• Handling: Use in well-ventilated areas; Avoid dust formation; Use dust masks (N95/FFP2) and protective equipment.

• Personal Protective Equipment: Dust mask (N95/FFP2 or higher), safety goggles, chemical-resistant gloves (nitrile, neoprene), protective clothing.

• Hygiene: Wash hands thoroughly after handling; Do not eat, drink, or smoke while using.

• Storage: Store in tightly closed, light-proof, moisture-proof containers; Store in a cool, dry, well-ventilated area; Protect from light, heat, and oxidizing agents; Shelf life: 24-48 months under proper conditions.

• Spill Management: Sweep or vacuum (HEPA) and place in suitable sealed container; Avoid dust formation; Do not allow entry into drains or waterways.

• Disposal: Dispose of in accordance with local, regional, and national regulations; Non-hazardous waste; Can be incinerated in compliance with regulations.

DETECTION METHODS:

BHA (E320) vs ALTERNATIVES COMPARISON:

LEGAL DISCLAIMER:
The information provided in this document is based on our current knowledge and experience and is presented in good faith. However, as all conditions of use are beyond our control, it does not constitute a binding specification or warranty. This Technical Data Sheet is for informational purposes only. Users are responsible for testing the suitability for their own applications and for complying with all local, regional, and national regulations. For complete safety, storage, use, handling, waste, and regulatory compliance information, please refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. Due to the carcinogenic risk, particular caution is advised regarding the use of BHA, and regulatory requirements should be closely monitored.